2024
Renaudineau, Y., Charras, A., Natoli, V., Fusaro, M., Smith, E. M. D., Beresford, M. W., . . . UK jSLE Cohort Study. (2024). Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus.. Clinical immunology (Orlando, Fla.), 262, 110194. doi:10.1016/j.clim.2024.110194DOI: 10.1016/j.clim.2024.110194
Charras, A., Hofmann, S. R., Cox, A., Schulze, F., Russ, S., Northey, S., . . . Hedrich, C. M. (2024). P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO).. Journal of autoimmunity, 144, 103183. doi:10.1016/j.jaut.2024.103183DOI: 10.1016/j.jaut.2024.103183
2023
Sposito, F., Northey, S., Charras, A., McNamara, P. S., & Hedrich, C. M. (2023). Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome.. Genes and immunity. doi:10.1038/s41435-023-00218-7DOI: 10.1038/s41435-023-00218-7
Sposito, F., Pennington, S. H., A W David, C., Duggan, J., Northey, S., Biagini, G., . . . Hedrich, C. M. (2023). Age differential CD13 and interferon expression in airway epithelia affect SARS-CoV-2 infection - effects of vitamin D.. Mucosal immunology, S1933-0219(23)00064-8. doi:10.1016/j.mucimm.2023.08.002DOI: 10.1016/j.mucimm.2023.08.002
Natoli, V., Charras, A., Hahn, G., & Hedrich, C. M. (2023). Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE). MOLECULAR AND CELLULAR PEDIATRICS, 10(1). doi:10.1186/s40348-023-00161-7DOI: 10.1186/s40348-023-00161-7
Garau, J., Charras, A., Varesio, C., Orcesi, S., Dragoni, F., Galli, J., . . . Hedrich, C. M. (2023). Altered DNA methylation and gene expression predict disease severity in patients with Aicardi-Goutieres syndrome. CLINICAL IMMUNOLOGY, 249. doi:10.1016/j.clim.2023.109299DOI: 10.1016/j.clim.2023.109299
Charras, A., Haldenby, S., Smith, E. M. D., Egbivwie, N., Olohan, L., Kenny, J. G., . . . Hedrich, C. M. (2023). Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE. RHEUMATOLOGY, 62(SI2), SI210-SI225. doi:10.1093/rheumatology/keac275DOI: 10.1093/rheumatology/keac275
<i>P2RX7</i> Gene Variants Associate with Altered Inflammasome Assembly and Reduced Pyroptosis in Chronic Nonbacterial Osteomyelitis (CNO) (Preprint)
DOI: 10.2139/ssrn.4498427
Natoli, V., Charras, A., Hofmann, S. R., Northey, S., Russ, S., Schulze, F., . . . Hedrich, C. M. (n.d.). DNA methylation patterns in CD4+ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis. Frontiers in Immunology, 14. doi:10.3389/fimmu.2023.1245876DOI: 10.3389/fimmu.2023.1245876
2022
Assessing the robustness of clinical trials by estimating Jadad's score using artificial intelligence approaches. (Journal article)
Casy, T., Grasseau, A., Charras, A., Rouvière, B., Pers, J. -O., Foulquier, N., & Saraux, A. (2022). Assessing the robustness of clinical trials by estimating Jadad's score using artificial intelligence approaches.. Computers in biology and medicine, 148, 105851. doi:10.1016/j.compbiomed.2022.105851DOI: 10.1016/j.compbiomed.2022.105851
2021
Charras, A., Garau, J., Hofmann, S. R., Carlsson, E., Cereda, C., Russ, S., . . . Hedrich, C. M. (2021). DNA Methylation Patterns in CD8<SUP>+</SUP> T Cells Discern Psoriasis From Psoriatic Arthritis and Correlate With Cutaneous Disease Activity. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9. doi:10.3389/fcell.2021.746145DOI: 10.3389/fcell.2021.746145
Charras, A., Smith, E., & Hedrich, C. M. (2021). Systemic Lupus Erythematosus in Children and Young People. CURRENT RHEUMATOLOGY REPORTS, 23(3). doi:10.1007/s11926-021-00985-0DOI: 10.1007/s11926-021-00985-0
TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment. (Journal article)
Montibus, B., Cercy, J., Bouschet, T., Charras, A., Maupetit-Méhouas, S., Nury, D., . . . Arnaud, P. (2021). TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.. Cellular and molecular life sciences : CMLS, 78(2), 757-768. doi:10.1007/s00018-020-03541-8DOI: 10.1007/s00018-020-03541-8
2020
JAK Inhibitors Suppress Innate Epigenetic Reprogramming: a Promise for Patients with Sjögren's Syndrome. (Journal article)
Charras, A., Arvaniti, P., Le Dantec, C., Arleevskaya, M. I., Zachou, K., Dalekos, G. N., . . . Renaudineau, Y. (2020). JAK Inhibitors Suppress Innate Epigenetic Reprogramming: a Promise for Patients with Sjögren's Syndrome.. Clinical reviews in allergy & immunology, 58(2), 182-193. doi:10.1007/s12016-019-08743-yDOI: 10.1007/s12016-019-08743-y
