2023
Brennan, S., Alnaimi, A. I. M., Mcguinness, L. R., Abdelaziz, M. I. M., Mckenzie, R. A., Draycott, S., . . . Rainbow, R. D. (2023). Slowly activating voltage-gated potassium current potentiation by ML277 is a novel cardioprotective intervention. PNAS NEXUS, 2(5). doi:10.1093/pnasnexus/pgad156DOI: 10.1093/pnasnexus/pgad156
2022
Brennan, S., Esposito, S., Abdelaziz, M. I. M., Martin, C. A. A., Makwana, S., Sims, M. W. W., . . . Rainbow, R. D. (2022). Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection. FRONTIERS IN CARDIOVASCULAR MEDICINE, 9. doi:10.3389/fcvm.2022.997013DOI: 10.3389/fcvm.2022.997013
2020
Brennan, S., Rubaiy, H. N., Imanzadeh, S., Reid, R., Lodwick, D., Norman, R. I., & Rainbow, R. D. (2020). Kir6.2-D323 and SUR2A-Q1336: an intersubunit interaction pairing for allosteric information transfer in the K<sub>ATP</sub> channel complex. BIOCHEMICAL JOURNAL, 477(3), 671-689. doi:10.1042/BCJ20190753DOI: 10.1042/BCJ20190753
Celik, N., O’Brien, F., Brennan, S., Rainbow, R. D., Dart, C., Zheng, Y., . . . Barrett-Jolley, R. (2020). Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data. Communications Biology, 3, 1-10. doi:10.1038/s42003-019-0729-3DOI: 10.1038/s42003-019-0729-3
2019
Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data (Journal article)
Celik, N., O’Brien, F., Brennan, S., Rainbow, R., Dart, C., Zheng, Y., . . . Barrett-Jolley, R. (n.d.). Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data. BioRxiv. doi:10.1101/767418DOI: 10.1101/767418
Brennan, S., Chen, S., Makwana, S., Martin, C. A., Sims, M. W., Alonazi, A. S. A., . . . Rainbow, R. D. (2019). A novel form of glycolytic metabolism-dependent cardioprotection revealed by PKCα and β inhibition. JOURNAL OF PHYSIOLOGY-LONDON, 597(17), 4481-4501. doi:10.1113/JP278332DOI: 10.1113/JP278332
2018
Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions (Journal article)
Rainbow, R. D., Brennan, S., Jackson, R., Beech, A. J., Bengreed, A., Waldschmidt, H. V., . . . Willets, J. M. (2018). Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions. MOLECULAR PHARMACOLOGY, 94(3), 1079-1091. doi:10.1124/mol.118.112524DOI: 10.1124/mol.118.112524
2016
Distinct and complementary roles for alpha and beta isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose (Journal article)
Jackson, R., Brennan, S., Fielding, P., Sims, M. W., Challiss, R. A. J., Adlam, D., . . . Rainbow, R. D. (2016). Distinct and complementary roles for alpha and beta isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose. BRITISH JOURNAL OF PHARMACOLOGY, 173(5), 870-887. doi:10.1111/bph.13399DOI: 10.1111/bph.13399
2015
Early opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection (Journal article)
Brennan, S., Jackson, R., Patel, M., Sims, M. W., Hudman, D., Norman, R. I., . . . Rainbow, R. D. (2015). Early opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 79, 42-53. doi:10.1016/j.yjmcc.2014.10.016DOI: 10.1016/j.yjmcc.2014.10.016
Role of Kv7 channels in responses of the pulmonary circulation to hypoxia (Journal article)
Sedivy, V., Joshi, S., Ghaly, Y., Mizera, R., Zaloudikova, M., Brennan, S., . . . Gurney, A. M. (2015). Role of Kv7 channels in responses of the pulmonary circulation to hypoxia. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 308(1), L48-L57. doi:10.1152/ajplung.00362.2013DOI: 10.1152/ajplung.00362.2013
2014
PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function (Journal article)
Sims, M. W., Winter, J., Brennan, S., Norman, R. I., Ng, G. A., Squire, I. B., & Rainbow, R. D. (2014). PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function. American Journal of Physiology: Heart and Circulatory Physiology, 307(04), H587-H597. doi:10.1152/ajpheart.00894.2013DOI: 10.1152/ajpheart.00894.2013
