Professor George Bou-Gharios BSc (Hons), PhD
Professor of Matrix Biology Musculoskeletal & Ageing Science
- +44 (0)151 794 9061
- Work email G.Bou-Gharios@liverpool.ac.uk
- Personal WebsiteBou-Gharios Lab
- ORCID0000-0002-9563-9418
Publications
Selected Publications
- Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis (Journal article - 2019)
- Aggrecan Gene Expression in Chondrocytes is Controlled by Multiple DNA Regulatory Elements. (Conference Paper - 2017)
- Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice. (Journal article - 2017)
- Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer. (Journal article - 2017)
- Venous identity requires BMP signalling through ALK3. (Journal article - 2019)
- Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism (Journal article - 2022)
- Syndecan-3 enhances anabolic bone formation through WNT signaling (Journal article - 2021)
- Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis (Journal article - 2020)
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2023
Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial (Journal article)
Ooi, N., Cooper, I. R., Norman, B., Gallagher, J. A., Sireau, N., Bou-Gharios, G., . . . Savage, V. J. (2023). Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial. CELLS, 12(13). doi:10.3390/cells12131683Increased prevalence of Parkinson's disease in alkaptonuria (Journal article)
Ranganath, L., Khedr, M., Milan, A. M., Davison, A. S., Norman, B. P., Janssen, M. C. H., . . . Gallagher, J. A. (2023). Increased prevalence of Parkinson's disease in alkaptonuria. JIMD Reports. doi:10.1002/jmd2.12367ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING (Conference Paper)
Pekovic-Vaughan, V., Sutton, E., Carter, A., Fawcett, S., Moore, H., Sarumi, D., & Bou-Gharios, G. (2023). ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 4). doi:10.1016/j.freeradbiomed.2023.03.042Hereditary Tyrosinemia Type 1 Mice under Continuous Nitisinone Treatment Display Remnants of an Uncorrected Liver Disease Phenotype (Journal article)
Neuckermans, J., Lequeue, S., Claes, P., Heymans, A., Hughes, J. H., Colemonts-Vroninks, H., . . . De Kock, J. (2023). Hereditary Tyrosinemia Type 1 Mice under Continuous Nitisinone Treatment Display Remnants of an Uncorrected Liver Disease Phenotype. GENES, 14(3). doi:10.3390/genes14030693Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin. (Journal article)
Quan, T., Xia, W., He, T., Calderone, K., Bou-Gharios, G., Voorhees, J. J., . . . Fisher, G. J. (2023). Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.. The Journal of investigative dermatology, S0022-202X(23)01827-4. doi:10.1016/j.jid.2023.02.028First decade anniversary of the United Kingdom National Alkaptonuria Centre. (Journal article)
Khedr, M., Sireau, N., Bou-Gharios, G., Gallagher, J. A., & Ranganath, L. R. (2023). First decade anniversary of the United Kingdom National Alkaptonuria Centre.. JIMD reports, 64(2), 212-213. doi:10.1002/jmd2.12340Characterising the relationship between muscle wasting and osteoarthritis in post-traumatic and spontaneous models of osteoarthritis (Conference Paper)
Shorter, E., Mucci, L. R., Goljanek-Whysall, K., Bou-Gharios, G., & Poulet, B. (2023). Characterising the relationship between muscle wasting and osteoarthritis in post-traumatic and spontaneous models of osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A16-A17). Retrieved from https://www.webofscience.com/Increased LANTA31 activates Akt signalling in breast cancer and changes the mode of tumour invasion into laminin matrixes (Conference Paper)
Asiri, F. M., Troughton, L. D., Zech, T., Bou-Gharios, G., Yamamoto, K., & Hamill, K. J. (2023). Increased LANTA31 activates Akt signalling in breast cancer and changes the mode of tumour invasion into laminin matrixes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A10). Retrieved from https://www.webofscience.com/Interaction of Wnts and low-density lipoprotein receptor-related protein 1 in cartilage development (Conference Paper)
Gremida, A. M. E., Jensen, A., Alhashmi, M., Mogensen, E. H., Thogersen, I. B., Enghild, J. J., . . . Yamamoto, K. (2023). Interaction of Wnts and low-density lipoprotein receptor-related protein 1 in cartilage development. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A6-A7). Retrieved from https://www.webofscience.com/Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin (Conference Paper)
Fisher, G. J., Xia, W., He, T., Bou-Gharios, G., Voorhees, J. J., Dlugosz, A., & Quan, T. (2023). Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 143 (pp. S52). Retrieved from https://www.webofscience.com/Targeted inhibition of aggrecanases inhibits the progression of age-dependent cartilage degradation in a temporomandibular joint in the STR/Ort mice (Conference Paper)
Kobayashi, Y., Yamamoto, K., Kanakis, I., Yamashita, Y., Sakai, T., Jarad, F., . . . Ooi, K. (2023). Targeted inhibition of aggrecanases inhibits the progression of age-dependent cartilage degradation in a temporomandibular joint in the STR/Ort mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A9). Retrieved from https://www.webofscience.com/Transcriptional elements driving MMP13 in development (Conference Paper)
AlSalhi, S. I., Alhashmi, M., Young, D., Tew, S., Yamamoto, K., & Bou-Gharios, G. (2023). Transcriptional elements driving MMP13 in development. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A5). Retrieved from https://www.webofscience.com/2022
MEF2 transcription factors are key regulators of sprouting angiogenesis (vol 30, pg 2297, 2016) (Journal article)
Sacilotto, N., Chouliaras, K. M., Nikitenko, L. L., Lu, Y. W., Fritzsche, M., Wallace, M. D., . . . De Val, S. (2022). MEF2 transcription factors are key regulators of sprouting angiogenesis (vol 30, pg 2297, 2016). GENES & DEVELOPMENT, 36(19-20), 1096. doi:10.1101/gad.350249.122Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria (Journal article)
Norman, B. P., Davison, A. S., Hickton, B., Ross, G. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2022). Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria. METABOLITES, 12(10). doi:10.3390/metabo12100927Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria (Journal article)
Ranganath, L. R., Hughes, A. T., Davison, A. S., Khedr, M., Imrich, R., Rudebeck, M., . . . Milan, A. M. (2022). Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria. METABOLITES, 12(10). doi:10.3390/metabo12100920Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria (Journal article)
Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Norman, B. P., . . . Olsson, B. (2022). Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-20424-zCollagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice (Journal article)
Lee, K. J., Rambault, L., Bou-Gharios, G., Clegg, P. D., Akhtar, R., Czanner, G., . . . Canty-Laird, E. G. (2022). Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice. DISEASE MODELS & MECHANISMS, 15(9). doi:10.1242/dmm.049428A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage. (Journal article)
Yamamoto, K., Scavenius, C., Meschis, M. M., Gremida, A. M. E., Mogensen, E. H., Thøgersen, I. B., . . . Nagase, H. (2022). A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.. Matrix biology : journal of the International Society for Matrix Biology, S0945-053X(22)00101-9. doi:10.1016/j.matbio.2022.08.007Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment (Journal article)
Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Imrich, R., . . . Gallagher, J. A. (2022). Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment. METABOLITES, 12(8). doi:10.3390/metabo12080772MiR-18a-5p Targets Connective Tissue Growth Factor Expression and Inhibits Transforming Growth Factor β2-Induced Trabecular Meshwork Cell Contractility (Journal article)
Knox, J., Bou-Gharios, G., Hamill, K. J., & Willoughby, C. E. (2022). MiR-18a-5p Targets Connective Tissue Growth Factor Expression and Inhibits Transforming Growth Factor β2-Induced Trabecular Meshwork Cell Contractility. GENES, 13(8). doi:10.3390/genes13081500Cartilage debris and osteoarthritis risk factors influence gene expression in the synovium in end stage osteoarthritis (Journal article)
Roebuck, M. M., Jamal, J., Lane, B., Wood, A., Santini, A., Wong, P. -F., . . . Frostick, S. P. (2022). Cartilage debris and osteoarthritis risk factors influence gene expression in the synovium in end stage osteoarthritis. KNEE, 37, 47-59. doi:10.1016/j.knee.2022.05.001Laminin N-terminus α31 expression during development is lethal and causes widespread tissue-specific defects in a transgenic mouse model (Journal article)
Sugden, C. J., Iorio, V., Troughton, L. D., Liu, K., Morais, M. R. P. T., Lennon, R., . . . Hamill, K. J. (2022). Laminin N-terminus α31 expression during development is lethal and causes widespread tissue-specific defects in a transgenic mouse model. FASEB JOURNAL, 36(7). doi:10.1096/fj.202002588RRRMetabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism (Journal article)
Norman, B. P., Davison, A. S., Hughes, J. H., Sutherland, H., Wilson, P. J. M., Berry, N. G., . . . Gallagher, J. A. (2022). Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism. GENES & DISEASES, 9(4), 1129-1142. doi:10.1016/j.gendis.2021.02.007Histopathological dataset and demographic details of synovial tissues from patients with end-stage osteoarthritis, soft tissue and traumatic injuries of the knee (Journal article)
Jamal, J., Roebuck, M. M., Wood, A., Santini, A., Bou-Gharios, G., Frostick, S. P., & Wong, P. -F. (2022). Histopathological dataset and demographic details of synovial tissues from patients with end-stage osteoarthritis, soft tissue and traumatic injuries of the knee. DATA IN BRIEF, 42. doi:10.1016/j.dib.2022.108082Temporal adaptations in the phenylalanine/tyrosine pathway and related factors during nitisinone-induced tyrosinaemia in alkaptonuria. (Journal article)
Ranganath, L. R., Hughes, A. T., Davison, A. S., Khedr, M., Olsson, B., Rudebeck, M., . . . Milan, A. M. (2022). Temporal adaptations in the phenylalanine/tyrosine pathway and related factors during nitisinone-induced tyrosinaemia in alkaptonuria.. Molecular genetics and metabolism, S1096-7192(22)00325-0. doi:10.1016/j.ymgme.2022.05.006The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics (Journal article)
Ramos-Mucci, L., Elsheikh, A., Keenan, C., Eliasy, A., D'Aout, K., Bou-Gharios, G., . . . Poulet, B. (2022). The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics. ARTHRITIS RESEARCH & THERAPY, 24(1). doi:10.1186/s13075-022-02798-7Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets (Preprint)
Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria (Journal article)
Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Norman, B. P., . . . Olsson, B. (2022). Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria. Molecular Genetics and Metabolism Reports, 30, 100846. doi:10.1016/j.ymgmr.2022.100846Altered bone metabolism in the rare inherited disease alkaptonuria (Conference Paper)
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A8-A9). Retrieved from https://www.webofscience.com/Altered bone metabolism in the rare inherited disease alkaptonuria (Conference Paper)
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A3). Retrieved from https://www.webofscience.com/CHARACTERIZING MANUFACTURED THERAPEUTIC CHONDROCYTES USING PROGNOSTIC BIOACTIVITY MARKERS (Conference Paper)
Al-Maslamani, N., Curran, J., Hoettges, K., Bou-Gharios, G., & Henstock, J. (2022). CHARACTERIZING MANUFACTURED THERAPEUTIC CHONDROCYTES USING PROGNOSTIC BIOACTIVITY MARKERS. In TISSUE ENGINEERING PART A Vol. 28 (pp. S116-S117). Retrieved from https://www.webofscience.com/2021
NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions (Conference Paper)
Sutton, E., Early, J., Hughes, A., Gall, L., Carter, A., Copple, I., . . . Pekovic-Vaughan, V. (2021). NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.042The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics (Preprint)
Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis (Journal article)
Yamamoto, K., Wilkinson, D., & Bou-Gharios, G. (n.d.). Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. Calcified Tissue International. doi:10.1007/s00223-020-00739-7Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension (Journal article)
Tam, A. Y. Y., Horwell, A. L., Trinder, S. L., Khan, K., Xu, S., Ong, V., . . . Abraham, D. J. (2021). Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 134. doi:10.1016/j.biocel.2021.105961Dermal Fibroblast <i>CCN1</i> Expression in Mice Recapitulates Human Skin Dermal Aging (Journal article)
Quan, T., Xiang, Y., Liu, Y., Qin, Z., Yang, Y., Bou-Gharios, G., . . . Fisher, G. J. (2021). Dermal Fibroblast <i>CCN1</i> Expression in Mice Recapitulates Human Skin Dermal Aging. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(4), 1007-1016. doi:10.1016/j.jid.2020.07.019Syndecan-3 enhances anabolic bone formation through WNT signaling (Journal article)
Johnson de Sousa Brito, F. M., Butcher, A., Pisconti, A., Poulet, B., Prior, A., Charlesworth, G., . . . Daroszewska, A. (2021). Syndecan-3 enhances anabolic bone formation through WNT signaling. FASEB JOURNAL, 35(4). doi:10.1096/fj.202002024RExpression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation. (Journal article)
Wilson, P. J. M., Ranganath, L. R., Bou-Gharios, G., Gallagher, J. A., & Hughes, J. H. (2021). Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation.. JIMD reports, 58(1), 52-60. doi:10.1002/jmd2.12184Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces (Journal article)
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Wilson, P. J. M., Ranganath, L. R., . . . Gallagher, J. A. (n.d.). Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces. Calcified Tissue International. doi:10.1007/s00223-020-00764-6<i>FHL2</i> PROMOTER DNA METHYLATION INCREASES WITH CHRONOLOGICAL AGE IN JOINT TISSUES AND IMPACTS TARGET GENE EXPRESSION (Conference Paper)
Fulea, R. C., Reynard, L., Young, D., & Bou-Gharios, G. (2021). <i>FHL2</i> PROMOTER DNA METHYLATION INCREASES WITH CHRONOLOGICAL AGE IN JOINT TISSUES AND IMPACTS TARGET GENE EXPRESSION. In OSTEOARTHRITIS AND CARTILAGE Vol. 29 (pp. S310). Retrieved from https://www.webofscience.com/<i>FHL2</i> promoter DNA methylation increases with chronological age in joint tissues and could impact target gene expression (Conference Paper)
Fulea, R. C., Young, D. A., Bou-Gharios, G., & Reynard, L. N. (2021). <i>FHL2</i> promoter DNA methylation increases with chronological age in joint tissues and could impact target gene expression. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 102 (pp. 132-133). Retrieved from https://www.webofscience.com/Cartilage-Specific Cre Recombinase Transgenes/Alleles in the Mouse (Chapter)
