Photo of Professor Calum Semple

Professor Calum Semple OBE PhD FRCPCH FRCPE FHEA

Professor of Child Health and Outbreak Medicine, Consultant Respiratory Paediatrician at Alder Hey Children's Hospital Clinical Infection, Microbiology & Immunology

Publications

2021

Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19 (Journal article)

Munblit, D., Bobkova, P., Spiridonova, E., Shikhaleva, A., Gamirova, A., Blyuss, O., . . . StopCO, S. (2021). Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19. CLINICAL AND EXPERIMENTAL ALLERGY, 51(9), 1107-1120. doi:10.1111/cea.13997

DOI: 10.1111/cea.13997

Soft drinks can be misused to give false “false positive” SARS-CoV-2 lateral flow device results (Journal article)

Oni, L., Hawcutt, D. B., Buchan, I. E., & Semple, M. G. (2021). Soft drinks can be misused to give false “false positive” SARS-CoV-2 lateral flow device results. doi:10.1101/2021.07.05.21260003

DOI: 10.1101/2021.07.05.21260003

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK (Journal article)

Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Investigators, I. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2

DOI: 10.1016/S2213-2600(21)00175-2

Going viral: misinformation in the time of COVID-19 (Journal article)

Going viral: misinformation in the time of COVID-19 (2021). LANCET RHEUMATOLOGY, 3(6), E393. doi:10.1016/S2665-9913(21)00104-1

DOI: 10.1016/S2665-9913(21)00104-1

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort (Journal article)

Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Investigato, I. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178

DOI: 10.1002/oby.23178

Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study. (Journal article)

Osmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., . . . Sechenov StopCOVID Research Team. (2021). Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study.. The European respiratory journal. doi:10.1183/13993003.01341-2021

DOI: 10.1183/13993003.01341-2021

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK (Journal article)

Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Investigators, I. S. A. R. I. C. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8

DOI: 10.1016/S2213-2600(21)00013-8

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study (Journal article)

Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Characterisation, I. S. A. R. I. C. C. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION. doi:10.1007/s15010-021-01599-5

DOI: 10.1007/s15010-021-01599-5

Evaluation of the effectiveness of remdesivir in treating severe COVID-19 using data from the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, national cohort study (Journal article)

Arch, B. N., Kovacs, D., Scott, J. T., Jones, A. P., Harrison, E. M., Rosala-Hallas, A., . . . Semple, M. G. (2021). Evaluation of the effectiveness of remdesivir in treating severe COVID-19 using data from the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, national cohort study. doi:10.1101/2021.06.18.21259072

DOI: 10.1101/2021.06.18.21259072

Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial (Journal article)

Pauley, E., Drake, T., Griffith, D., Lone, N., Harrison, E., Baillie, K., . . . Docherty, A. (2021). Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial. doi:10.1101/2021.06.15.21258879

DOI: 10.1101/2021.06.15.21258879

COVID-19 Pneumothorax in the United Kingdom: a prospective observational study using the ISARIC WHO clinical characterisation protocol. (Journal article)

Marciniak, S. J., Farrell, J., Rostron, A., Smith, I., Openshaw, P. J. M., Baillie, J. K., . . . Semple, M. G. (2021). COVID-19 Pneumothorax in the United Kingdom: a prospective observational study using the ISARIC WHO clinical characterisation protocol.. The European respiratory journal. doi:10.1183/13993003.00929-2021

DOI: 10.1183/13993003.00929-2021

Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England (Journal article)

Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-x

DOI: 10.1186/s12913-021-06509-x

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. (Journal article)

Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . ISARIC4C investigators. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study.. The Lancet. Microbe, 2(8), e354-e365. doi:10.1016/s2666-5247(21)00090-2

DOI: 10.1016/s2666-5247(21)00090-2

Fatal COVID-19 Outcomes are Associated with an Antibody Response Targeting Epitopes Shared with Endemic Coronaviruses (Journal article)

McNaughton, A., Paton, R., Edmans, M., Youngs, J., Wellens, J., Phalora, P., . . . Thompson, C. (2021). Fatal COVID-19 Outcomes are Associated with an Antibody Response Targeting Epitopes Shared with Endemic Coronaviruses. doi:10.2139/ssrn.3858917

DOI: 10.2139/ssrn.3858917

Occupational inequalities in the prevalence of COVID-19: A longitudinal observational study of England, August 2020 to January 2021 (Journal article)

Green, M., & Semple, M. (2021). Occupational inequalities in the prevalence of COVID-19: A longitudinal observational study of England, August 2020 to January 2021. doi:10.1101/2021.06.01.21258140

DOI: 10.1101/2021.06.01.21258140

Legacy of COVID-19 infection in children: long-COVID will have a lifelong health/economic impact. (Journal article)

Munblit, D., Simpson, F., Mabbitt, J., Dunn-Galvin, A., Semple, C., & Warner, J. O. (2021). Legacy of COVID-19 infection in children: long-COVID will have a lifelong health/economic impact.. Archives of disease in childhood. doi:10.1136/archdischild-2021-321882

DOI: 10.1136/archdischild-2021-321882

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity (Journal article)

COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium., Ahern, D., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., . . . Zurke, Y. -X. (2021). A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. doi:10.1101/2021.05.11.21256877

DOI: 10.1101/2021.05.11.21256877

Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses (Journal article)

McNaughton, A., Paton, R., Edmans, M., Youngs, J., Wellens, J., Phalora, P., . . . ISARIC4C Investigators. (2021). Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses. doi:10.1101/2021.05.04.21256571

DOI: 10.1101/2021.05.04.21256571

Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study (Journal article)

Osmanov, I., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., . . . Sechenov StopCOVID Research Team. (2021). Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study. doi:10.1101/2021.04.26.21256110

DOI: 10.1101/2021.04.26.21256110

Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19 (Journal article)

Mina, M. J., Peto, T. E., Garcia-Finana, M., Semple, M. G., & Buchan, I. E. (2021). Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19. LANCET, 397(10283), 1425-1427. doi:10.1016/S0140-6736(21)00425-6

DOI: 10.1016/S0140-6736(21)00425-6

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality (Journal article)

Shaw, R. J., Abrams, S. T., Austin, J., Taylor, J. M., Lane, S., Dutt, T., . . . investigators, I. (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. HAEMATOLOGICA, 106(9), 2493-2498. doi:10.3324/haematol.2021.278492

DOI: 10.3324/haematol.2021.278492

Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study (Journal article)

Davies, N. G., Barnard, R. C., Jarvis, C. I., Russell, T. W., Semple, M. G., Jit, M., . . . Investigators, I. (2021). Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study. LANCET INFECTIOUS DISEASES, 21(4), 482-492. doi:10.1016/S1473-3099(20)30984-1

DOI: 10.1016/S1473-3099(20)30984-1

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study (Journal article)

Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Investigators, I. S. A. R. I. C. C. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2

DOI: 10.1016/S2213-2600(20)30559-2

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. (Journal article)

Flood, J., Shingleton, J., Bennett, E., Walker, B., Amin-Chowdhury, Z., Oligbu, G., . . . Ladhani, S. N. (2021). Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020.. The Lancet regional health. Europe, 3, 100075. doi:10.1016/j.lanepe.2021.100075

DOI: 10.1016/j.lanepe.2021.100075

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context (Journal article)

Prince, T., Dong, X., Penrice-Randal, R., Randle, N., Hartley, C., Goldswain, H., . . . ISARIC4C Investigators. (2021). Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context. doi:10.1101/2021.03.30.437704

DOI: 10.1101/2021.03.30.437704

A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (Journal article)

Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y. A., Schimanski, L., . . . Joly, E. (2021). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-22045-y

DOI: 10.1038/s41467-021-22045-y

Physical, cognitive and mental health impacts of COVID-19 following hospitalisation – a multi-centre prospective cohort study (Journal article)

PHOSP-COVID Collaborative Group., Evans, R. A., McAuley, H., Harrison, E., Shikotra, A., Singapuri, A., . . . Brightling, C. (2021). Physical, cognitive and mental health impacts of COVID-19 following hospitalisation – a multi-centre prospective cohort study. doi:10.1101/2021.03.22.21254057

