Professor Calum Semple OBE PhD FRCPCH FRCPE FFPH FHEA

Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study. (Journal article)

DOI: 10.1371/journal.pmed.1004086

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. (Journal article)

DOI: 10.1016/j.ebiom.2022.104402

CO-CONNECT: A hybrid architecture to facilitate rapid discovery and access to UK wide data in the response to the COVID-19 pandemic. (Journal article)

DOI: 10.2196/40035

Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people (Journal article)

DOI: 10.1186/s12879-022-07878-2

Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales (Journal article)

DOI: 10.1136/bmjopen-2022-063271

Symptom‐based case definitions for COVID‐19: Time and geographical variations for detection at hospital admission among 260,000 patients (Journal article)

DOI: 10.1111/irv.13039

Fewer COVID-19 Neurological Complications with Dexamethasone and Remdesivir. (Journal article)

DOI: 10.1002/ana.26536

Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study (Journal article)

DOI: 10.1093/ofid/ofac531

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity. (Journal article)

DOI: 10.1182/blood.2022015721

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19 (Journal article)

DOI: 10.1016/S2589-7500(22)00132-7

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19. (Journal article)

DOI: 10.1111/imm.13585

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study (Journal article)

DOI: 10.1186/s13054-022-04155-1

Nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (Preprint)

DOI: 10.1101/2022.09.09.22279759

Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number (Journal article)

DOI: 10.1177/09622802211070257

Outcome of COVID-19 in hospitalised immunocompromised patients: an analysis of the WHO ISARIC CCP-UK prospective cohort study (Preprint)

DOI: 10.1101/2022.08.08.22278576

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (Journal article)

DOI: 10.1016/S2213-2600(22)00127-8

Clinical features and management of human monkeypox: a retrospective observational study in the UK. (Journal article)

DOI: 10.1016/s1473-3099(22)00228-6

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients (Journal article)

DOI: 10.1016/j.jinf.2022.05.033

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19 (Journal article)

DOI: 10.1038/s41597-022-01534-9

Adeno-associated virus 2 infection in children with non-A-E hepatitis (Preprint)

DOI: 10.1101/2022.07.19.22277425

Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19 (Journal article)

DOI: 10.1136/heartjnl-2021-320047

Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses. (Journal article)

DOI: 10.1172/jci.insight.156372

Whole genome sequencing reveals host factors underlying critical Covid-19. (Journal article)

DOI: 10.1038/s41586-022-04576-6

Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) (Journal article)

DOI: 10.1186/s12916-022-02448-4

A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study (Journal article)

DOI: 10.1016/S2213-2600(22)00169-2

Long COVID (post-COVID-19 condition) in children: a modified Delphi process (Journal article)

DOI: 10.1136/archdischild-2021-323624

Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages (Journal article)

DOI: 10.1128/msphere.00913-21

An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients (Preprint)

DOI: 10.1101/2022.06.22.22276764

The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020 (Journal article)

DOI: 10.1186/s12879-022-07490-4

Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (Journal article)

DOI: 10.1136/thoraxjnl-2021-217629

Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers (Journal article)

DOI: 10.1093/gigascience/giac045

H-1 NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization (Journal article)

DOI: 10.1021/acs.analchem.2c00466

Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus (Journal article)

DOI: 10.3389/fimmu.2022.807104

Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service (Journal article)

DOI: 10.1111/anae.15677

Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission (Journal article)

DOI: 10.1093/ofid/ofac179

Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study (Journal article)

DOI: 10.1038/s41598-022-08032-3

Risk of Paediatric Multisystem Inflammatory Syndrome (PIMS-TS) During the SARS-CoV-2 <i>Alpha</i> and <i>Delta</i> Variant Waves: National Observational Study, 2020-21, England (Preprint)

DOI: 10.2139/ssrn.4094844

Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves (Journal article)

DOI: 10.1038/s41390-022-02052-5

Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol. (Journal article)

DOI: 10.1371/journal.pmed.1003969

SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses (Journal article)

DOI: 10.1016/S0140-6736(22)00383-X

Quality of life, healthcare use and costs in 'at-risk' children after early antibiotic treatment versus placebo for influenza- like illness: within-trial descriptive economic analyses of the ARCHIE randomised controlled trial (Journal article)

DOI: 10.1136/bmjopen-2021-049373

Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: A cohort analysis of 2.7M people (Preprint)