Kanakis, I., Alhashmi, M., Liu, K., Keenan, C., Mucci, L. R., Poulet, B., & Bou-Gharios, G. (2021). Cartilage-Specific Cre Recombinase Transgenes/Alleles in the Mouse. In CHONDROCYTES (Vol. 2245, pp. 23-38). doi:10.1007/978-1-0716-1119-7_3Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice (Journal article)
Yamashita-Futani, Y., Jokaji, R., Ooi, K., Kobayashi, K., Kanakis, I., Liu, K., . . . Nakamura, H. (2021). Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice. BIOMEDICAL REPORTS, 14(6). doi:10.3892/br.2021.1427Short term exposure to physiologically relevant levels of interleukin 1β initiate sustained changes in chondrocyte (Conference Paper)
Horne, R., Bou-Gharios, G., Young, D., & Tew, S. (2021). Short term exposure to physiologically relevant levels of interleukin 1β initiate sustained changes in chondrocyte. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 102 (pp. 131-132). Retrieved from https://www.webofscience.com/The anatomical distribution of ochronotic pigment in alkaptonuric mice reveals that ageing and mechanical loading make collagen susceptible to chemical attack (Conference Paper)
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2021). The anatomical distribution of ochronotic pigment in alkaptonuric mice reveals that ageing and mechanical loading make collagen susceptible to chemical attack. In JOURNAL OF ANATOMY Vol. 238 (pp. 200). Retrieved from https://www.webofscience.com/\ Fibroblast-specific deletion of cell-surface endocytic receptor LRP1 prevents the development of pulmonary fibrosis in mouse in vivo (Conference Paper)
Meschis, M. M., Scavenius, C., Enghild, J. J., Craig, S., Bou-Gharios, G., & Yamamoto, K. (2021). \ Fibroblast-specific deletion of cell-surface endocytic receptor LRP1 prevents the development of pulmonary fibrosis in mouse in vivo. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 102 (pp. A14). Retrieved from https://www.webofscience.com/2020
Modulation of the mechanical responses of synovial fibroblasts by osteoarthritis-associated inflammatory stressors. (Journal article)
Jamal, J., Roebuck, M. M., Lee, S. -Y., Frostick, S. P., Abbas, A. A., Merican, A. M., . . . Wong, P. -F. (2020). Modulation of the mechanical responses of synovial fibroblasts by osteoarthritis-associated inflammatory stressors.. The International Journal of Biochemistry and Cell Biology, 126. doi:10.1016/j.biocel.2020.105800Laminin N-terminus α31 expression during development is lethal and causes widespread tissue-specific defects in a transgenic mouse model (Preprint)
Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis (Journal article)
Ramos-Mucci, L., Javaheri, B., van ‘t Hof, R., Bou-Gharios, G., Pitsillides, A. A., Comerford, E., & Poulet, B. (n.d.). Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis. Arthritis Research & Therapy, 22(1). doi:10.1186/s13075-020-02261-5Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice (Journal article)
Lee, K., Rambault, L., Bou-Gharios, G., Clegg, P., Akhtar, R., Czanner, G., . . . Canty-Laird, E. (2020). Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice. doi:10.1101/2020.07.13.198283Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of <i>Ccn2</i> (Journal article)
Keenan, C. M., Ramos-Mucci, L., Kanakis, I., Milner, P. I., Leask, A., Abraham, D., . . . Poulet, B. (2020). Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of <i>Ccn2</i>. DISEASE MODELS & MECHANISMS, 13(7). doi:10.1242/dmm.044719Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis (Journal article)
Nakamura, H., Phoung, V., Kanakis, I., Liu, K., & Bou-Gharios, G. (2020). Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-66233-0Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis. (Journal article)
Perry, J., McCarthy, H. S., Bou-Gharios, G., van 't Hof, R., Milner, P. I., Mennan, C., & Roberts, S. (2020). Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis.. Osteoarthritis and cartilage open, 2(2), 100044. doi:10.1016/j.ocarto.2020.100044SIRT1 directly activates autophagy in human chondrocytes (Journal article)
Sacitharan, P. K., Bou-Gharios, G., & Edwards, J. R. (2020). SIRT1 directly activates autophagy in human chondrocytes. Cell Death Discovery, 6(1). doi:10.1038/s41420-020-0277-0Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria (Journal article)
Hughes, J. H., Wilson, P. J. M., Sutherland, H., Judd, S., Hughes, A. T., Milan, A. M., . . . Gallagher, J. A. (2020). Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43(2), 259-268. doi:10.1002/jimd.12172Development and validation of an inducible LaNt α31 overexpressing mouse model (Conference Paper)
Sugden, C. J., Troughton, L. D., Liu, K., Bou-Gharios, G., & Hamill, K. J. (2020). Development and validation of an inducible LaNt α31 overexpressing mouse model. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 101 (pp. A5). Retrieved from https://www.webofscience.com/Endocytosis of extracellular molecules in respiratory health and disease (Conference Paper)
Meschis, M. M., Scavenius, C., Enghild, J. J., Craig, S., Bou-Gharios, G., & Yamamoto, K. (2020). Endocytosis of extracellular molecules in respiratory health and disease. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 101 (pp. A3). Retrieved from https://www.webofscience.com/SEMAPHORIN-3A EXPRESSION IS UP-REGULATED IN INNERVATED JOINT TISSUES DURING THE DEVELOPMENT OF OSTEOARTHRITIS (Conference Paper)
Li, X., Ter Heegde, F., Javaheri, B., Pitsillides, A., Bou-Gharios, G., & Chenu, C. (2020). SEMAPHORIN-3A EXPRESSION IS UP-REGULATED IN INNERVATED JOINT TISSUES DURING THE DEVELOPMENT OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 28 (pp. S199). Retrieved from https://www.webofscience.com/2019
The contribution of mouse models in the rare disease alkaptonuria (Journal article)
Hughes, J. H., Bou-Gharios, G., Ranganath, L. R., & Gallagher, J. A. (2019). The contribution of mouse models in the rare disease alkaptonuria. Drug Discovery Today: Disease Models. doi:10.1016/j.ddmod.2019.10.005Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria (Journal article)
Hughes, J. H., Liu, K., Plagge, A., Wilson, P. J. M., Sutherland, H., Norman, B. P., . . . Bou-Gharios, G. (2019). Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human Molecular Genetics, 28(23), 3928-3939. doi:10.1093/hmg/ddz234Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis (Preprint)
Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients (Journal article)
Scavenius, C., Poulsen, E. C., Thøgersen, I. B., Roebuck, M., Frostick, S., Bou-Gharios, G., . . . Enghild, J. J. (2019). Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients. Journal of Biological Chemistry, 294(42), 15495-15504. doi:10.1074/jbc.ra119.008844Selectively high efficacy of eribulin against high-grade invasive recurrent and/or metastatic squamous cell carcinoma of the head and neck (Journal article)
Kobayashi, Y., Kitahara, H., Hirai, M., Tanaka, A., Jokaji, R., Kobayashi, K., . . . Kawashiri, S. (2019). Selectively high efficacy of eribulin against high-grade invasive recurrent and/or metastatic squamous cell carcinoma of the head and neck. ONCOLOGY LETTERS, 17(6), 5064-5072. doi:10.3892/ol.2019.10165Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging (vol 15, 68, 2019) (Journal article)