DOI: 10.1101/2021.03.22.21254057

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol (Journal article)

Sigfrid, L., Drake, T., Pauley, E., Jesudason, E., Olliaro, P., Lim, W. S., . . . ISARIC4C investigators. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. doi:10.1101/2021.03.18.21253888

DOI: 10.1101/2021.03.18.21253888

The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial. (Journal article)

Wang, K., Semple, M. G., Moore, M., Hay, A. D., Tonner, S., Galal, U., . . . Harnden, A. (2021). The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial.. The European respiratory journal. doi:10.1183/13993003.02819-2020

DOI: 10.1183/13993003.02819-2020

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19. (Journal article)

Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873

DOI: 10.1126/sciimmunol.abg9873

Performance of the Innova SARS-CoV-2 Antigen Rapid Lateral Flow Test in the Liverpool Asymptomatic Testing Pilot (Journal article)

García-Fiñana, M., Hughes, D. M., Cheyne, C., Burnside, G., Stockbridge, M., Fowler, T. A., . . . Buchan, I. (2021). Performance of the Innova SARS-CoV-2 Antigen Rapid Lateral Flow Test in the Liverpool Asymptomatic Testing Pilot. doi:10.2139/ssrn.3798558

DOI: 10.2139/ssrn.3798558

What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol. (Journal article)

Sigfrid, L., Cevik, M., Jesudason, E., Lim, W. S., Rello, J., Amuasi, J., . . . Scott, J. T. (2021). What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol.. BMJ Open, 11(3), e043887. doi:10.1136/bmjopen-2020-043887

DOI: 10.1136/bmjopen-2020-043887

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity (Journal article)

Thomson, E. C., Rosen, L. E., Shepherd, J. G., Spreafico, R., Filipe, A. D. S., Wojcechowskyj, J. A., . . . Consor, C. G. U. C. O. G. -U. K. (2021). Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. CELL, 184(5), 1171-+. doi:10.1016/j.cell.2021.01.037

DOI: 10.1016/j.cell.2021.01.037

Genetic mechanisms of critical illness in COVID-19. (Journal article)

Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Investigators, G. -C. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-y

DOI: 10.1038/s41586-020-03065-y

Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans (Journal article)

Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Salguero, J., . . . COVID-19 Genomics UK (COG-UK) Consortium. (2021). Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans. doi:10.1101/2021.03.03.433753

DOI: 10.1101/2021.03.03.433753

Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps (Journal article)

De Luca, D., Cogo, P., Kneyber, M. C., Biban, P., Semple, M. G., Perez-Gil, J., . . . Rimensberger, P. C. (2021). Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps. CRITICAL CARE, 25(1). doi:10.1186/s13054-021-03489-6

DOI: 10.1186/s13054-021-03489-6

Risk factors for long-term consequences of COVID-19 in hospitalised adults in Moscow using the ISARIC Global follow-up protocol: StopCOVID cohort study (Journal article)

Munblit, D., Bobkova, P., Spiridonova, E., Shikhaleva, A., Gamirova, A., Blyuss, O., . . . Sechenov StopCOVID Research Team. (2021). Risk factors for long-term consequences of COVID-19 in hospitalised adults in Moscow using the ISARIC Global follow-up protocol: StopCOVID cohort study. doi:10.1101/2021.02.17.21251895

DOI: 10.1101/2021.02.17.21251895

Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort Study (Journal article)

Russell, C. D., Fairfield, C., Drake, T., Turtle, L., Seaton, A., Wootton, D., . . . Group, I. I. (2021). Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort Study. doi:10.2139/ssrn.3786694

DOI: 10.2139/ssrn.3786694

A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process (Journal article)

Harwood, R., Allin, B., Jones, C. E., Whittaker, E., Ramnarayan, P., Ramanan, A. V., . . . Management, P. I. M. S. -T. S. N. C. (2021). A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. LANCET CHILD & ADOLESCENT HEALTH, 5(2), 133-141. doi:10.1016/S2352-4642(20)30304-7

DOI: 10.1016/S2352-4642(20)30304-7

Comparative evaluation of ten lateral flow immunoassays to detect SARS-CoV-2 antibodies (Journal article)

Garrod, G., Owen, S., Baillie, K., Baldwin, L., Brown, L., Byrne, R., . . . ISARIC4C Investigators. (2021). Comparative evaluation of ten lateral flow immunoassays to detect SARS-CoV-2 antibodies. doi:10.12688/wellcomeopenres.16522.1

DOI: 10.12688/wellcomeopenres.16522.1

Ebola virus antibody decay-stimulation in a high proportion of survivors (Journal article)

Adaken, C., Scott, J. T., Sharma, R., Gopal, R., Dicks, S., Niazi, S., . . . Consortium, E. B. O. L. A. -C. P. (2021). Ebola virus antibody decay-stimulation in a high proportion of survivors. NATURE. doi:10.1038/s41586-020-03146-y

DOI: 10.1038/s41586-020-03146-y

Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England (Journal article)

Leclerc, Q., Fuller, N., Keogh, R., Diaz-Ordaz, K., Sekula, R., Semple, M., . . . CMMID COVID-19 Working Group. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England. doi:10.1101/2021.01.14.21249791

DOI: 10.1101/2021.01.14.21249791

Detection and Quantification of Antibody to SARS-CoV-2 Receptor Binding Domain Provides Enhanced Sensitivity, Specificity and Utility (Journal article)

Tedder, R., Parker, E., Sureda-Vives, M., Fernandez, N., Randell, P., Marchesin, F., . . . McLure, M. (2021). Detection and Quantification of Antibody to SARS-CoV-2 Receptor Binding Domain Provides Enhanced Sensitivity, Specificity and Utility. doi:10.2139/ssrn.3739821

DOI: 10.2139/ssrn.3739821

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol (Journal article)

Sigfrid, L., Drake, T. M., Pauley, E., Jesudason, E. C., Olliaro, P., Lim, W. S., . . . Scott, J. T. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. The Lancet Regional Health - Europe, 8, 100186. doi:10.1016/j.lanepe.2021.100186

DOI: 10.1016/j.lanepe.2021.100186

2020

Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study (Journal article)

Docherty, A., Mulholland, R., Lone, N., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . for ISARIC4C investigators. (2020). Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study. doi:10.1101/2020.12.19.20248559

DOI: 10.1101/2020.12.19.20248559

Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison (Journal article)

Stoesser, N., & Assay, N. S. -C. S. (2020). Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison. LANCET INFECTIOUS DISEASES, 20(12), 1390-1400. doi:10.1016/S1473-3099(20)30634-4

DOI: 10.1016/s1473-3099(20)30634-4

COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study (Journal article)

Pritchard, M. G. (n.d.). COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study. doi:10.1101/2020.10.26.20219519

DOI: 10.1101/2020.10.26.20219519

Short-term forecasts to inform the response to the Covid-19 epidemic in the UK (Journal article)

Funk, S., Abbott, S., Atkins, B. D., Baguelin, M., Baillie, J. K., Birrell, P., . . . ISARIC4C Investigators. (2020). Short-term forecasts to inform the response to the Covid-19 epidemic in the UK. doi:10.1101/2020.11.11.20220962

DOI: 10.1101/2020.11.11.20220962

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity (Journal article)

Thomson, E., Rosen, L., Shepherd, J., Spreafico, R., da Silva Filipe, A., Wojcechowskyj, J., . . . the COVID-19 Genomics UK (COG-UK) consortium. (2020). The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity. doi:10.1101/2020.11.04.355842

DOI: 10.1101/2020.11.04.355842

Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (Journal article)

Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., . . . Investigators, I. (2020). Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. NATURE IMMUNOLOGY, 21(11), 1336-1345. doi:10.1038/s41590-020-0782-6

DOI: 10.1038/s41590-020-0782-6

Comment on: Dark without pressure retinal changes in a paediatric age group (Journal article)

Steptoe, P. J., Beare, N. A. V., & Semple, M. G. (2020). Comment on: Dark without pressure retinal changes in a paediatric age group. EYE. doi:10.1038/s41433-020-01252-9

DOI: 10.1038/s41433-020-01252-9

Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study. (Journal article)