DOI: 10.1101/2022.04.05.22273169

Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. (Journal article)

DOI: 10.1016/j.jviromet.2022.114475

Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (Journal article)

Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study. (Journal article)

DOI: 10.1016/s2352-4642(22)00022-0

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults (Journal article)

DOI: 10.1038/s41591-022-01780-9

Impact of Dexamethasone and Remdesivir on Neurological Complications during COVID-19 (Journal article)

DOI: 10.2139/ssrn.4065552

Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study of the ISARIC cohort (Preprint)

DOI: 10.1101/2022.03.18.22272601

Interstitial lung damage following COVID-19 hospitalisation: an interim analysis of the UKILD Post-COVID study (Preprint)

DOI: 10.1101/2022.03.10.22272081

Admission Blood Glucose Level and Its Association With Cardiovascular and Renal Complications in Patients Hospitalized With COVID-19. (Journal article)

DOI: 10.2337/dc21-1709

GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19 (Preprint)

DOI: 10.1101/2022.03.07.22271833

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. (Journal article)

DOI: 10.1016/j.cell.2022.01.012

The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020. (Preprint)

DOI: 10.21203/rs.3.rs-1140332/v1

Legacy of COVID-19 infection in children: long-COVID will have a lifelong health/economic impact. (Journal article)

DOI: 10.1136/archdischild-2021-321882

SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures (Journal article)

DOI: 10.1136/thoraxjnl-2021-218035

Prevention of Neurological Complications During COVID-19: Protocol for a Retrospective Analysis of the ISARIC4C National Cohort (Preprint)

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. (Journal article)

DOI: 10.1016/j.cell.2021.12.046

Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. (Journal article)

DOI: 10.1183/13993003.01341-2021

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge (Journal article)

DOI: 10.21203/rs.3.rs-1121993/v1

Paediatric Multisystem Inflammatory Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS): Prospective, National Surveillance, UK and Ireland, 2020 (Preprint)

DOI: 10.2139/ssrn.3771324

Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study (Journal article)

DOI: 10.1093/ndt/gfab303

Validation of the russian version of the 4C Mortality Score and prediction of outcomes of severe COVID-19 (Journal article)

DOI: 10.33029/2305-3496-2022-11-1-57-63

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype (Preprint)

DOI: 10.1101/2021.12.23.474030

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses (Journal article)

DOI: 10.1101/2021.12.03.471045

Mapping the human genetic architecture of COVID-19 (Journal article)

DOI: 10.1038/s41586-021-03767-x

Clinical characteristics with inflammation profiling of Long-COVID and association with one-year recovery following hospitalisation in the UK: a prospective observational study (Preprint)

DOI: 10.1101/2021.12.13.21267471

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity. (Journal article)

DOI: 10.1007/s00439-021-02397-7

The value of open-source clinical science in pandemic response: lessons from ISARIC (Journal article)

DOI: 10.1016/S1473-3099(21)00565-X

Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort. (Journal article)

DOI: 10.7554/elife.70970

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells (Journal article)

DOI: 10.1016/j.isci.2021.103353

Hereditary haemorrhagic telangiectasia: development of a regional life-course collaborative clinical care pathway (Journal article)

DOI: 10.12968/hmed.2020.0537

Comment on: Dark without pressure retinal changes in a paediatric age group (Journal article)

DOI: 10.1038/s41433-020-01252-9

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. (Journal article)

DOI: 10.1016/s2213-2600(21)00383-0

Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic (Journal article)

DOI: 10.1177/20552076211048654

A prenylated dsRNA sensor protects against severe COVID-19 (Journal article)

DOI: 10.1126/science.abj3624

Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study (Journal article)

DOI: 10.1136/bmjopen-2021-055435

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study (Journal article)

DOI: 10.1007/s15010-021-01599-5

Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital (Journal article)

DOI: 10.1016/j.ijid.2021.08.022

The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial (Journal article)

DOI: 10.1183/13993003.02819-2020

Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID) (Journal article)

DOI: 10.1136/bmjresp-2021-001049

Characteristics and outcomes of an international cohort of 400,000 hospitalised patients with Covid-19 (Preprint)

DOI: 10.1101/2021.09.11.21263419

Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave. (Journal article)

