2024
Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community. (Journal article)
Dalby, M. J., Pekovic-Vaughan, V., Shanley, D. P., Swift, J., White, L. J., & Canty-Laird, E. G. (2024). Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.. BioEssays : news and reviews in molecular, cellular and developmental biology, e2300223. doi:10.1002/bies.202300223DOI: 10.1002/bies.202300223
2023
2022
Lee, K. J., Rambault, L., Bou-Gharios, G., Clegg, P. D., Akhtar, R., Czanner, G., . . . Canty-Laird, E. G. (2022). Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice. DISEASE MODELS & MECHANISMS, 15(9). doi:10.1242/dmm.049428DOI: 10.1242/dmm.049428
Janvier, A. J., Pendleton, E. G., Mortensen, L. J., Green, D. C., Henstock, J. R., & Canty-Laird, E. G. (2022). Multimodal analysis of the differential effects of cyclic strain on collagen isoform composition, fibril architecture and biomechanics of tissue engineered tendon. JOURNAL OF TISSUE ENGINEERING, 13. doi:10.1177/20417314221130486DOI: 10.1177/20417314221130486
2021
Allaith, S., Tew, S. R., Hughes, C. E., Clegg, P. D., Canty-Laird, E. G., & Comerford, E. J. (2021). Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture.. Veterinary journal (London, England : 1997), 272, 105657. doi:10.1016/j.tvjl.2021.105657DOI: 10.1016/j.tvjl.2021.105657
Ali, O. J., Ehrle, A., Comerford, E. J., Canty-Laird, E. G., Mead, A., Clegg, P. D., & Maddox, T. W. (2021). Intra-Fascicular Chondroid-like Bodies in the Ageing Equine Superficial Digital Flexor Tendon comprise Glycosaminoglycans and Type II Collagen.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. doi:10.1002/jor.25002DOI: 10.1002/jor.25002
2020
Henstock, J., Laird, E., & Janvier, A. J. (2020). A Universal Multi-Platform 3D Printed Bioreactor Chamber for Tendon Tissue Engineering. Journal of Tissue Engineering, 11. doi:10.1177/2041731420942462DOI: 10.1177/2041731420942462
Williamson, K., Lee, K., Beamish, E., Carter, A., Gumbs, J., Cooper, G., . . . Canty-Laird, E. (2020). Active synthesis of type I collagen homotrimer in Dupuytren’s fibrosis is unaffected by anti-TNF-α treatment. doi:10.1101/2020.07.13.195107DOI: 10.1101/2020.07.13.195107
2019
Turlo, A. J., Mueller-Breckenridge, A. J., Zamboulis, D. E., Tew, S. R., Canty-Laird, E. G., & Clegg, P. D. (2019). Insulin-like growth factor binding protein (IGFBP6) is a cross-species tendon marker.. European Cells and Materials, 38, 123-136. doi:10.22203/ecm.v038a10DOI: 10.22203/ecm.v038a10
Lee, K. J., Comerford, E. J., Simpson, D. M., Clegg, P. D., & Canty-Laird, E. G. (2019). Identification and Characterization of Canine Ligament Progenitor Cells and Their Extracellular Matrix Niche. Journal of Proteome Research, 18(3), 1328-1339. doi:10.1021/acs.jproteome.8b00933DOI: 10.1021/acs.jproteome.8b00933
O'Loughlin, D. A., Kearns, V. R., Levis, H. J., Sheridan, C., & Canty-Laird, E. G. (2019). Nanotopography of substrates directs the deposition of fibrillar collagen by corneal stromal cells and deposition is accelerated by macromolecular crowding. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 60. Retrieved from https://www.webofscience.com/
2018
Kharaz, Y. A., Canty-Laird, E. G., Tew, S. R., & Comerford, E. J. (2018). Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons. JOURNAL OF ANATOMY, 232(6), 943-955. doi:10.1111/joa.12802DOI: 10.1111/joa.12802
Lee, K. J., Clegg, P. D., Comerford, E. J., & Canty-Laird, E. G. (2018). A comparison of the stem cell characteristics of murine tenocytes and tendon-derived stem cells. BMC MUSCULOSKELETAL DISORDERS, 19. doi:10.1186/s12891-018-2038-2DOI: 10.1186/s12891-018-2038-2
