Professor Calum Semple OBE PhD FRCPCH FRCPE FFPH FHEA
Professor of Child Health and Outbreak Medicine, Consultant Respiratory Paediatrician at Alder Hey Children's Hospital Clinical Infection, Microbiology & Immunology
- Work email M.G.Semple@liverpool.ac.uk
Publications
Selected Publications
- A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. (Journal article - 2022)
- SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. (Journal article - 2022)
- Genetic mechanisms of critical illness in COVID-19. (Journal article - 2021)
- A prenylated dsRNA sensor protects against severe COVID-19 (Journal article - 2021)
- Ebola virus antibody decay-stimulation in a high proportion of survivors (Journal article - 2021)
- Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial (Journal article - 2020)
- Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. (Journal article - 2020)
- Features of 20?133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. (Journal article - 2020)
- Post-Ebola Syndrome, Sierra Leone (Journal article - 2016)
- Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea (Journal article - 2016)
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2022
1H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization (Journal article)
Correia, G. D. S., Takis, P. G., Sands, C. J., Kowalka, A. M., Tan, T., Turtle, L., . . . Lewis, M. R. (2022). 1H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization. Analytical Chemistry, 94(19), 6919-6923. doi:10.1021/acs.analchem.2c00466Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages (Journal article)
Prince, T., Dong, X., Penrice-Randal, R., Randle, N., Hartley, C., Goldswain, H., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages. MSPHERE. doi:10.1128/msphere.00913-21Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission (Journal article)
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study (Journal article)
Millar, J. E., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . ISARIC-4C. (2022). Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08032-3Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves (Journal article)
Swann, O. V., Pollock, L., Holden, K. A., Munro, A. P. S., Bennett, A., Williams, T. C., . . . Investigators, I. (2022). Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves. PEDIATRIC RESEARCH. doi:10.1038/s41390-022-02052-5Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol. (Journal article)
Wainstein, M., MacDonald, S., Fryer, D., Young, K., Balan, V., Begum, H., . . . ISARIC Clinical Characterisation Group. (2022). Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol.. PLoS medicine, 19(4), e1003969. doi:10.1371/journal.pmed.1003969SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses. (Journal article)
Swets, M. C., Russell, C. D., Harrison, E. M., Docherty, A. B., Lone, N., Girvan, M., . . . Baillie, J. K. (2022). SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses.. Lancet (London, England), 399(10334), 1463-1464. doi:10.1016/s0140-6736(22)00383-xClinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (Journal article)
Evans, R. A., Leavy, O. C., Richardson, M., Elneima, O., McCauley, H. J. C., Shikotra, A., . . . Zongo, O. (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. The Lancet Respiratory Medicine. doi:10.1016/s2213-2600(22)00127-8Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. (Journal article)
Rosadas, C., Khan, M., Parker, E., Marchesin, F., Katsanovskaja, K., Sureda-Vives, M., . . . Investigators, I. (2022). Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. JOURNAL OF VIROLOGICAL METHODS, 302. doi:10.1016/j.jviromet.2022.114475Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. (Journal article)
Närhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . ISARIC4C investigators. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study.. The Lancet. Digital health, 4(4), e220-e234. doi:10.1016/s2589-7500(22)00018-8Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study. (Journal article)
Stephenson, T., Pinto Pereira, S. M., Shafran, R., de Stavola, B. L., Rojas, N., McOwat, K., . . . Ladhani, S. N. (2022). Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study.. The Lancet. Child & adolescent health, 6(4), 230-239. doi:10.1016/s2352-4642(22)00022-0Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults (Journal article)
Killingley, B., Mann, A. J., Kalinova, M., Boyers, A., Goonawardane, N., Zhou, J., . . . Chiu, C. (2022). Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults. NATURE MEDICINE. doi:10.1038/s41591-022-01780-9Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study of the ISARIC cohort (Preprint)