Davison, A. S., Strittmatter, N., Sutherland, H., Hughes, A. T., Hughes, J., Bou-Gharios, G., . . . Gallagher, J. A. (2019). Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.. Metabolomics : Official journal of the Metabolomic Society, 15(5), 68. doi:10.1007/s11306-019-1531-4CHONDROCYTE SPECIFIC EXPRESSION OF CCN2 DOES NOT MODIFY OSTEOARTHRITIS DEVELOPMENT IN MICE (Conference Paper)
Keenan, C., Ramos, L., Kanakis, I., Milner, P., Abraham, D., Bou-Gharios, G., & Poulet, B. (2019). CHONDROCYTE SPECIFIC EXPRESSION OF CCN2 DOES NOT MODIFY OSTEOARTHRITIS DEVELOPMENT IN MICE. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S162). doi:10.1016/j.joca.2019.02.240HUMAN UMBILICAL CORD MESENCHYMAL STROMAL CELLS DO NOT EVOKE AN IMMUNE RESPONSE IN THE PARTIAL MEDIAL MENISCECTOMY MURINE MODEL OF OSTEOARTHRITIS (Conference Paper)
Perry, J., Mennan, C., McCarthy, H. S., Bou-Gharios, G., van 't Hof, R., Milner, P., . . . Roberts, S. (2019). HUMAN UMBILICAL CORD MESENCHYMAL STROMAL CELLS DO NOT EVOKE AN IMMUNE RESPONSE IN THE PARTIAL MEDIAL MENISCECTOMY MURINE MODEL OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S438-S439). doi:10.1016/j.joca.2019.02.468Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis (Journal article)
Kanakis, I., Liu, K., Poulet, B., Javaheri, B., van 't Hof, R. J., Pitsillides, A. A., & Bou-Gharios, G. (2019). Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis. Arthritis and Rheumatology, 71(4), 571-582. doi:10.1002/art.40765Venous identity requires BMP signalling through ALK3. (Journal article)
Neal, A., Nornes, S., Payne, S., Wallace, M. D., Fritzsche, M., Louphrasitthiphol, P., . . . De Val, S. (2019). Venous identity requires BMP signalling through ALK3.. Nature communications, 10(1), 453. doi:10.1038/s41467-019-08315-wEffects of Fibrillin-1 mutation (Tight skin mouse) in joint health (Conference Paper)
Keenan, C., Ramos, L., Smith, H., Ramanayake, W., Andrew, P., Bou-Gharios, G., . . . Blandine, P. (2019). Effects of Fibrillin-1 mutation (Tight skin mouse) in joint health. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A22). Retrieved from https://www.webofscience.com/The miRNA miR-21a-5p targets SMAD7, and its inhibition decreases lung fibrosis in the mouse (Conference Paper)
di Mase, M. S., Whysall, K., Bou-Gharios, G., & Van't Hof, R. (2019). The miRNA miR-21a-5p targets SMAD7, and its inhibition decreases lung fibrosis in the mouse. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A33-A34). Retrieved from https://www.webofscience.com/Type I collagen structure, synthesis, and regulation (Chapter)
Bou-Gharios, G., Abraham, D., & de Crombrugghe, B. (2020). Type I collagen structure, synthesis, and regulation. In Principles of Bone Biology (pp. 295-337). Elsevier. doi:10.1016/b978-0-12-814841-9.00013-02018
Targeted inhibition of aggrecanases prevents articular cartilage degradation and augments bone mass in the STR/Ort spontaneous model of osteoarthritis. (Journal article)
Bou-Gharios, G. (n.d.). Targeted inhibition of aggrecanases prevents articular cartilage degradation and augments bone mass in the STR/Ort spontaneous model of osteoarthritis.. Arthritis and Rheumatology.Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300 (Journal article)
Sacitharan, P. K., Lwin, S., Gharios, G. B., & Edwards, J. R. (2018). Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300. EXPERIMENTAL AND MOLECULAR MEDICINE, 50. doi:10.1038/s12276-018-0149-3The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within? (Journal article)
Javaheri, B., Caetano-Silva, S. P., Kanakis, I., Bou-Gharios, G., & Pitsillides, A. A. (2018). The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?. Frontiers in Bioengineering and Biotechnology, 6. doi:10.3389/fbioe.2018.00028Multiple enhancer regions govern the transcription of CCN2 during embryonic development (Journal article)
Frost, S. L., Liu, K., Li, I. M. H., Poulet, B., Comerford, E., De Val, S., & Bou-Gharios, G. (2018). Multiple enhancer regions govern the transcription of CCN2 during embryonic development. JOURNAL OF CELL COMMUNICATION AND SIGNALING, 12(1), 231-243. doi:10.1007/s12079-017-0440-4Chondrocyte specific deletion of CCN2 does not exacerbate osteoarthritis in models of post-traumatic osteoarthritis in mice (Conference Paper)
Keenan, C., Jaffa, M., Milner, P., Kanakis, I., Carter, A., Abraham, D., . . . Poulet, B. (2018). Chondrocyte specific deletion of CCN2 does not exacerbate osteoarthritis in models of post-traumatic osteoarthritis in mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A14). Retrieved from https://www.webofscience.com/Murine cruciate ligament pathology and mechanics during osteoarthritis development (Conference Paper)
Ramos, L., Bou-Gharios, G., Pitsillides, A. A., Comerford, E., & Poulet, B. (2018). Murine cruciate ligament pathology and mechanics during osteoarthritis development. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A63-A64). Retrieved from https://www.webofscience.com/The effect of [-1A]TIMP3 overexpression on bone mass in the naturally developing OA STR/Ort mice (Conference Paper)
Kanakis, I., van't Hof, R., Liu, K., Pitsillides, A., & Bou-Gharios, G. (2018). The effect of [-1A]TIMP3 overexpression on bone mass in the naturally developing OA STR/Ort mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A17-A18). Retrieved from https://www.webofscience.com/Ubiquitous removal of ccn2 in a bleomycin induced pulmonary fibrosis model is detrimental to survival (Conference Paper)
Horwell, A. L., Liu, K., Spencer, L., Moots, R., Van 'T Hof, R., & Bou-Gharios, G. (2018). Ubiquitous removal of ccn2 in a bleomycin induced pulmonary fibrosis model is detrimental to survival. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A40-A41). Retrieved from https://www.webofscience.com/2017
Aggrecan Gene Expression in Chondrocytes is Controlled by Multiple DNA Regulatory Elements. (Conference Paper)
Li, I. M. H., Liu, K., Neal, A., Clegg, P. D., De Val, S., & Bou-Gharios, G. (2017). Aggrecan Gene Expression in Chondrocytes is Controlled by Multiple DNA Regulatory Elements.. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 32 (pp. S314). Retrieved from https://www.webofscience.com/Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer. (Journal article)
Li, I. M. H., Horwell, A. L., Chu, G., de Crombrugghe, B., & Bou-Gharios, G. (2017). Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.. Methods in molecular biology (Clifton, N.J.), 1627, 139-161. doi:10.1007/978-1-4939-7113-8_10SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development (Journal article)
Chiang, I. K. -N., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K., Lagendijk, A., . . . Francois, M. (2017). SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, 144(14), 2629-2639. doi:10.1242/dev.146241Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice. (Journal article)
Miller, B., Spevak, L., Lukashova, L., Javaheri, B., Pitsillides, A. A., Boskey, A., . . . Carriero, A. (2017). Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice. CALCIFIED TISSUE INTERNATIONAL, 100(6), 631-640. doi:10.1007/s00223-017-0248-5Murine cruciate ligament degeneration and marker expression during osteoarthritis (Conference Paper)
