MRC CDSS & AstraZeneca Paper Published in Hepatology
Idiosyncratic drug-induced liver injury is a rare, often difficult-to-predict adverse reaction with complex pathomechanisms. However, it is now evident that certain forms of reaction are immune-mediated and may involve the activation of drug-specific T cells.
Our recent manuscript published in Hepatology (collaboration between MRC CDSS and AstraZeneca) shows that hepatocyte-derived exosomes have the potential to transmit drug-specific tissue-derived signals to the immune system and provide a pathway for the induction of drug hapten-specific T-cell responses.
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Exosomal Transport of Hepatocyte-Derived Drug-Modified Proteins to the Immune System.
Ogese MO, Jenkins RE, Adair K, Tailor A, Meng X, Faulkner L, Enyindah BO, Schofield A, Diaz-Nieto R, Ressel L, Eagle GL, Kitteringham NR, Goldring CE, Park BK, Naisbitt DJ, Betts C.
Hepatology. 2019 May 9. doi: 10.1002/hep.30701. [Epub ahead of print]