2023
Haaike, C. -V., Brendan, N. P., Sven, V. L., Andrew, D. S., Lionel, M., Georges, C., . . . Joery, D. K. (2023). Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation pathways. GENES & DISEASES, 10(5), 1759-1762. doi:10.1016/j.gendis.2022.11.013DOI: 10.1016/j.gendis.2022.11.013
Ooi, N., Cooper, I. R., Norman, B., Gallagher, J. A., Sireau, N., Bou-Gharios, G., . . . Savage, V. J. (2023). Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial. CELLS, 12(13). doi:10.3390/cells12131683DOI: 10.3390/cells12131683
Ranganath, L., Khedr, M., Milan, A. M., Davison, A. S., Norman, B. P., Janssen, M. C. H., . . . Gallagher, J. A. (2023). Increased prevalence of Parkinson's disease in alkaptonuria. JIMD Reports. doi:10.1002/jmd2.12367DOI: 10.1002/jmd2.12367
Loh, H. -Y., Norman, B. P., Lai, K. -S., Cheng, W. -H., Nik Abd Rahman, N. M. A., Mohamed Alitheen, N. B., & Osman, M. A. (2023). Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review.. International journal of molecular sciences, 24(7), 6423. doi:10.3390/ijms24076423DOI: 10.3390/ijms24076423
Alkaptonuria - Past, present and future. (Chapter)
Davison, A. S., & Norman, B. P. (2023). Alkaptonuria - Past, present and future.. In Unknown Book (Vol. 114, pp. 47-81). doi:10.1016/bs.acc.2023.02.005DOI: 10.1016/bs.acc.2023.02.005
2022
Norman, B. P., Davison, A. S., Hickton, B., Ross, G. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2022). Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria. METABOLITES, 12(10). doi:10.3390/metabo12100927DOI: 10.3390/metabo12100927
Ranganath, L. R., Hughes, A. T., Davison, A. S., Khedr, M., Imrich, R., Rudebeck, M., . . . Milan, A. M. (2022). Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria. METABOLITES, 12(10). doi:10.3390/metabo12100920DOI: 10.3390/metabo12100920
Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Norman, B. P., . . . Olsson, B. (2022). Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-20424-zDOI: 10.1038/s41598-022-20424-z
Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Imrich, R., . . . Gallagher, J. A. (2022). Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment. METABOLITES, 12(8). doi:10.3390/metabo12080772DOI: 10.3390/metabo12080772
Norman, B. P., Davison, A. S., Hughes, J. H., Sutherland, H., Wilson, P. J. M., Berry, N. G., . . . Gallagher, J. A. (2022). Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism. GENES & DISEASES, 9(4), 1129-1142. doi:10.1016/j.gendis.2021.02.007DOI: 10.1016/j.gendis.2021.02.007
Ranganath, L. R., Hughes, A. T., Davison, A. S., Khedr, M., Olsson, B., Rudebeck, M., . . . Milan, A. M. (2022). Temporal adaptations in the phenylalanine/tyrosine pathway and related factors during nitisinone-induced tyrosinaemia in alkaptonuria.. Molecular genetics and metabolism, S1096-7192(22)00325-0. doi:10.1016/j.ymgme.2022.05.006DOI: 10.1016/j.ymgme.2022.05.006
Davison, A. S., Norman, B. P., Sutherland, H., Milan, A. M., Gallagher, J. A., Jarvis, J. C., & Ranganath, L. R. (2022). Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria. METABOLITES, 12(6). doi:10.3390/metabo12060477DOI: 10.3390/metabo12060477
Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Norman, B. P., . . . Olsson, B. (2022). Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria. Molecular Genetics and Metabolism Reports, 30, 100846. doi:10.1016/j.ymgmr.2022.100846DOI: 10.1016/j.ymgmr.2022.100846
Altered bone metabolism in the rare inherited disease alkaptonuria (Conference Paper)
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A8-A9). Retrieved from https://www.webofscience.com/
Altered bone metabolism in the rare inherited disease alkaptonuria (Conference Paper)
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A3). Retrieved from https://www.webofscience.com/
Ranganath, L. R., Milan, A. M., Hughes, A. T., Khedr, M., Norman, B. P., Alsbou, M., . . . Jackson, R. (2022). Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria-An approach using statistical modelling.. JIMD reports, 63(1), 80-92. doi:10.1002/jmd2.12261DOI: 10.1002/jmd2.12261
2021
