Professor Calum Semple OBE PhD FRCPCH FRCPE FFPH FHEA
Professor of Child Health and Outbreak Medicine, Consultant Respiratory Paediatrician at Alder Hey Children's Hospital Clinical Infection, Microbiology & Immunology
- About
- Research
- Publications
- Teaching
- Professional Activities
Publications
Selected Publications
- Adeno-associated virus 2 infection in children with non-A-E hepatitis. (Journal article - 2023)
- Genomic investigations of unexplained acute hepatitis in children. (Journal article - 2023)
- Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. (Journal article - 2021)
- Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. (Journal article - 2020)
- Ebola virus antibody decay-stimulation in a high proportion of survivors (Journal article - 2021)
- Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea (Journal article - 2016)
- Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults (Journal article - 2022)
- Genetic mechanisms of critical illness in COVID-19. (Journal article - 2021)
- Mapping the human genetic architecture of COVID-19 (Journal article - 2021)
- Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. (Journal article - 2020)
Filter the publication list
Filter list by type
- Show all
- Journal article
- Conference paper
- Chapter
- Other
2024
Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study. (Journal article)
Turtle, L., Elliot, S., Drake, T. M., Thorpe, M., Khoury, E. G., Greenhalf, W., . . . ISARIC4C Investigators. (2024). Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.. The Lancet. Oncology, S1470-2045(24)00107-4. doi:10.1016/s1470-2045(24)00107-4Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease. (Journal article)
Liew, F., Efstathiou, C., Fontanella, S., Richardson, M., Saunders, R., Swieboda, D., . . . ISARIC investigators. (2024). Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.. Nature immunology, 25(4), 607-621. doi:10.1038/s41590-024-01778-0Can self-testing be enhanced to hasten safe return of healthcare workers in pandemics? Random order, open label trial using two manufacturers’ SARS-CoV-2 lateral flow devices concurrently (Preprint)
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. (Journal article)
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 15(1), 2918. doi:10.1038/s41467-024-47320-6Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children". (Journal article)
Seylanova, N., Chernyavskaya, A., Degtyareva, N., Mursalova, A., Ajam, A., Xiao, L., . . . PC-COS Children Study Group. (2024). Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".. The European respiratory journal, 63(3), 2301761. doi:10.1183/13993003.01761-2023Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study. (Journal article)
Cho, S. -M., Premraj, L., Battaglini, D., Fanning, J. P., Suen, J., Bassi, G. L., . . . ISARIC Clinical Characterization Group. (2024). Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.. Brain communications, 6(2), fcae036. doi:10.1093/braincomms/fcae036A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies. (Journal article)
Costigan, D., Fenn, J., Yen, S., Ilott, N., Bullers, S., Hale, J., . . . Thornton, E. E. (2024). A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies.. Mucosal immunology, 17(1), 111-123. doi:10.1016/j.mucimm.2023.11.005Data Resource Profile: the Children and Young People with Long COVID (CLoCk) Study. (Journal article)
Nugawela, M. D., Pinto Pereira, S. M., Rojas, N. K., McOwat, K., Simmons, R., Dalrymple, E., . . . CLoCk Consortium. (2024). Data Resource Profile: the Children and Young People with Long COVID (CLoCk) Study.. International journal of epidemiology, 53(1), dyad158. doi:10.1093/ije/dyad158Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID). (Journal article)
Pazukhina, E., Rumyantsev, M., Baimukhambetova, D., Bondarenko, E., Markina, N., El-Taravi, Y., . . . Sechenov StopCOVID Research Team. (2024). Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).. BMC medicine, 22(1), 48. doi:10.1186/s12916-023-03221-xRespiratory Syncytial Virus Maternal Vaccination in Infants below 6 Months of Age: Meta-Analysis of Safety, Immunogenicity, and Efficacy. (Journal article)
Mapindra, M. P., Mahindra, M. P., McNamara, P., Semple, M. G., Clark, H., & Madsen, J. (2024). Respiratory Syncytial Virus Maternal Vaccination in Infants below 6 Months of Age: Meta-Analysis of Safety, Immunogenicity, and Efficacy.. Neonatology, 1-12. doi:10.1159/000536031Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial. (Journal article)
RECOVERY Collaborative Group. (2024). Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.. The Lancet. Child & adolescent health, S2352-4642(23)00316-4. doi:10.1016/s2352-4642(23)00316-4Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19. (Journal article)
Devine, K., Russell, C. D., Blanco, G. R., Walker, B. R., Homer, N. Z. M., Denham, S. G., . . . ISARIC4C Investigators and PHOSP-COVID Study Collaborative Group. (2024). Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.. Clinical endocrinology. doi:10.1111/cen.15012Accelarated immune ageing is associated with COVID-19 disease severity. (Journal article)
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., . . . ISARIC4C investigators. (2024). Accelarated immune ageing is associated with COVID-19 disease severity.. Immunity & ageing : I & A, 21(1), 6. doi:10.1186/s12979-023-00406-zStakeholders' perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study. (Journal article)
Deja, E., Donohue, C., Semple, M. G., Woolfall, K., & BESS Investigators. (2024). Stakeholders' perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study.. BMJ open, 14(1), e077023. doi:10.1136/bmjopen-2023-077023Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study. (Journal article)
Battaglini, D., White, N. M., Premraj, L., Wanjiru Citarella, B., Merson, L., Robba, C., . . . ISARIC Clinical Characterization Group. (2024). Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study.. Journal of neurology, 271(1), 79-86. doi:10.1007/s00415-023-12133-y2023
Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury. (Journal article)
Taquet, M., Skorniewska, Z., Zetterberg, H., Geddes, J. R., Mummery, C. J., Chalmers, J. D., . . . PHOSP-COVID Study Collaborative Group . (2024). Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury.. Brain communications, 6(1), fcad357. doi:10.1093/braincomms/fcad357Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19. (Journal article)
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.. The Journal of infectious diseases, jiad590. doi:10.1093/infdis/jiad590Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. (Journal article)
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study (Journal article)
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L. -P., . . . Williams, N. (2023). Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International Journal of Epidemiology, 53(1). doi:10.1093/ije/dyad165Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisation (Preprint)
Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19. (Journal article)
Camirand-Lemyre, F., Merson, L., Tirupakuzhi Vijayaraghavan, B. K., Burrell, A. J. C., Citarella, B. W., Domingue, M. -P., . . . ISARIC Clinical Characterisation Group. (2023). Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19.. JAMA network open, 6(12), e2346502. doi:10.1001/jamanetworkopen.2023.46502Enrichment of SARS-CoV-2 sequence from nasopharyngeal swabs whilst identifying the nasal microbiome (Journal article)
Alrezaihi, A., Penrice-Randal, R., Dong, X., Prince, T., Randle, N., Semple, M. G., . . . Hiscox, J. A. (2023). Enrichment of SARS-CoV-2 sequence from nasopharyngeal swabs whilst identifying the nasal microbiome. Journal of Clinical Virology, 105620. doi:10.1016/j.jcv.2023.105620Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity. (Journal article)
Swets, M. C., Kerr, S., Scott-Brown, J., Brown, A. B., Gupta, R., Millar, J. E., . . . Baillie, J. K. (2023). Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.. Nature communications, 14(1), 7374. doi:10.1038/s41467-023-42205-6A multi-country analysis of COVID-19 hospitalizations by vaccination status. (Journal article)
Gonçalves, B. P., Jassat, W., Baruch, J., Hashmi, M., Rojek, A., Dasgupta, A., . . . ISARIC Clinical Characterisation Group. (2023). A multi-country analysis of COVID-19 hospitalizations by vaccination status.. Med (New York, N.Y.), 4(11), 797-812.e2. doi:10.1016/j.medj.2023.08.005Long COVID research: an update from the PHOSP-COVID Scientific Summit. (Journal article)
Brightling, C. E., Evans, R. A., Singapuri, A., Smith, N., Wain, L. V., & PHOSP-COVID Collaborative Group. (2023). Long COVID research: an update from the PHOSP-COVID Scientific Summit.. The Lancet. Respiratory medicine, 11(11), e93-e94. doi:10.1016/s2213-2600(23)00341-7The CLoCk study: A retrospective exploration of loneliness in children and young people during the COVID-19 pandemic, in England. (Journal article)
McOwat, K., Pinto Pereira, S. M., Nugawela, M. D., Ladhani, S. N., Newlands, F., Stephenson, T., . . . Shafran, R. (2023). The CLoCk study: A retrospective exploration of loneliness in children and young people during the COVID-19 pandemic, in England.. PloS one, 18(11), e0294165. doi:10.1371/journal.pone.0294165International Pediatric COVID-19 Severity Over the Course of the Pandemic (Journal article)
Zhu, Y., Almeida, F. J., Baillie, J. K., Bowen, A. C., Britton, P. N., Brizuela, M. E., . . . Short, K. R. (2023). International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA PEDIATRICS. doi:10.1001/jamapediatrics.2023.3117Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study. (Journal article)
C-MORE/PHOSP-COVID Collaborative Group. (2023). Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.. The Lancet. Respiratory medicine, S2213-2600(23)00262-X. doi:10.1016/s2213-2600(23)00262-xLiver injury in hospitalized patients with COVID-19: An International observational cohort study. (Journal article)
Tirupakuzhi Vijayaraghavan, B. K., Bishnu, S., Baruch, J., Citarella, B. W., Kartsonaki, C., Meeyai, A., . . . ISARIC Clinical Characterisation Group. (2023). Liver injury in hospitalized patients with COVID-19: An International observational cohort study.. PloS one, 18(9), e0277859. doi:10.1371/journal.pone.0277859Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera. (Journal article)
Roper, K. J., Thomas, J., Albalawi, W., Maddocks, E., Dobson, S., Alshehri, A., . . . Pollakis, G. (2023). Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.. Scientific reports, 13(1), 15014. doi:10.1038/s41598-023-41928-2A second update on mapping the human genetic architecture of COVID-19. (Journal article)
COVID-19 Host Genetics Initiative. (2023). A second update on mapping the human genetic architecture of COVID-19.. Nature, 621(7977), E7-E26. doi:10.1038/s41586-023-06355-3Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort. (Journal article)