Geretti, A. M., Stockdale, A. J., Kelly, S. H., Cevik, M., Collins, S., Waters, L., . . . Semple, M. G. (2020). Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. doi:10.1093/cid/ciaa1605

DOI: 10.1093/cid/ciaa1605

Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. (Journal article)

Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Investigators, I. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685

DOI: 10.2807/1560-7917.es.2020.25.42.2000685

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study (Journal article)

Clift, A. K., Coupland, C. A. C., Keogh, R. H., Diaz-Ordaz, K., Williamson, E., Harrison, E. M., . . . Hippisley-Cox, J. (2020). Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ-BRITISH MEDICAL JOURNAL, 371. doi:10.1136/bmj.m3731

DOI: 10.1136/bmj.m3731

Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism (Journal article)

Moore, S. C., Penrice-Randal, R., Alruwaili, M., Randle, N., Armstrong, S., Hartley, C., . . . Hiscox, J. A. (2020). Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism. VIRUSES-BASEL, 12(10). doi:10.3390/v12101164

DOI: 10.3390/v12101164

Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19 (Journal article)

Gupta, R., Harrison, E., Ho, A., Docherty, A., Knight, S., van Smeden, M., . . . Noursadeghi, M. (2020). Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19. doi:10.1101/2020.10.09.20209957

DOI: 10.1101/2020.10.09.20209957

Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19 (Journal article)

Thwaites, R., Sevilla Uruchurtu, A. S., Siggins, M., Liew, F., Russell, C., Moore, S., . . . Openshaw, P. J. M. (2020). Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19. doi:10.1101/2020.10.08.20209411

DOI: 10.1101/2020.10.08.20209411

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients (Journal article)

Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., . . . Dong, T. (n.d.). Broad and strong memory CD4+and CD8+T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients. doi:10.1101/2020.06.05.134551

DOI: 10.1101/2020.06.05.134551

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus (Journal article)

Andersson, M., Arancibia-Carcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. doi:10.12688/wellcomeopenres.16002.2

DOI: 10.12688/wellcomeopenres.16002.2

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. (Journal article)

Andersson, M. I., Arancibia-Carcamo, C. V., Auckland, K., Baillie, J. K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus.. Wellcome open research, 5, 181. doi:10.12688/wellcomeopenres.16002.2

DOI: 10.12688/wellcomeopenres.16002.1

A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (Journal article)

Townsend, A., Rijal, P., Xiao, J., Tan, T. K., Huang, K. -Y., Schimanski, L., . . . Joly, E. (2020). A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. doi:10.1101/2020.10.02.20205831

DOI: 10.1101/2020.10.02.20205831

Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study. (Journal article)

Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OC

DOI: 10.1164/rccm.202007-2794OC

Genetic mechanisms of critical illness in Covid-19 (Journal article)

Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A., Rawlik, K., Parkinson, N., . . . The Covid-19 Human Genetics Initiative. (2020). Genetic mechanisms of critical illness in Covid-19. doi:10.1101/2020.09.24.20200048

DOI: 10.1101/2020.09.24.20200048

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. (Journal article)

Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339

DOI: 10.1136/bmj.m3339

Empowering children with asthma: a framework for clinical practice based on a qualitative literature review (Conference Paper)

Gait, L., Longworth, M., Brown, L., Worrall, V., Hepworth, C., Mingaud, N., . . . Sinha, I. (2020). Empowering children with asthma: a framework for clinical practice based on a qualitative literature review. In EUROPEAN RESPIRATORY JOURNAL Vol. 56. doi:10.1183/13993003.congress-2020.414

DOI: 10.1183/13993003.congress-2020.414

The prevalence of poor fitness in children in a regional multidisciplinary severe asthma clinic, UK (Conference Paper)

Hepworth, C., Mingaud, N., Davies, S., Lawrence, P., Lilley, A., Gait, L., . . . Semple, M. (2020). The prevalence of poor fitness in children in a regional multidisciplinary severe asthma clinic, UK. In EUROPEAN RESPIRATORY JOURNAL Vol. 56. doi:10.1183/13993003.congress-2020.2878

DOI: 10.1183/13993003.congress-2020.2878

Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium (Conference Paper)

Palmieri, C., Turtle, L., Docherty, A., Harrison, E., Drake, T., Greenhalf, B., . . . Semple, M. G. (2020). Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium. In ANNALS OF ONCOLOGY Vol. 31 (pp. S992). doi:10.1016/j.annonc.2020.08.1735

DOI: 10.1016/j.annonc.2020.08.1735

What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study (Journal article)

Sigfrid, L., Cevik, M., Jesudason, E., Lim, W. S., Rello, J., Amuasi, J. H., . . . Scott, J. (2020). What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study. doi:10.1101/2020.08.26.20180950

DOI: 10.1101/2020.08.26.20180950

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study (Journal article)

Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249

DOI: 10.1136/bmj.m3249

Robust, reproducible clinical patterns in hospitalised patients with COVID-19 (Journal article)

Millar, J., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . ISARIC-4C Investigators. (2020). Robust, reproducible clinical patterns in hospitalised patients with COVID-19. doi:10.1101/2020.08.14.20168088

DOI: 10.1101/2020.08.14.20168088

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial (Journal article)

Folegatti, P. M., Ewer, K. J., Aley, P. K., Angus, B., Becker, S., Belij-Rammerstorfer, S., . . . Grp, O. C. O. V. I. D. V. T. (2020). Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. LANCET, 396(10249), 467-478. doi:10.1016/S0140-6736(20)31604-4

DOI: 10.1016/s0140-6736(20)31604-4

Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. (Journal article)

Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., ISARIC4C Investigators., . . . Hill, E. M. (2020). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number.. medRxiv. doi:10.1101/2020.08.04.20163782

DOI: 10.1101/2020.08.04.20163782

Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: prospective observational study (Journal article)

Geretti, A., Stockdale, A., Kelly, S., Villa, G., Turtle, L., Semple, M., & Sabin, C. (2020). Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol (UK): a prospective observational study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 23, 13-14. Retrieved from http://gateway.webofknowledge.com/

DOI: 10.1101/2020.08.07.20170449

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score (Journal article)

Knight, S., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T., . . . Harrison, E. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. doi:10.1101/2020.07.30.20165464

DOI: 10.1101/2020.07.30.20165464

Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database (Journal article)

Jacob, J., Alexander, D., Baillie, J. K., Berka, R., Bertolli, O., Blackwood, J., . . . Joshi, I. (2020). Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database. EUROPEAN RESPIRATORY JOURNAL, 56(2). doi:10.1183/13993003.01809-2020

DOI: 10.1183/13993003.01809-2020

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus (Journal article)

Andersson, M., Arancibia-Carcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. doi:10.12688/wellcomeopenres.16002.1

DOI: 10.12688/wellcomeopenres.16002.1

ISARIC Clinical Data Report 20 November 2020 (Journal article)

ISARIC Clinical Characterisation Group., Baillie, K., Baillie, K., Baruch, J., Beane, A., Blumberg, L., . . . Merson, L. (2020). ISARIC Clinical Data Report issued: 14 July 2021. doi:10.1101/2020.07.17.20155218

DOI: 10.1101/2020.07.17.20155218

Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study (Journal article)

Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . Semple, M. (2020). Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study. doi:10.1101/2020.07.14.20153320

DOI: 10.1101/2020.07.14.20153320

Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study. (Journal article)

Drake, T., Docherty, A., Harrison, E., Quint, J., Adamali, H., Adamali, H., . . . ISARIC4C Investigators. (2020). Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.. doi:10.1101/2020.07.15.20152967

DOI: 10.1101/2020.07.15.20152967

Global outbreak research: harmony not hegemony (Journal article)

Characterisation, I. S. A. R. I. C. C. (2020). Global outbreak research: harmony not hegemony. LANCET INFECTIOUS DISEASES, 20(7), 770-772. doi:10.1016/S1473-3099(20)30440-0

DOI: 10.1016/S1473-3099(20)30440-0

The UK hibernated pandemic influenza research portfolio: triggered for COVID-19 (Journal article)

Simpson, C. R., Thomas, B. D., Challen, K., De Angelis, D., Fragaszy, E., Goodacre, S., . . . Studies, N. I. H. R. H. P. (2020). The UK hibernated pandemic influenza research portfolio: triggered for COVID-19. LANCET INFECTIOUS DISEASES, 20(7), 767-769. doi:10.1016/S1473-3099(20)30398-4