Coyle, S., Chapman, E., Baker, J., Coleman, H., Norman, B., Hughes, D., . . . Probert, C. (2021). Predicting dying from lung cancer: Urine metabolites predict the last weeks and days of life.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 39. doi:10.1200/JCO.2021.39.15_suppl.12030DOI: 10.1200/JCO.2021.39.15_suppl.12030
2020
Ranganath, L. R., Psarelli, E. E., Arnoux, J. -B., Braconi, D., Briggs, M., Broijersen, A., . . . Gallagher, J. A. (2020). Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial. The Lancet Diabetes and Endocrinology, 8(9), 762-772. doi:10.1016/S2213-8587(20)30228-XDOI: 10.1016/S2213-8587(20)30228-X
Khedr, M., Cooper, M. S., Hughes, A. T., Milan, A. M., Davison, A. S., Norman, B. P., . . . Ranganath, L. R. (2020). Nitisinone causes acquired tyrosinosis in alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43(5), 1014-1023. doi:10.1002/jimd.12229DOI: 10.1002/jimd.12229
Innentitelbild: Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose (Angew. Chem. 29/2020) (Journal article)
Chow, W. Y., Norman, B. P., Roberts, N. B., Ranganath, L. R., Teutloff, C., Bittl, R., . . . Oschkinat, H. (2020). Innentitelbild: Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose (Angew. Chem. 29/2020). Angewandte Chemie, 132(29), 11770. doi:10.1002/ange.202005824DOI: 10.1002/ange.202005824
Inside Cover: Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage (Angew. Chem. Int. Ed. 29/2020) (Journal article)
Chow, W. Y., Norman, B. P., Roberts, N. B., Ranganath, L. R., Teutloff, C., Bittl, R., . . . Oschkinat, H. (2020). Inside Cover: Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage (Angew. Chem. Int. Ed. 29/2020). Angewandte Chemie International Edition, 59(29), 11674. doi:10.1002/anie.202005824DOI: 10.1002/anie.202005824
Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage (Journal article)
Chow, W. Y., Norman, B. P., Roberts, N. B., Ranganath, L. R., Teutloff, C., Bittl, R., . . . Oschkinat, H. (2020). Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(29), 11937-11942. doi:10.1002/anie.202000618DOI: 10.1002/anie.202000618
Chow, W. Y., Norman, B. P., Roberts, N. B., Ranganath, L. R., Teutloff, C., Bittl, R., . . . Oschkinat, H. (2020). Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose. Angewandte Chemie, 132(29), 12035-12040. doi:10.1002/ange.202000618DOI: 10.1002/ange.202000618
Ranganath, L. R., Milan, A. M., Hughes, A. T., Khedr, M., Davison, A. S., Shweihdi, E., . . . Gallagher, J. A. (2020). Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43(4), 737-747. doi:10.1002/jimd.12181DOI: 10.1002/jimd.12181
Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage (Journal article)
Chow, W. Y., Norman, B. P., Roberts, N., Ranganath, L., Teutloff, C., Bittl, R., . . . Oschkinat, H. (2020). Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage. doi:10.26434/chemrxiv.11590950DOI: 10.26434/chemrxiv.11590950
Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage (Journal article)
Chow, W. Y., Norman, B., Roberts, N., Ranganath, L., Teutloff, C., Bittl, R., . . . Oschkinat, H. (2020). Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage. doi:10.26434/chemrxiv.11590950.v2DOI: 10.26434/chemrxiv.11590950.v2
Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage (Journal article)
Chow, W. Y., Norman, B. P., Roberts, N., Ranganath, L., Teutloff, C., Bittl, R., . . . Oschkinat, H. (2020). Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage. doi:10.26434/chemrxiv.11590950.v1DOI: 10.26434/chemrxiv.11590950.v1
2019
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria (Journal article)
Hughes, J. H., Liu, K., Plagge, A., Wilson, P. J. M., Sutherland, H., Norman, B. P., . . . Bou-Gharios, G. (2019). Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human Molecular Genetics, 28(23), 3928-3939. doi:10.1093/hmg/ddz234DOI: 10.1093/hmg/ddz234
Loh, H. -Y., Norman, B. P., Lai, K. -S., Abd Rahman, N. M. A. N., Alitheen, N. B. M., & Osman, M. A. (2019). The Regulatory Role of MicroRNAs in Breast Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(19). doi:10.3390/ijms20194940DOI: 10.3390/ijms20194940
Norman, B. (2019, September 30). Biochemical Investigations in the Rare Disease Alkaptonuria: Studies on the Metabolome and the Nature of Ochronotic Pigment.