Interstitial lung damage following COVID-19 hospitalisation: an interim analysis of the UKILD Post-COVID study (Preprint)
Admission Blood Glucose Level and Its Association With Cardiovascular and Renal Complications in Patients Hospitalized With COVID-19. (Journal article)
Norris, T., Razieh, C., Yates, T., Zaccardi, F., Gillies, C. L., Chudasama, Y. V., . . . Khunti, K. (2022). Admission Blood Glucose Level and Its Association With Cardiovascular and Renal Complications in Patients Hospitalized With COVID-19.. Diabetes care. doi:10.2337/dc21-1709GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19 (Preprint)
Whole genome sequencing reveals host factors underlying critical Covid-19. (Journal article)
Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., . . . Baillie, J. K. (2022). Whole genome sequencing reveals host factors underlying critical Covid-19. . Nature. doi:10.1038/s41586-022-04576-6A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. (Journal article)
Ahern, D. J., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., Angus, B., . . . Consortium, I. (2022). A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. CELL, 185(5), 916-+. doi:10.1016/j.cell.2022.01.012SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures (Journal article)
Winslow, R. L., Zhou, J., Windle, E. F., Nur, I., Lall, R., Ji, C., . . . Green, C. A. (2022). SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures. THORAX, 77(3), 259-267. doi:10.1136/thoraxjnl-2021-218035Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service (Journal article)
Egan, C., Turtle, L., Thorpe, M., Harrison, E. M., Semple, M. G., & Docherty, A. B. (2022). Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service. ANAESTHESIA, 77(5), 605-608. doi:10.1111/anae.15677Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. (Journal article)
Osmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., . . . and the Sechenov StopCOVID Research Team. (2022). Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. . The European respiratory journal, 59(2), 2101341. doi:10.1183/13993003.01341-2021SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. (Journal article)
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge (Journal article)
Killingley, B., Mann, A., Kalinova, M., Boyers, A., Goonawardane, N., Zhou, J., . . . Chiu, C. (2022). Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge. doi:10.21203/rs.3.rs-1121993/v1Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study (Journal article)
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., . . . Investigators, I. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 37(2), 271-284. doi:10.1093/ndt/gfab303Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number (Journal article)
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH. doi:10.1177/09622802211070257Validation of the russian version of the 4C Mortality Score and prediction of outcomes of severe COVID-19 (Journal article)
Vechorko, V. I., Averkov, O. V., Suponeva, N. A., Piradov, M. A., Zimin, A. A., Yusupova, J. G., . . . Harrison, E. M. (2022). Validation of the russian version of the 4C Mortality Score and prediction of outcomes of severe COVID-19. Infectious diseases: News, Opinions, Training, 11(1), 57-63. doi:10.33029/2305-3496-2022-11-1-57-632021
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses (Journal article)
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (n.d.). Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. doi:10.1101/2021.12.03.471045Mapping the human genetic architecture of COVID-19 (Journal article)
Initiative, C. H. G. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-xImpact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19 (Journal article)
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Investigators, I. (2021). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. HEART. doi:10.1136/heartjnl-2021-320047Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity. (Journal article)
Fallerini, C., Picchiotti, N., Baldassarri, M., Zguro, K., Daga, S., Fava, F., . . . Furini, S. (2021). Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.. Human genetics, 141(1), 147-173. doi:10.1007/s00439-021-02397-7The value of open-source clinical science in pandemic response: lessons from ISARIC (Journal article)
ISARIC, C. C. G. (2021). The value of open-source clinical science in pandemic response: lessons from ISARIC. LANCET INFECTIOUS DISEASES, 21(12), 1623-1624. doi:10.1016/S1473-3099(21)00565-XTen months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort. (Journal article)
ISARIC Clinical Characterisation Group., Hall, M. D., Baruch, J., Carson, G., Citarella, B. W., Dagens, A., . . . Olliaro, P. L. (2021). Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort. . eLife, 10, e70970. doi:10.7554/elife.70970Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (Journal article)