Ramos, L. D., Bou-Gharios, G., Pitsillides, A. A., Comerford, E., & Poulet, B. (2017). Murine cruciate ligament degeneration and marker expression during osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 98 (pp. A8-A9). Retrieved from https://www.webofscience.com/2016
Overexpression of TIMP-3 in chondrocytes produces transient reduction in growth plate length but permanently reduces adult bone quality and quantity (Journal article)
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., . . . Bou-Gharios, G. (2016). Overexpression of TIMP-3 in chondrocytes produces transient reduction in growth plate length but permanently reduces adult bone quality and quantity. PLoS ONE, 11(12). doi:10.1371/journal.pone.0167971Aggrecan gene expression in chondrocytes is controlled by multiple regulatory elements (Conference Paper)
Li, I. M., Liu, K., Neal, A., Clegg, P. D., De Val, S., & Bou-Gharios, G. (2016). Aggrecan gene expression in chondrocytes is controlled by multiple regulatory elements. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A8-A9). Retrieved from https://www.webofscience.com/Chondrocyte-specific TIMP3 overexpression disrupts endochondral growth and compromises bone structure and integrity: functional impact of the chondrocyte-to-osteoblast lineage (Conference Paper)
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., . . . Carrierro, A. (2016). Chondrocyte-specific TIMP3 overexpression disrupts endochondral growth and compromises bone structure and integrity: functional impact of the chondrocyte-to-osteoblast lineage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A7). Chester. doi:10.1111/iep.12211Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition (Journal article)
Kitahara, H., Hirai, M., Kato, K., Bou-Gharios, G., Nakamura, H., & Kawashiri, S. (2016). Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition. ONCOLOGY REPORTS, 36(6), 3139-3144. doi:10.3892/or.2016.5189Investigating the role of the RNA binding protein HuR during chondrogenesis (Conference Paper)
Johnson, K. A., McDermott, B. T., Milner, P. I., Bou-Gharios, G., & Tew, S. R. (2016). Investigating the role of the RNA binding protein HuR during chondrogenesis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A23). Retrieved from https://www.webofscience.com/MEF2 transcription factors are key regulators of sprouting angiogenesis (Journal article)
Sacilotto, N., Chouliaras, K. M., Nikitenko, L. L., Lu, Y. W., Fritzsche, M., Wallace, M. D., . . . De Val, S. (2016). MEF2 transcription factors are key regulators of sprouting angiogenesis. GENES & DEVELOPMENT, 30(20), 2297-2309. doi:10.1101/gad.290619.116Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections (Journal article)
Ikeda, T., Fragiadaki, M., Xu, S. -W., Ponticos, M., Khan, K., Denton, C., . . . Abraham, D. (2016). Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections. DATA IN BRIEF, 8, 1377-1380. doi:10.1016/j.dib.2016.08.014Transforming growth factor-<i>β</i>-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts. (Journal article)
Ikeda, T., Fragiadaki, M., Shi-Wen, X., Ponticos, M., Khan, K., Denton, C., . . . Abraham, D. (2016). Transforming growth factor-<i>β</i>-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts.. Biochemistry and biophysics reports, 7, 246-252. doi:10.1016/j.bbrep.2016.06.022Deficiency and also transgenic overexpression of Timp-3 both lead to compromised bone mass and architecture in vivo (Journal article)
Javaheri, B., Hopkinson, M., Poulet, B., Pollard, A. S., Shefelbine, S. J., Chang, Y. M., . . . Pitsillides, A. A. (2016). Deficiency and also transgenic overexpression of Timp-3 both lead to compromised bone mass and architecture in vivo. PLoS ONE, 11(8). doi:10.1371/journal.pone.0159657RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes (Journal article)
McDermott, B., Ellis, S., Bou-Gharios, G., Clegg, P., & Tew, S. (2016). RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis and Cartilage, 24(7), 1263-1273. doi:10.1016/j.joca.2016.01.988An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression (Journal article)
Becker, P. W., Sacilotto, N., Nornes, S., Neal, A., Thomas, M. O., Liu, K., . . . De Val, S. (2016). An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression. Arteriosclerosis, Thrombosis and Vascular Biology, 36(6), 1209-1219. doi:10.1161/ATVBAHA.116.307517Loss of the longevity gene SirT1 dysregulates chondrocytes and leads to an arthritic phenotype in vivo, via impaired autophagy (Journal article)
Sacitharan, P. K., Zarebska, J., Gharios, G. B., Vincent, T., & Edwards, J. (n.d.). Loss of the longevity gene SirT1 dysregulates chondrocytes and leads to an arthritic phenotype in vivo, via impaired autophagy. Bone Abstracts. doi:10.1530/boneabs.5.oc6.6A CLUSTER OF REGULATORY ELEMENTS THAT DRIVES THE AGGRECAN GENE EXPRESSION IN CHONDROCYTES (Conference Paper)
Li, I. M., Liu, K., Neal, A., Clegg, P. D., De Val, S., & Bou-Gharios, G. (2016). A CLUSTER OF REGULATORY ELEMENTS THAT DRIVES THE AGGRECAN GENE EXPRESSION IN CHONDROCYTES. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S136-S137). doi:10.1016/j.joca.2016.01.268CONNECTIVE TISSUE GROWTH FACTOR DEFICIENCY IN ADULT ARTICULAR CARTILAGE PROMOTES CARTILAGE DEGENERATION AT EARLY TIMEPOINTSIN MOUSE POSTTRAUMATIC OSTEOARTHRITIS (Conference Paper)
Poulet, B., Milner, P., Kanakis, I., Carter, A., Abraham, D., Leask, A., . . . Bou-Gharios, G. (2016). CONNECTIVE TISSUE GROWTH FACTOR DEFICIENCY IN ADULT ARTICULAR CARTILAGE PROMOTES CARTILAGE DEGENERATION AT EARLY TIMEPOINTSIN MOUSE POSTTRAUMATIC OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S392). doi:10.1016/j.joca.2016.01.705THE ROLE OF MICRORNAS IN OSTEOARTHRITIS AND AGEING RELATED FUNCTIONAL DECLINE IN JOINT TISSUE HOMEOSTASIS. (Conference Paper)
House, L., Bou-Gharios, G., Peffers, M., Milner, P., Clegg, P. D., Young, D. A., & Whysall, K. A. (2016). THE ROLE OF MICRORNAS IN OSTEOARTHRITIS AND AGEING RELATED FUNCTIONAL DECLINE IN JOINT TISSUE HOMEOSTASIS.. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S63-S64). doi:10.1016/j.joca.2016.01.141Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome (Journal article)
Moschidou, D., Corcelli, M., Hau, K. -L., Ekwalla, V. J., Behmoaras, J. V., De Coppi, P., . . . Guillot, P. V. (2016). Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome. STEM CELLS AND DEVELOPMENT, 25(5), 395-404. doi:10.1089/scd.2015.03052015
SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS (Conference Paper)
Poulet, B., Bou-Gharios, G., & Pitsillides, A. A. (2015). SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 23 (pp. A283). doi:10.1016/j.joca.2015.02.516Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis (Journal article)
Gardiner, M. D., Vincent, T. L., Driscoll, C., Burleigh, A., Bou-Gharios, G., Saklatvala, J., . . . Chanalaris, A. (2015). Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis. Osteoarthritis and Cartilage, 23(4), 616-628. doi:10.1016/j.joca.2014.12.014Failed Degradation of JunB Contributes to Overproduction of Type I Collagen and Development of Dermal Fibrosis in Patients With Systemic Sclerosis (Journal article)
Ponticos, M., Papaioannou, I., Xu, S., Holmes, A. M., Khan, K., Denton, C. P., . . . Abraham, D. J. (2015). Failed Degradation of JunB Contributes to Overproduction of Type I Collagen and Development of Dermal Fibrosis in Patients With Systemic Sclerosis. Arthritis and Rheumatology, 67(1), 243-253. doi:10.1002/art.388972014