Ali, O., Comerford, E., Clegg, P., & Laird, E. G. (2018). Variations during ageing in the three-dimensional anatomical arrangement of fascicles within the equine superficial digital flexor tendon. European Cells and Materials, 35, 87-102. doi:10.22203/eCM.v035a07DOI: 10.22203/eCM.v035a07
O'Loughlin, D. A., Levis, H. J., Kearns, V. R., Sheridan, C., & Canty-Laird, E. G. (2018). Nanotopography of substrates directs the deposition of organised fibrillar collagen by corneal stromal cells. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A6). Retrieved from https://www.webofscience.com/
2017
Mueller, A. J., Canty-Laird, E. G., Clegg, P. D., & Tew, S. R. (2017). Cross-species gene modules emerge from a systems biologyapproach to osteoarthritis. NPJ Systems Biology and Applications, 3. doi:10.1038/s41540-017-0014-3DOI: 10.1038/s41540-017-0014-3
Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application (Journal article)
Lee, K. J., Clegg, P. D., Comerford, E. J., & Canty-Laird, E. G. (2017). Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application. STEM CELLS INTERNATIONAL, 2017. doi:10.1155/2017/1919845DOI: 10.1155/2017/1919845
2016
Gumbs, J. A., Chapman, N. R., Young, D. A., Clegg, P. D., & Canty-Laird, E. G. (2016). Impact of ageing on TGF-Beta stimulated type I collagen production. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A15). Retrieved from https://www.webofscience.com/
Mueller, A. J., Tew, S. R., Vasieva, O., Clegg, P. D., & Canty-Laird, E. G. (2016). A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes. SCIENTIFIC REPORTS, 6, 1-14. doi:10.1038/srep33956DOI: 10.1038/srep33956
Application of shortwave ultrasound to tendon-like constructs cultured from bone marrow derived mesenchymal stem cells in vitro produces tissue of greater strength (Conference Paper)
Application of Shortwave Ultrasound to Tendon‐Like Constructs Cultured from Bone Marrow Derived Mesenchymal Stem Cells <i>in vitro</i> Produces Tissue of Greater Strength (2016). In Equine Veterinary Journal Vol. 48 (pp. 27-28). Wiley. doi:10.1111/evj.54_12612DOI: 10.1111/evj.54_12612
Ali, O. J. (2016, July 26). A descriptive study of the ultrastucture of the equine superficial digital flexor tendon.
Soriano-Arroquia, A., House, L., Tregilgas, L., Canty-Laird, E., & Goljanek-Whysall, K. (2016). The functional consequences of age-related changes in microRNA expression in skeletal muscle. Biogerontology, 17(3), 641-654. doi:10.1007/s10522-016-9638-8DOI: 10.1007/s10522-016-9638-8
Proteomic differences between native and tissue-engineered tendon and ligament (Journal article)
Kharaz, Y. A., Tew, S. R., Peffers, M., Canty-Laird, E. G., & Comerford, E. (2016). Proteomic differences between native and tissue-engineered tendon and ligament. PROTEOMICS, 16(10), 1547-1556. doi:10.1002/pmic.201500459DOI: 10.1002/pmic.201500459
Investigating the effects of high-glucose exposure on DNA methylation and gene transcription in musculoskeletal cells (Conference Paper)
Tregilgas, L., Reynard, L. N., Tew, S. R., Loughlin, J., Clegg, P. D., & Canty-Laird, E. G. (2016). INVESTIGATING THE EFFECTS OF HIGH-GLUCOSE EXPOSURE ON DNA METHYLATION AND GENE TRANSCRIPTION IN MUSCULOSKELETAL CELLS. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S228). doi:10.1016/j.joca.2016.01.440DOI: 10.1016/j.joca.2016.01.440
Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage (Conference Paper)
Tregilgas, L., Reynard, L., Tew, S., Loughlin, J., Clegg, P., & Canty-Laird, E. (2016). Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A14). Retrieved from https://www.webofscience.com/
2015
PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation (Conference Paper)