DOI: 10.1016/s0140-6736(21)01786-4

Comparison of children and young people admitted with SARS-CoV-2 across the UK in the first and second pandemic waves: prospective multicentre observational cohort study (Preprint)

DOI: 10.1101/2021.09.14.21263567

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study (Journal article)

DOI: 10.1136/bmj.n2244

The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020 (Preprint)

DOI: 10.1101/2021.09.02.21262480

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19 (Preprint)

DOI: 10.1101/2021.09.02.21262965

COVID-19 pneumothorax in the UK: a prospective observational study using the ISARIC WHO clinical characterisation protocol. (Journal article)

DOI: 10.1183/13993003.00929-2021

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality (Journal article)

DOI: 10.3324/haematol.2021.278492

Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19 (Journal article)

DOI: 10.1111/cea.13997

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol (Journal article)

DOI: 10.1016/j.lanepe.2021.100186

Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK (Conference Paper)

Long COVID and the mental and physical health of children and young people: national matched cohort study protocol (the CLoCk study) (Journal article)

DOI: 10.1136/bmjopen-2021-052838

Pandemic, epidemic, endemic: B cell repertoire analysis reveals unique anti-viral responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus (Preprint)

DOI: 10.1101/2021.08.19.456951

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. (Journal article)

DOI: 10.1016/s2666-5247(21)00090-2

Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort (Journal article)

DOI: 10.1186/s12879-021-06466-0

Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. (Journal article)

DOI: 10.1101/2020.08.04.20163782

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study (Journal article)

Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study (Journal article)

DOI: 10.1136/bmj.n1637

SARS-CoV-2 environmental contamination from hospitalised COVID-19 patients receiving aerosol generating procedures (Journal article)

DOI: 10.1101/2021.07.04.21259945

Soft drinks can be misused to give false “false positive” SARS-CoV-2 lateral flow device results (Preprint)

DOI: 10.1101/2021.07.05.21260003

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK (Journal article)

DOI: 10.1016/S2213-2600(21)00175-2

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study (Journal article)

DOI: 10.1016/s2665-9913(21)00104-1

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort (Journal article)

DOI: 10.1002/oby.23178

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK (Journal article)

DOI: 10.1016/S2213-2600(21)00013-8

Could expanding the covid-19 case definition improve the UK's pandemic response? (Journal article)

DOI: 10.1136/bmj.n1625

Evaluation of the effectiveness of remdesivir in severe COVID-19 using observational data from a prospective national cohort study (Preprint)

DOI: 10.1101/2021.06.18.21259072

Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial (Preprint)

DOI: 10.1101/2021.06.15.21258879

Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England (Journal article)

DOI: 10.1186/s12913-021-06509-x

Fatal COVID-19 Outcomes are Associated with an Antibody Response Targeting Epitopes Shared with Endemic Coronaviruses (Preprint)

DOI: 10.2139/ssrn.3858917

Occupational inequalities in the prevalence of COVID-19: A longitudinal observational study of England, August 2020 to January 2021 (Preprint)

DOI: 10.1101/2021.06.01.21258140

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity (Journal article)

DOI: 10.1101/2021.05.11.21256877

Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses (Preprint)

DOI: 10.1101/2021.05.04.21256571

Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study (Preprint)

DOI: 10.1101/2021.04.26.21256110

Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19 (Journal article)

DOI: 10.1016/S0140-6736(21)00425-6

Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study (Journal article)

DOI: 10.1016/S1473-3099(20)30984-1

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study (Journal article)

DOI: 10.1016/S2213-2600(20)30559-2

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. (Journal article)

DOI: 10.1016/j.lanepe.2021.100075

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context (Preprint)

DOI: 10.1101/2021.03.30.437704

A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (Journal article)

DOI: 10.1038/s41467-021-22045-y

Physical, cognitive and mental health impacts of COVID-19 following hospitalisation – a multi-centre prospective cohort study (Preprint)

DOI: 10.1101/2021.03.22.21254057

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol (Journal article)

DOI: 10.1101/2021.03.18.21253888

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19. (Journal article)

DOI: 10.1126/sciimmunol.abg9873

Performance of the Innova SARS-CoV-2 Antigen Rapid Lateral Flow Test in the Liverpool Asymptomatic Testing Pilot (Journal article)

DOI: 10.2139/ssrn.3798558

What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol. (Journal article)

DOI: 10.1136/bmjopen-2020-043887

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity (Journal article)