DOI: 10.1016/S1473-3099(20)30398-4

Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population (Journal article)

Hippisley-Cox, J., Clift, A., Coupland, C., Keogh, R., Diaz-Ordaz, K., Williamson, E., . . . Coggon, D. (2020). Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population. doi:10.1101/2020.06.28.20141986

DOI: 10.1101/2020.06.28.20141986

Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients (Journal article)

Harrison, E. M., Docherty, A. B., Barr, B., Buchan, I., Carson, G., Drake, T. M., . . . Semple, M. G. (n.d.). Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients. SSRN Electronic Journal. doi:10.2139/ssrn.3618215

DOI: 10.2139/ssrn.3618215

Appropriate selection of convalescent plasma donors for COVID-19. (Journal article)

Tedder, R. S., & Semple, M. G. (2020). Appropriate selection of convalescent plasma donors for COVID-19.. Lancet Infectious Diseases. doi:10.1016/s1473-3099(20)30470-9

DOI: 10.1016/s1473-3099(20)30470-9

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved] (Journal article)

Adams, E. R., Ainsworth, M., Anand, R., Andersson, M. I., Auckland, K., Baillie, J. K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]. Wellcome Open Research, 5. doi:10.12688/wellcomeopenres.15927.1

DOI: 10.12688/wellcomeopenres.15927.1

SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus (Journal article)

Andersson, M., Arancibia-Cárcamo, C., Auckland, K., Baillie, K., Barnes, E., Beneke, T., . . . Zambon, M. (2020). SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus. doi:10.1101/2020.05.21.20105486

DOI: 10.1101/2020.05.21.20105486

Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration. (Journal article)

Palmieri, C., Palmer, D., Openshaw, P. J., Baille, J. K., Semple, M. G., & Turtle, L. (2020). Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration.. ESMO Open, 5(3). doi:10.1136/esmoopen-2020-000825

DOI: 10.1136/esmoopen-2020-000825

Features of 20?133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. (Journal article)

Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H. E., Pius, R., Norman, L., . . . ISARIC4C investigators. (2020). Features of 20?133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.. BMJ (Clinical research ed.), 369. doi:10.1136/bmj.m1985

DOI: 10.1136/bmj.m1985

COVID-19 infection in children (Journal article)

Sinha, I. P., Harwood, R., Semple, M. G., Hawcutt, D. B., Thursfield, R., Narayan, O., . . . Southern, K. W. (2020). COVID-19 infection in children. LANCET RESPIRATORY MEDICINE, 8(5), 446-447. Retrieved from http://gateway.webofknowledge.com/

Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (Journal article)

Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H., Pius, R., Norman, L., . . . ISARIC4C Investigators. (2020). Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. doi:10.1101/2020.04.23.20076042

DOI: 10.1101/2020.04.23.20076042

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel (Journal article)

National COVID Testing Scientific Advisory Panel., Adams, E., Ainsworth, M., Anand, R., Andersson, M., Auckland, K., . . . Whitehouse, J. (2020). Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel. doi:10.1101/2020.04.15.20066407

DOI: 10.1101/2020.04.15.20066407

Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors – a pilot study of the value of serology to determine population exposure (Journal article)

Thompson, C. P., Grayson, N., Paton, R. S., Bolton, J., Lourenco, J., Penman, B. S., . . . ISARIC4C Investigators. (2020). Detection of neutralising antibodies to SARS coronavirus 2 to determine population exposure in Scottish blood donors between March and May 2020. doi:10.1101/2020.04.13.20060467

DOI: 10.1101/2020.04.13.20060467

Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. (Journal article)

Liu, W., Zhang, Q., Chen, J., Xiang, R., Song, H., Shu, S., . . . Liu, Y. (2020). Detection of Covid-19 in Children in Early January 2020 in Wuhan, China.. New England Journal of Medicine. doi:10.1056/NEJMc2003717

DOI: 10.1056/NEJMc2003717

Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease (Journal article)

Steptoe, P. J., Momorie, F., Fornah, A. D., Komba, P., Emsley, E., Scott, J. T., . . . Semple, M. G. (n.d.). Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease. JAMA Ophthalmology. doi:10.1001/jamaophthalmol.2020.0173

DOI: 10.1001/jamaophthalmol.2020.0173

Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19 (Journal article)

Moore, S., Penrice-Randal, R., Alruwaili, M., Dong, X., Pullan, S., Carter, D., . . . Hiscox, J. (2020). Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19. doi:10.1101/2020.03.05.20032011

DOI: 10.1101/2020.03.05.20032011

2019

A new regional multidisciplinary clinic for children with difficult asthma (Conference Paper)

Brown, L., Worrall, V., Lilley, A., Thursfield, R., Grime, C., Hepworth, C., . . . Sinha, I. (2019). A new regional multidisciplinary clinic for children with difficult asthma. In EUROPEAN RESPIRATORY JOURNAL Vol. 54. doi:10.1183/13993003.congress-2019.PA1269

DOI: 10.1183/13993003.congress-2019.PA1269

Convalescent plasma therapy for persistent hepatitis E virus infection (Journal article)

Ankcorn, M., Gallacher, J., Ijaz, S., Taha, Y., Harvala, H., Maclennan, S., . . . McPherson, S. (2019). Convalescent plasma therapy for persistent hepatitis E virus infection. JOURNAL OF HEPATOLOGY, 71(2), 434-438. doi:10.1016/j.jhep.2019.04.008

DOI: 10.1016/j.jhep.2019.04.008

The UK's pandemic influenza research portfolio: a model for future research on emerging infections (Journal article)

Simpson, C. R., Beever, D., Challen, K., De Angelis, D., Fragaszy, E., Goodacre, S., . . . Studie, N. I. H. R. H. I. (2019). The UK's pandemic influenza research portfolio: a model for future research on emerging infections. LANCET INFECTIOUS DISEASES, 19(8), E295-E300. doi:10.1016/S1473-3099(18)30786-2

DOI: 10.1016/S1473-3099(18)30786-2

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018) (Journal article)

Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Investigators, M. O. S. A. I. C. (2019). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018). NATURE IMMUNOLOGY, 20(3), 373. doi:10.1038/s41590-019-0328-y

DOI: 10.1038/s41590-019-0328-y

Using research to prepare for outbreaks of severe acute respiratory infection (Journal article)

Mich, V., Pho, Y., Bory, S., Vann, M., Teav, B., Som, L., . . . Investigators, S. P. R. I. N. T. -S. A. R. I. (2019). Using research to prepare for outbreaks of severe acute respiratory infection. BMJ GLOBAL HEALTH, 4(1). doi:10.1136/bmjgh-2018-001061

DOI: 10.1136/bmjgh-2018-001061

2018

Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma (Journal article)

Cordell, R. L., Valkenburg, T. S. E., Pandya, H. C., Hawcutt, D. B., Semple, M. G., & Monks, P. S. (2018). Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma. JOURNAL OF ASTHMA, 55(11), 1205-1213. doi:10.1080/02770903.2017.1402341

DOI: 10.1080/02770903.2017.1402341

Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone (Journal article)

Howlett, P. J., Walder, A. R., Lisk, D. R., Fitzgerald, F., Sevalie, S., Lado, M., . . . Scott, J. T. (2018). Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone. EMERGING INFECTIOUS DISEASES, 24(8), 1412-1421. doi:10.3201/eid2408.171367

DOI: 10.3201/eid2408.171367

Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease (Journal article)

Steptoe, P. J., Momorie, F., Fornah, A. D., Komba, S. P., Emsley, E., Scott, J. T., . . . Semple, M. G. (2018). Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease. JAMA Ophthalmology, 136(6), 689-693. doi:10.1001/jamaophthalmol.2018.1248

DOI: 10.1001/jamaophthalmol.2018.1248

Optimising the dosing of intravenous theophylline in acute severe asthma in children (Journal article)

Saint, G. L., Semple, M., Sinha, I., & Hawcutt, D. B. (2018). Optimising the dosing of intravenous theophylline in acute severe asthma in children. Pediatric Drugs, 20(3), 209-214. doi:10.1007/s40272-017-0281-x

