Professor Dan Cuthbertson BSc (Hons) PhD FRCP

Professor of Medicine and Honorary Consultant Physician Cardiovascular & Metabolic Medicine

Research

Research Interest 1

Insulin resistance, obesity, insulin signalling, AMPK, skeletal muscle, NASH, PCOS, magnetic resonance spectroscopy, MEN

Research Grants

Multi-organ abnormality prevalence in type 2 diabetes mellitus

INNOVATE UK (UK)

April 2019 - March 2022

Randomised, single blind study to assess efficacy of combination therapy of dapagliflozin with exanitide LAR versus exanatide LAR monotherapy in obese (BMI>35 kg/m2) patients with type 2 diabetes mellitus (RESILIENT)

ASTRAZENECA LIMITED (UK)

July 2016 - November 2023

Prospective assessment of impact on length of hospital stay, outcome and cost benefit of tolvaptan in patients with aneurysmal subarachnoid haemorrhage with SIADH associated hyponatraemia in a large tertiary neurosurgical centre

OTSUKA PHARMACEUTICAL EUROPE LTD (UK)

June 2011 - May 2013

The effects of exercise training on visceral fat, insulin sensitivity, beta cell function and triglyceride kinetics in patients with non-alcoholic fatty liver disease (NAFLD)

EUROPEAN FOUNDATION FOR THE STUDY OF DIABETES (GERMANY)

October 2008 - March 2013

Characterising the metabolic disruption caused by brief periods of reduced physical activity in people with a family history of type 2 diabetes mellitus (T2DM).

DIABETES UK (UK)

March 2014 - December 2017

The effect of AICAR on skeletal muscle glucose uptake in type 2 diabetes

PEEL MEDICAL RESEARCH TRUST (UK)

February 2008 - January 2009

VIP 2007/08

WELLCOME TRUST (UK)

October 2007 - September 2008

Effects of non-nutritive sweetened (NNS) beverages on appetite during active weight loss: Does the consumption of low calorie sweetened beverages (versus water) support or undermine weight management through effects on hunger, satiety, liking, wanting or changes in food preference?

AMERICAN BEVERAGE ASSOCIATION (ABA) (USA)

November 2014 - December 2024

Zinc-alpha2-glycoprotein (ZAG): A ‘friend or foe’ in obesity-induced insulin resistance and non-alcoholic fatty liver disease (NAFLD)?

DIABETES RESEARCH AND WELLNESS FOUNDATION (UK)

June 2010 - May 2011

Pancreatic and extra-pancreatic effects of glucose-dependent insulinotropic polypeptide (GIP) in humans in health and type 2 diabetes mellitus

THE NOVO NORDISK UK RESEARCH FOUNDATION (UK)

May 2010 - April 2012

Research Collaborations

Professor Malcolm Jackson

Internal

Dr Graham Kemp

Internal

Estimation of intrahepatic fat and intramyocellular fat in insulin resistant states

Professor Paul Trayhurn

Internal

Professor John Wilding

Internal

Examining aspects of whole body and muscle physiology in obesity

Dr Martin Lombard

External: Royal Liverpool and Broadgreen University Hospital NHS Trust

Involved in investigation into insulin resistance in NASH and hepatitis C

Professor D.Grahame Hardie

External: The University of Dundee

Analysis of AMPK activity

Dr Calum Sutherland

External: The University of Dundee

Molecular biology of insulin resistance

Professor Michael Rennie

External: The University of Nottingham

Examination of muscle protein synthesis