DOI: 10.1016/j.cell.2021.01.037

Genetic mechanisms of critical illness in COVID-19. (Journal article)

DOI: 10.1038/s41586-020-03065-y

Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans (Journal article)

DOI: 10.1101/2021.03.03.433753

Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps (Journal article)

DOI: 10.1186/s13054-021-03489-6

Risk factors for long-term consequences of COVID-19 in hospitalised adults in Moscow using the ISARIC Global follow-up protocol: StopCOVID cohort study (Preprint)

DOI: 10.1101/2021.02.17.21251895

Ebola virus antibody decay-stimulation in a high proportion of survivors (Journal article)

DOI: 10.1038/s41586-020-03146-y

Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort Study (Preprint)

DOI: 10.2139/ssrn.3786694

A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process (Journal article)

DOI: 10.1016/S2352-4642(20)30304-7

Comparative evaluation of ten lateral flow immunoassays to detect SARS-CoV-2 antibodies (Journal article)

DOI: 10.12688/wellcomeopenres.16522.1

Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England (Journal article)

DOI: 10.1101/2021.01.14.21249791

Detection and Quantification of Antibody to SARS-CoV-2 Receptor Binding Domain Provides Enhanced Sensitivity, Specificity and Utility (Preprint)

DOI: 10.2139/ssrn.3739821

Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial (Journal article)

DOI: 10.1177/17511437211052226

Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study (Journal article)

DOI: 10.1101/2020.12.19.20248559

Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison (Journal article)

DOI: 10.1016/s1473-3099(20)30634-4

Short-term forecasts to inform the response to the Covid-19 epidemic in the UK (Journal article)

DOI: 10.1101/2020.11.11.20220962

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity (Journal article)

DOI: 10.1101/2020.11.04.355842

A catalog of associations between rare coding variants and COVID-19 outcomes (Preprint)

DOI: 10.1101/2020.10.28.20221804

Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (Journal article)

DOI: 10.1038/s41590-020-0782-6

COVID-19 symptoms at hospital admission vary with age and sex: ISARIC multinational study (Journal article)

DOI: 10.1101/2020.10.26.20219519

Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study. (Journal article)

DOI: 10.1093/cid/ciaa1605

Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. (Journal article)

DOI: 10.2807/1560-7917.es.2020.25.42.2000685

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study (Journal article)

DOI: 10.1136/bmj.m3731

A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (Journal article)

DOI: 10.21203/rs.3.rs-91353/v2

Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism (Journal article)

DOI: 10.3390/v12101164

Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19 (Journal article)

DOI: 10.1101/2020.10.09.20209957

Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19 (Journal article)

DOI: 10.1101/2020.10.08.20209411

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. (Journal article)

DOI: 10.12688/wellcomeopenres.16002.1

A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (Journal article)

DOI: 10.1101/2020.10.02.20205831

Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study. (Journal article)

DOI: 10.1164/rccm.202007-2794OC

Genetic mechanisms of critical illness in Covid-19 (Journal article)

DOI: 10.1101/2020.09.24.20200048

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. (Journal article)

DOI: 10.1136/bmj.m3339

Empowering children with asthma: a framework for clinical practice based on a qualitative literature review (Conference Paper)

DOI: 10.1183/13993003.congress-2020.414

The prevalence of poor fitness in children in a regional multidisciplinary severe asthma clinic, UK (Conference Paper)

DOI: 10.1183/13993003.congress-2020.2878

Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium (Conference Paper)

DOI: 10.1016/j.annonc.2020.08.1735

What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study (Journal article)

DOI: 10.1101/2020.08.26.20180950

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study (Journal article)

DOI: 10.1136/bmj.m3249

Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study (Journal article)

DOI: 10.2139/ssrn.3666248

Robust, reproducible clinical patterns in hospitalised patients with COVID-19 (Journal article)

DOI: 10.1101/2020.08.14.20168088

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial (Journal article)

DOI: 10.1016/s0140-6736(20)31604-4

Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: prospective observational study (Journal article)

DOI: 10.1101/2020.08.07.20170449

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score (Journal article)

DOI: 10.1101/2020.07.30.20165464

Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database (Journal article)

DOI: 10.1183/13993003.01809-2020

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus (Journal article)

DOI: 10.12688/wellcomeopenres.16002.1

ISARIC Clinical Data Report 20 November 2020 (Journal article)