DOI: 10.1007/s40272-017-0281-x

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Journal article)

Dunning, J., Blankley, S., Hoang, L. T., Cox, M., Graham, C. M., James, P. L., . . . Openshaw, P. J. M. (2018). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nature Immunology, 19(06), 625-635. doi:10.1038/s41590-018-0111-5

DOI: 10.1038/s41590-018-0111-5

Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE ): protocol for a double-blind, randomised, placebo-controlled trial (Journal article)

Wang, K., Carver, T., Tonner, S., Semple, M. G., Hay, A. D., Moore, M., . . . Hamden, A. (2018). Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE ): protocol for a double-blind, randomised, placebo-controlled trial. BMJ OPEN, 8(5). doi:10.1136/bmjopen-2017-021144

DOI: 10.1136/bmjopen-2017-021144

Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone (Journal article)

Tedder, R. S., Samuel, D., Dicks, S., Scott, J. T., Ijaz, S., Smith, C. C., . . . Investigators, E. C. P. C. (2018). Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone. TRANSFUSION, 58(5), 1289-1298. doi:10.1111/trf.14580

DOI: 10.1111/trf.14580

Visual Disability in Ebola Survivors (Journal article)

Steptoe, P. J., Beare, N. A. V., Fornah, A. D., Momorie, F., Komba, P., Vandy, M., & Semple, M. G. (2018). Visual Disability in Ebola Survivors. CLINICAL INFECTIOUS DISEASES, 66(8), 1318-1319. doi:10.1093/cid/cix979

DOI: 10.1093/cid/cix979

Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (Ophthalmology. 2017;124:170-177) (Journal article)

Steptoe, P. J., Scott, J. T., Sahr, F., Vandy, M., Harding, S. P., Beare, N. A. V., & Semple, M. G. (2018). Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (Ophthalmology. 2017;124:170-177). OPHTHALMOLOGY, 125(3), E19. Retrieved from http://gateway.webofknowledge.com/

Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study. (Journal article)

Jagadesh, S., Sevalie, S., Fatoma, R., Sesay, F., Sahr, F., Faragher, B., . . . Scott, J. T. (2018). Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study.. Clinical Infectious Diseases, 66(1), 131-133. doi:10.1093/cid/cix705

DOI: 10.1093/cid/cix705

2017

Reply to Lee and colleagues Viral posterior uveitis (Journal article)

Steptoe, P. J., Scott, J. T., & Semple, M. G. (2017). Reply to Lee and colleagues Viral posterior uveitis. SURVEY OF OPHTHALMOLOGY, 62(6), 886-887. doi:10.1016/j.survophthal.2017.06.002

DOI: 10.1016/j.survophthal.2017.06.002

Reply to Lee and colleagues-Viral posterior uveitis. (Journal article)

Steptoe, P. J., Scott, J. T., & Semple, M. G. (2017). Reply to Lee and colleagues-Viral posterior uveitis.. Survey of ophthalmology, 62(6), 886-887. doi:10.1016/j.survophthal.2017.06.002

DOI: 10.1016/j.survophthal.2017.06.002

WHO collaborative study to assess the suitability of the 1st International Standard and the 1st International Reference Panel for antibodies to Ebola virus (Report)

Wilkinson, D. E., Hassall, M., Mattiuzzo, G., Stone, L., Atkinson, E., Hockley, J., . . . Minor, P. D. (2017). WHO collaborative study to assess the suitability of the 1st International Standard and the 1st International Reference Panel for antibodies to Ebola virus. World Health Organization. Retrieved from http://www.who.int/

Ocular Complications in Survivors of the Ebola Outbreak in Guinea (Journal article)

Steptoe, P. J., Scott, J. T., Harding, S. P., Beare, N. A. V., Semple, M. G., Vandy, M. J., & Sahr, F. (2017). Ocular Complications in Survivors of the Ebola Outbreak in Guinea. AMERICAN JOURNAL OF OPHTHALMOLOGY, 181, 180. doi:10.1016/j.ajo.2017.05.029

DOI: 10.1016/j.ajo.2017.05.029

Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016 (Journal article)

Steptoe, P. J., Scott, J. T., Baxter, J. M., Parkes, C. K., Dwivedi, R., Czanner, G., . . . Semple, M. G. (2017). Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016. EMERGING INFECTIOUS DISEASES, 23(7), 1102-1109. doi:10.3201/eid2307.161608

DOI: 10.3201/eid2307.161608

Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus (Journal article)

Semple, M. G., & Scott, J. T. (2017). Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus. The Lancet Infectious Diseases, 17(6), 645-653. doi:10.1016/S1473-3099(17)30111-1

DOI: 10.1016/S1473-3099(17)30111-1

Longitudinal Changes of Geographic Retinal Darkening in a Cohort of Ebola Survivors (Conference Paper)

Steptoe, P. J., Beare, N. V., Scott, J. T., Vandy, M. J., Harrison-Williams, L., Momorie, F., . . . Semple, M. G. (2017). Longitudinal Changes of Geographic Retinal Darkening in a Cohort of Ebola Survivors. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 58. Retrieved from http://gateway.webofknowledge.com/

SPRINT-SARI: Short-Period Incidence Study for Severe Acute Respiratory Infections: Year 1 Rapid Data from 2015-16 (Conference Paper)

Semple, M. G. (2017). SPRINT-SARI: Short-Period Incidence Study for Severe Acute Respiratory Infections: Year 1 Rapid Data from 2015-16. In http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2017.195.1_MeetingAbstracts.A6854. Washington, DC.

Ebola virus disease sequelae: a challenge that is not going away (Journal article)

Scott, J. T., & Semple, M. G. (2017). Ebola virus disease sequelae: a challenge that is not going away. LANCET INFECTIOUS DISEASES, 17(5), 470-471. doi:10.1016/S1473-3099(17)30027-0

DOI: 10.1016/S1473-3099(17)30027-0

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza (Journal article)

Cole, S. L., Dunning, J., Kok, W. L., Benam, K. H., Benlahrech, A., Repapi, E., . . . Investigators, M. O. S. A. I. C. (2017). M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI INSIGHT, 2(7). doi:10.1172/jci.insight.91868

DOI: 10.1172/jci.insight.91868

Neurological and psychiatric manifestations of post Ebola syndrome in Sierra Leone (Conference Paper)

Howlett, P., Walder, A., Lisk, D., N'jai, A., Lado, M., Brown, C., . . . Scott, J. T. (2017). Neurological and psychiatric manifestations of post Ebola syndrome in Sierra Leone. In LANCET Vol. 389 (pp. 48). Retrieved from http://gateway.webofknowledge.com/

2016

Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies (Journal article)

van Griensven, J., Edwards, T., & Baize, S. (2016). Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies. New England Journal of Medicine, 375(23), 2307-2309. doi:10.1056/NEJMc1609116

DOI: 10.1056/NEJMc1609116

Electrolyte and metabolic disturbances in ebola patients during a clinical Trial, Guinea, 2015 (Journal article)

van Griensven, J., Bah, E. I., Haba, N., Delamou, A., Camara, B. S., Olivier, K. J. -J., . . . Consortium, E. -T. (2016). Electrolyte and Metabolic Disturbances in Ebola Patients during a Clinical Trial, Guinea, 2015. EMERGING INFECTIOUS DISEASES, 22(12), 2120-2127. doi:10.3201/eid2212.161136

DOI: 10.3201/eid2212.161136

Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea (Journal article)

Delamou, A., Haba, N. Y., Mari-Saez, A., Gallian, P., Ronse, M., Jacobs, J., . . . van Griensven, J. (2016). Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea. The American Journal of Tropical Medicine and Hygiene, 95(3), 647-653. doi:10.4269/ajtmh.15-0890

DOI: 10.4269/ajtmh.15-0890

Prescribing antibiotics to "at-risk' children with influenza-like illness in primary care: qualitative study (Journal article)

Ashdown, H. F., Raeisaenen, U., Wang, K., Ziebland, S., Harnden, A., & Investigators, A. R. C. H. I. E. (2016). Prescribing antibiotics to "at-risk' children with influenza-like illness in primary care: qualitative study. BMJ OPEN, 6(6). doi:10.1136/bmjopen-2016-011497