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Investigators, I. (2021). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX. doi:10.1136/thoraxjnl-2021-217629The impact of viral mutations on recognition by SARS-CoV-2 specific T cells (Journal article)
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Investigators, I. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353Hereditary haemorrhagic telangiectasia: development of a regional life-course collaborative clinical care pathway (Journal article)
Anderson, E., Green, R., Swift, A., & Semple, M. G. (2021). Hereditary haemorrhagic telangiectasia: development of a regional life-course collaborative clinical care pathway. BRITISH JOURNAL OF HOSPITAL MEDICINE, 82(11). doi:10.12968/hmed.2020.0537Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. (Journal article)
Evans, R. A., McAuley, H., Harrison, E. M., Shikotra, A., Singapuri, A., Sereno, M., . . . Grp, P. H. O. S. P. -C. O. V. I. D. C. (2021). Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(11), 1275-1287. doi:10.1016/S2213-2600(21)00383-0Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic (Journal article)
Cushnan, D., Berka, R., Bertolli, O., Williams, P., Schofield, D., Joshi, I., . . . Collaborative, N. C. C. I. D. (2021). Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic. DIGITAL HEALTH, 7. doi:10.1177/20552076211048654A prenylated dsRNA sensor protects against severe COVID-19 (Journal article)
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Investigators, I. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study (Journal article)
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Investigators, I. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital (Journal article)
Wright, J., Achana, F., Diwakar, L., Semple, M. G., Carroll, W. D., Baillie, K., . . . Kemp, T. S. (2021). Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 111, 333-335. doi:10.1016/j.ijid.2021.08.022The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial (Journal article)
Wang, K., Semple, M. G., Moore, M., Hay, A. D., Tonner, S., Galal, U., . . . Harnden, A. (2021). The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial. EUROPEAN RESPIRATORY JOURNAL, 58(4). doi:10.1183/13993003.02819-2020Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID) (Journal article)
Wild, J. M., Porter, J. C., Molyneaux, P. L., George, P. M., Stewart, I., Allen, R. J., . . . Jenkins, R. G. (2021). Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID). BMJ Open Respiratory Research, 8(1), e001049. doi:10.1136/bmjresp-2021-001049Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. (Journal article)
Read, J. M., Green, C. A., Harrison, E. M., Docherty, A. B., Funk, S., Harrison, J., . . . Investigators, I. (2021). Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. LANCET, 398(10305), 1037-1038. doi:10.1016/S0140-6736(21)01786-4Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study (Journal article)
Hippisley-Cox, J., Coupland, C. A. C., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., . . . Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n2244COVID-19 pneumothorax in the UK: a prospective observational study using the ISARIC WHO clinical characterisation protocol. (Journal article)
Marciniak, S. J., Farrell, J., Rostron, A., Smith, I., Openshaw, P. J. M., Baillie, J. K., . . . Semple, M. G. (2021). COVID-19 pneumothorax in the UK: a prospective observational study using the ISARIC WHO clinical characterisation protocol. EUROPEAN RESPIRATORY JOURNAL, 58(3). doi:10.1183/13993003.00929-2021Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19 (Journal article)
Munblit, D., Bobkova, P., Spiridonova, E., Shikhaleva, A., Gamirova, A., Blyuss, O., . . . StopCO, S. (2021). Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19. CLINICAL AND EXPERIMENTAL ALLERGY, 51(9), 1107-1120. doi:10.1111/cea.13997Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol (Journal article)
Sigfrid, L., Drake, T. M., Pauley, E., Jesudason, E. C., Olliaro, P., Lim, W. S., . . . ISARIC4C investigators. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol.. The Lancet regional health. Europe, 8, 100186. doi:10.1016/j.lanepe.2021.100186Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK (Conference Paper)
Palmieri, C., Turtle, L., Drake, T., Harrison, E., Docherty, A., Greenhalf, B., . . . Semple, M. M. G. (2021). LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK. In Annals of oncology : official journal of the European Society for Medical Oncology Vol. 32 (pp. S1337).Long COVID and the mental and physical health of children and young people: national matched cohort study protocol (the CLoCk study) (Journal article)