Generation of a Mouse Line Harboring a Bi-Transgene Expressing Luciferase and Tamoxifen-Activatable CreER<SUP>T2</SUP> Recombinase in Cartilage (Journal article)
Lo Cascio, L., Liu, K., Nakamura, H., Chu, G., Lim, N. H., Chanalaris, A., . . . Bou-Gharios, G. (2014). Generation of a Mouse Line Harboring a Bi-Transgene Expressing Luciferase and Tamoxifen-Activatable CreER<SUP>T2</SUP> Recombinase in Cartilage. GENESIS, 52(2), 110-119. doi:10.1002/dvg.22734<i>In vivo</i> imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis (Journal article)
Lim, N. H., Meinjohanns, E., Meldal, M., Bou-Gharios, G., & Nagase, H. (2014). <i>In vivo</i> imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis. OSTEOARTHRITIS AND CARTILAGE, 22(6), 862-868. doi:10.1016/j.joca.2014.04.006Biphasic recruitment of microchimeric fetal mesenchymal cells in fibrosis following acute kidney injury (Journal article)
Roy, E., Seppanen, E., Ellis, R., Lee, E. S., Khosroterani, K., Fisk, N. M., & Bou-Gharios, G. (2014). Biphasic recruitment of microchimeric fetal mesenchymal cells in fibrosis following acute kidney injury. KIDNEY INTERNATIONAL, 85(3), 600-610. doi:10.1038/ki.2013.459In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen-Induced Arthritis (Journal article)
Lim, N. H., Meinjohanns, E., Bou-Gharios, G., Gompels, L. L., Nuti, E., Rossello, A., . . . Nagase, H. (2014). In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen-Induced Arthritis. Arthritis and Rheumatology, 66(3), 589-598. doi:10.1002/art.38295Transforming Growth Factor-β–Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis (Journal article)
Sakai, K., Jawaid, S., Sasaki, T., Bou-Gharios, G., & Sakai, T. (2014). Transforming Growth Factor-β–Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis. AMERICAN JOURNAL OF PATHOLOGY, 184(10), 2611-2617. doi:10.1016/j.ajpath.2014.06.0092013
Heat shock protein B1-deficient mice display impaired wound healing. (Journal article)
Crowe, J., Aubareda, A., McNamee, K., Przybycien, P. M., Lu, X., Williams, R. O., . . . Dean, J. L. E. (2013). Heat shock protein B1-deficient mice display impaired wound healing.. PloS one, 8(10), e77383. doi:10.1371/journal.pone.0077383Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease. (Journal article)
Lindahl, G. E., Stock, C. J., Shi-Wen, X., Leoni, P., Sestini, P., Howat, S. L., . . . Renzoni, E. A. (2013). Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.. Respiratory research, 14, 80. doi:10.1186/1465-9921-14-80Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development. (Journal article)
Sacilotto, N., Monteiro, R., Fritzsche, M., Becker, P. W., Sanchez-Del-Campo, L., Liu, K., . . . De Val, S. (2013). Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development.. Proceedings of the National Academy of Sciences of the United States of America, 110(29), 11893-11898. doi:10.1073/pnas.1300805110Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model. (Journal article)
Seppanen, E., Roy, E., Ellis, R., Bou-Gharios, G., Fisk, N. M., & Khosrotehrani, K. (2013). Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model.. PloS one, 8(5), e62662. doi:10.1371/journal.pone.0062662Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing. (Journal article)
Rodero, M. P., Legrand, J. M. D., Bou-Gharios, G., & Khosrotehrani, K. (2013). Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing.. Experimental dermatology, 22(2), 143-145. doi:10.1111/exd.120682012
Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females. (Journal article)
Seppanen, E. J., Hodgson, S. S., Khosrotehrani, K., Bou-Gharios, G., & Fisk, N. M. (2012). Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females.. Stem cells and development, 21(15), 2809-2816. doi:10.1089/scd.2012.0047Ontological differences in first compared to third trimester human fetal placental chorionic stem cells. (Journal article)
Jones, G. N., Moschidou, D., Puga-Iglesias, T. -I., Kuleszewicz, K., Vanleene, M., Shefelbine, S. J., . . . Guillot, P. V. (2012). Ontological differences in first compared to third trimester human fetal placental chorionic stem cells.. PloS one, 7(9), e43395. doi:10.1371/journal.pone.0043395Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy. (Journal article)
Fragiadaki, M., Hill, N., Hewitt, R., Bou-Gharios, G., Cook, T., Tam, F. W., . . . Mason, R. M. (2012). Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.. Diabetes, 61(9), 2280-2288. doi:10.2337/db11-1138TGF-b signaling in cartilage homeostasis and osteoarthritis. (Journal article)
Finnson, K. W., Chi, Y., Bou-Gharios, G., Leask, A., & Philip, A. (2012). TGF-b signaling in cartilage homeostasis and osteoarthritis.. Frontiers in bioscience (Scholar edition), 4, 251-268. doi:10.2741/s2662011
Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo. (Journal article)
Fragiadaki, M., Witherden, A. S., Kaneko, T., Sonnylal, S., Pusey, C. D., Bou-Gharios, G., & Mason, R. M. (2011). Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo.. Matrix biology : journal of the International Society for Matrix Biology, 30(7-8), 396-403. doi:10.1016/j.matbio.2011.07.004High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1. (Journal article)
Fragiadaki, M., Ikeda, T., Witherden, A., Mason, R. M., Abraham, D., & Bou-Gharios, G. (2011). High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1.. Molecular biology of the cell, 22(11), 1836-1844. doi:10.1091/mbc.e10-08-0669Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription. (Journal article)
Bou-Gharios, G., Amin, F., Hill, P., Nakamura, H., Maxwell, P., & Fisk, N. M. (2011). Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription.. Cells, tissues, organs, 193(6), 379-392. doi:10.1159/000321172Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties. (Journal article)
Vanleene, M., Saldanha, Z., Cloyd, K. L., Jell, G., Bou-Gharios, G., Bassett, J. H. D., . . . Shefelbine, S. J. (2011). Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties.. Blood, 117(3), 1053-1060. doi:10.1182/blood-2010-05-287565Differential Contribution of Dermal Resident and Bone Marrow–Derived Cells to Collagen Production during Wound Healing and Fibrogenesis in Mice (Journal article)
Higashiyama, R., Nakao, S., Shibusawa, Y., Ishikawa, O., Moro, T., Mikami, K., . . . Inagaki, Y. (2011). Differential Contribution of Dermal Resident and Bone Marrow–Derived Cells to Collagen Production during Wound Healing and Fibrogenesis in Mice. Journal of Investigative Dermatology, 131(2), 529-536. doi:10.1038/jid.2010.3142010
Fetal stem cell microchimerism: natural-born healers or killers? (Journal article)
Lee, E. S. M., Bou-Gharios, G., Seppanen, E., Khosrotehrani, K., & Fisk, N. M. (2010). Fetal stem cell microchimerism: natural-born healers or killers?. Molecular human reproduction, 16(11), 869-878. doi:10.1093/molehr/gaq067Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. (Journal article)
Sonnylal, S., Shi-Wen, X., Leoni, P., Naff, K., Van Pelt, C. S., Nakamura, H., . . . de Crombrugghe, B. (2010). Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.. Arthritis and rheumatism, 62(5), 1523-1532. doi:10.1002/art.273822009
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. (Journal article)