Curtis, S. L., Norman, B. P., Milan, A. M., Gallagher, J. A., Olsson, B., Ranganath, L. R., & Roberts, N. B. (2019). Interference of hydroxyphenylpyruvic acid, hydroxyphenyllactic acid and tyrosine on routine serum and urine clinical chemistry assays; implications for biochemical monitoring of patients with alkaptonuria treated with nitisinone. CLINICAL BIOCHEMISTRY, 71, 24-30. doi:10.1016/j.clinbiochem.2019.06.010DOI: 10.1016/j.clinbiochem.2019.06.010
Ranganath, L. R., Norman, B. P., & Gallagher, J. A. (2019). Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease-A review. JOURNAL OF INHERITED METABOLIC DISEASE, 42(5), 776-792. doi:10.1002/jimd.12152DOI: 10.1002/jimd.12152
Taylor, A. M., Jenks, D. D., Kammath, V. D., Norman, B. P., Dillon, J. P., Gallagher, J. A., . . . Kerns, J. G. (2019). Raman Spectroscopy identifies differences in ochronotic and non-ochronotic cartilage; a potential novel technique for monitoring ochronosis. OSTEOARTHRITIS AND CARTILAGE, 27(8), 1244-1251. doi:10.1016/j.joca.2019.04.012DOI: 10.1016/j.joca.2019.04.012
Davison, A. S., Norman, B. P., Ross, G. A., Hughes, A. T., Khedr, M., Milan, A. M., . . . Ranganath, L. R. (2019). Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC-QTOF-MS.. JIMD reports, 48(1), 67-74. doi:10.1002/jmd2.12042DOI: 10.1002/jmd2.12042
EXTRACELLULAR CHEMICAL PROFILING BY LC-QTOF-MS IDENTIFIES NOVEL BONE RESORPTION MARKERS FOR MONITORING PROGRESSION OF OSTEOARTHROPATHY IN THE RARE DISEASE ALKAPTONURIA (Conference Paper)
Norman, B. P., Dillon, J. P., Wilson, P. J., Davison, A. S., Milan, A. M., Ross, G. R., . . . Gallagher, J. A. (2019). EXTRACELLULAR CHEMICAL PROFILING BY LC-QTOF-MS IDENTIFIES NOVEL BONE RESORPTION MARKERS FOR MONITORING PROGRESSION OF OSTEOARTHROPATHY IN THE RARE DISEASE ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S181-S182). doi:10.1016/j.joca.2019.02.274DOI: 10.1016/j.joca.2019.02.274
Norman, B. P., Davison, A. S., Ross, G. A., Milan, A. M., Hughes, A. T., Sutherland, H., . . . Ranganath, L. R. (2019). A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria.. Clinical chemistry. doi:10.1373/clinchem.2018.295345DOI: 10.1373/clinchem.2018.295345
Untargeted extracellular chemical profiling by LC-QTOF-MS identifies novel markers of bone collagen degradation (Conference Paper)
Norman, B. P., Dillon, J. P., Nzenwa, I., Wilson, P. J., Davison, A. S., Milan, A. M., . . . Gallagher, J. A. (2019). Untargeted extracellular chemical profiling by LC-QTOF-MS identifies novel markers of bone collagen degradation. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A29). Retrieved from https://www.webofscience.com/
2018
Norman, B., Davison, A., Ross, G., Milan, A., Hughes, A., Roberts, N., . . . Gallagher, J. (2018). Comprehensive targeted LC-QTOF-MS metabolomics identifies novel metabolite changes associated with treatment of the rare bone disease Alkaptonuria. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 33 (pp. 145). Retrieved from http://gateway.webofknowledge.com/
Davison, A. S., Harrold, J. A., Hughes, G., Norman, B., Devine, J., Usher, J., . . . Ranganath, L. R. (2018). Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone. Molecular Genetics and Metabolism, 125(1-2), 135-143. doi:10.1016/j.ymgme.2018.07.008DOI: 10.1016/j.ymgme.2018.07.008