Stephenson, T., Shafran, R., De Stavola, B., Rojas, N., Aiano, F., Amin-Chowdhury, Z., . . . Members, C. C. (2021). Long COVID and the mental and physical health of children and young people: national matched cohort study protocol (the CLoCk study). BMJ OPEN, 11(8). doi:10.1136/bmjopen-2021-052838Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort (Journal article)
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort. BMC INFECTIOUS DISEASES, 21(1). doi:10.1186/s12879-021-06466-0Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study (Journal article)
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Investigator, I. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from http://gateway.webofknowledge.com/Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study (Journal article)
Garcia-Finana, M., Hughes, D. M., Cheyne, C. P., Burnside, G., Stockbridge, M., Fowler, T. A., . . . Buchan, I. (2021). Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n1637SARS-CoV-2 environmental contamination from hospitalised COVID-19 patients receiving aerosol generating procedures (Journal article)
Winslow, R. L., Zhou, J., Windle, E. F., Nur, I., Lall, R., Ji, C., . . . Green, C. A. (2021). SARS-CoV-2 environmental contamination from hospitalised COVID-19 patients receiving aerosol generating procedures. doi:10.1101/2021.07.04.21259945Soft drinks can be misused to give false “false positive” SARS-CoV-2 lateral flow device results (Preprint)
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK (Journal article)
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Investigators, I. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2Could expanding the covid-19 case definition improve the UK's pandemic response? (Journal article)
Crozier, A., Dunning, J., Rajan, S., Semple, M. G., & Buchan, I. E. (2021). Could expanding the covid-19 case definition improve the UK's pandemic response?. BMJ-BRITISH MEDICAL JOURNAL, 374. doi:10.1136/bmj.n1625Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study (Journal article)
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort (Journal article)
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Investigato, I. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK (Journal article)
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Investigators, I. S. A. R. I. C. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study (Journal article)
Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Characterisation, I. S. A. R. I. C. C. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION, 49(5), 889-905. doi:10.1007/s15010-021-01599-5Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England (Journal article)
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Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . Semple, M. (2020). Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study. doi:10.1101/2020.07.14.20153320Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study. (Journal article)
Drake, T., Docherty, A., Harrison, E., Quint, J., Adamali, H., Adamali, H., . . . ISARIC4C Investigators. (2020). Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.. doi:10.1101/2020.07.15.20152967Global outbreak research: harmony not hegemony (Journal article)
Characterisation, I. S. A. R. I. C. C. (2020). Global outbreak research: harmony not hegemony. LANCET INFECTIOUS DISEASES, 20(7), 770-772. doi:10.1016/S1473-3099(20)30440-0The UK hibernated pandemic influenza research portfolio: triggered for COVID-19 (Journal article)
Simpson, C. R., Thomas, B. D., Challen, K., De Angelis, D., Fragaszy, E., Goodacre, S., . . . Studies, N. I. H. R. H. P. (2020). The UK hibernated pandemic influenza research portfolio: triggered for COVID-19. LANCET INFECTIOUS DISEASES, 20(7), 767-769. doi:10.1016/S1473-3099(20)30398-4Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population (Journal article)
Hippisley-Cox, J., Clift, A., Coupland, C., Keogh, R., Diaz-Ordaz, K., Williamson, E., . . . Coggon, D. (2020). Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population. doi:10.1101/2020.06.28.20141986Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients (Journal article)
Harrison, E., Docherty, A., Barr, B., Buchan, I., Carson, G., Drake, T., . . . Investigators, I. (2020). Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients. doi:10.2139/ssrn.3618215Appropriate selection of convalescent plasma donors for COVID-19. (Journal article)
Tedder, R. S., & Semple, M. G. (2020). Appropriate selection of convalescent plasma donors for COVID-19.. Lancet Infectious Diseases. doi:10.1016/s1473-3099(20)30470-9Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved] (Journal article)