Ponticos, M., Holmes, A. M., Shi-wen, X., Leoni, P., Khan, K., Rajkumar, V. S., . . . Lindahl, G. E. (2009). Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.. Arthritis and rheumatism, 60(7), 2142-2155. doi:10.1002/art.24620JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction. (Journal article)
Ponticos, M., Harvey, C., Ikeda, T., Abraham, D., & Bou-Gharios, G. (2009). JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.. Nucleic acids research, 37(16), 5378-5389. doi:10.1093/nar/gkp544Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. (Journal article)
Higashiyama, R., Moro, T., Nakao, S., Mikami, K., Fukumitsu, H., Ueda, Y., . . . Inagaki, Y. (2009). Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.. Gastroenterology, 137(4), 1459-66.e1. doi:10.1053/j.gastro.2009.07.0062008
Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse. (Journal article)
Guillot, P. V., Cook, H. T., Pusey, C. D., Fisk, N. M., Harten, S., Moss, J., . . . Bou-Gharios, G. (2008). Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse.. The Journal of pathology, 214(5), 627-636. doi:10.1002/path.2325Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction. (Journal article)
van Amerongen, M. J., Bou-Gharios, G., Popa, E., van Ark, J., Petersen, A. H., van Dam, G. M., . . . Harmsen, M. C. (2008). Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction.. The Journal of pathology, 214(3), 377-386. doi:10.1002/path.2281Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice. (Journal article)
Guillot, P. V., Abass, O., Bassett, J. H. D., Shefelbine, S. J., Bou-Gharios, G., Chan, J., . . . Fisk, N. M. (2008). Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.. Blood, 111(3), 1717-1725. doi:10.1182/blood-2007-08-105809Type I Collagen Structure, Synthesis, and Regulation (Chapter)
Bou-Gharios, G., & de Crombrugghe, B. (2008). Type I Collagen Structure, Synthesis, and Regulation. In PRINCIPLES OF BONE BIOLOGY, VOL 1, 3RD EDITION (pp. 285-318). doi:10.1016/B978-0-12-373884-4.00034-32007
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. (Journal article)
Shi-wen, X., Kennedy, L., Renzoni, E. A., Bou-Gharios, G., du Bois, R. M., Black, C. M., . . . Leask, A. (2007). Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.. Arthritis and rheumatism, 56(12), 4189-4194. doi:10.1002/art.23134Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. (Journal article)
Shi-Wen, X., Renzoni, E. A., Kennedy, L., Howat, S., Chen, Y., Pearson, J. D., . . . Leask, A. (2007). Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.. Matrix biology : journal of the International Society for Matrix Biology, 26(8), 625-632. doi:10.1016/j.matbio.2007.06.003Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction. (Journal article)
Alexakis, C., Partridge, T., & Bou-Gharios, G. (2007). Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction.. American journal of physiology. Cell physiology, 293(2), C661-C669. doi:10.1152/ajpcell.00061.20072006
Transcriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases. (Journal article)
Ramirez, F., Tanaka, S., & Bou-Gharios, G. (2006). Transcriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases.. Matrix biology : journal of the International Society for Matrix Biology, 25(6), 365-372. doi:10.1016/j.matbio.2006.05.002Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1. (Journal article)
Menon, R. P., Menon, M. R., Shi-Wen, X., Renzoni, E., Bou-Gharios, G., Black, C. M., & Abraham, D. J. (2006). Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1.. Experimental cell research, 312(9), 1463-1474. doi:10.1016/j.yexcr.2006.01.011CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. (Journal article)
Shi-wen, X., Stanton, L. A., Kennedy, L., Pala, D., Chen, Y., Howat, S. L., . . . Leask, A. (2006). CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.. The Journal of biological chemistry, 281(16), 10715-10726. doi:10.1074/jbc.m511343200Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis. (Journal article)
Roufosse, C., Bou-Gharios, G., Prodromidi, E., Alexakis, C., Jeffery, R., Khan, S., . . . Cook, H. T. (2006). Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis.. Journal of the American Society of Nephrology : JASN, 17(3), 775-782. doi:10.1681/asn.2005080795Organ-specific collagen expression: implications for renal disease. (Journal article)
Alexakis, C., Maxwell, P., & Bou-Gharios, G. (2006). Organ-specific collagen expression: implications for renal disease.. Nephron. Experimental nephrology, 102(3-4), e71-e75. doi:10.1159/000089684Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing. (Journal article)
Rajkumar, V. S., Shiwen, X., Bostrom, M., Leoni, P., Muddle, J., Ivarsson, M., . . . Abraham, D. J. (2006). Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.. The American journal of pathology, 169(6), 2254-2265. doi:10.2353/ajpath.2006.060196The bone marrow functionally contributes to liver fibrosis. (Journal article)
Russo, F. P., Alison, M. R., Bigger, B. W., Amofah, E., Florou, A., Amin, F., . . . Forbes, S. J. (2006). The bone marrow functionally contributes to liver fibrosis.. Gastroenterology, 130(6), 1807-1821. doi:10.1053/j.gastro.2006.01.0362005
Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2). (Journal article)
Antoniv, T. T., Tanaka, S., Sudan, B., De Val, S., Liu, K., Wang, L., . . . Ramirez, F. (2005). Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2).. The Journal of biological chemistry, 280(42), 35417-35423. doi:10.1074/jbc.m502681200Activation of Key Profibrotic Mechanisms in Transgenic Fibroblasts Expressing Kinase-deficient Type II Transforming Growth Factor-β Receptor (TβRIIΔk) (Journal article)
Denton, C. P., Lindahl, G. E., Khan, K., Shiwen, X., Ong, V. H., Gaspar, N. J., . . . Black, C. M. (2005). Activation of Key Profibrotic Mechanisms in Transgenic Fibroblasts Expressing Kinase-deficient Type II Transforming Growth Factor-β Receptor (TβRIIΔk). Journal of Biological Chemistry, 280(16), 16053-16065. doi:10.1074/jbc.m413134200Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles. (Journal article)
Lu, Q. L., Rabinowitz, A., Chen, Y. C., Yokota, T., Yin, H., Alter, J., . . . Partridge, T. (2005). Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles.. Proceedings of the National Academy of Sciences of the United States of America, 102(1), 198-203. doi:10.1073/pnas.0406700102Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice. (Journal article)
Inagaki, Y., Kushida, M., Higashi, K., Itoh, J., Higashiyama, R., Hong, Y. Y., . . . Ikeda, K. (2005). Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.. Gastroenterology, 129(1), 259-268. doi:10.1053/j.gastro.2005.03.088Effects of T-lymphocyte depletion on muscle fibrosis in the mdx mouse. (Journal article)
Morrison, J., Palmer, D. B., Cobbold, S., Partridge, T., & Bou-Gharios, G. (2005). Effects of T-lymphocyte depletion on muscle fibrosis in the mdx mouse.. The American journal of pathology, 166(6), 1701-1710. doi:10.1016/s0002-9440(10)62480-7Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease. (Journal article)
Chen, Y., Shi-Wen, X., van Beek, J., Kennedy, L., McLeod, M., Renzoni, E. A., . . . Leask, A. (2005). Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.. The American journal of pathology, 167(6), 1699-1711. doi:10.1016/s0002-9440(10)61252-7Nude mutation influences limb skeletal muscle development. (Journal article)
