Professor John Wilding DM FRCP

Professor of Medicine Cardiovascular & Metabolic Medicine

Research

Research Interest 1

My research interests concern the pathophysiology and treatment of obesity and type 2 diabetes. I have extensive experience in the design and conduct of clinical trials in these areas. My group has expertise in the hyperinsulinaemic euglycaemic clamp and other measurements of insulin sensitivity in vivo, non-invasive measurements of heart rate variability and baroreflex sensitivity, pulse wave analysis, measurement of body composition, metabolic rate and hormonal assessment (eg insulin, leptin, ghrelin, adiponectin). Preclinical expertise includes study of metabolism (assessment of insulin secretion and sensitivity) in animal models of obesity and type 2 diabetes, and molecular and in-vivo studies related to control of energy balance such as intracerebal administration of compounds and assessment of feeding, and measurement of expression of relevant hypothalamic neurotransmitters

Research Grants

PROGROUP ImPROving GROUP treatment for people with severe obesity

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

February 2021 - January 2026

Characterising the metabolic disruption caused by brief periods of reduced physical activity in people with a family history of type 2 diabetes mellitus (T2DM).

DIABETES UK (UK)

March 2014 - December 2017

DECIDE study: Dapagliflozin Pragmatic Randomized Trial

MEDICINES & HEALTHCARE REGULATORY AGENCY (MHRA) (UK)

April 2018 - December 2022

MECNUT: Impact of dietary exposure to emulsifiers on the intestinal mucosa - implications for inflammatory bowel disease and metabolic syndrome

MEDICAL RESEARCH COUNCIL

November 2017 - September 2021

Research SPR

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK)

January 2018 - March 2021

Randomised, single blind study to assess efficacy of combination therapy of dapagliflozin with exanitide LAR versus exanatide LAR monotherapy in obese (BMI>35 kg/m2) patients with type 2 diabetes mellitus (RESILIENT)

ASTRAZENECA LIMITED (UK)

July 2016 - March 2023

Genetics in diabetes

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK)

February 2017 - December 2017

Indirect calorimetry for measurement of energy expenditure in humans

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK)

January 2015 - June 2015

Clinical Sciences centre

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK), LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (UK)

January 2018 - December 2021

North West Diabetes Local Research Network

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

November 2006 - March 2014

Cardiac autonomic dysfunction in adult growth hormone deficiency?

CHILD GROWTH FOUNDATION (UK)

July 2000 - June 2002

Diabetes Endocrinology Research Fellow

ST HELENS & KNOWSLEY TEACHING HOSPITALS NHS TRUST (UK)

October 2007 - September 2010

Clinical Sciences Centre

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK)

January 2015 - December 2018

Diabetes and Endocrinology Research.

LIVERPOOL DIABETES RESEARCH ACTION FUND

April 2006 - December 2007

Tackling Obesity-Related Restrictions in Activities of Daily Living Programmes (TORRNADO)

LIVERPOOL PRIMARY CARE TRUST (UK)

April 2012 - September 2012

Benefits of weightloss in obese patients with asthma: mechanical or immunological mechanisms?

ASTHMA UK (UK)

October 2004 - December 2008

MerseyBeat- Best Evidence, Application and Translation of Research. Obesity in pregnancy a prospective cohort study

LIVERPOOL PRIMARY CARE TRUST (UK)

April 2009 - December 2012

Urinary proteomics in Diabetes and cardiovascular disease

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK), WHISTON HOSPITAL NHS TRUST (UK)

November 2011 - October 2014

Research Nurse Support

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK)

July 2010 - December 2014

Pancreatic and extra-pancreatic effects of glucose-dependent insulinotropic polypeptide (GIP) in humans in health and type 2 diabetes mellitus

THE NOVO NORDISK UK RESEARCH FOUNDATION (UK)

May 2010 - April 2012

Pulse wave velocity measurement and arterial stiffness in elderly patients with insulin resitance and heart failure.

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

April 2004 - December 2006

Does low vitamin D cause adipose tissue inflammation and insulin resistance?

DIABETES RESEARCH AND WELLNESS FOUNDATION (UK)

January 2014 - June 2016

Diabetes Research Support

LIVERPOOL DIABETES RESEARCH ACTION FUND

April 2011 - June 2012

Patients’ expectations, beliefs and attitudes towards glucose-lowering drugs and their effects on body weight in type 2 diabetes: a prospective study and pilot intervention.

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK), DIABETES UK (UK)

September 2011 - May 2016

Baroreceptor function, sympathetic activity and insulin resistance in obstructive sleep apnoea.

BRITISH HEART FOUNDATION (UK)

October 1999 - September 2002

MerseyBeat - Best Evidence, Application and Translation of research

LIVERPOOL PRIMARY CARE TRUST (UK)

March 2008 - September 2019

PhD studentship Dr Bing / Prof Wilding

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK)

February 2012 - January 2015

Research in diabetes and endocrinology.

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK)

June 1999 - July 2012

Roles of peripheral and central cannabinoids in energy homeostasis.

LIVERPOOL DIABETES RESEARCH ACTION FUND

September 2004 - October 2007

The manipulation of ghrelin in the treatment of nutritional disorders.

LIVERPOOL DIABETES RESEARCH ACTION FUND

April 2003 - June 2005

Are the weight-sparing effects of metformin mediated through prolonged postprandial ghrelin suppression? A prospective study of patients with type 2 diabetes mellitus treated with metformin monotherapy.

DIABETES UK (UK)

May 2005 - December 2006

Role of ependyma in controlling feeding in the rat.

LIVERPOOL DIABETES RESEARCH ACTION FUND

January 2003 - December 2006

Obesity and Endocrinology study

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST (UK), LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (UK)

February 2015 - February 2022