Adams, E. R., Ainsworth, M., Anand, R., Andersson, M. I., Auckland, K., Baillie, J. K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]. Wellcome Open Research, 5. doi:10.12688/wellcomeopenres.15927.1SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus (Journal article)
Andersson, M., Arancibia-Cárcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus. doi:10.1101/2020.05.21.20105486Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration. (Journal article)
Palmieri, C., Palmer, D., Openshaw, P. J., Baille, J. K., Semple, M. G., & Turtle, L. (2020). Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration.. ESMO Open, 5(3). doi:10.1136/esmoopen-2020-000825Features of 20?133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. (Journal article)
Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H. E., Pius, R., Norman, L., . . . ISARIC4C investigators. (2020). Features of 20?133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.. BMJ (Clinical research ed.), 369. doi:10.1136/bmj.m1985COVID-19 infection in children (Journal article)
Sinha, I. P., Harwood, R., Semple, M. G., Hawcutt, D. B., Thursfield, R., Narayan, O., . . . Southern, K. W. (2020). COVID-19 infection in children. LANCET RESPIRATORY MEDICINE, 8(5), 446-447. Retrieved from http://gateway.webofknowledge.com/Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel (Journal article)
National COVID Testing Scientific Advisory Panel., Adams, E., Ainsworth, M., Anand, R., Andersson, M., Auckland, K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel. doi:10.1101/2020.04.15.20066407Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors – a pilot study of the value of serology to determine population exposure (Journal article)
Thompson, C. P., Grayson, N., Paton, R. S., Bolton, J., Lourenco, J., Penman, B. S., . . . ISARIC4C Investigators. (2020). Detection of neutralising antibodies to SARS coronavirus 2 to determine population exposure in Scottish blood donors between March and May 2020. doi:10.1101/2020.04.13.20060467Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. (Journal article)
Liu, W., Zhang, Q., Chen, J., Xiang, R., Song, H., Shu, S., . . . Liu, Y. (2020). Detection of Covid-19 in Children in Early January 2020 in Wuhan, China.. New England Journal of Medicine. doi:10.1056/NEJMc2003717Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease (Journal article)
Steptoe, P. J., Momorie, F., Fornah, A. D., Komba, P., Emsley, E., Scott, J. T., . . . Semple, M. G. (n.d.). Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease. JAMA Ophthalmology. doi:10.1001/jamaophthalmol.2020.0173Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19 (Journal article)
Moore, S., Penrice-Randal, R., Alruwaili, M., Dong, X., Pullan, S., Carter, D., . . . Hiscox, J. (2020). Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19. doi:10.1101/2020.03.05.200320112019
A new regional multidisciplinary clinic for children with difficult asthma (Conference Paper)
Brown, L., Worrall, V., Lilley, A., Thursfield, R., Grime, C., Hepworth, C., . . . Sinha, I. (2019). A new regional multidisciplinary clinic for children with difficult asthma. In EUROPEAN RESPIRATORY JOURNAL Vol. 54. doi:10.1183/13993003.congress-2019.PA1269Convalescent plasma therapy for persistent hepatitis E virus infection (Journal article)
Ankcorn, M., Gallacher, J., Ijaz, S., Taha, Y., Harvala, H., Maclennan, S., . . . McPherson, S. (2019). Convalescent plasma therapy for persistent hepatitis E virus infection. JOURNAL OF HEPATOLOGY, 71(2), 434-438. doi:10.1016/j.jhep.2019.04.008The UK's pandemic influenza research portfolio: a model for future research on emerging infections (Journal article)
Simpson, C. R., Beever, D., Challen, K., De Angelis, D., Fragaszy, E., Goodacre, S., . . . Studie, N. I. H. R. H. I. (2019). The UK's pandemic influenza research portfolio: a model for future research on emerging infections. LANCET INFECTIOUS DISEASES, 19(8), E295-E300. doi:10.1016/S1473-3099(18)30786-2Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018) (Journal article)
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Investigators, M. O. S. A. I. C. (2019). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018). NATURE IMMUNOLOGY, 20(3), 373. doi:10.1038/s41590-019-0328-yUsing research to prepare for outbreaks of severe acute respiratory infection (Journal article)
Mich, V., Pho, Y., Bory, S., Vann, M., Teav, B., Som, L., . . . Investigators, S. P. R. I. N. T. -S. A. R. I. (2019). Using research to prepare for outbreaks of severe acute respiratory infection. BMJ GLOBAL HEALTH, 4(1). doi:10.1136/bmjgh-2018-0010612018
Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma (Journal article)
Cordell, R. L., Valkenburg, T. S. E., Pandya, H. C., Hawcutt, D. B., Semple, M. G., & Monks, P. S. (2018). Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma. JOURNAL OF ASTHMA, 55(11), 1205-1213. doi:10.1080/02770903.2017.1402341Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone (Journal article)
Howlett, P. J., Walder, A. R., Lisk, D. R., Fitzgerald, F., Sevalie, S., Lado, M., . . . Scott, J. T. (2018). Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone. EMERGING INFECTIOUS DISEASES, 24(8), 1412-1421. doi:10.3201/eid2408.171367Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease (Journal article)
Steptoe, P. J., Momorie, F., Fornah, A. D., Komba, S. P., Emsley, E., Scott, J. T., . . . Semple, M. G. (2018). Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease. JAMA Ophthalmology, 136(6), 689-693. doi:10.1001/jamaophthalmol.2018.1248Optimising the dosing of intravenous theophylline in acute severe asthma in children (Journal article)
Saint, G. L., Semple, M., Sinha, I., & Hawcutt, D. B. (2018). Optimising the dosing of intravenous theophylline in acute severe asthma in children. Pediatric Drugs, 20(3), 209-214. doi:10.1007/s40272-017-0281-xProgression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Journal article)
Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Openshaw, P. J. M. (2018). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nature Immunology, 19(06), 625-635. doi:10.1038/s41590-018-0111-5Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE ): protocol for a double-blind, randomised, placebo-controlled trial (Journal article)
Wang, K., Carver, T., Tonner, S., Semple, M. G., Hay, A. D., Moore, M., . . . Hamden, A. (2018). Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE ): protocol for a double-blind, randomised, placebo-controlled trial. BMJ OPEN, 8(5). doi:10.1136/bmjopen-2017-021144Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone (Journal article)
Tedder, R. S., Samuel, D., Dicks, S., Scott, J. T., Ijaz, S., Smith, C. C., . . . Investigators, E. C. P. C. (2018). Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone. TRANSFUSION, 58(5), 1289-1298. doi:10.1111/trf.14580Visual Disability in Ebola Survivors (Journal article)
Steptoe, P. J., Beare, N. A. V., Fornah, A. D., Momorie, F., Komba, P., Vandy, M., & Semple, M. G. (2018). Visual Disability in Ebola Survivors. CLINICAL INFECTIOUS DISEASES, 66(8), 1318-1319. doi:10.1093/cid/cix979Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (Ophthalmology. 2017;124:170-177) (Journal article)
Steptoe, P. J., Scott, J. T., Sahr, F., Vandy, M., Harding, S. P., Beare, N. A. V., & Semple, M. G. (2018). Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (Ophthalmology. 2017;124:170-177). OPHTHALMOLOGY, 125(3), E19. doi:10.1016/j.ophtha.2017.09.009Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study. (Journal article)
Jagadesh, S., Sevalie, S., Fatoma, R., Sesay, F., Sahr, F., Faragher, B., . . . Scott, J. T. (2018). Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study.. Clinical Infectious Diseases, 66(1), 131-133. doi:10.1093/cid/cix7052017
Reply to Lee and colleagues Viral posterior uveitis (Journal article)
Steptoe, P. J., Scott, J. T., & Semple, M. G. (2017). Reply to Lee and colleagues Viral posterior uveitis. SURVEY OF OPHTHALMOLOGY, 62(6), 886-887. doi:10.1016/j.survophthal.2017.06.002Reply to Lee and colleagues-Viral posterior uveitis. (Journal article)
Steptoe, P. J., Scott, J. T., & Semple, M. G. (2017). Reply to Lee and colleagues-Viral posterior uveitis.. Survey of ophthalmology, 62(6), 886-887. doi:10.1016/j.survophthal.2017.06.002WHO collaborative study to assess the suitability of the 1st International Standard and the 1st International Reference Panel for antibodies to Ebola virus (Report)
Wilkinson, D. E., Hassall, M., Mattiuzzo, G., Stone, L., Atkinson, E., Hockley, J., . . . Minor, P. D. (2017). WHO collaborative study to assess the suitability of the 1st International Standard and the 1st International Reference Panel for antibodies to Ebola virus. World Health Organization. Retrieved from http://www.who.int/Ocular Complications in Survivors of the Ebola Outbreak in Guinea (Journal article)
Steptoe, P. J., Scott, J. T., Harding, S. P., Beare, N. A. V., Semple, M. G., Vandy, M. J., & Sahr, F. (2017). Ocular Complications in Survivors of the Ebola Outbreak in Guinea. AMERICAN JOURNAL OF OPHTHALMOLOGY, 181, 180. doi:10.1016/j.ajo.2017.05.029Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016 (Journal article)
Steptoe, P. J., Scott, J. T., Baxter, J. M., Parkes, C. K., Dwivedi, R., Czanner, G., . . . Semple, M. G. (2017). Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016. EMERGING INFECTIOUS DISEASES, 23(7), 1102-1109. doi:10.3201/eid2307.161608Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus (Journal article)