DOI: 10.1101/2020.07.17.20155218

A national consensus management pathway for Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS): The results of a national Delphi process (Journal article)

DOI: 10.1101/2020.07.17.20156075

Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study (Journal article)

DOI: 10.1101/2020.07.14.20153320

Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study. (Journal article)

DOI: 10.1101/2020.07.15.20152967

Global outbreak research: harmony not hegemony (Journal article)

DOI: 10.1016/S1473-3099(20)30440-0

The UK hibernated pandemic influenza research portfolio: triggered for COVID-19 (Journal article)

DOI: 10.1016/S1473-3099(20)30398-4

Protocol for the development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population (Journal article)

DOI: 10.1101/2020.06.28.20141986

Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients (Journal article)

DOI: 10.2139/ssrn.3618215

Appropriate selection of convalescent plasma donors for COVID-19. (Journal article)

DOI: 10.1016/s1473-3099(20)30470-9

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved] (Journal article)

DOI: 10.12688/wellcomeopenres.15927.1

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients (Journal article)

DOI: 10.1101/2020.06.05.134551

SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus (Journal article)

DOI: 10.1101/2020.05.21.20105486

Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration. (Journal article)

DOI: 10.1136/esmoopen-2020-000825

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. (Journal article)

DOI: 10.1136/bmj.m1985

COVID-19 infection in children (Journal article)

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel (Journal article)

DOI: 10.1101/2020.04.15.20066407

Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors – a pilot study of the value of serology to determine population exposure (Journal article)

DOI: 10.1101/2020.04.13.20060467

Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. (Journal article)

DOI: 10.1056/NEJMc2003717

Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease (Journal article)

DOI: 10.1001/jamaophthalmol.2020.0173

Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19 (Journal article)

DOI: 10.1101/2020.03.05.20032011

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus (Journal article)

DOI: 10.12688/wellcomeopenres.16002.2

A new regional multidisciplinary clinic for children with difficult asthma (Conference Paper)

DOI: 10.1183/13993003.congress-2019.PA1269

Convalescent plasma therapy for persistent hepatitis E virus infection (Journal article)

DOI: 10.1016/j.jhep.2019.04.008

The UK's pandemic influenza research portfolio: a model for future research on emerging infections (Journal article)

DOI: 10.1016/S1473-3099(18)30786-2

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018) (Journal article)

DOI: 10.1038/s41590-019-0328-y

Using research to prepare for outbreaks of severe acute respiratory infection (Journal article)

DOI: 10.1136/bmjgh-2018-001061

Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma (Journal article)

DOI: 10.1080/02770903.2017.1402341

Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone (Journal article)

DOI: 10.3201/eid2408.171367

Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease (Journal article)

DOI: 10.1001/jamaophthalmol.2018.1248

Optimising the dosing of intravenous theophylline in acute severe asthma in children (Journal article)

DOI: 10.1007/s40272-017-0281-x

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Journal article)

DOI: 10.1038/s41590-018-0111-5

Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE ): protocol for a double-blind, randomised, placebo-controlled trial (Journal article)

DOI: 10.1136/bmjopen-2017-021144

Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone (Journal article)

DOI: 10.1111/trf.14580

Visual Disability in Ebola Survivors (Journal article)

DOI: 10.1093/cid/cix979

Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (Ophthalmology. 2017;124:170-177) (Journal article)

DOI: 10.1016/j.ophtha.2017.09.009

Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study. (Journal article)

DOI: 10.1093/cid/cix705

Reply to Lee and colleagues Viral posterior uveitis (Journal article)

DOI: 10.1016/j.survophthal.2017.06.002

Reply to Lee and colleagues-Viral posterior uveitis. (Journal article)

DOI: 10.1016/j.survophthal.2017.06.002

WHO collaborative study to assess the suitability of the 1st International Standard and the 1st International Reference Panel for antibodies to Ebola virus (Report)

Ocular Complications in Survivors of the Ebola Outbreak in Guinea (Journal article)

DOI: 10.1016/j.ajo.2017.05.029

Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016 (Journal article)

DOI: 10.3201/eid2307.161608

Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus (Journal article)

DOI: 10.1016/S1473-3099(17)30111-1

Longitudinal Changes of Geographic Retinal Darkening in a Cohort of Ebola Survivors (Conference Paper)