Shah, N., Xue, B., Xu, Z., Yang, H., Marwali, E., Dalton, H., . . . ISARIC Clinical Characterisation Group. (2023). Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort.. Artificial organs, 47(9), 1490-1502. doi:10.1111/aor.14542Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19 (Journal article)
Wainstein, M., Spyrison, N., Dai, D., Ghadimi, M., Chávez-Iñiguez, J. S., Rizo-Topete, L., . . . Zucman, D. (2023). Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19. Kidney International Reports, 8(8), 1514-1530. doi:10.1016/j.ekir.2023.05.015Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. (Journal article)
Jackson, C., Stewart, I., Plekhanova, T., Cunningham, P. S., Hazel, A. L., Al-Sheklly, B., . . . PHOSP-COVID, S. C. G. (2023). Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. LANCET RESPIRATORY MEDICINE, 11(8), 673-684. doi:10.1016/S2213-2600(23)00124-8Symptom Profiles of Children and Young People 12 Months after SARS-CoV-2 Testing: A National Matched Cohort Study (The CLoCk Study) (Journal article)
Pereira, S. M. P. M., Nugawela, M. D. D., McOwat, K., Dalrymple, E., Xu, L., Ladhani, S. N. N., . . . Stephenson, T. (2023). Symptom Profiles of Children and Young People 12 Months after SARS-CoV-2 Testing: A National Matched Cohort Study (The CLoCk Study). Children, 10(7). doi:10.3390/children10071227HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation (Journal article)
Yang, H., Sun, H., Brackenridge, S., Zhuang, X., Wing, P. A. C., Quastel, M., . . . McMichael, A. J. (2023). HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation. SCIENCE IMMUNOLOGY, 8(84). doi:10.1126/sciimmunol.abl8881Patient emergency health-care use before hospital admission for COVID-19 and long-term outcomes in Scotland: a national cohort study. (Journal article)
Docherty, A. B., Farrell, J., Thorpe, M., Egan, C., Dunn, S., Norman, L., . . . Lone, N. I. (2023). Patient emergency health-care use before hospital admission for COVID-19 and long-term outcomes in Scotland: a national cohort study.. The Lancet. Digital health, 5(7), e446-e457. doi:10.1016/s2589-7500(23)00051-1Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry (Journal article)
Griffee, M. J., Bozza, P. T., Reyes, L. F., Eddington, D. P., Rosenberger, D., Merson, L., . . . Zucman, D. (2023). Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry. Research and Practice in Thrombosis and Haemostasis, 7(5), 102142. doi:10.1016/j.rpth.2023.102142COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region (Journal article)
Burnside, G., Cheyne, C. P., Leeming, G., Humann, M., Darby, A., Green, M. A., . . . Buchan, I. E. (2023). COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region. Journal of the Royal Society of Medicine. doi:10.1177/01410768231182389Enrichment of Sars-Cov-2 and Seasonal Coronavirus Sequence from Nasopharyngeal Swabs Whilst Maintaining the Background Context of the Microbiome (Journal article)
Alrezaihi, A., Penrice-Randal, R., Dong, X., Prince, T., Randle, N., Semple, M., . . . Hiscox, J. (2023). Enrichment of Sars-Cov-2 and Seasonal Coronavirus Sequence from Nasopharyngeal Swabs Whilst Maintaining the Background Context of the Microbiome. doi:10.2139/ssrn.4484216Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease (Preprint)
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls (Journal article)
Zheng, B., Vivaldi, G., Daines, L., Leavy, O. C., Richardson, M., Elneima, O., . . . Zongo, O. (2023). Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls. The Lancet Regional Health - Europe, 29, 100635. doi:10.1016/j.lanepe.2023.100635GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (Journal article)
Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., . . . Baillie, J. K. (2023). GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. NATURE, 617(7962), 764-+. doi:10.1038/s41586-023-06034-3Long COVID in Children and Young after Infection or Reinfection with the Omicron Variant: A Prospective Observational Study. (Journal article)
Pinto Pereira, S. M., Mensah, A., Nugawela, M. D., Stephenson, T., Ladhani, S. N., Dalrymple, E., . . . Shafran, R. (2023). Long COVID in Children and Young after Infection or Reinfection with the Omicron Variant: A Prospective Observational Study.. The Journal of pediatrics, 259, 113463. doi:10.1016/j.jpeds.2023.113463Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial (Journal article)
Pauley, E., Drake, T. M., Griffith, D. M., Sigfrid, L., Lone, N. I., Harrison, E. M., . . . Docherty, A. B. (2023). Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial. JOURNAL OF THE INTENSIVE CARE SOCIETY, 24(2), 162-169. doi:10.1177/17511437211052226Neurological manifestations of COVID-19 in adults and children. (Journal article)
Cho, S. -M., White, N., Premraj, L., Battaglini, D., Fanning, J., Suen, J., . . . ISARIC Clinical Characterisation Group. (2023). Neurological manifestations of COVID-19 in adults and children.. Brain : a journal of neurology, 146(4), 1648-1661. doi:10.1093/brain/awac332Occupational inequalities in the prevalence of COVID-19: A longitudinal observational study of England, August 2020 to January 2021 (Journal article)
Green, M., & Semple, M. (2023). Occupational inequalities in the prevalence of COVID-19: A longitudinal observational study of England, August 2020 to January 2021. PLoS One.Adeno-associated virus 2 infection in children with non-A-E hepatitis. (Journal article)
Ho, A., Orton, R., Tayler, R., Asamaphan, P., Herder, V., Davis, C., . . . Thomson, E. C. (2023). Adeno-associated virus 2 infection in children with non-A-E hepatitis.. Nature. doi:10.1038/s41586-023-05948-2Genomic investigations of unexplained acute hepatitis in children. (Journal article)
Morfopoulou, S., Buddle, S., Montaguth, O. E. T., Atkinson, L., Guerra-Assunção, J. A., Marjaneh, M. M., . . . Breuer, J. (2023). Genomic investigations of unexplained acute hepatitis in children.. Nature. doi:10.1038/s41586-023-06003-wResidual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID-19 Study. (Journal article)
Stewart, I., Jacob, J., George, P. M., Molyneaux, P. L., Porter, J. C., Allen, R. J., . . . Jenkins, G. R. (2023). Residual Lung Abnormalities after COVID-19 Hospitalization Interim Analysis of the UKILD Post-COVID-19 Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207(6), 693-703. doi:10.1164/rccm.202203-0564OCThe P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection. (Journal article)
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (Journal article)
McAuley, H. J. C., Evans, R. A., Bolton, C. E., Brightling, C. E., Chalmers, J. D., Docherty, A. B., . . . Zongo, O. (2023). Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study. eClinicalMedicine, 57, 101896. doi:10.1016/j.eclinm.2023.101896Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19. (Journal article)
Kartsonaki, C., Baillie, J. K., Barrio, N. G., Baruch, J., Beane, A., Blumberg, L., . . . ISARIC Clinical Characterisation Group. (2023). Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.. International journal of epidemiology, dyad012. doi:10.1093/ije/dyad012Prevention of Neurological Complications During COVID-19: Protocol for a Retrospective Analysis of the ISARIC4C National Cohort (Journal article)
Grundmann, A., Hardwick, M., Wu, C. -H., Semple, M. G., Böhning, D., Pett, S., . . . Galea, I. (n.d.). Prevention of Neurological Complications During COVID-19: Protocol for a Retrospective Analysis of the ISARIC4C National Cohort. SSRN Electronic Journal. doi:10.2139/ssrn.4037376Estimating distribution of length of stay in a multi-state model conditional on the pathway, with an application to patients hospitalised with Covid-19 (Journal article)
Keogh, R. H., Diaz-Ordaz, K., Jewell, N. P., Semple, M. G., de Wreede, L. C., & Putter, H. (2023). Estimating distribution of length of stay in a multi-state model conditional on the pathway, with an application to patients hospitalised with Covid-19. Lifetime Data Analysis. doi:10.1007/s10985-022-09586-0Prevalence and Risk Factors of Post-COVID-19 Condition in Adults and Children at 6 and 12 Months After Hospital Discharge: A Prospective, Cohort Study in Moscow (Stop COVID) (Journal article)
Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., . . . Team, S. S. R. (n.d.). Prevalence and Risk Factors of Post-COVID-19 Condition in Adults and Children at 6 and 12 Months After Hospital Discharge: A Prospective, Cohort Study in Moscow (Stop COVID). SSRN Electronic Journal. doi:10.2139/ssrn.4020142The role of pandemic planning in the management of COVID-19 in England from an infection prevention and control perspective: results of a national survey. (Journal article)
Greene, C., Wilson, J., Griffin, H., Tingle, A., Cooper, T., Semple, M. G., . . . Loveday, H. (2023). The role of pandemic planning in the management of COVID-19 in England from an infection prevention and control perspective: results of a national survey.. Public health, 217, 89-94. doi:10.1016/j.puhe.2023.01.028Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study. (Journal article)
Turtle, L., Thorpe, M., Drake, T. M., Swets, M., Palmieri, C., Russell, C. D., . . . Docherty, A. B. (2023). Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.. PLoS medicine, 20(1), e1004086. doi:10.1371/journal.pmed.1004086Association of SARS-CoV-2 viral load distributions with individual demographics and suspected variant type: Results from the Liverpool Community Testing Pilot - England, 6 November 2020‒8 September 2021 (Journal article)
Hughes, D., Cheyne, C., Ashton, M., Coffee, E., Crozier, A., Semple, M., . . . Garcia-Finana, M. (n.d.). Association of SARS-CoV-2 viral load distributions with individual demographics and suspected variant type: Results from the Liverpool Community Testing Pilot - England, 6 November 2020‒8 September 2021. Eurosurveillance. doi:10.2807/1560-7917.ES.2023.28.4.2200129SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study (Journal article)
Parker, E., Thomas, J., Roper, K. J., Ijaz, S., Edwards, T., Marchesin, F., . . . Pollakis, G. (2023). SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1146702SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (Journal article)
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402The early use of Antibiotics for At-risk children with InfluEnza in Primary Care (the ARCHIE programme) (Journal article)
Wang, K., Tonner, S., Semple, M. G., Wolstenholme, J., Perera, R., & Harnden, A. (2023). The early use of Antibiotics for At-risk children with InfluEnza in Primary Care (the ARCHIE programme). Programme Grants for Applied Research, 1-57. doi:10.3310/wdfr73312022
CO-CONNECT: A hybrid architecture to facilitate rapid discovery and access to UK wide data in the response to the COVID-19 pandemic. (Journal article)
Jefferson, E., Cole, C., Mumtaz, S., Cox, S., Giles, T. C., Adejumo, S., . . . Quinlan, P. (2022). A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study. JOURNAL OF MEDICAL INTERNET RESEARCH, 24(12). doi:10.2196/40035260. Corticosteroid treatment in influenza virus and SARS-CoV-2 co-infected patients (Journal article)