Semple, M. G., & Scott, J. T. (2017). Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus. The Lancet Infectious Diseases, 17(6), 645-653. doi:10.1016/S1473-3099(17)30111-1Longitudinal Changes of Geographic Retinal Darkening in a Cohort of Ebola Survivors (Conference Paper)
Steptoe, P. J., Beare, N. V., Scott, J. T., Vandy, M. J., Harrison-Williams, L., Momorie, F., . . . Semple, M. G. (2017). Longitudinal Changes of Geographic Retinal Darkening in a Cohort of Ebola Survivors. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 58. Retrieved from http://gateway.webofknowledge.com/SPRINT-SARI: Short-Period Incidence Study for Severe Acute Respiratory Infections: Year 1 Rapid Data from 2015-16 (Conference Paper)
Semple, M. G. (2017). SPRINT-SARI: Short-Period Incidence Study for Severe Acute Respiratory Infections: Year 1 Rapid Data from 2015-16. In http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2017.195.1_MeetingAbstracts.A6854. Washington, DC.Ebola virus disease sequelae: a challenge that is not going away (Journal article)
Scott, J. T., & Semple, M. G. (2017). Ebola virus disease sequelae: a challenge that is not going away. LANCET INFECTIOUS DISEASES, 17(5), 470-471. doi:10.1016/S1473-3099(17)30027-0M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza (Journal article)
Cole, S. L., Dunning, J., Kok, W. L., Benam, K. H., Benlahrech, A., Repapi, E., . . . Investigators, M. O. S. A. I. C. (2017). M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI INSIGHT, 2(7). doi:10.1172/jci.insight.91868Neurological and psychiatric manifestations of post Ebola syndrome in Sierra Leone (Conference Paper)
Howlett, P., Walder, A., Lisk, D., N'jai, A., Lado, M., Brown, C., . . . Scott, J. T. (2017). Neurological and psychiatric manifestations of post Ebola syndrome in Sierra Leone. In LANCET Vol. 389 (pp. 48). doi:10.1016/S0140-6736(17)30444-02016
Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies (Journal article)
van Griensven, J., Edwards, T., & Baize, S. (2016). Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies. New England Journal of Medicine, 375(23), 2307-2309. doi:10.1056/NEJMc1609116Electrolyte and metabolic disturbances in ebola patients during a clinical Trial, Guinea, 2015 (Journal article)
van Griensven, J., Bah, E. I., Haba, N., Delamou, A., Camara, B. S., Olivier, K. J. -J., . . . Consortium, E. -T. (2016). Electrolyte and Metabolic Disturbances in Ebola Patients during a Clinical Trial, Guinea, 2015. EMERGING INFECTIOUS DISEASES, 22(12), 2120-2127. doi:10.3201/eid2212.161136Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea (Journal article)
Delamou, A., Haba, N. Y., Mari-Saez, A., Gallian, P., Ronse, M., Jacobs, J., . . . van Griensven, J. (2016). Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea. The American Journal of Tropical Medicine and Hygiene, 95(3), 647-653. doi:10.4269/ajtmh.15-0890Prescribing antibiotics to "at-risk' children with influenza-like illness in primary care: qualitative study (Journal article)
Ashdown, H. F., Raeisaenen, U., Wang, K., Ziebland, S., Harnden, A., & Investigators, A. R. C. H. I. E. (2016). Prescribing antibiotics to "at-risk' children with influenza-like illness in primary care: qualitative study. BMJ OPEN, 6(6). doi:10.1136/bmjopen-2016-011497Post-Ebola Syndrome, Sierra Leone (Journal article)
Scott, J., Sesay, F., Massaquoi, T., Idriss, B., Sahr, F., & Semple, M. G. (2016). Post-Ebola Syndrome, Sierra Leone. Emerging Infectious Diseases, 22(4), 641-646. doi:10.3201/eid2204.151302Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak (Journal article)
Edwards, T., Semple, M. G., De Weggheleire, A., Claeys, Y., De Crop, M., Menten, J., . . . Consortium, E. T. (2016). Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak. CLINICAL TRIALS, 13(1), 13-21. doi:10.1177/1740774515621056Stemming the tide of hospital admissions for bronchiolitis (Journal article)
Cheung, C. R., & Semple, M. G. (2016). Stemming the tide of hospital admissions for bronchiolitis. ARCHIVES OF DISEASE IN CHILDHOOD, 101(2), 118-119. doi:10.1136/archdischild-2015-309452Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea (Journal article)
Semple, M. G. (2016). Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The New England Journal of Medicine, 374(1), 33-42. doi:10.1056/NEJMoa15118122015
DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION? (Conference Paper)
Shorthouse, L., & Semple, M. G. (2015). DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION?. In THORAX Vol. 70 (pp. A120). doi:10.1136/thoraxjnl-2015-207770.226Ebola: Europe-Africa research collaborations (Journal article)