SPRINT-SARI: Short-Period Incidence Study for Severe Acute Respiratory Infections: Year 1 Rapid Data from 2015-16 (Conference Paper)

Ebola virus disease sequelae: a challenge that is not going away (Journal article)

DOI: 10.1016/S1473-3099(17)30027-0

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza (Journal article)

DOI: 10.1172/jci.insight.91868

Neurological and psychiatric manifestations of post Ebola syndrome in Sierra Leone (Conference Paper)

Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies (Journal article)

DOI: 10.1056/NEJMc1609116

Electrolyte and metabolic disturbances in ebola patients during a clinical Trial, Guinea, 2015 (Journal article)

DOI: 10.3201/eid2212.161136

Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea (Journal article)

DOI: 10.4269/ajtmh.15-0890

Prescribing antibiotics to "at-risk' children with influenza-like illness in primary care: qualitative study (Journal article)

DOI: 10.1136/bmjopen-2016-011497

Post-Ebola Syndrome, Sierra Leone (Journal article)

DOI: 10.3201/eid2204.151302

Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak (Journal article)

DOI: 10.1177/1740774515621056

Stemming the tide of hospital admissions for bronchiolitis (Journal article)

DOI: 10.1136/archdischild-2015-309452

Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea (Journal article)

DOI: 10.1056/NEJMoa1511812

DOES THE DEPARTMENT OF HEALTH'S PAEDIATRIC COMMUNITY ASSESSMENT TOOL PREDICT SEVERE BRONCHIOLITIS IN INFANTS ON ADMISSION? (Conference Paper)

DOI: 10.1136/thoraxjnl-2015-207770.226

Ebola: Europe-Africa research collaborations (Journal article)

DOI: 10.1016/S1473-3099(15)00375-8

Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study (Journal article)

DOI: 10.3310/hta19890

Evaluation and refinement of pandemic inFLUenza Community Assessment Tools (Dataset)

DOI: 10.1186/isrctn87130712

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus (Journal article)

DOI: 10.1164/rccm.201412-2256OC

JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS WITH OVERLAP FEATURES OF ANCA-ASSOCIATED VASCULITIS : A CASE REPORT (Conference Paper)

DOI: 10.1093/rheumatology/keu508

Convalescent plasma for early Ebola virus disease in Sierra Leone (Dataset)

DOI: 10.1186/isrctn13990511

Effect of Ethnicity on Care Pathway and Outcomes in Patients Hospitalized With Influenza A(H1N1)pdm09 in the UK (Journal article)

DOI: 10.1017/S0950268814001873

Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom (Journal article)

DOI: 10.1128/JVI.01636-14

Open source clinical science for emerging infections (Journal article)

DOI: 10.1016/S1473-3099(13)70327-X

An Evaluation of Community Assessment Tools (CATs) in Predicting Use of Clinical Interventions and Severe Outcomes during the A(H1N1)pdm09 Pandemic (Journal article)

DOI: 10.1371/journal.pone.0075384

Design, development and initiation of the Liverpool Respiratory Birth Cohort Study (Thesis / Dissertation)

Differences between asthmatics and nonasthmatics hospitalised with influenza A infection (Journal article)

DOI: 10.1183/09031936.00015512

Population variation in admission rates and duration of inpatient stay for bronchiolitis in England (Journal article)

DOI: 10.1136/archdischild-2012-302277

The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection (Journal article)

DOI: 10.1371/journal.pone.0041638

Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis (Conference Paper)

DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1026

Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data (Journal article)

DOI: 10.1371/journal.pone.0034428

IFITM3 restricts the morbidity and mortality associated with influenza (Journal article)

DOI: 10.1038/nature10921

Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK (Journal article)

DOI: 10.1136/thoraxjnl-2011-200266

Problems of the Respiratory System: Rate of admissions and mean length of stay for bronchiolitis in children under 2 years of age by PCT in England, Maps 20 & 21 (Chapter)

Suction versus no suction for chest drain management (Journal article)

DOI: 10.1002/14651858.cd009939

The increasing importance of innate antimicrobials response (Journal article)

DOI: 10.1136/thoraxjnl-2011-200600

Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study (Journal article)

DOI: 10.1371/journal.pone.0022425

Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease (Journal article)

DOI: 10.1371/journal.pone.0018120

Nosocomial Pandemic (H1N1) 2009, United Kingdom, 2009-2010 (Journal article)