Morrison, J., Partridge, T., & Bou-Gharios, G. (2005). Nude mutation influences limb skeletal muscle development.. Matrix biology : journal of the International Society for Matrix Biology, 23(8), 535-542. doi:10.1016/j.matbio.2004.10.0032004
Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice. (Journal article)
Tanaka, S., Antoniv, T. T., Liu, K., Wang, L., Wells, D. J., Ramirez, F., & Bou-Gharios, G. (2004). Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice.. The Journal of biological chemistry, 279(53), 56024-56031. doi:10.1074/jbc.m411406200Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts. (Journal article)
Renzoni, E. A., Abraham, D. J., Howat, S., Shi-Wen, X., Sestini, P., Bou-Gharios, G., . . . du Bois, R. M. (2004). Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.. Respiratory research, 5, 24. doi:10.1186/1465-9921-5-24Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1. (Journal article)
Ponticos, M., Partridge, T., Black, C. M., Abraham, D. J., & Bou-Gharios, G. (2004). Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1.. Molecular and cellular biology, 24(14), 6151-6161. doi:10.1128/mcb.24.14.6151-6161.2004Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. (Journal article)
Shi-Wen, X., Chen, Y., Denton, C. P., Eastwood, M., Renzoni, E. A., Bou-Gharios, G., . . . Abraham, D. J. (2004). Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.. Molecular biology of the cell, 15(6), 2707-2719. doi:10.1091/mbc.e03-12-0902Extra-cellular matrix in vascular networks. (Journal article)
Bou-Gharios, G., Ponticos, M., Rajkumar, V., & Abraham, D. (2004). Extra-cellular matrix in vascular networks.. Cell proliferation, 37(3), 207-220. doi:10.1111/j.1365-2184.2004.00306.xEndothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. (Journal article)
Xu, S. -W., Howat, S. L., Renzoni, E. A., Holmes, A., Pearson, J. D., Dashwood, M. R., . . . Abraham, D. J. (2004). Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.. The Journal of biological chemistry, 279(22), 23098-23103. doi:10.1074/jbc.m311430200Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium. (Journal article)
Murtuza, B., Suzuki, K., Bou-Gharios, G., Beauchamp, J. R., Smolenski, R. T., Partridge, T. A., & Yacoub, M. H. (2004). Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium.. Proceedings of the National Academy of Sciences of the United States of America, 101(12), 4216-4221. doi:10.1073/pnas.0306205101Col1a2 enhancer regulates collagen activity during development and in adult tissue repair. (Journal article)
Ponticos, M., Abraham, D., Alexakis, C., Lu, Q. -L., Black, C., Partridge, T., & Bou-Gharios, G. (2004). Col1a2 enhancer regulates collagen activity during development and in adult tissue repair.. Matrix biology : journal of the International Society for Matrix Biology, 22(8), 619-628. doi:10.1016/j.matbio.2003.12.0022003
Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse. (Journal article)
Lu, Q. L., Mann, C. J., Lou, F., Bou-Gharios, G., Morris, G. E., Xue, S. -A., . . . Wilton, S. D. (2003). Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse.. Nature medicine, 9(8), 1009-1014. doi:10.1038/nm897Non-viral gene delivery in skeletal muscle: a protein factory. (Journal article)
Lu, Q. L., Bou-Gharios, G., & Partridge, T. A. (2003). Non-viral gene delivery in skeletal muscle: a protein factory.. Gene therapy, 10(2), 131-142. doi:10.1038/sj.gt.33018742002
Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model. (Journal article)
Vernet, D., Ferrini, M. G., Valente, E. G., Magee, T. R., Bou-Gharios, G., Rajfer, J., & Gonzalez-Cadavid, N. F. (2002). Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model.. Nitric oxide : biology and chemistry, 7(4), 262-276. doi:10.1016/s1089-8603(02)00124-6Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer. (Journal article)
De Val, S., Ponticos, M., Antoniv, T. T., Wells, D. J., Abraham, D., Partridge, T., & Bou-Gharios, G. (2002). Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer.. The Journal of biological chemistry, 277(11), 9286-9292. doi:10.1074/jbc.m1110402002001
Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene. (Journal article)
Antoniv, T. T., De Val, S., Wells, D., Denton, C. P., Rabe, C., de Crombrugghe, B., . . . Bou-Gharios, G. (2001). Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene.. The Journal of biological chemistry, 276(24), 21754-21764. doi:10.1074/jbc.m101397200Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice. (Journal article)
Denton, C. P., Zheng, B., Shiwen, X., Zhang, Z., Bou-Gharios, G., Eberspaecher, H., . . . de Crombrugghe, B. (2001). Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.. Arthritis and rheumatism, 44(3), 712-722. doi:3.0.co;2-1">10.1002/1529-0131(200103)44:3<712::aid-anr121>3.0.co;2-1DOI: 10.1002/1529-0131(200103)44:3<712::aid-anr121>3.0.co;2-1
Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1. (Journal article)
Shi-Wen, X., Denton, C. P., Dashwood, M. R., Holmes, A. M., Bou-Gharios, G., Pearson, J. D., . . . Abraham, D. J. (2001). Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.. The Journal of investigative dermatology, 116(3), 417-425. doi:10.1046/j.1523-1747.2001.01256.x2000
T-cell-dependent fibrosis in the mdx dystrophic mouse. (Journal article)
Morrison, J., Lu, Q. L., Pastoret, C., Partridge, T., & Bou-Gharios, G. (2000). T-cell-dependent fibrosis in the mdx dystrophic mouse.. Laboratory investigation; a journal of technical methods and pathology, 80(6), 881-891. doi:10.1038/labinvest.37800921999
Potentiation of myoblast transplantation by host muscle irradiation is dependent on the rate of radiation delivery. (Journal article)
Gross, J. G., Bou-Gharios, G., & Morgan, J. E. (1999). Potentiation of myoblast transplantation by host muscle irradiation is dependent on the rate of radiation delivery.. Cell and tissue research, 298(2), 371-375. doi:10.1007/s004419900062Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast. (Journal article)
Bou-Gharios, G., Wells, D. J., Lu, Q. L., Morgan, J. E., & Partridge, T. (1999). Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast.. Gene therapy, 6(6), 1021-1029. doi:10.1038/sj.gt.33009331998
Activation of Proalpha2(I) collagen promoter during hepatic fibrogenesis in transgenic mice. (Journal article)
Inagaki, Y., Truter, S., Bou-Gharios, G., Garrett, L. A., de Crombrugghe, B., Nemoto, T., & Greenwel, P. (1998). Activation of Proalpha2(I) collagen promoter during hepatic fibrogenesis in transgenic mice.. Biochemical and biophysical research communications, 250(3), 606-611. doi:10.1006/bbrc.1998.93451997
Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis (Journal article)
Shi-Wen, X., Denton, C. P., McWhirter, A., Bou-Gharios, G., Abraham, D. J., du Bois, R. M., & Black, C. M. (1997). Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis. Arthritis Rheum, 40(7), 1237-1244. doi:10.1002/1529-0131(199707)40:7<1237::AID-ART7>3.0.CO;2-YDOI: 10.1002/1529-0131(199707)40:7<1237::AID-ART7>3.0.CO;2-Y
Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis. (Journal article)
Shi-Wen, X., Denton, C. P., McWhirter, A., Bou-Gharios, G., Abraham, D. J., du Bois, R. M., & Black, C. M. (1997). Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis.. Arthritis and rheumatism, 40(7), 1237-1244. doi:3.0.co;2-y">10.1002/1529-0131(199707)40:7<1237::aid-art7>3.0.co;2-yDOI: 10.1002/1529-0131(199707)40:7<1237::aid-art7>3.0.co;2-y