Linking genetic variation with epigenetic profiles in Sjogren's syndrome (Journal article)
Arvaniti, P., Le Dantec, C., Charras, A., Arleevskaya, M. A., Hedrich, C. M., Zachou, K., . . . Renaudineau, Y. (2020). Linking genetic variation with epigenetic profiles in Sjogren's syndrome. CLINICAL IMMUNOLOGY, 210. doi:10.1016/j.clim.2019.108314DOI: 10.1016/j.clim.2019.108314
2019
Charras, A., Arvaniti, P., Le Dantec, C., Dalekos, G. N., Zachou, K., Bordron, A., & Renaudineau, Y. (2019). JAK Inhibitors and Oxidative Stress Control.. Frontiers in immunology, 10, 2814. doi:10.3389/fimmu.2019.02814DOI: 10.3389/fimmu.2019.02814
The role of epigenetics in paediatric rheumatic disease (Journal article)
Charras, A., & Hedrich, C. M. (2019). The role of epigenetics in paediatric rheumatic disease. CURRENT OPINION IN RHEUMATOLOGY, 31(5), 450-463. doi:10.1097/BOR.0000000000000627DOI: 10.1097/BOR.0000000000000627
Sjögren’s Syndrome (Chapter)
Le Pottier, L., Amrouche, K., Charras, A., Bordron, A., & Pers, J. -O. (2019). Sjögren’s Syndrome. In Genetics of Rare Autoimmune Diseases (pp. 53-94). Springer International Publishing. doi:10.1007/978-3-030-03934-9_4DOI: 10.1007/978-3-030-03934-9_4
2018
[Influence of epigenetic in Sjögren's syndrome]. (Journal article)
Bordron, A., Charras, A., Le Dantec, C., & Renaudineau, Y. (2018). [Influence of epigenetic in Sjögren's syndrome].. La Revue de medecine interne, 39(5), 346-351. doi:10.1016/j.revmed.2017.09.003DOI: 10.1016/j.revmed.2017.09.003
Primary Sjögren’s Syndrome and Epigenetics (Chapter)
Charras, A., Le Dantec, C., Konsta, O. D., Brooks, W. H., Bordron, A., & Renaudineau, Y. (2018). Primary Sjögren’s Syndrome and Epigenetics. In The Epigenetics of Autoimmunity (pp. 221-239). Elsevier. doi:10.1016/b978-0-12-809912-4.00011-8DOI: 10.1016/b978-0-12-809912-4.00011-8
2017
Signature et conséquences des anomalies de méthylation de l’ADN au cours du syndrome sec de Gougerot–Sjögren (Journal article)
Charras, A., Le Dantec, C., Konsta, O. D., Bagacean, C., Pers, J. O., Kapsogeorgou, E. K., . . . Renaudineau, Y. (2017). Signature et conséquences des anomalies de méthylation de l’ADN au cours du syndrome sec de Gougerot–Sjögren. La Revue de Médecine Interne, 38, A71. doi:10.1016/j.revmed.2017.03.055DOI: 10.1016/j.revmed.2017.03.055
Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjögren's syndrome. (Journal article)
Charras, A., Konsta, O. D., Le Dantec, C., Bagacean, C., Kapsogeorgou, E. K., Tzioufas, A. G., . . . Renaudineau, Y. (2017). Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjögren's syndrome.. Annals of the rheumatic diseases, 76(3), 625-628. doi:10.1136/annrheumdis-2016-210167DOI: 10.1136/annrheumdis-2016-210167
2016
Epigenetic modifications in salivary glands from patients with Sjögren's syndrome affect cytokeratin 19 expression. (Journal article)
Konsta, O. D., Charras, A., Le Dantec, C., Kapsogeorgeou, E., Bordron, A., Brooks, W. H., . . . Renaudineau, Y. (2016). Epigenetic modifications in salivary glands from patients with Sjögren's syndrome affect cytokeratin 19 expression.. Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie, 53(1), e01.
Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration. (Journal article)
Konsta, O. D., Le Dantec, C., Charras, A., Cornec, D., Kapsogeorgou, E. K., Tzioufas, A. G., . . . Renaudineau, Y. (2016). Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration.. Journal of autoimmunity, 68, 30-38. doi:10.1016/j.jaut.2015.12.002DOI: 10.1016/j.jaut.2015.12.002
Similarities and Differences of Epigenetic Mechanisms in Lupus and Sjogren's Syndrome (Journal article)
C, L. D., A, C., H Brooks, W., & Renaudineau, Y. (n.d.). Similarities and Differences of Epigenetic Mechanisms in Lupus and Sjogren's Syndrome. Lupus: Open Access, 01(01). doi:10.35248/2684-1630.16.1.e101DOI: 10.35248/2684-1630.16.1.e101
2015
Konsta, O. D., Le Dantec, C., Charras, A., Brooks, W. H., Arleevskaya, M. I., Bordron, A., & Renaudineau, Y. (2015). An in silico Approach Reveals Associations between Genetic and Epigenetic Factors within Regulatory Elements in B Cells from Primary Sjögren's Syndrome Patients.. Frontiers in immunology, 6, 437. doi:10.3389/fimmu.2015.00437DOI: 10.3389/fimmu.2015.00437