Swets, M. C., Russell, C., Harrison, E., Docherty, A., Lone, N., Girvan, M., . . . Baillie, K. (2022). 260. Corticosteroid treatment in influenza virus and SARS-CoV-2 co-infected patients. Open Forum Infectious Diseases, 9(Supplement_2). doi:10.1093/ofid/ofac492.338Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people (Journal article)
Green, M. A., Hungerford, D. J., Hughes, D. M., Garcia-Finana, M., Turtle, L., Cheyne, C., . . . Buchan, I. (2022). Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people. BMC INFECTIOUS DISEASES, 22(1). doi:10.1186/s12879-022-07878-2Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales (Journal article)
Swann, O. V., Lone, N. I., Harrison, E. M., Tomlinson, L. A., Walker, A. J., Seaborne, M. J., . . . Docherty, A. B. (2022). Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales. BMJ OPEN, 12(11). doi:10.1136/bmjopen-2022-063271OP040 [Infections » Covid-19 / Sars-CoV-2]: PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY (Journal article)
Marwali, E. M., Kekalih, A., Yuliarto, S., Wati, D. K., Rayhan, M., Valerie, I. C., . . . Dalton, H. (2022). OP040 [Infections » Covid-19 / Sars-CoV-2]: PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY. Pediatric Critical Care Medicine, 23(Supplement 1 11S). doi:10.1097/01.pcc.0000899840.38573.88PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY (Conference Paper)
Marwali, E. M., Kekalih, A., Yuliarto, S., Wati, D. K., Rayhan, M., Valerie, I. C., . . . Dalton, H. (2022). PEDIATRIC COVID-19 MORTALITY: TWO-SIDED CHALLENGES FROM HEALTH RESOURCE DISPARITY. In PEDIATRIC CRITICAL CARE MEDICINE Vol. 23. Retrieved from https://www.webofscience.com/Symptom‐based case definitions for COVID‐19: Time and geographical variations for detection at hospital admission among 260,000 patients (Journal article)
Baruch, J., Rojek, A., Kartsonaki, C., Vijayaraghavan, B. K. T., Gonçalves, B. P., Pritchard, M. G., . . . ISARIC Clinical Characterisation Group. (2022). Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients.. Influenza and other respiratory viruses, 16(6), 1040-1050. doi:10.1111/irv.13039Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity (Journal article)
Marwali, E. M., Kekalih, A., Yuliarto, S., Wati, D. K., Rayhan, M., Valerie, I. C., . . . Dalton, H. J. (2022). Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity. BMJ PAEDIATRICS OPEN, 6(1). doi:10.1136/bmjpo-2022-001657Plasma steroid concentrations reflect disease severity during acute illness but not recovery after hospitalisation with COVID-19 (Journal article)
Devine, K., Walker, B. R., Homer, N. Z. M., Openshaw, P. J. M., Kenneth, B. J., Andrew, R., . . . Reynolds, R. M. (n.d.). Plasma steroid concentrations reflect disease severity during acute illness but not recovery after hospitalisation with COVID-19. Endocrine Abstracts. doi:10.1530/endoabs.86.oc4.3Fewer COVID-19 Neurological Complications with Dexamethasone and Remdesivir. (Journal article)
Grundmann, A., Wu, C. -H., Hardwick, M., Baillie, J. K., Openshaw, P. J. M., Semple, M. G., . . . ISARIC4C investigators. (2022). Fewer COVID-19 Neurological Complications with Dexamethasone and Remdesivir.. Annals of neurology. doi:10.1002/ana.26536Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study (Journal article)
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531Clonal hematopoiesis is not significantly associated with COVID-19 disease severity (Journal article)
Zhou, Y., Shalhoub, R., Rogers, S. N., Yu, S., Gu, M., Fabre, M. A., . . . Vassiliou, G. S. (2022). Clonal hematopoiesis is not significantly associated with COVID-19 disease severity. BLOOD, 140(14), 1650-1656. doi:10.1182/blood.2022015721An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients (Journal article)
Goncalves, B. P., Hall, M., Jassat, W., Balan, V., Murthy, S., Kartsonaki, C., . . . Olliaro, P. L. (2022). An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients. ELIFE, 11. doi:10.7554/eLife.80556Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19 (Journal article)
Kotanidis, C. P., Xie, C., Alexander, D., Rodrigues, J. C. L., Burnham, K., Mentzer, A., . . . Antoniades, C. (2022). Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19. LANCET DIGITAL HEALTH, 4(10), E705-E716. doi:10.1016/S2589-7500(22)00132-7Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19. (Journal article)
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585Evaluation of <i>S</i>/<i>F</i><sub>94</sub> as a proxy for COVID-19 severity (Preprint)
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study (Journal article)
Reyes, L. F., Murthy, S., Garcia-Gallo, E., Merson, L., Ibanez-Prada, E. D., Rello, J., . . . Olliaro, P. L. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. CRITICAL CARE, 26(1). doi:10.1186/s13054-022-04155-1Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number (Journal article)
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH, 31(9), 1716-1737. doi:10.1177/09622802211070257PREVENTION OF NEUROLOGICAL COMPLICATIONS DURING COVID-19: A RETROSPECTIVE ANALYSIS OF THE ISARIC4C NATIONAL COHORT (Conference Paper)
Grundmann, A., Hardwick, M., Wu, C. -H., Semple, M., Bohning, D., Pett, S., . . . Galea, I. (2022). PREVENTION OF NEUROLOGICAL COMPLICATIONS DURING COVID-19: A RETROSPECTIVE ANALYSIS OF THE ISARIC4C NATIONAL COHORT. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 93. doi:10.1136/jnnp-2022-abn2.22Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (Journal article)
Evans, R. A., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J. C., Shikotra, A., . . . Brightling, C. E. (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. LANCET RESPIRATORY MEDICINE, 10(8), 761-775. doi:10.1016/S2213-2600(22)00127-8Clinical features and management of human monkeypox: a retrospective observational study in the UK (Journal article)
Adler, H., Gould, S., Hine, P., Snell, L. B., Wong, W., Houlihan, C. F., . . . Price, N. M. (2022). Clinical features and management of human monkeypox: a retrospective observational study in the UK. LANCET INFECTIOUS DISEASES, 22(8), 1153-1162. doi:10.1016/S1473-3099(22)00228-6Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients (Journal article)
Ijaz, S., Dicks, S., Jegatheesan, K., Parker, E., Katsanovskaja, K., Vink, E., . . . Tedder, R. S. (2022). Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients. JOURNAL OF INFECTION, 85(2), 152-160. doi:10.1016/j.jinf.2022.05.033ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19 (Journal article)
Garcia-Gallo, E., Merson, L., Kennon, K., Kelly, S., Citarella, B. W., Fryer, D. V., . . . Reyes, L. F. (2022). ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. SCIENTIFIC DATA, 9(1). doi:10.1038/s41597-022-01534-9Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19 (Journal article)
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Khunti, K. (2022). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. HEART, 108(15), 1200-1208. doi:10.1136/heartjnl-2021-320047Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses (Journal article)
McNaughton, A. L., Paton, R. S., Edmans, M., Youngs, J., Wellens, J., Phalora, P., . . . Thompson, C. P. (2022). Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses. JCI INSIGHT, 7(13). doi:10.1172/jci.insight.156372Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum (Journal article)
Tuekprakhon, A., Nutalai, R., Dijokaite-Guraliuc, A., Zhou, D., Ginn, H. M., Selvaraj, M., . . . Screaton, G. R. (2022). Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum. CELL, 185(14), 2422-+. doi:10.1016/j.cell.2022.06.005Whole genome sequencing reveals host factors underlying critical Covid-19. (Journal article)
Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., . . . Baillie, J. K. (2022). Whole-genome sequencing reveals host factors underlying critical COVID-19. NATURE, 607(7917), 97-+. doi:10.1038/s41586-022-04576-6Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) (Journal article)
Pazukhina, E., Andreeva, M., Spiridonova, E., Bobkova, P., Shikhaleva, A., El-Taravi, Y., . . . Munblit, D. (2022). Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID). BMC MEDICINE, 20(1). doi:10.1186/s12916-022-02448-4Long COVID (post-COVID-19 condition) in children: a modified Delphi process (Journal article)
Stephenson, T., Allin, B., Nugawela, M. D., Rojas, N., Dalrymple, E., Pereira, S. P., . . . Shafran, R. (2022). Long COVID (post-COVID-19 condition) in children: a modified Delphi process. ARCHIVES OF DISEASE IN CHILDHOOD, 107(7), 674-680. doi:10.1136/archdischild-2021-323624Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages (Journal article)
Prince, T., Dong, X., Penrice-Randal, R., Randle, N., Hartley, C., Goldswain, H., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages. MSPHERE, 7(3). doi:10.1128/msphere.00913-21The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020 (Journal article)
Knight, G. M., Thi, M. P., Stimson, J., Funk, S., Jafari, Y., Pople, D., . . . Robotham, J. V. (2022). The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020. BMC INFECTIOUS DISEASES, 22(1). doi:10.1186/s12879-022-07490-4A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study (Journal article)
Munblit, D., Nicholson, T., Akrami, A., Apfelbacher, C., Chen, J., De Groote, W., . . . Williamson, P. R. (2022). A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study. LANCET RESPIRATORY MEDICINE, 10(7), 715-724. doi:10.1016/S2213-2600(22)00169-2CO-CONNECT: A hybrid architecture to facilitate rapid discovery and access to UK wide data in the response to the COVID-19 pandemic (Preprint) (Preprint)
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers (Journal article)
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Donovan-Banfield, I., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers. GIGASCIENCE, 11. doi:10.1093/gigascience/giac045<SUP>1</SUP>H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization (Journal article)
Correia, G. D. S., Takis, P. G., Sands, C. J., Kowalka, A. M., Tan, T., Turtle, L., . . . Lewis, M. R. (2022). <SUP>1</SUP>H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization. ANALYTICAL CHEMISTRY, 94(19), 6919-6923. doi:10.1021/acs.analchem.2c00466Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus (Journal article)
Stewart, A., Sinclair, E., Ng, J. C. -F., O'Hare, J. S., Page, A., Serangeli, I., . . . Dunn-Walters, D. K. (2022). Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.807104Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission (Journal article)
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study (Journal article)
Millar, J. E., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, J. K. (2022). Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08032-3Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves (Journal article)
Swann, O. V., Pollock, L., Holden, K. A., Munro, A. P. S., Bennett, A., Williams, T. C., . . . Investigators, I. (2022). Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves. PEDIATRIC RESEARCH. doi:10.1038/s41390-022-02052-5Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol. (Journal article)