Horby, P. W., Endzt, H., Muyembe-Tamfum, J. -J., van Griensven, J., Gevao, S., Goossens, H., . . . Kennedy, S. (2015). Ebola: Europe-Africa research collaborations. LANCET INFECTIOUS DISEASES, 15(11), 1258-1259. doi:10.1016/S1473-3099(15)00375-8Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study (Journal article)
Venkatesan, S., Myles, P. R., McCann, G., Kousoulis, A. A., Hashmi, M., Belatri, R., . . . Semple, M. G. (2015). Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study. Health Technology Assessment, 19(89), 1-132. doi:10.3310/hta19890Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus (Journal article)
Habibi, M. S., Jozwik, A., Makris, S., Dunning, J., Paras, A., The Mechanisms of Severe Acute Influenza Consortium Investigators., . . . Chiu, C. (2015). Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191(9), 1040-1049. doi:10.1164/rccm.201412-2256OCJUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT (Conference Paper)
Brown, L. E., Sampath, S., Ryan, F., Cleary, G., McCann, L., Pain, C., . . . Baildam, E. (2015). JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT. In RHEUMATOLOGY Vol. 54 (pp. 11). doi:10.1093/rheumatology/keu508Convalescent plasma for early Ebola virus disease in Sierra Leone (Dataset)
Winters, V., & Semple, C. (n.d.). Convalescent plasma for early Ebola virus disease in Sierra Leone. doi:10.1186/isrctn13990511Effect of Ethnicity on Care Pathway and Outcomes in Patients Hospitalized With Influenza A(H1N1)pdm09 in the UK (Journal article)
Nyland, G. A., McKenzie, B. C., Myles, P. R., Semple, M. G., Lim, W. S., Openshaw, P. J. M., . . . Nguyen-Van-Tam, J. S. (2015). Effect of Ethnicity on Care Pathway and Outcomes in Patients Hospitalized With Influenza A(H1N1)pdm09 in the UK. Epidemiology and Infection, 143(6), 1129-1138. doi:10.1017/S09502688140018732014
Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom (Journal article)
Elderfield, R. A., Watson, S. J., Godlee, A., Adamson, W. E., Thompson, C. I., Dunning, J., . . . Investigators, M. O. S. A. I. C. (2014). Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom. JOURNAL OF VIROLOGY, 88(22), 13269-13283. doi:10.1128/JVI.01636-14Open source clinical science for emerging infections (Journal article)
Dunning, J. W., Merson, L., Rohde, G. G. U., Gao, Z., Semple, M. G., Tran, D., . . . Council, I. S. A. R. I. C. (2014). Open source clinical science for emerging infections. LANCET INFECTIOUS DISEASES, 14(1), 8-9. doi:10.1016/S1473-3099(13)70327-X2013
An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic (Journal article)
Semple, M. G., Myles, P. R., Nicholson, K. G., Lim, W. S., Read, R. C., Taylor, B. L., . . . Nguyen-Van-Tam, J. S. (2013). An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic. PLOS ONE, 8(9). doi:10.1371/journal.pone.0075384Design, development and initiation of the Liverpool Respiratory Birth Cohort Study (Thesis / Dissertation)
Pickles, R. (2013, July 1). Design, development and initiation of the Liverpool Respiratory Birth Cohort Study. (Master's Thesis, University of Liverpool).Differences between asthmatics and nonasthmatics hospitalised with influenza A infection (Journal article)
Myles, P., Nguyen-Van-Tam, J. S., Semple, M. G., Brett, S. J., Bannister, B., Read, R. C., . . . Net, I. C. I. (2013). Differences between asthmatics and nonasthmatics hospitalised with influenza A infection. EUROPEAN RESPIRATORY JOURNAL, 41(4), 824-831. doi:10.1183/09031936.00015512Evaluation and refinement of pandemic inFLUenza Community Assessment Tools (Dataset)
Semple, M. (n.d.). Evaluation and refinement of pandemic inFLUenza Community Assessment Tools. doi:10.1186/isrctn87130712Population variation in admission rates and duration of inpatient stay for bronchiolitis in England (Journal article)
Cheung, C. R., Smith, H., Thurland, K., Duncan, H., & Semple, M. G. (2013). Population variation in admission rates and duration of inpatient stay for bronchiolitis in England. ARCHIVES OF DISEASE IN CHILDHOOD, 98(1), 57-59. doi:10.1136/archdischild-2012-3022772012
The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection (Journal article)
Dolan, G. P., Myles, P. R., Brett, S. J., Enstone, J. E., Read, R. C., Openshaw, P. J. M., . . . Net, I. C. I. (2012). The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection. PLOS ONE, 7(8). doi:10.1371/journal.pone.0041638Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis (Conference Paper)
Semple, M. G., Flanagan, B., & Smyth, R. L. (2012). Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis. In A15. AIRWAY RESPONSES TO RESPIRATORY VIRAL INFECTION. American Thoracic Society. doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026