DOI: 10.1136/bmjopen-2016-011497

Post-Ebola Syndrome, Sierra Leone (Journal article)

Scott, J., Sesay, F., Massaquoi, T., Idriss, B., Sahr, F., & Semple, M. G. (2016). Post-Ebola Syndrome, Sierra Leone. Emerging Infectious Diseases, 22(4), 641-646. doi:10.3201/eid2204.151302

DOI: 10.3201/eid2204.151302

Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak (Journal article)

Edwards, T., Semple, M. G., De Weggheleire, A., Claeys, Y., De Crop, M., Menten, J., . . . Consortium, E. T. (2016). Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak. CLINICAL TRIALS, 13(1), 13-21. doi:10.1177/1740774515621056

DOI: 10.1177/1740774515621056

Stemming the tide of hospital admissions for bronchiolitis (Journal article)

Cheung, C. R., & Semple, M. G. (2016). Stemming the tide of hospital admissions for bronchiolitis. ARCHIVES OF DISEASE IN CHILDHOOD, 101(2), 118-119. doi:10.1136/archdischild-2015-309452

DOI: 10.1136/archdischild-2015-309452

Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea (Journal article)

Semple, M. G. (2016). Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The New England Journal of Medicine, 374(1), 33-42. doi:10.1056/NEJMoa1511812

DOI: 10.1056/NEJMoa1511812

2015

DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION? (Conference Paper)

Shorthouse, L., & Semple, M. G. (2015). DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION?. In THORAX Vol. 70 (pp. A120). doi:10.1136/thoraxjnl-2015-207770.226

DOI: 10.1136/thoraxjnl-2015-207770.226

Ebola: Europe-Africa research collaborations (Journal article)

Horby, P. W., Endzt, H., Muyembe-Tamfum, J. -J., van Griensven, J., Gevao, S., Goossens, H., . . . Kennedy, S. (2015). Ebola: Europe-Africa research collaborations. LANCET INFECTIOUS DISEASES, 15(11), 1258-1259. doi:10.1016/S1473-3099(15)00375-8

DOI: 10.1016/S1473-3099(15)00375-8

Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study (Journal article)

Venkatesan, S., Myles, P. R., McCann, G., Kousoulis, A. A., Hashmi, M., Belatri, R., . . . Semple, M. G. (2015). Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study. Health Technology Assessment, 19(89), 1-132. doi:10.3310/hta19890

DOI: 10.3310/hta19890

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus (Journal article)

Habibi, M. S., Jozwik, A., Makris, S., Dunning, J., Paras, A., The Mechanisms of Severe Acute Influenza Consortium Investigators., . . . Chiu, C. (2015). Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191(9), 1040-1049. doi:10.1164/rccm.201412-2256OC

DOI: 10.1164/rccm.201412-2256OC

JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT (Conference Paper)

Brown, L. E., Sampath, S., Ryan, F., Cleary, G., McCann, L., Pain, C., . . . Baildam, E. (2015). JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT. In RHEUMATOLOGY Vol. 54 (pp. 11). doi:10.1093/rheumatology/keu508

DOI: 10.1093/rheumatology/keu508

Convalescent plasma for early Ebola virus disease in Sierra Leone (Dataset)

Winters, V., & Semple, C. (n.d.). Convalescent plasma for early Ebola virus disease in Sierra Leone. doi:10.1186/isrctn13990511

DOI: 10.1186/isrctn13990511

Effect of Ethnicity on Care Pathway and Outcomes in Patients Hospitalized With Influenza A(H1N1)pdm09 in the UK (Journal article)

Nyland, G. A., McKenzie, B. C., Myles, P. R., Semple, M. G., Lim, W. S., Openshaw, P. J. M., . . . Nguyen-Van-Tam, J. S. (2015). Effect of Ethnicity on Care Pathway and Outcomes in Patients Hospitalized With Influenza A(H1N1)pdm09 in the UK. Epidemiology and Infection, 143(6), 1129-1138. doi:10.1017/S0950268814001873

DOI: 10.1017/S0950268814001873

2014

Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom (Journal article)

Elderfield, R. A., Watson, S. J., Godlee, A., Adamson, W. E., Thompson, C. I., Dunning, J., . . . Investigators, M. O. S. A. I. C. (2014). Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom. JOURNAL OF VIROLOGY, 88(22), 13269-13283. doi:10.1128/JVI.01636-14

DOI: 10.1128/JVI.01636-14

Open source clinical science for emerging infections (Journal article)

Dunning, J. W., Merson, L., Rohde, G. G. U., Gao, Z., Semple, M. G., Tran, D., . . . Council, I. S. A. R. I. C. (2014). Open source clinical science for emerging infections. LANCET INFECTIOUS DISEASES, 14(1), 8-9. doi:10.1016/S1473-3099(13)70327-X

DOI: 10.1016/S1473-3099(13)70327-X

2013

An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic (Journal article)

Semple, M. G., Myles, P. R., Nicholson, K. G., Lim, W. S., Read, R. C., Taylor, B. L., . . . Nguyen-Van-Tam, J. S. (2013). An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic. PLOS ONE, 8(9). doi:10.1371/journal.pone.0075384

DOI: 10.1371/journal.pone.0075384

Design, development and initiation of the Liverpool Respiratory Birth Cohort Study (Thesis / Dissertation)

Pickles, R. (2013, July 1). Design, development and initiation of the Liverpool Respiratory Birth Cohort Study. (Master's Thesis, University of Liverpool).

Differences between asthmatics and nonasthmatics hospitalised with influenza A infection (Journal article)

Myles, P., Nguyen-Van-Tam, J. S., Semple, M. G., Brett, S. J., Bannister, B., Read, R. C., . . . Net, I. C. I. (2013). Differences between asthmatics and nonasthmatics hospitalised with influenza A infection. EUROPEAN RESPIRATORY JOURNAL, 41(4), 824-831. doi:10.1183/09031936.00015512

DOI: 10.1183/09031936.00015512

Evaluation and refinement of pandemic inFLUenza Community Assessment Tools (Dataset)

Semple, M. (n.d.). Evaluation and refinement of pandemic inFLUenza Community Assessment Tools. doi:10.1186/isrctn87130712

DOI: 10.1186/isrctn87130712

Population variation in admission rates and duration of inpatient stay for bronchiolitis in England (Journal article)

Cheung, C. R., Smith, H., Thurland, K., Duncan, H., & Semple, M. G. (2013). Population variation in admission rates and duration of inpatient stay for bronchiolitis in England. ARCHIVES OF DISEASE IN CHILDHOOD, 98(1), 57-59. doi:10.1136/archdischild-2012-302277

DOI: 10.1136/archdischild-2012-302277

2012

The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection (Journal article)

Dolan, G. P., Myles, P. R., Brett, S. J., Enstone, J. E., Read, R. C., Openshaw, P. J. M., . . . Net, I. C. I. (2012). The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection. PLOS ONE, 7(8). doi:10.1371/journal.pone.0041638

DOI: 10.1371/journal.pone.0041638

Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis (Conference Paper)

Semple, M. G., Flanagan, B., & Smyth, R. L. (2012). Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis. In A15. AIRWAY RESPONSES TO RESPIRATORY VIRAL INFECTION. American Thoracic Society. doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026

DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026

IFITM3 restricts the morbidity and mortality associated with influenza (Journal article)

Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., . . . Investigators, M. O. S. A. I. C. (2012). IFITM3 restricts the morbidity and mortality associated with influenza. NATURE, 484(7395), 519-U146. doi:10.1038/nature10921

DOI: 10.1038/nature10921

Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data (Journal article)

Myles, P. R., Nguyen-Van-Tam, J. S., Lim, W. S., Nicholson, K. G., Brett, S. J., Enstone, J. E., . . . Semple, M. G. (2012). Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data. PLOS ONE, 7(4). doi:10.1371/journal.pone.0034428

DOI: 10.1371/journal.pone.0034428

Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK (Journal article)

Myles, P. R., Semple, M. G., Lim, W. S., Openshaw, P. J. M., Gadd, E. M., Read, R. C., . . . Information, I. C. (2012). Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK. THORAX, 67(8), 709-717. doi:10.1136/thoraxjnl-2011-200266