Wainstein, M., MacDonald, S., Fryer, D., Young, K., Balan, V., Begum, H., . . . ISARIC Clinical Characterisation Group. (2022). Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol.. PLoS medicine, 19(4), e1003969. doi:10.1371/journal.pmed.1003969SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses (Journal article)
Swets, M. C., Russell, C. D., Harrison, E. M., Docherty, A. B., Lone, N., Girvan, M., . . . Baillie, J. K. (2022). SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses. LANCET, 399(10334), 1463-1464. doi:10.1016/S0140-6736(22)00383-XQuality of life, healthcare use and costs in 'at-risk' children after early antibiotic treatment versus placebo for influenza- like illness: within-trial descriptive economic analyses of the ARCHIE randomised controlled trial (Journal article)
Rombach, I., Wang, K., Tonner, S., Grabey, J., Harnden, A., & Wolstenholme, J. (2022). Quality of life, healthcare use and costs in 'at-risk' children after early antibiotic treatment versus placebo for influenza- like illness: within-trial descriptive economic analyses of the ARCHIE randomised controlled trial. BMJ OPEN, 12(4). doi:10.1136/bmjopen-2021-049373Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. (Journal article)
Rosadas, C., Khan, M., Parker, E., Marchesin, F., Katsanovskaja, K., Sureda-Vives, M., . . . Tedder, R. S. (2022). Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. JOURNAL OF VIROLOGICAL METHODS, 302. doi:10.1016/j.jviromet.2022.114475Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (Journal article)
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study. (Journal article)
Stephenson, T., Pinto Pereira, S. M., Shafran, R., de Stavola, B. L., Rojas, N., McOwat, K., . . . Ladhani, S. N. (2022). Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study.. The Lancet. Child & adolescent health, 6(4), 230-239. doi:10.1016/s2352-4642(22)00022-0Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults (Journal article)
Killingley, B., Mann, A. J., Kalinova, M., Boyers, A., Goonawardane, N., Zhou, J., . . . Chiu, C. (2022). Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults. NATURE MEDICINE. doi:10.1038/s41591-022-01780-9Impact of Dexamethasone and Remdesivir on Neurological Complications during COVID-19 (Journal article)
Grundmann, A., Wu, C. -H., Hardwick, M., Baillie, K., Openshaw, P., Semple, M., . . . Galea, I. (2022). Impact of Dexamethasone and Remdesivir on Neurological Complications during COVID-19. doi:10.2139/ssrn.4065552Admission Blood Glucose Level and Its Association With Cardiovascular and Renal Complications in Patients Hospitalized With COVID-19. (Journal article)
Norris, T., Razieh, C., Yates, T., Zaccardi, F., Gillies, C. L., Chudasama, Y. V., . . . Khunti, K. (2022). Admission Blood Glucose Level and Its Association With Cardiovascular and Renal Complications in Patients Hospitalized With COVID-19.. Diabetes care. doi:10.2337/dc21-1709GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19 (Preprint)
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. (Journal article)
Ahern, D. J., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., Angus, B., . . . Zurke, Y. -X. (2022). A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. CELL, 185(5), 916-+. doi:10.1016/j.cell.2022.01.012Legacy of COVID-19 infection in children: long-COVID will have a lifelong health/economic impact. (Journal article)
Munblit, D., Simpson, F., Mabbitt, J., Dunn-Galvin, A., Semple, C., & Warner, J. O. (2022). Legacy of COVID-19 infection in children: long-COVID will have a lifelong health/economic impact. ARCHIVES OF DISEASE IN CHILDHOOD, 107(3). doi:10.1136/archdischild-2021-321882SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures (Journal article)
Winslow, R. L., Zhou, J., Windle, E. F., Nur, I., Lall, R., Ji, C., . . . Green, C. A. (2022). SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures. THORAX, 77(3), 259-267. doi:10.1136/thoraxjnl-2021-218035Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service (Journal article)
Egan, C., Turtle, L., Thorpe, M., Harrison, E. M., Semple, M. G., & Docherty, A. B. (2022). Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service. ANAESTHESIA. doi:10.1111/anae.15677SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. (Journal article)
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. (Journal article)
Osmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., . . . Munblit, D. (2022). Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. EUROPEAN RESPIRATORY JOURNAL, 59(2). doi:10.1183/13993003.01341-2021Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge (Journal article)
Killingley, B., Mann, A., Kalinova, M., Boyers, A., Goonawardane, N., Zhou, J., . . . Chiu, C. (2022). Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge. doi:10.21203/rs.3.rs-1121993/v1Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study (Journal article)
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., . . . Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 37(2), 271-284. doi:10.1093/ndt/gfab303Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (Journal article)
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629Validation of the russian version of the 4C Mortality Score and prediction of outcomes of severe COVID-19 (Journal article)
Vechorko, V. I., Averkov, O. V., Suponeva, N. A., Piradov, M. A., Zimin, A. A., Yusupova, J. G., . . . Harrison, E. M. (2022). Validation of the russian version of the 4C Mortality Score and prediction of outcomes of severe COVID-19. Infectious diseases: News, Opinions, Training, 11(1), 57-63. doi:10.33029/2305-3496-2022-11-1-57-632021
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses (Journal article)
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2021). Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. bioRxiv. doi:10.1101/2021.12.03.471045Mapping the human genetic architecture of COVID-19 (Journal article)
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-xCommon, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity. (Journal article)
Fallerini, C., Picchiotti, N., Baldassarri, M., Zguro, K., Daga, S., Fava, F., . . . Furini, S. (2021). Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.. Human genetics, 141(1), 147-173. doi:10.1007/s00439-021-02397-7The value of open-source clinical science in pandemic response: lessons from ISARIC (Journal article)
The value of open-source clinical science in pandemic response: lessons from ISARIC (2021). LANCET INFECTIOUS DISEASES, 21(12), 1623-1624. doi:10.1016/S1473-3099(21)00565-XTen months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort. (Journal article)
Hall, M. D., Baruch, J., Carson, G., Citarella, B. W., Dagens, A., Dankwa, E. A., . . . Olliaro, P. L. (2021). Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort. ELIFE, 10. doi:10.7554/eLife.70970The impact of viral mutations on recognition by SARS-CoV-2 specific T cells (Journal article)
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353Hereditary haemorrhagic telangiectasia: development of a regional life-course collaborative clinical care pathway (Journal article)
Anderson, E., Green, R., Swift, A., & Semple, M. G. (2021). Hereditary haemorrhagic telangiectasia: development of a regional life-course collaborative clinical care pathway. BRITISH JOURNAL OF HOSPITAL MEDICINE, 82(11). doi:10.12968/hmed.2020.0537Comment on: Dark without pressure retinal changes in a paediatric age group (Journal article)
Steptoe, P. J., Beare, N. A. V., & Semple, M. G. (2021). Comment on: Dark without pressure retinal changes in a paediatric age group. EYE, 35(11), 3163-3164. doi:10.1038/s41433-020-01252-9EXPRESSION OF THE SARS-COV-2 RECEPTORS ACE2 AND TMPRSS2 IN THE RESPIRATORY TRACT OF CHILDREN AND ADULTS (Conference Paper)
Nuttall, A. G., Hedrich, C., Semple, C., Losty, P., Shukla, R., McPartland, J., . . . McNamara, P. (2021). EXPRESSION OF THE SARS-COV-2 RECEPTORS ACE2 AND TMPRSS2 IN THE RESPIRATORY TRACT OF CHILDREN AND ADULTS. In THORAX Vol. 76 (pp. A39). doi:10.1136/thorax-2021-BTSabstracts.63Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. (Journal article)
Evans, R. A., McAuley, H., Harrison, E. M., Shikotra, A., Singapuri, A., Sereno, M., . . . Brightling, C. E. (2021). Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(11), 1275-1287. doi:10.1016/S2213-2600(21)00383-0Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic (Journal article)
Cushnan, D., Berka, R., Bertolli, O., Williams, P., Schofield, D., Joshi, I., . . . Collaborative, N. C. C. I. D. (2021). Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic. DIGITAL HEALTH, 7. doi:10.1177/20552076211048654A prenylated dsRNA sensor protects against severe COVID-19 (Journal article)
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study (Journal article)
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435Plasma steroid profiles in patients hospitalised with COVID-19 - an ISARIC/WHO CCP-UK cohort study (Journal article)
Devine, K., Russell, C. D., Moore, S. C., Thwaites, R. S., Hardwick, H. E., Oosthuyzen, W., . . . Reynolds, R. M. (n.d.). Plasma steroid profiles in patients hospitalised with COVID-19 - an ISARIC/WHO CCP-UK cohort study. Endocrine Abstracts. doi:10.1530/endoabs.77.p11370 Is the liverpool respiratory symptom questionnaire (LRSQ) an acceptable tool to use in longitudinal cohort studies? (Conference Paper)
Naylor, C., Stead, J., Lane, S., McNamara, P., Southern, K., & Semple, M. (2021). 1370 Is the liverpool respiratory symptom questionnaire (LRSQ) an acceptable tool to use in longitudinal cohort studies?. In Abstracts. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2021-rcpch.594286 BE FIT study: biomarkers rElated to weight and lifestyle in young adults (Conference Paper)
Fairhurst, K., Semple, M. G., Kemp, G. J., & Cuthbertson, D. J. (2021). 286 BE FIT study: biomarkers rElated to weight and lifestyle in young adults. In Abstracts. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2021-rcpch.17COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study (Journal article)
Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Zucman, D. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION, 49(5), 889-905. doi:10.1007/s15010-021-01599-5Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital (Journal article)
Wright, J., Achana, F., Diwakar, L., Semple, M. G., Carroll, W. D., Baillie, K., . . . Kemp, T. S. (2021). Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 111, 333-335. doi:10.1016/j.ijid.2021.08.022The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial (Journal article)
Wang, K., Semple, M. G., Moore, M., Hay, A. D., Tonner, S., Galal, U., . . . Harnden, A. (2021). The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial. EUROPEAN RESPIRATORY JOURNAL, 58(4). doi:10.1183/13993003.02819-2020Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID) (Journal article)