Mueller, A. J., Tew, S. R., Canty-Laird, E. G., & Clegg, P. D. (2015). PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation. In Bone and Joint Journal Vol. 97-B. British Editorial Society of Bone and Joint Surgery. Retrieved from http://www.bjjprocs.boneandjoint.org.uk/content/97-B/SUPP_11/8
Taylor, S. H., Yeung, C. -Y. C., Kalson, N. S., Lu, Y., Zigrino, P., Starborg, T., . . . Kadler, K. E. (2015). Matrix metalloproteinase 14 is required for fibrous tissue expansion. elife, 4, 18 pages. doi:10.7554/eLife.09345DOI: 10.7554/eLife.09345
Yeung, C. Y., Zeef, L. A., Lallyett, C., Lu, Y., Canty-Laird, E., & Kadler, K. E. (2015). Chick tendon fibroblast transcriptome and shape depend on whether the cell has made its own collagen matrix. Scientific Reports, 5. doi:10.1038/srep13555DOI: 10.1038/srep13555
Williamson, K. A., Lee, K. J., Humphreys, W. J. E., Comerford, E. J. V., Clegg, P. D., & Canty-Laird, E. G. (2015). Restricted Differentiation Potential of Progenitor Cell Populations Obtained From the Equine Superficial Digital Flexor Tendon (SDFT). JOURNAL OF ORTHOPAEDIC RESEARCH, 33(6), 849-858. doi:10.1002/jor.22891DOI: 10.1002/jor.22891
Ashraf Kharaz, Y. (2015, March 15). The molecular and cellular differences between tendons and ligaments. (PhD Thesis, University of Liverpool).
2014
Biosynthetic alterations in collagen production in ruptured canine anterior cruciate ligament (Conference Paper)
Under pressure: the cell's response (2014). In International Journal of Experimental Pathology Vol. 95. Wiley. doi:10.1111/iep.12078DOI: 10.1111/iep.12078
2012
Collagen biosynthesis and modifying enzymes (Journal article)
Jupe, S. (n.d.). Collagen biosynthesis and modifying enzymes. Reactome - a curated knowledgebase of biological pathways, 41. doi:10.3180/react_121139.1DOI: 10.3180/react_121139.1
Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts <i>in situ</i> (Journal article)
Canty-Laird, E. G., Lu, Y., & Kadler, K. E. (2012). Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts <i>in situ</i>. BIOCHEMICAL JOURNAL, 441, 707-717. doi:10.1042/BJ20111379DOI: 10.1042/BJ20111379
2011
Evaluation of the relative inhibition of intracellular and extracellular procollagen C-proteinase (PCP) activity in tendon explants by synthetic PCP inhibitors (PCPi) (Conference Paper)
British Society for Matrix Biology - Spring 2011 Meeting Report (2011). In International Journal of Experimental Pathology Vol. 92 (pp. A1-A38). Wiley. doi:10.1111/j.1365-2613.2011.00780.xDOI: 10.1111/j.1365-2613.2011.00780.x
Expression of the osteoarthritis-associated gene <i>GDF5</i> is modulated epigenetically by DNA methylation (Journal article)
Reynard, L. N., Bui, C., Canty-Laird, E. G., Young, D. A., & Loughlin, J. (2011). Expression of the osteoarthritis-associated gene <i>GDF5</i> is modulated epigenetically by DNA methylation. HUMAN MOLECULAR GENETICS, 20(17), 3450-3460. doi:10.1093/hmg/ddr253DOI: 10.1093/hmg/ddr253
2010
An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery (Journal article)
Kalson, N. S., Holmes, D. F., Kapacee, Z., Otermin, I., Lu, Y., Ennos, R. A., . . . Kadler, K. E. (2010). An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery. MATRIX BIOLOGY, 29(8), 678-689. doi:10.1016/j.matbio.2010.08.009DOI: 10.1016/j.matbio.2010.08.009
First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles (Journal article)
Canty-Laird, E., Carre, G. -A., Mandon-Pepin, B., Kadler, K. E., & Fabre, S. (2010). First Evidence of Bone Morphogenetic Protein 1 Expression and Activity in Sheep Ovarian Follicles. BIOLOGY OF REPRODUCTION, 83(1), 138-146. doi:10.1095/biolreprod.109.082115DOI: 10.1095/biolreprod.109.082115
2009
Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid (Journal article)
Berry, R., Jowitt, T. A., Ferrand, J., Roessle, M., Grossmann, J. G., Canty-Laird, E. G., . . . Baldock, C. (2009). Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(21), 8561-8566. doi:10.1073/pnas.0812178106DOI: 10.1073/pnas.0812178106
Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid (Journal article)
Berry, R., Jowitt, T. A., Ferrand, J., Roessle, M., Grossmann, J. G., Canty-Laird, E. G., . . . Baldock, C. (2009). Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid. Proceedings of the National Academy of Sciences, 106(21), 8561-8566. doi:10.1073/pnas.0812178106DOI: 10.1073/pnas.0812178106
2008
Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators (Journal article)
Kadler, K. E., Hill, A., & Canty-Laird, E. G. (2008). Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators. CURRENT OPINION IN CELL BIOLOGY, 20(5), 495-501. doi:10.1016/j.ceb.2008.06.008DOI: 10.1016/j.ceb.2008.06.008
Active negative control of collagen fibrillogenesis in vivo. Intracellular cleavage of the type I procollagen propeptides in tendon fibroblasts without intracellular fibrils (Journal article)
Humphries, S. M., Lu, Y., Canty, E. G., & Kadler, K. E. (2008). Active negative control of collagen fibrillogenesis <i>in vivo</i> -: Intracellular cleavage of the type I procollagen propeptides in tendon fibroblasts without intracellular fibrils. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(18), 12129-12135. doi:10.1074/jbc.M708198200DOI: 10.1074/jbc.M708198200
2006
Actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon (Journal article)
Canty, E. G., Starborg, T., Lu, Y., Humphries, S. M., Holmes, D. F., Meadows, R. S., . . . Kadler, K. E. (2006). Actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(50), 38592-38598. doi:10.1074/jbc.M607581200DOI: 10.1074/jbc.M607581200
A complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation (Journal article)
Canty, E. G., Garrigue-Antar, L., & Kadler, K. E. (2006). A complete domain structure of <i>Drosophila</i> tolloid is required for cleavage of short gastrulation. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(19), 13258-13267. doi:10.1074/jbc.M510483200DOI: 10.1074/jbc.M510483200
2005
Procollagen trafficking, processing and fibrillogenesis (Journal article)
Canty, E. G., & Kadler, K. E. (2005). Procollagen trafficking, processing and fibrillogenesis. JOURNAL OF CELL SCIENCE, 118(7), 1341-1353. doi:10.1242/jcs.01731DOI: 10.1242/jcs.01731
2004
Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon (Journal article)
Canty, E. G., Lu, Y. H., Meadows, R. S., Shaw, M. K., Holmes, D. F., & Kadler, K. E. (2004). Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon. JOURNAL OF CELL BIOLOGY, 165(4), 553-563. doi:10.1083/jcb.200312071DOI: 10.1083/jcb.200312071
2002
Collagen fibril biosynthesis in tendon: a review and recent insights (Journal article)
Canty, E. G., & Kadler, K. E. (2002). Collagen fibril biosynthesis in tendon: a review and recent insights. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY, 133(4), 979-985. doi:10.1016/S1095-6433(02)00212-XDOI: 10.1016/S1095-6433(02)00212-X
1999
Identification of novel pro-alpha2(IX) collagen gene mutations in two families with distinctive oligo-epiphyseal forms of multiple epiphyseal dysplasia (Journal article)
Holden, P., Canty, E. G., Mortier, G. R., Zabel, B., Spranger, J., Carr, A., . . . Briggs, M. D. (1999). Identification of novel pro-α2(IX) collagen gene mutations in two families with distinctive olgo-epiphyseal forms of multiple epiphyseal dysplasia. AMERICAN JOURNAL OF HUMAN GENETICS, 65(1), 31-38. doi:10.1086/302440DOI: 10.1086/302440