DOI: 10.3201/eid1704.101679

Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults (Journal article)

DOI: 10.1136/thx.2010.151522

Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009) (Journal article)

DOI: 10.1136/thx.2010.135210

Paediatric practice note for the management of critically ill children with pandemic (H1N1) 2009 Influenza. (Journal article)

Evidence That RSV Directly Infects Neutrophils in the Airways and Blood of Infants with Severe Bronchiolitis (Conference Paper)

Medikidz Explain Swine Flu (Book)

Pandemic H1N1 2009 Influenza: Clinical Management Guidelines for Adults and Children (Journal article)

Pandemic H1N1 2009 influenza: clinical management guidelines for pregnancy (Journal article)

Pandemic flu:Managing Demand and Capacity in Health Care Organisations. (Report)

Swine flu clinical package (Report)

Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK (Journal article)

DOI: 10.1016/j.jcv.2008.03.011

CD8(+) T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections (Journal article)

DOI: 10.4049/jimmunol.179.12.8410

Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free (Journal article)

DOI: 10.1016/j.jcv.2007.08.019

Severe Respiratory Syncytial Virus Bronchiolitis in Infants Is Associated with Reduced Airway Interferon Gamma and Substance P (Journal article)

DOI: 10.1371/journal.pone.0001038

Pathophysiology. Lessons from humanrespiratory syncytial virus bronchiolitisand acute wheezing episodes in infants (Chapter)

DOI: 10.1201/b14633-14

CD8+ T cell responses in bronchoalveolar lavage fluid and PBMC of infants with severe primary respiratory syncytial virus infections. (Journal article)

Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis (Journal article)

DOI: 10.1086/426457

Interleukin 9 concentrations in infants with Respiratory Syncytial Virus Bronchiolitis. (Journal article)

Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis--the TOPIC study: a randomised controlled trial. (Journal article)

Reduced interferon-gamma concentration in infants with severe respiratory syncytial virus bronchiolitis (Journal article)

TLR expression and localisation in the airway cells of infants with severe bronchiolitis (Conference Paper)

Left pulmonary artery sling presenting as unilateral echogenic lung on 20-week detailed antenatal ultrasound examination (Journal article)

DOI: 10.1007/s00247-003-0942-5

Update on Cochrane data on paediatric respiratory diseases. (Journal article)

DOI: 10.1016/s1526-0542(03)00048-4

Academic Mentoiring (Report)

MORTALITY BEFORE AND AFTER HIV-INFECTION IN THE COMPLETE UK POPULATION OF HEMOPHILIACS (Journal article)

DOI: 10.1038/377079a0

HIV RESULTS IN THE FRAME - RESULTS CONFIRMED (Journal article)

DOI: 10.1038/375193a0

HIV-1 RNA SERUM-LOAD AND RESISTANT VIRAL GENOTYPES DURING EARLY ZIDOVUDINE THERAPY (Journal article)

DOI: 10.1016/S0140-6736(95)92963-0

HIV results in the frame. Results confirmed. (Journal article)

DOI: 10.1038/375193a0

HIV-1 PLASMA VIREMIA QUANTIFICATION - A NONCULTURE MEASUREMENT NEEDED FOR THERAPEUTIC TRIALS (Journal article)

DOI: 10.1016/0166-0934(93)90124-A

LACK OF SUPPRESSION BY RIBAVIRIN OF HIV VIREMIA (Journal article)

DOI: 10.1016/0140-6736(92)91867-8

Quantitative viral assay (Patent)

HIV, AIDS, AND ZIDOVUDINE (Journal article)

DOI: 10.1016/0140-6736(92)91929-3

DETECTION OF HIV-1 RNA IN FACTOR-VIII CONCENTRATE (Journal article)

DOI: 10.1097/00002030-199105000-00021

DIRECT MEASUREMENT OF VIREMIA IN PATIENTS INFECTED WITH HIV-1 AND ITS RELATIONSHIP TO DISEASE PROGRESSION AND ZIDOVUDINE THERAPY (Journal article)

DOI: 10.1002/jmv.1890350109

Prevalence and Risk Factors of Post-COVID-19 Condition in Adults and Children at 6 and 12 Months After Hospital Discharge: A Prospective, Cohort Study in Moscow (Stop COVID) (Preprint)