Wild, J. M., Porter, J. C., Molyneaux, P. L., George, P. M., Stewart, I., Allen, R. J., . . . Jenkins, R. G. (2021). Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID). BMJ Open Respiratory Research, 8(1), e001049. doi:10.1136/bmjresp-2021-001049Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study (vol 374, n2244, 2021) (Journal article)
Hippisley-Cox, J., Coupland, C. A., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., . . . Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study (vol 374, n2244, 2021). BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n2300Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. (Journal article)
Read, J. M., Green, C. A., Harrison, E. M., Docherty, A. B., Funk, S., Harrison, J., . . . Semple, M. G. (2021). Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. LANCET, 398(10305), 1037-1038. doi:10.1016/S0140-6736(21)01786-4Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study (Journal article)
Hippisley-Cox, J., Coupland, C. A. C., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., . . . Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n2244COVID-19 pneumothorax in the UK: a prospective observational study using the ISARIC WHO clinical characterisation protocol. (Journal article)
Marciniak, S. J., Farrell, J., Rostron, A., Smith, I., Openshaw, P. J. M., Baillie, J. K., . . . Semple, M. G. (2021). COVID-19 pneumothorax in the UK: a prospective observational study using the ISARIC WHO clinical characterisation protocol. EUROPEAN RESPIRATORY JOURNAL, 58(3). doi:10.1183/13993003.00929-2021Circulating histones play a central role in COVID-19-associated coagulopathy and mortality (Journal article)
Shaw, R. J., Abrams, S. T., Austin, J., Taylor, J. M., Lane, S., Dutt, T., . . . Toh, C. -H. (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. HAEMATOLOGICA, 106(9), 2493-2498. doi:10.3324/haematol.2021.278492Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19 (Journal article)
Munblit, D., Bobkova, P., Spiridonova, E., Shikhaleva, A., Gamirova, A., Blyuss, O., . . . StopCO, S. (2021). Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19. CLINICAL AND EXPERIMENTAL ALLERGY, 51(9), 1107-1120. doi:10.1111/cea.13997Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol (Journal article)
Sigfrid, L., Drake, T. M., Pauley, E., Jesudason, E. C., Olliaro, P., Lim, W. S., . . . Scott, J. T. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. LANCET REGIONAL HEALTH-EUROPE, 8. doi:10.1016/j.lanepe.2021.100186Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK (Conference Paper)
Palmieri, C., Turtle, L., Drake, T., Harrison, E., Docherty, A., Greenhalf, B., . . . Semple, M. M. G. (2021). Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK. In ANNALS OF ONCOLOGY Vol. 32 (pp. S1337). doi:10.1016/j.annonc.2021.08.2141Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK (Conference Paper)
Palmieri, C., Turtle, L., Drake, T., Harrison, E., Docherty, A., Greenhalf, B., . . . Semple, M. M. G. (2021). LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK. In Annals of oncology : official journal of the European Society for Medical Oncology Vol. 32 (pp. S1337).Long COVID and the mental and physical health of children and young people: national matched cohort study protocol (the CLoCk study) (Journal article)
Stephenson, T., Shafran, R., De Stavola, B., Rojas, N., Aiano, F., Amin-Chowdhury, Z., . . . Members, C. C. (2021). Long COVID and the mental and physical health of children and young people: national matched cohort study protocol (the CLoCk study). BMJ OPEN, 11(8). doi:10.1136/bmjopen-2021-052838Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. (Journal article)
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort (Journal article)
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06466-0Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. (Journal article)
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., ISARIC4C Investigators., . . . Hill, E. M. (2021). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number.. medRxiv. doi:10.1101/2020.08.04.20163782Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study (Journal article)
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study (Journal article)
Garcia-Finana, M., Hughes, D. M., Cheyne, C. P., Burnside, G., Stockbridge, M., Fowler, T. A., . . . Buchan, I. (2021). Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n1637SARS-CoV-2 environmental contamination from hospitalised COVID-19 patients receiving aerosol generating procedures (Journal article)
Winslow, R. L., Zhou, J., Windle, E. F., Nur, I., Lall, R., Ji, C., . . . Green, C. A. (2021). SARS-CoV-2 environmental contamination from hospitalised COVID-19 patients receiving aerosol generating procedures. doi:10.1101/2021.07.04.21259945Soft drinks can be misused to give false “false positive” SARS-CoV-2 lateral flow device results (Preprint)
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK (Journal article)
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study (Journal article)
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort (Journal article)
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK (Journal article)
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8Could expanding the covid-19 case definition improve the UK's pandemic response? (Journal article)
Crozier, A., Dunning, J., Rajan, S., Semple, M. G., & Buchan, I. E. (2021). Could expanding the covid-19 case definition improve the UK's pandemic response?. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n1625Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England (Journal article)
Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-xA blood atlas of COVID-19 defines hallmarks of disease severity and specificity (Journal article)
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium., Ahern, D., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., . . . Zurke, Y. -X. (2021). A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. doi:10.1101/2021.05.11.21256877Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19 (Journal article)
Mina, M. J., Peto, T. E., Garcia-Finana, M., Semple, M. G., & Buchan, I. E. (2021). Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19. LANCET, 397(10283), 1425-1427. doi:10.1016/S0140-6736(21)00425-6Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study (Journal article)
Davies, N. G., Barnard, R. C., Jarvis, C. I., Russell, T. W., Semple, M. G., Jit, M., & Edmunds, W. J. (2021). Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study. LANCET INFECTIOUS DISEASES, 21(4), 482-492. doi:10.1016/S1473-3099(20)30984-1Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study (Journal article)
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. (Journal article)
Flood, J., Shingleton, J., Bennett, E., Walker, B., Amin-Chowdhury, Z., Oligbu, G., . . . Ladhani, S. N. (2021). Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. LANCET REGIONAL HEALTH-EUROPE, 3. doi:10.1016/j.lanepe.2021.100075A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (Journal article)
Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y. A., Schimanski, L., . . . Joly, E. (2021). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-22045-yLong Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol (Journal article)
Sigfrid, L., Drake, T., Pauley, E., Jesudason, E., Olliaro, P., Lim, W. S., . . . ISARIC4C investigators. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. doi:10.1101/2021.03.18.21253888Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19. (Journal article)
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873Performance of the Innova SARS-CoV-2 Antigen Rapid Lateral Flow Test in the Liverpool Asymptomatic Testing Pilot (Journal article)
García-Fiñana, M., Hughes, D. M., Cheyne, C., Burnside, G., Stockbridge, M., Fowler, T. A., . . . Buchan, I. (2021). Performance of the Innova SARS-CoV-2 Antigen Rapid Lateral Flow Test in the Liverpool Asymptomatic Testing Pilot. doi:10.2139/ssrn.3798558What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol. (Journal article)
Sigfrid, L., Cevik, M., Jesudason, E., Lim, W. S., Rello, J., Amuasi, J., . . . Scott, J. T. (2021). What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol.. BMJ Open, 11(3), e043887. doi:10.1136/bmjopen-2020-043887Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity (Journal article)
Thomson, E. C., Rosen, L. E., Shepherd, J. G., Spreafico, R., Filipe, A. D. S., Wojcechowskyj, J. A., . . . Snell, G. (2021). Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. CELL, 184(5), 1171-+. doi:10.1016/j.cell.2021.01.037Genetic mechanisms of critical illness in COVID-19. (Journal article)
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-yIdentification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans (Journal article)
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Salguero, J., . . . COVID-19 Genomics UK (COG-UK) Consortium. (2021). Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans. doi:10.1101/2021.03.03.433753Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps (Journal article)
De Luca, D., Cogo, P., Kneyber, M. C., Biban, P., Semple, M. G., Perez-Gil, J., . . . Rimensberger, P. C. (2021). Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps. CRITICAL CARE, 25(1). doi:10.1186/s13054-021-03489-6Ebola virus antibody decay-stimulation in a high proportion of survivors (Journal article)
Adaken, C., Scott, J. T., Sharma, R., Gopal, R., Dicks, S., Niazi, S., . . . Pollakis, G. (2021). Ebola virus antibody decay-stimulation in a high proportion of survivors. NATURE, 590(7846), 468-+. doi:10.1038/s41586-020-03146-yA national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process (Journal article)
Harwood, R., Allin, B., Jones, C. E., Whittaker, E., Ramnarayan, P., Ramanan, A. V., . . . Kenny, S. (2021). A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. LANCET CHILD & ADOLESCENT HEALTH, 5(2), 133-141. doi:10.1016/S2352-4642(20)30304-7Comparative evaluation of ten lateral flow immunoassays to detect SARS-CoV-2 antibodies (Journal article)
Garrod, G., Owen, S., Baillie, K., Baldwin, L., Brown, L., Byrne, R., . . . ISARIC4C Investigators. (2021). Comparative evaluation of ten lateral flow immunoassays to detect SARS-CoV-2 antibodies. doi:10.12688/wellcomeopenres.16522.1Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England (Journal article)
Leclerc, Q., Fuller, N., Keogh, R., Diaz-Ordaz, K., Sekula, R., Semple, M., . . . CMMID COVID-19 Working Group. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England. doi:10.1101/2021.01.14.212497912020
Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study (Journal article)
Docherty, A., Mulholland, R., Lone, N., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . for ISARIC4C investigators. (2020). Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study. doi:10.1101/2020.12.19.20248559Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison (Journal article)
Stoesser, N. (2020). Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison. LANCET INFECTIOUS DISEASES, 20(12), 1390-1400. doi:10.1016/S1473-3099(20)30634-4COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study (Journal article)