Norman, B. P., Taylor, L. F., Davison, A. S., Milan, A. M., Ross, G. A., Roberts, N. B., . . . Gallagher, J. A. (2018). COMBINED LC-QTOF-MS URINE METABOLOMICS AND 18F-NAF PET IMAGING INDICATES NOVEL COMPOUNDS ASSOCIATED WITH SPINE OSTEOARTHROPATHY IN THE RARE DISEASE ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S170). doi:10.1016/j.joca.2018.02.369DOI: 10.1016/j.joca.2018.02.369
DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (Conference Paper)
Norman, B. P., Ying, C. W., Sutherland, H., Wilson, P. J., Roberts, N. B., Duer, M. J., . . . Gallagher, J. A. (2018). DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S99). doi:10.1016/j.joca.2018.02.214DOI: 10.1016/j.joca.2018.02.214
Taylor, A. M., Jenks, D., Kammath, V. D., Norman, B., Dillon, J. P., Gallagher, J. A., . . . Kerns, J. G. (2018). RAMAN SPECTROSCOPY CAN NON-INVASIVELY DISTINGUISH BETWEEN OCHRONOTIC AND NON-OCHRONOTIC CARTILAGE. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S105). doi:10.1016/j.joca.2018.02.227DOI: 10.1016/j.joca.2018.02.227
Davison, A. S., Norman, B., Milan, A. M., Hughes, A. T., Khedr, M., Rovensky, J., . . . Ranganath, L. R. (2018). Assessment of the Effect of Once Daily Nitisinone Therapy on 24-h Urinary Metadrenalines and 5-Hydroxyindole Acetic Acid Excretion in Patients with Alkaptonuria After 4 Weeks of Treatment. JIMD REPORTS: FOCUS ISSUE: ADULTS AND METABOLISM, VOL 41, 41, 1-10. doi:10.1007/8904_2017_72DOI: 10.1007/8904_2017_72
Davison, A. S., Norman, B. P., Smith, E. A., Devine, J., Usher, J., Hughes, A. T., . . . Ranganath, L. R. (2018). Serum Amino Acid Profiling in Patients with Alkaptonuria Before and After Treatment with Nitisinone. JIMD REPORTS: FOCUS ISSUE: ADULTS AND METABOLISM, VOL 41, 41, 109-117. doi:10.1007/8904_2018_109DOI: 10.1007/8904_2018_109
2017
Early Onset Parkinson's Disease in a family of Moroccan origin caused by a p.A217D mutation in PINK1: a case report (Journal article)
Norman, B. P., Lubbe, S. J., Tan, M., Warren, N., & Morris, H. R. (2017). Early Onset Parkinson's Disease in a family of Moroccan origin caused by a p.A217D mutation in PINK1: a case report. BMC NEUROLOGY, 17. doi:10.1186/s12883-017-0933-zDOI: 10.1186/s12883-017-0933-z
URINE METABOLOMICS USING LIQUID CHROMATOGRAPHY QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY INDICATES COMMON MARKERS OF DISEASE IN ALKAPTONURIA AND IDIOPATHIC OSTEOARTHRITIS IN HUMAN (Conference Paper)
Norman, B., Davison, A., Wilson, P., Ross, G., Milan, A., Roberts, N., . . . Gallagher, J. (2017). URINE METABOLOMICS USING LIQUID CHROMATOGRAPHY QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY INDICATES COMMON MARKERS OF DISEASE IN ALKAPTONURIA AND IDIOPATHIC OSTEOARTHRITIS IN HUMAN. In OSTEOARTHRITIS AND CARTILAGE Vol. 25 (pp. S97-S98). doi:10.1016/j.joca.2017.02.156DOI: 10.1016/j.joca.2017.02.156
2014
Are mobile phone conversations always so annoying? The 'need-to-listen' effect re-visited (Journal article)
Norman, B., & Bennett, D. (2014). Are mobile phone conversations always so annoying? The 'need-to-listen' effect re-visited. BEHAVIOUR & INFORMATION TECHNOLOGY, 33(12), 1294-1305. doi:10.1080/0144929X.2013.876098DOI: 10.1080/0144929X.2013.876098
Undated