DOI: 10.1136/thoraxjnl-2011-200266

Problems of the Respiratory System: Rate of admissions and mean length of stay for bronchiolitis in children under 2 years of age by PCT in England, Maps 20 & 21 (Chapter)

Semple, M. G., Cheung, R., Duncan, H., Smith, H., Chaplin, S., & Ridler, C. (2012). Problems of the Respiratory System: Rate of admissions and mean length of stay for bronchiolitis in children under 2 years of age by PCT in England, Maps 20 & 21. In R. Cheung, & R. Cheung (Eds.), NHS Atlas of variation in healthcare for children and young people. (pp. 58-61, 74). London: NHS Right Care Department of Health. Retrieved from http://www.rightcare.nhs.uk/index.php/nhs-atlas/

Suction versus no suction for chest drain management (Journal article)

van Miert, C., Dwan, K., Hill, R., Hoenig, M. R., Gruen, R. L., & Semple, M. G. (n.d.). Suction versus no suction for chest drain management. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd009939

DOI: 10.1002/14651858.cd009939

2011

The increasing importance of innate antimicrobials response (Journal article)

Lim, W. S., Bewick, T., Myles, P., Greenwood, S., Nguyen-Van-Tam, J. S., Brett, S., . . . Information, I. C. (2011). The increasing importance of innate antimicrobials response. THORAX, 66(12), 1091. doi:10.1136/thoraxjnl-2011-200600

DOI: 10.1136/thoraxjnl-2011-200600

Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study (Journal article)

Semple, M. G., Taylor-Robinson, D. C., Lane, S., & Smyth, R. L. (2011). Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study. PLOS ONE, 6(7). doi:10.1371/journal.pone.0022425

DOI: 10.1371/journal.pone.0022425

Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease (Journal article)

Brett, S. J., Myles, P., Lim, W. S., Enstone, J. E., Bannister, B., Semple, M. G., . . . Information, I. C. (2011). Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease. PLOS ONE, 6(4). doi:10.1371/journal.pone.0018120

DOI: 10.1371/journal.pone.0018120

Nosocomial Pandemic (H1N1) 2009, United Kingdom, 2009-2010 (Journal article)

Enstone, J. E., Myles, P. R., Openshaw, P. J. M., Gadd, E. M., Lim, W. S., Semple, M. G., . . . Nguyen-Van-Tam, J. S. (2011). Nosocomial Pandemic (H1N1) 2009, United Kingdom, 2009-2010. EMERGING INFECTIOUS DISEASES, 17(4), 592-598. doi:10.3201/eid1704.101679

DOI: 10.3201/eid1704.101679

Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults (Journal article)

Bewick, T., Myles, P., Greenwood, S., Nguyen-Van-Tam, J. S., Brett, S. J., Semple, M. G., . . . Information, I. C. (2011). Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults. THORAX, 66(3), 247-252. doi:10.1136/thx.2010.151522

DOI: 10.1136/thx.2010.151522

2010

Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009) (Journal article)

Nguyen-Van-Tam, J. S., Openshaw, P. J. M., Hashim, A., Gadd, E. M., Lim, W. S., Semple, M. G., . . . Net, I. C. I. (2010). Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). THORAX, 65(7), 645-651. doi:10.1136/thx.2010.135210

DOI: 10.1136/thx.2010.135210

Paediatric practice note for the management of critically ill children with pandemic (H1N1) 2009 Influenza. (Journal article)

Semple, M. G., Thomson, G., Taylor, D. J., Lister, P., Hackett, S., Faust, S. N., . . . Wilkinson, K. (2010). Paediatric practice note for the management of critically ill children with pandemic (H1N1) 2009 Influenza.. Royal College of Paediatrics and Child Health Swine FLu Policy.

2009

Evidence That RSV Directly Infects Neutrophils in the Airways and Blood of Infants with Severe Bronchiolitis (Conference Paper)

Halfhide, C. P., Brearey, S., Howarth, D., Semple, M. G., Kipar, A., Hunt, J. A., . . . Smyth, R. L. (2009). Evidence That RSV Directly Infects Neutrophils in the Airways and Blood of Infants with Severe Bronchiolitis. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 179. Retrieved from http://gateway.webofknowledge.com/

Medikidz Explain Swine Flu (Book)

Semple, M. G., & McCauley, J. (Eds.) (2009). Medikidz Explain Swine Flu. London: Medikidz.

Pandemic H1N1 2009 Influenza: Clinical Management Guidelines for Adults and Children (Journal article)

Semple, M. G., Lim, W. S., Reid, R. C., & al, E. (2009). Pandemic H1N1 2009 Influenza: Clinical Management Guidelines for Adults and Children. Delphi, Department of Health., 25. Retrieved from http://www.dh.gov.uk/

Pandemic H1N1 2009 influenza: clinical management guidelines for pregnancy (Journal article)

Lim, B. H., Semple, M. G., Lim, W. S., & al, E. (2009). Pandemic H1N1 2009 influenza: clinical management guidelines for pregnancy. Delphi, Department of Health., 27. Retrieved from http://www.dh.gov.uk/

Pandemic flu:Managing Demand and Capacity in Health Care Organisations. (Report)

Wilson, L., Bannister, B., & Semple, M. G. (2009). Pandemic flu:Managing Demand and Capacity in Health Care Organisations.. London: HMG UK. Retrieved from http://www.dh.gov.uk/

Swine flu clinical package (Report)

Semple, M. G., & Bannister, B. (2009). Swine flu clinical package. London: HMG UK. Retrieved from http://www.dh.gov.uk/

2008

Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK (Journal article)

Hopkins, M. J., Redmond, C., Shaw, J. M., Hart, I. J., Hart, C. A., Smyth, R. L., & Semple, M. G. (2008). Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK. JOURNAL OF CLINICAL VIROLOGY, 42(3), 273-279. doi:10.1016/j.jcv.2008.03.011

DOI: 10.1016/j.jcv.2008.03.011

2007

CD8(+) T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections (Journal article)

Heidema, J., Lukens, M. V., van Maren, W. W. C., van Dijk, M. E. A., Otten, H. G., van Vught, A. J., . . . van Bleek, G. M. (2007). CD8(+) T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections. JOURNAL OF IMMUNOLOGY, 179(12), 8410-8417. doi:10.4049/jimmunol.179.12.8410

DOI: 10.4049/jimmunol.179.12.8410

Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free (Journal article)

Semple, M. G., Booth, J. A., & Ebrahimi, B. (2007). Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free. JOURNAL OF CLINICAL VIROLOGY, 40(3), 241-244. doi:10.1016/j.jcv.2007.08.019

DOI: 10.1016/j.jcv.2007.08.019

Severe Respiratory Syncytial Virus Bronchiolitis in Infants Is Associated with Reduced Airway Interferon Gamma and Substance P (Journal article)

Semple, M. G., Dankert, H. M., Ebrahimi, B., Correia, J. B., Booth, J. A., Stewart, J. P., . . . Hart, C. A. (2007). Severe Respiratory Syncytial Virus Bronchiolitis in Infants Is Associated with Reduced Airway Interferon Gamma and Substance P. PLOS ONE, 2(10). doi:10.1371/journal.pone.0001038

DOI: 10.1371/journal.pone.0001038

Pathophysiology. Lessons from humanrespiratory syncytial virus bronchiolitisand acute wheezing episodes in infants (Chapter)

Semple, M., & Smyth, R. (2007). Pathophysiology. Lessons from humanrespiratory syncytial virus bronchiolitisand acute wheezing episodes in infants. In Exacerbations of Asthma (pp. 187-202). CRC Press. doi:10.1201/b14633-14

DOI: 10.1201/b14633-14

CD8+ T cell responses in bronchoalveolar lavage fluid and PBMC of infants with severe primary respiratory syncytial virus infections. (Journal article)

Heidema, J., Lukens, M. V., van Maren, W. W. C., van Dijk, M. E. A., Otten, H. G., van Vught, A. J., . . . van Bleek, G. M. (2007). CD8+ T cell responses in bronchoalveolar lavage fluid and PBMC of infants with severe primary respiratory syncytial virus infections.. Journal of Immunology, 179(12), 8410-8417. Retrieved from http://www.jimmunol.org/cgi/content/full/179/12/8410