ISARIC Clinical Characterisation Group. (2020). COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study.. medRxiv. doi:10.1101/2020.10.26.20219519Short-term forecasts to inform the response to the Covid-19 epidemic in the UK (Journal article)
Funk, S., Abbott, S., Atkins, B. D., Baguelin, M., Baillie, J. K., Birrell, P., . . . ISARIC4C Investigators. (2020). Short-term forecasts to inform the response to the Covid-19 epidemic in the UK. doi:10.1101/2020.11.11.20220962The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity (Journal article)
Thomson, E., Rosen, L., Shepherd, J., Spreafico, R., da Silva Filipe, A., Wojcechowskyj, J., . . . the COVID-19 Genomics UK (COG-UK) consortium. (2020). The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity. doi:10.1101/2020.11.04.355842Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (Journal article)
Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., . . . Investigators, I. (2020). Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. NATURE IMMUNOLOGY, 21(11), 1336-1345. doi:10.1038/s41590-020-0782-6Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study. (Journal article)
Geretti, A. M., Stockdale, A. J., Kelly, S. H., Cevik, M., Collins, S., Waters, L., . . . Semple, M. G. (2020). Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. doi:10.1093/cid/ciaa1605Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. (Journal article)
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study (Journal article)
Clift, A. K., Coupland, C. A. C., Keogh, R. H., Diaz-Ordaz, K., Williamson, E., Harrison, E. M., . . . Hippisley-Cox, J. (2020). Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ-BRITISH MEDICAL JOURNAL, 371. doi:10.1136/bmj.m3731A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (Journal article)
Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y., Schimanski, L., . . . Joly, E. (2020). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. doi:10.21203/rs.3.rs-91353/v2Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism (Journal article)
Moore, S. C., Penrice-Randal, R., Alruwaili, M., Randle, N., Armstrong, S., Hartley, C., . . . Hiscox, J. A. (2020). Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism. VIRUSES-BASEL, 12(10). doi:10.3390/v12101164A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (Preprint)
Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19 (Journal article)
Gupta, R., Harrison, E., Ho, A., Docherty, A., Knight, S., van Smeden, M., . . . Noursadeghi, M. (2020). Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19. doi:10.1101/2020.10.09.20209957Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19 (Journal article)
Thwaites, R., Sevilla Uruchurtu, A. S., Siggins, M., Liew, F., Russell, C., Moore, S., . . . Openshaw, P. J. M. (2020). Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19. doi:10.1101/2020.10.08.20209411SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. (Journal article)
Andersson, M. I., Arancibia-Carcamo, C. V., Auckland, K., Baillie, J. K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus.. Wellcome open research, 5, 181. doi:10.12688/wellcomeopenres.16002.2A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (Journal article)
Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y., Schimanski, L., . . . Joly, E. (2020). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. doi:10.1101/2020.10.02.20205831Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study. (Journal article)
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OCG154(P) User service evaluation of the regional paediatric bronchoscopy service focusing on satisfaction: ‘do we pass the friends and family test?’ (Conference Paper)
Semple, M. G., & Haigh, A. C. (2020). G154(P) User service evaluation of the regional paediatric bronchoscopy service focusing on satisfaction: ‘do we pass the friends and family test?’. In Quality improvement and patient safety. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.125G169 Are children at risk of severe influenza and its complications receiving protection from seasonal flu? (Conference Paper)
Gokulakrishnan, D., Khaliq, R., & Semple, M. G. (2020). G169 Are children at risk of severe influenza and its complications receiving protection from seasonal flu?. In British association of child and adolescent public health. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.140G301(P) Diagnosing hereditary haemorrhagic telangiectasia in children: a service evaluation project (Conference Paper)
Anderson, E. R., & Semple, M. G. (2020). G301(P) Diagnosing hereditary haemorrhagic telangiectasia in children: a service evaluation project. In Down syndrome medical interest group, british association of community child health and british paediatric respiratory society. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.262G303(P) Parent and patient perceived side effects of paediatric flexible bronchoscopy (Conference Paper)
Semple, M. G., & Bamforth, J. H. (2020). G303(P) Parent and patient perceived side effects of paediatric flexible bronchoscopy. In Down syndrome medical interest group, british association of community child health and british paediatric respiratory society. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2020-rcpch.264Genetic mechanisms of critical illness in Covid-19 (Journal article)
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A., Rawlik, K., Parkinson, N., . . . The Covid-19 Human Genetics Initiative. (2020). Genetic mechanisms of critical illness in Covid-19. doi:10.1101/2020.09.24.20200048Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. (Journal article)
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339Empowering children with asthma: a framework for clinical practice based on a qualitative literature review (Conference Paper)
Gait, L., Longworth, M., Brown, L., Worrall, V., Hepworth, C., Mingaud, N., . . . Sinha, I. (2020). Empowering children with asthma: a framework for clinical practice based on a qualitative literature review. In EUROPEAN RESPIRATORY JOURNAL Vol. 56. doi:10.1183/13993003.congress-2020.414The prevalence of poor fitness in children in a regional multidisciplinary severe asthma clinic, UK (Conference Paper)
Hepworth, C., Mingaud, N., Davies, S., Lawrence, P., Lilley, A., Gait, L., . . . Semple, M. (2020). The prevalence of poor fitness in children in a regional multidisciplinary severe asthma clinic, UK. In EUROPEAN RESPIRATORY JOURNAL Vol. 56. doi:10.1183/13993003.congress-2020.2878Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium (Conference Paper)
Palmieri, C., Turtle, L., Docherty, A., Harrison, E., Drake, T., Greenhalf, B., . . . Semple, M. G. (2020). Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium. In ANNALS OF ONCOLOGY Vol. 31 (pp. S992). doi:10.1016/j.annonc.2020.08.1735What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study (Journal article)
Sigfrid, L., Cevik, M., Jesudason, E., Lim, W. S., Rello, J., Amuasi, J. H., . . . Scott, J. (2020). What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study. doi:10.1101/2020.08.26.20180950Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study (Journal article)
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study (Journal article)
Geretti, A. M., Stockdale, A., Kelly, S., Cevik, M., Collins, S., Waters, L., . . . Group, C. H. A. S. E. S. (2020). Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study. doi:10.2139/ssrn.3666248Robust, reproducible clinical patterns in hospitalised patients with COVID-19 (Journal article)
Millar, J., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . ISARIC-4C Investigators. (2020). Robust, reproducible clinical patterns in hospitalised patients with COVID-19. doi:10.1101/2020.08.14.20168088Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial (Journal article)
Folegatti, P. M., Ewer, K. J., Aley, P. K., Angus, B., Becker, S., Belij-Rammerstorfer, S., . . . Pollard, A. J. (2020). Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. LANCET, 396(10249), 467-478. doi:10.1016/S0140-6736(20)31604-4Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: prospective observational study (Journal article)
Geretti, A., Stockdale, A., Kelly, S., Villa, G., Turtle, L., Semple, M., & Sabin, C. (2020). Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol (UK): a prospective observational study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 23, 13-14. Retrieved from https://www.webofscience.com/Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score (Journal article)
Knight, S., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T., . . . Harrison, E. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. doi:10.1101/2020.07.30.20165464Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database (Journal article)
Jacob, J., Alexander, D., Baillie, J. K., Berka, R., Bertolli, O., Blackwood, J., . . . Joshi, I. (2020). Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database. EUROPEAN RESPIRATORY JOURNAL, 56(2). doi:10.1183/13993003.01809-2020SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus (Journal article)
Andersson, M., Arancibia-Carcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. doi:10.12688/wellcomeopenres.16002.1ISARIC Clinical Data Report 20 November 2020 (Journal article)
ISARIC Clinical Characterisation Group., Baillie, K., Baruch, J., Beane, A., Blumberg, L., Bozza, F. A., . . . Merson, L. (2020). ISARIC COVID-19 Clinical Data Report: Final report January 2020 – January 2023. doi:10.1101/2020.07.17.20155218A national consensus management pathway for Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS): The results of a national Delphi process (Journal article)
Harwood, R., Allin, B., Jones, C., Whittaker, E., Ramnarayan, P., Ramanan, A., . . . Kenny, S. (2020). A national consensus management pathway for Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS): The results of a national Delphi process. doi:10.1101/2020.07.17.20156075Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study (Journal article)
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . Semple, M. (2020). Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study. doi:10.1101/2020.07.14.20153320Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study. (Journal article)
Drake, T., Docherty, A., Harrison, E., Quint, J., Adamali, H., Adamali, H., . . . ISARIC4C Investigators. (2020). Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.. doi:10.1101/2020.07.15.20152967Global outbreak research: harmony not hegemony (Journal article)
Global outbreak research: harmony not hegemony (2020). LANCET INFECTIOUS DISEASES, 20(7), 770-772. doi:10.1016/S1473-3099(20)30440-0The UK hibernated pandemic influenza research portfolio: triggered for COVID-19 (Journal article)
Simpson, C. R., Thomas, B. D., Challen, K., De Angelis, D., Fragaszy, E., Goodacre, S., . . . Knight, M. (2020). The UK hibernated pandemic influenza research portfolio: triggered for COVID-19. LANCET INFECTIOUS DISEASES, 20(7), 767-769. doi:10.1016/S1473-3099(20)30398-4Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population (Journal article)
Hippisley-Cox, J., Clift, A., Coupland, C., Keogh, R., Diaz-Ordaz, K., Williamson, E., . . . Coggon, D. (2020). Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population. doi:10.1101/2020.06.28.20141986Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients (Journal article)
Harrison, E., Docherty, A., Barr, B., Buchan, I., Carson, G., Drake, T., . . . Investigators, I. (2020). Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients. doi:10.2139/ssrn.3618215Appropriate selection of convalescent plasma donors for COVID-19. (Journal article)
Tedder, R. S., & Semple, M. G. (2020). Appropriate selection of convalescent plasma donors for COVID-19.. Lancet Infectious Diseases. doi:10.1016/s1473-3099(20)30470-9Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved] (Journal article)
Adams, E. R., Ainsworth, M., Anand, R., Andersson, M. I., Auckland, K., Baillie, J. K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]. Wellcome Open Research, 5. doi:10.12688/wellcomeopenres.15927.1Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients (Journal article)
Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., . . . Dong, T. (2020). Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.. bioRxiv. doi:10.1101/2020.06.05.134551SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus (Journal article)
Andersson, M., Arancibia-Cárcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus. doi:10.1101/2020.05.21.20105486Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration. (Journal article)
Palmieri, C., Palmer, D., Openshaw, P. J., Baille, J. K., Semple, M. G., & Turtle, L. (2020). Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration.. ESMO Open, 5(3). doi:10.1136/esmoopen-2020-000825Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. (Journal article)
Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H. E., Pius, R., Norman, L., . . . ISARIC4C investigators. (2020). Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.. BMJ (Clinical research ed.), 369. doi:10.1136/bmj.m1985COVID-19 infection in children (Journal article)
Sinha, I. P., Harwood, R., Semple, M. G., Hawcutt, D. B., Thursfield, R., Narayan, O., . . . Southern, K. W. (2020). COVID-19 infection in children. LANCET RESPIRATORY MEDICINE, 8(5), 446-447. Retrieved from https://www.webofscience.com/Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel (Journal article)
National COVID Testing Scientific Advisory Panel., Adams, E., Ainsworth, M., Anand, R., Andersson, M., Auckland, K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel. doi:10.1101/2020.04.15.20066407Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors – a pilot study of the value of serology to determine population exposure (Journal article)
Thompson, C. P., Grayson, N., Paton, R. S., Bolton, J., Lourenco, J., Penman, B. S., . . . ISARIC4C Investigators. (2020). Detection of neutralising antibodies to SARS coronavirus 2 to determine population exposure in Scottish blood donors between March and May 2020. doi:10.1101/2020.04.13.20060467Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. (Journal article)
Liu, W., Zhang, Q., Chen, J., Xiang, R., Song, H., Shu, S., . . . Liu, Y. (2020). Detection of Covid-19 in Children in Early January 2020 in Wuhan, China.. New England Journal of Medicine. doi:10.1056/NEJMc2003717Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease (Journal article)
Steptoe, P. J., Momorie, F., Fornah, A. D., Komba, P., Emsley, E., Scott, J. T., . . . Semple, M. G. (n.d.). Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease. JAMA Ophthalmology. doi:10.1001/jamaophthalmol.2020.0173Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19 (Journal article)
Moore, S., Penrice-Randal, R., Alruwaili, M., Dong, X., Pullan, S., Carter, D., . . . Hiscox, J. (2020). Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19. doi:10.1101/2020.03.05.20032011SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus (Journal article)
Andersson, M., Arancibia-Carcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. doi:10.12688/wellcomeopenres.16002.22019
A new regional multidisciplinary clinic for children with difficult asthma (Conference Paper)
Brown, L., Worrall, V., Lilley, A., Thursfield, R., Grime, C., Hepworth, C., . . . Sinha, I. (2019). A new regional multidisciplinary clinic for children with difficult asthma. In EUROPEAN RESPIRATORY JOURNAL Vol. 54. doi:10.1183/13993003.congress-2019.PA1269Convalescent plasma therapy for persistent hepatitis E virus infection (Journal article)
Ankcorn, M., Gallacher, J., Ijaz, S., Taha, Y., Harvala, H., Maclennan, S., . . . McPherson, S. (2019). Convalescent plasma therapy for persistent hepatitis E virus infection. JOURNAL OF HEPATOLOGY, 71(2), 434-438. doi:10.1016/j.jhep.2019.04.008The UK's pandemic influenza research portfolio: a model for future research on emerging infections (Journal article)
Simpson, C. R., Beever, D., Challen, K., De Angelis, D., Fragaszy, E., Goodacre, S., . . . Knight, M. (2019). The UK's pandemic influenza research portfolio: a model for future research on emerging infections. LANCET INFECTIOUS DISEASES, 19(8), E295-E300. doi:10.1016/S1473-3099(18)30786-2Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018) (Journal article)
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Griffiths, M. J. (2019). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018). NATURE IMMUNOLOGY, 20(3), 373. doi:10.1038/s41590-019-0328-yUsing research to prepare for outbreaks of severe acute respiratory infection (Journal article)
Mich, V., Pho, Y., Bory, S., Vann, M., Teav, B., Som, L., . . . Mahesh, V. (2019). Using research to prepare for outbreaks of severe acute respiratory infection. BMJ GLOBAL HEALTH, 4(1). doi:10.1136/bmjgh-2018-0010612018
Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma (Journal article)
Cordell, R. L., Valkenburg, T. S. E., Pandya, H. C., Hawcutt, D. B., Semple, M. G., & Monks, P. S. (2018). Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma. JOURNAL OF ASTHMA, 55(11), 1205-1213. doi:10.1080/02770903.2017.1402341Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone (Journal article)
Howlett, P. J., Walder, A. R., Lisk, D. R., Fitzgerald, F., Sevalie, S., Lado, M., . . . Scott, J. T. (2018). Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone. EMERGING INFECTIOUS DISEASES, 24(8), 1412-1421. doi:10.3201/eid2408.171367Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease (Journal article)
Steptoe, P. J., Momorie, F., Fornah, A. D., Komba, S. P., Emsley, E., Scott, J. T., . . . Semple, M. G. (2018). Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease. JAMA Ophthalmology, 136(6), 689-693. doi:10.1001/jamaophthalmol.2018.1248Optimising the dosing of intravenous theophylline in acute severe asthma in children (Journal article)
Saint, G. L., Semple, M., Sinha, I., & Hawcutt, D. B. (2018). Optimising the dosing of intravenous theophylline in acute severe asthma in children. Pediatric Drugs, 20(3), 209-214. doi:10.1007/s40272-017-0281-xProgression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Journal article)
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Openshaw, P. J. M. (2018). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nature Immunology, 19(06), 625-635. doi:10.1038/s41590-018-0111-5Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE ): protocol for a double-blind, randomised, placebo-controlled trial (Journal article)
Wang, K., Carver, T., Tonner, S., Semple, M. G., Hay, A. D., Moore, M., . . . Hamden, A. (2018). Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE ): protocol for a double-blind, randomised, placebo-controlled trial. BMJ OPEN, 8(5). doi:10.1136/bmjopen-2017-021144Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone (Journal article)
Tedder, R. S., Samuel, D., Dicks, S., Scott, J. T., Ijaz, S., Smith, C. C., . . . Semple, M. G. (2018). Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone. TRANSFUSION, 58(5), 1289-1298. doi:10.1111/trf.14580Visual Disability in Ebola Survivors (Journal article)
Steptoe, P. J., Beare, N. A. V., Fornah, A. D., Momorie, F., Komba, P., Vandy, M., & Semple, M. G. (2018). Visual Disability in Ebola Survivors. CLINICAL INFECTIOUS DISEASES, 66(8), 1318-1319. doi:10.1093/cid/cix979G447 The cross-sectional and longitudinal assessment of the effects of nursery attendance and breastfeeding on respiratory symptoms and their impact on quality of life in the first 22 months of life- results from the liverpool baby breathing study (Conference Paper)
Stead, J., Semple, M., Griffith, B., Pickles, R., Patel, S., & Barclay, J. (2018). G447 The cross-sectional and longitudinal assessment of the effects of nursery attendance and breastfeeding on respiratory symptoms and their impact on quality of life in the first 22 months of life- results from the liverpool baby breathing study. In British Paediatric Respiratory Society and British Society for Paediatric and Adolescent Rheumatology. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2018-rcpch.436G453(P) A survey of paediatric bronchoscopy decontamination practice in uk regional centres (Conference Paper)
Letch, E. G., Batchelor, E. G. L., & Semple, M. G. (2018). G453(P) A survey of paediatric bronchoscopy decontamination practice in uk regional centres. In British Paediatric Respiratory Society and British Society for Paediatric and Adolescent Rheumatology. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2018-rcpch.442G58(P) Are children at risk of severe influenza receiving seasonal influenza vaccine? an audit of outpatient clinics at alder hey children’s hospital (Conference Paper)
Lythgoe, C. N., Baxter, M. R., Cooke, R. P. D., & Semple, M. G. (2018). G58(P) Are children at risk of severe influenza receiving seasonal influenza vaccine? an audit of outpatient clinics at alder hey children’s hospital. In British Paediatric Allergy, Immunity and Infection Group. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi:10.1136/archdischild-2018-rcpch.56Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (<i>Ophthalmology</i>. 2017;124:170-177) (Journal article)
Steptoe, P. J., Scott, J. T., Sahr, F., Vandy, M., Harding, S. P., Beare, N. A. V., & Semple, M. G. (2018). Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (<i>Ophthalmology</i>. 2017;124:170-177). OPHTHALMOLOGY, 125(3), E19. doi:10.1016/j.ophtha.2017.09.009Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study. (Journal article)
Jagadesh, S., Sevalie, S., Fatoma, R., Sesay, F., Sahr, F., Faragher, B., . . . Scott, J. T. (2018). Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study.. Clinical Infectious Diseases, 66(1), 131-133. doi:10.1093/cid/cix7052017
Reply to Lee and colleagues Viral posterior uveitis (Journal article)
Steptoe, P. J., Scott, J. T., & Semple, M. G. (2017). Reply to Lee and colleagues Viral posterior uveitis. SURVEY OF OPHTHALMOLOGY, 62(6), 886-887. doi:10.1016/j.survophthal.2017.06.002Reply to Lee and colleagues-Viral posterior uveitis. (Journal article)