2005

TLR expression and localisation in the airway cells of infants with severe bronchiolitis (Conference Paper)

Brearey, S. P., Flanagan, B. F., Hunt, J. A., Cummerson, J. A., McNamara, P. S., Semple, M. G., . . . Smyth, R. L. (2005). TLR expression and localisation in the airway cells of infants with severe bronchiolitis. In IMMUNOLOGY Vol. 116 (pp. 79). Retrieved from http://gateway.webofknowledge.com/

Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis (Journal article)

Semple, M. G., Cowell, A., Dove, W., Greensill, J., McNamara, P. S., Halfhide, C., . . . Hart, C. A. (2005). Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis. JOURNAL OF INFECTIOUS DISEASES, 191(3), 382-386. doi:10.1086/426457

DOI: 10.1086/426457

Interleukin 9 concentrations in infants with Respiratory Syncytial Virus Bronchiolitis. (Journal article)

Semple, M. G., Dankert, H. M., Hart, C. A., & Smyth, R. L. (2005). Interleukin 9 concentrations in infants with Respiratory Syncytial Virus Bronchiolitis.. European Respiratory Journal, 26(49), 28. Retrieved from http://www.ersnet.org/ers/lr/browse/media.aspx?id_dossier=46084&id_fiche=211554

Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis--the TOPIC study: a randomised controlled trial. (Journal article)

A, S., & et.al., F. T. T. S. G. (2005). Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis--the TOPIC study: a randomised controlled trial.. Lancet, 365(9459), 573-578. Retrieved from http://dx.doi.org/10.1016/S0140-6736(05)17906-9

Reduced interferon-gamma concentration in infants with severe respiratory syncytial virus bronchiolitis (Journal article)

Dankert, H. M., Semple, M. G., Hart, C. A., & Smyth, R. L. (2005). Reduced interferon-gamma concentration in infants with severe respiratory syncytial virus bronchiolitis. European Respiratory Journal, 26(49), 27. Retrieved from http://www.ersnet.org/ers/lr/browse/media.aspx?id_dossier=46083&id_fiche=211552

2003

Left pulmonary artery sling presenting as unilateral echogenic lung on 20-week detailed antenatal ultrasound examination (Journal article)

Semple, M. G., Bricker, L., Shaw, B. N. J., & Pilling, D. W. (2003). Left pulmonary artery sling presenting as unilateral echogenic lung on 20-week detailed antenatal ultrasound examination. PEDIATRIC RADIOLOGY, 33(8), 567-569. doi:10.1007/s00247-003-0942-5

DOI: 10.1007/s00247-003-0942-5

Update on Cochrane data on paediatric respiratory diseases. (Journal article)

Semple, M. G., & Smyth, R. L. (2003). Update on Cochrane data on paediatric respiratory diseases.. Paediatric respiratory reviews, 4(3), 250-266. doi:10.1016/s1526-0542(03)00048-4

DOI: 10.1016/s1526-0542(03)00048-4

2002

Academic Mentoiring (Report)

Openshaw, P., Semple, M. G., & Smyth, R. L. (2002). Academic Mentoiring. London: Academy of Medical Sciences.

1995

MORTALITY BEFORE AND AFTER HIV-INFECTION IN THE COMPLETE UK POPULATION OF HEMOPHILIACS (Journal article)

DARBY, S. C., EWART, D. W., GIANGRANDE, P. L. F., DOLIN, P. J., SPOONER, R. J. D., & RIZZA, C. R. (1995). MORTALITY BEFORE AND AFTER HIV-INFECTION IN THE COMPLETE UK POPULATION OF HEMOPHILIACS. NATURE, 377(6544), 79-82. doi:10.1038/377079a0

DOI: 10.1038/377079a0

HIV RESULTS IN THE FRAME - RESULTS CONFIRMED (Journal article)

NOWAK, M. A., BONHOEFFER, S., LOVEDAY, C., BALFE, P., SEMPLE, M., KAYE, S., . . . TEDDER, R. (1995). HIV RESULTS IN THE FRAME - RESULTS CONFIRMED. NATURE, 375(6528), 193. doi:10.1038/375193a0

DOI: 10.1038/375193a0

HIV-1 RNA SERUM-LOAD AND RESISTANT VIRAL GENOTYPES DURING EARLY ZIDOVUDINE THERAPY (Journal article)

LOVEDAY, C., KAYE, S., TENANTFLOWERS, M., SEMPLE, M., AYLIFFE, U., WELLER, I. V. D., & TEDDER, R. S. (1995). HIV-1 RNA SERUM-LOAD AND RESISTANT VIRAL GENOTYPES DURING EARLY ZIDOVUDINE THERAPY. LANCET, 345(8953), 820-824. doi:10.1016/S0140-6736(95)92963-0

DOI: 10.1016/S0140-6736(95)92963-0

HIV results in the frame. Results confirmed. (Journal article)

Nowak, M. A., Bonhoeffer, S., Loveday, C., Balfe, P., Semple, M., Kaye, S., . . . Tedder, R. (1995). HIV results in the frame. Results confirmed.. Nature, 375(6528), 193. doi:10.1038/375193a0

DOI: 10.1038/375193a0

1993

HIV-1 PLASMA VIREMIA QUANTIFICATION - A NONCULTURE MEASUREMENT NEEDED FOR THERAPEUTIC TRIALS (Journal article)

SEMPLE, M. G., KAYE, S., LOVEDAY, C., & TEDDER, R. S. (1993). HIV-1 PLASMA VIREMIA QUANTIFICATION - A NONCULTURE MEASUREMENT NEEDED FOR THERAPEUTIC TRIALS. JOURNAL OF VIROLOGICAL METHODS, 41(2), 167-179. doi:10.1016/0166-0934(93)90124-A

DOI: 10.1016/0166-0934(93)90124-A

1992

LACK OF SUPPRESSION BY RIBAVIRIN OF HIV VIREMIA (Journal article)

GILSON, R. J. C., SEMPLE, M., GILL, S. K., LOVEDAY, C., TEDDER, R. S., & WELLER, I. V. D. (1992). LACK OF SUPPRESSION BY RIBAVIRIN OF HIV VIREMIA. LANCET, 339(8809), 1605-1606. doi:10.1016/0140-6736(92)91867-8

DOI: 10.1016/0140-6736(92)91867-8

Quantitative viral assay (Patent)

Semple, M. G., Tedder, R. S., Loveday, C., & Kaye, S. (1993, April 8). WO1993021339 A1, Quantitative viral assay. WO.

HIV, AIDS, AND ZIDOVUDINE (Journal article)

TEDDER, R. S., SEMPLE, M. G., TENANTFLOWERS, M., & LOVEDAY, C. (1992). HIV, AIDS, AND ZIDOVUDINE. LANCET, 339(8796), 805. doi:10.1016/0140-6736(92)91929-3

DOI: 10.1016/0140-6736(92)91929-3

1991

DETECTION OF HIV-1 RNA IN FACTOR-VIII CONCENTRATE (Journal article)

SEMPLE, M. G., LOVEDAY, C., PRESTON, E., & TEDDER, R. S. (1991). DETECTION OF HIV-1 RNA IN FACTOR-VIII CONCENTRATE. AIDS, 5(5), 597-598. doi:10.1097/00002030-199105000-00021

DOI: 10.1097/00002030-199105000-00021

DIRECT MEASUREMENT OF VIREMIA IN PATIENTS INFECTED WITH HIV-1 AND ITS RELATIONSHIP TO DISEASE PROGRESSION AND ZIDOVUDINE THERAPY (Journal article)

SEMPLE, M., LOVEDAY, C., WELLER, I., & TEDDER, R. (1991). DIRECT MEASUREMENT OF VIREMIA IN PATIENTS INFECTED WITH HIV-1 AND ITS RELATIONSHIP TO DISEASE PROGRESSION AND ZIDOVUDINE THERAPY. JOURNAL OF MEDICAL VIROLOGY, 35(1), 38-45. doi:10.1002/jmv.1890350109

DOI: 10.1002/jmv.1890350109