Steptoe, P. J., Scott, J. T., & Semple, M. G. (2017). Reply to Lee and colleagues-Viral posterior uveitis.. Survey of ophthalmology, 62(6), 886-887. doi:10.1016/j.survophthal.2017.06.002WHO collaborative study to assess the suitability of the 1st International Standard and the 1st International Reference Panel for antibodies to Ebola virus (Report)
Wilkinson, D. E., Hassall, M., Mattiuzzo, G., Stone, L., Atkinson, E., Hockley, J., . . . Minor, P. D. (2017). WHO collaborative study to assess the suitability of the 1st International Standard and the 1st International Reference Panel for antibodies to Ebola virus. World Health Organization. Retrieved from http://www.who.int/Ocular Complications in Survivors of the Ebola Outbreak in Guinea (Journal article)
Steptoe, P. J., Scott, J. T., Harding, S. P., Beare, N. A. V., Semple, M. G., Vandy, M. J., & Sahr, F. (2017). Ocular Complications in Survivors of the Ebola Outbreak in Guinea. AMERICAN JOURNAL OF OPHTHALMOLOGY, 181, 180. doi:10.1016/j.ajo.2017.05.029Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016 (Journal article)
Steptoe, P. J., Scott, J. T., Baxter, J. M., Parkes, C. K., Dwivedi, R., Czanner, G., . . . Semple, M. G. (2017). Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016. EMERGING INFECTIOUS DISEASES, 23(7), 1102-1109. doi:10.3201/eid2307.161608Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus (Journal article)
Semple, M. G., & Scott, J. T. (2017). Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus. The Lancet Infectious Diseases, 17(6), 645-653. doi:10.1016/S1473-3099(17)30111-1Longitudinal Changes of Geographic Retinal Darkening in a Cohort of Ebola Survivors (Conference Paper)
Steptoe, P. J., Beare, N. V., Scott, J. T., Vandy, M. J., Harrison-Williams, L., Momorie, F., . . . Semple, M. G. (2017). Longitudinal Changes of Geographic Retinal Darkening in a Cohort of Ebola Survivors. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 58. Retrieved from https://www.webofscience.com/SPRINT-SARI: Short-Period Incidence Study for Severe Acute Respiratory Infections: Year 1 Rapid Data from 2015-16 (Conference Paper)
Semple, M. G. (2017). SPRINT-SARI: Short-Period Incidence Study for Severe Acute Respiratory Infections: Year 1 Rapid Data from 2015-16. In http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2017.195.1_MeetingAbstracts.A6854. Washington, DC.Ebola virus disease sequelae: a challenge that is not going away (Journal article)
Scott, J. T., & Semple, M. G. (2017). Ebola virus disease sequelae: a challenge that is not going away. LANCET INFECTIOUS DISEASES, 17(5), 470-471. doi:10.1016/S1473-3099(17)30027-0M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza (Journal article)
Cole, S. L., Dunning, J., Kok, W. L., Benam, K. H., Benlahrech, A., Repapi, E., . . . Ho, L. -P. (2017). M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI INSIGHT, 2(7). doi:10.1172/jci.insight.91868Neurological and psychiatric manifestations of post Ebola syndrome in Sierra Leone (Conference Paper)
Howlett, P., Walder, A., Lisk, D., N'jai, A., Lado, M., Brown, C., . . . Scott, J. T. (2017). Neurological and psychiatric manifestations of post Ebola syndrome in Sierra Leone. In LANCET Vol. 389 (pp. 48). doi:10.1016/S0140-6736(17)30444-02016
Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies (Journal article)
van Griensven, J., Edwards, T., & Baize, S. (2016). Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies. New England Journal of Medicine, 375(23), 2307-2309. doi:10.1056/NEJMc1609116Electrolyte and metabolic disturbances in ebola patients during a clinical Trial, Guinea, 2015 (Journal article)
van Griensven, J., Bah, E. I., Haba, N., Delamou, A., Camara, B. S., Olivier, K. J. -J., . . . De Weggheleire, A. (2016). Electrolyte and Metabolic Disturbances in Ebola Patients during a Clinical Trial, Guinea, 2015. EMERGING INFECTIOUS DISEASES, 22(12), 2120-2127. doi:10.3201/eid2212.161136Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea (Journal article)
Delamou, A., Haba, N. Y., Mari-Saez, A., Gallian, P., Ronse, M., Jacobs, J., . . . van Griensven, J. (2016). Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea.. The American journal of tropical medicine and hygiene, 95(3), 647-653. doi:10.4269/ajtmh.15-0890Prescribing antibiotics to "at-risk' children with influenza-like illness in primary care: qualitative study (Journal article)
Ashdown, H. F., Raeisaenen, U., Wang, K., Ziebland, S., & Harnden, A. (2016). Prescribing antibiotics to "at-risk' children with influenza-like illness in primary care: qualitative study. BMJ OPEN, 6(6). doi:10.1136/bmjopen-2016-011497G487 Does the department of health’s community assessment tool (CAT) predict severe bronchiolitis in infants on admission? (Journal article)
Shorthouse, L., & Semple, M. (2016). G487 Does the department of health’s community assessment tool (CAT) predict severe bronchiolitis in infants on admission?. Archives of Disease in Childhood, 101(Suppl 1), A288.3-A289. doi:10.1136/archdischild-2016-310863.474Post-Ebola Syndrome, Sierra Leone (Journal article)
Scott, J., Sesay, F., Massaquoi, T., Idriss, B., Sahr, F., & Semple, M. G. (2016). Post-Ebola Syndrome, Sierra Leone. Emerging Infectious Diseases, 22(4), 641-646. doi:10.3201/eid2204.151302Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak (Journal article)
Edwards, T., Semple, M. G., De Weggheleire, A., Claeys, Y., De Crop, M., Menten, J., . . . van Griensven, J. (2016). Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak. CLINICAL TRIALS, 13(1), 13-21. doi:10.1177/1740774515621056Stemming the tide of hospital admissions for bronchiolitis (Journal article)
Cheung, C. R., & Semple, M. G. (2016). Stemming the tide of hospital admissions for bronchiolitis. ARCHIVES OF DISEASE IN CHILDHOOD, 101(2), 118-119. doi:10.1136/archdischild-2015-309452Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea (Journal article)
Semple, M. G. (2016). Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The New England Journal of Medicine, 374(1), 33-42. doi:10.1056/NEJMoa15118122015
DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION? (Conference Paper)
Shorthouse, L., & Semple, M. G. (2015). DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION?. In THORAX Vol. 70 (pp. A120). doi:10.1136/thoraxjnl-2015-207770.226Ebola: Europe-Africa research collaborations (Journal article)
Horby, P. W., Endzt, H., Muyembe-Tamfum, J. -J., van Griensven, J., Gevao, S., Goossens, H., . . . Kennedy, S. (2015). Ebola: Europe-Africa research collaborations. LANCET INFECTIOUS DISEASES, 15(11), 1258-1259. doi:10.1016/S1473-3099(15)00375-8Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study (Journal article)
Venkatesan, S., Myles, P. R., McCann, G., Kousoulis, A. A., Hashmi, M., Belatri, R., . . . Semple, M. G. (2015). Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study. Health Technology Assessment, 19(89), 1-132. doi:10.3310/hta19890Evaluation and refinement of pandemic inFLUenza Community Assessment Tools (Dataset)
Semple, M. (n.d.). Evaluation and refinement of pandemic inFLUenza Community Assessment Tools. doi:10.1186/isrctn87130712Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus (Journal article)
Habibi, M. S., Jozwik, A., Makris, S., Dunning, J., Paras, A., The Mechanisms of Severe Acute Influenza Consortium Investigators., . . . Chiu, C. (2015). Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191(9), 1040-1049. doi:10.1164/rccm.201412-2256OCJUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT (Conference Paper)
Brown, L. E., Sampath, S., Ryan, F., Cleary, G., McCann, L., Pain, C., . . . Baildam, E. (2015). JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT. In RHEUMATOLOGY Vol. 54 (pp. 11). doi:10.1093/rheumatology/keu508Convalescent plasma for early Ebola virus disease in Sierra Leone (Dataset)
Winters, V., & Semple, C. (n.d.). Convalescent plasma for early Ebola virus disease in Sierra Leone. doi:10.1186/isrctn13990511Effect of Ethnicity on Care Pathway and Outcomes in Patients Hospitalized With Influenza A(H1N1)pdm09 in the UK (Journal article)
Nyland, G. A., McKenzie, B. C., Myles, P. R., Semple, M. G., Lim, W. S., Openshaw, P. J. M., . . . Nguyen-Van-Tam, J. S. (2015). Effect of Ethnicity on Care Pathway and Outcomes in Patients Hospitalized With Influenza A(H1N1)pdm09 in the UK. Epidemiology and Infection, 143(6), 1129-1138. doi:10.1017/S09502688140018732014
Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom (Journal article)
Elderfield, R. A., Watson, S. J., Godlee, A., Adamson, W. E., Thompson, C. I., Dunning, J., . . . Barclay, W. S. (2014). Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom. JOURNAL OF VIROLOGY, 88(22), 13269-13283. doi:10.1128/JVI.01636-14Open source clinical science for emerging infections (Journal article)
Dunning, J. W., Merson, L., Rohde, G. G. U., Gao, Z., Semple, M. G., Dat, T., . . . Baillie, J. K. (2014). Open source clinical science for emerging infections. LANCET INFECTIOUS DISEASES, 14(1), 8-9. doi:10.1016/S1473-3099(13)70327-X2013
An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic (Journal article)
Semple, M. G., Myles, P. R., Nicholson, K. G., Lim, W. S., Read, R. C., Taylor, B. L., . . . Nguyen-Van-Tam, J. S. (2013). An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic. PLOS ONE, 8(9). doi:10.1371/journal.pone.0075384Design, development and initiation of the Liverpool Respiratory Birth Cohort Study (Thesis / Dissertation)
Pickles, R. (2013, July 1). Design, development and initiation of the Liverpool Respiratory Birth Cohort Study. (Master's Thesis, University of Liverpool).Differences between asthmatics and nonasthmatics hospitalised with influenza A infection (Journal article)
Myles, P., Nguyen-Van-Tam, J. S., Semple, M. G., Brett, S. J., Bannister, B., Read, R. C., . . . Lim, W. S. (2013). Differences between asthmatics and nonasthmatics hospitalised with influenza A infection. EUROPEAN RESPIRATORY JOURNAL, 41(4), 824-831. doi:10.1183/09031936.00015512Population variation in admission rates and duration of inpatient stay for bronchiolitis in England (Journal article)
Cheung, C. R., Smith, H., Thurland, K., Duncan, H., & Semple, M. G. (2013). Population variation in admission rates and duration of inpatient stay for bronchiolitis in England. ARCHIVES OF DISEASE IN CHILDHOOD, 98(1), 57-59. doi:10.1136/archdischild-2012-3022772012
The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection (Journal article)
Dolan, G. P., Myles, P. R., Brett, S. J., Enstone, J. E., Read, R. C., Openshaw, P. J. M., . . . Nguyen-Van-Tam, J. S. (2012). The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection. PLOS ONE, 7(8). doi:10.1371/journal.pone.0041638Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis (Conference Paper)
Semple, M. G., Flanagan, B., & Smyth, R. L. (2012). Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis. In A15. AIRWAY RESPONSES TO RESPIRATORY VIRAL INFECTION. American Thoracic Society. doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026