Photo of Dr Helen Wright

Dr Helen Wright PhD, BSc

Career Development Fellow Versus Arthritis / Tenure Track Fellow Musculoskeletal Biology I

Publications

Selected Publications

  1. Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus (Journal article - 2019)
  2. A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling (Journal article - 2018)
  3. Neutrophil biomarkers predict response to therapy with tumour necrosis factor inhibitors in rheumatoid arthritis (Journal article - 2016)
  4. Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling (Journal article - 2016)
  5. The multifactorial role of neutrophils in rheumatoid arthritis (Journal article - 2014)

2019

The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients. (Journal article)

Rodsaward, P., Chottawornsak, N., Suwanchote, S., Rachayon, M., Deekajorndech, T., Wright, H. L., . . . Chiewchengchol, D. (2019). The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients.. Asian Pacific journal of allergy and immunology. doi:10.12932/ap-211218-0465

DOI: 10.12932/ap-211218-0465

APPA INHIBITS NEUTROPHIL PRO-INFLAMMATORY FUNCTIONS WITHOUT IMPAIRING HOST DEFENCE: IS THIS A POTENTIAL NEW THERAPY FOR ARTHRITIS? (Conference Paper)

Cross, A. L., Hawkes, J. J., Wright, H. L., Moots, R. J., & Edwards, S. W. (2019). APPA INHIBITS NEUTROPHIL PRO-INFLAMMATORY FUNCTIONS WITHOUT IMPAIRING HOST DEFENCE: IS THIS A POTENTIAL NEW THERAPY FOR ARTHRITIS?. In RHEUMATOLOGY Vol. 58 (pp. 46). Retrieved from http://gateway.webofknowledge.com/

PROTEOMIC ANALYSIS OF NEUTROPHIL EXTRACELLULAR TRAPS IN RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS (Journal article)

Chapman, E. A., Lyon, M., Simpson, D., Mason, D., Beynon, R. J., Moots, R. J., & Wright, H. L. (2019). PROTEOMIC ANALYSIS OF NEUTROPHIL EXTRACELLULAR TRAPS IN RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS. RHEUMATOLOGY, 58. Retrieved from http://gateway.webofknowledge.com/

Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus (Journal article)

Chapman, E. A., Lyon, M., Simpson, D., Mason, D., Beynon, R. J., Moots, R. J., & Wright, H. L. (2019). Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.00423

DOI: 10.3389/fimmu.2019.00423

Human neutrophils activated via TLR8 promote Th17 polarization through IL-23 (Journal article)

Tamassia, N., Arruda-Silva, F., Wright, H. L., Moots, R. J., Gardiman, E., Bianchetto-Aguilera, F., . . . Cassatella, M. A. (2019). Human neutrophils activated via TLR8 promote Th17 polarization through IL-23. JOURNAL OF LEUKOCYTE BIOLOGY, 105(6), 1155-1165. doi:10.1002/JLB.MA0818-308R

DOI: 10.1002/JLB.MA0818-308R

2018

A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling (Journal article)

Chokesuwattanaskul, S., Phelan, M., Edwards, S., & Wright, H. L. (2018). A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling. PLoS One.

H-1 NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints (Journal article)

Anderson, J. R., Chokesuwattanaskul, S., Phelan, M. M., Welting, T. J. M., Lian, L. -Y., Peffers, M. J., & Wright, H. L. (2018). H-1 NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints. JOURNAL OF PROTEOME RESEARCH, 17(11), 3780-3790. doi:10.1021/acs.jproteome.8b00455

DOI: 10.1021/acs.jproteome.8b00455

Opisthorchiasis-Induced Cholangiocarcinoma: How Innate Immunity May Cause Cancer (Journal article)

Edwards, S., Spofford, E., Price, C., Wright, H. L., Salao, K., Suttiprapa, S., & Sripa, B. (2018). Opisthorchiasis-Induced Cholangiocarcinoma: How Innate Immunity May Cause Cancer. Advances in Parasitology. doi:10.1016/bs.apar.2018.05.006

DOI: 10.1016/bs.apar.2018.05.006

The CDK inhibitor purvalanol A induces neutrophil apoptosis and increases the turnover rate of Mcl-1: potential role of p38-MAPK in regulation of Mcl-1 turnover (Journal article)

Phoomvuthisarn, P., Cross, A., Glennon-Alty, L., Wright, H. L., & Edwards, S. W. (2018). The CDK inhibitor purvalanol A induces neutrophil apoptosis and increases the turnover rate of Mcl-1: potential role of p38-MAPK in regulation of Mcl-1 turnover. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(2), 171-180. doi:10.1111/cei.13107

DOI: 10.1111/cei.13107

Anti-neutrophil cytoplasmic antibodies and their clinical significance (Journal article)

Suwanchote, S., Rachayon, M., Rodsaward, P., Wongpiyabovorn, J., Deekajorndech, T., Wright, H. L., . . . Chiewchengchol, D. (2018). Anti-neutrophil cytoplasmic antibodies and their clinical significance. CLINICAL RHEUMATOLOGY, 37(4), 875-884. doi:10.1007/s10067-018-4062-x

DOI: 10.1007/s10067-018-4062-x

Neutrophils and redox stress in the pathogenesis of autoimmune disease (Journal article)

Glennon-Alty, L., Hackett, A. P., Chapman, E. A., & Wright, H. L. (2018). Neutrophils and redox stress in the pathogenesis of autoimmune disease. FREE RADICAL BIOLOGY AND MEDICINE, 125, 25-35. doi:10.1016/j.freeradbiomed.2018.03.049

DOI: 10.1016/j.freeradbiomed.2018.03.049

Neutrophil activation signature in juvenile idiopathic arthritis indicates the presence of low-density granulocytes (Journal article)

Ramanathan, K., Glaser, A., Lythgoe, H., Ong, J., Beresford, M. W., Midgley, A., & Wright, H. L. (2018). Neutrophil activation signature in juvenile idiopathic arthritis indicates the presence of low-density granulocytes. RHEUMATOLOGY, 57(3), 488-498. doi:10.1093/rheumatology/kex441

DOI: 10.1093/rheumatology/kex441

2017

Janus kinase inhibitors prevent migration of rheumatoid arthritis neutrophils towards interleukin-8, but do not inhibit priming of the respiratory burst or reactive oxygen species production (Journal article)

Mitchell, T. S., Moots, R. J., & Wright, H. L. (2017). Janus kinase inhibitors prevent migration of rheumatoid arthritis neutrophils towards interleukin-8, but do not inhibit priming of the respiratory burst or reactive oxygen species production. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 189(2), 250-258. doi:10.1111/cei.12970

DOI: 10.1111/cei.12970

GARROD PRIZE WINNER. INSIDE THE CHAMBER OF SECRETS: OMICS ANALYSIS OF NEUTROPHILS IN RHEUMATOID ARTHRITIS (Conference Paper)

Wright, H. L. (2017). GARROD PRIZE WINNER. INSIDE THE CHAMBER OF SECRETS: OMICS ANALYSIS OF NEUTROPHILS IN RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 56 (pp. 6). Retrieved from http://gateway.webofknowledge.com/

2016

Neutrophil biomarkers predict response to therapy with tumour necrosis factor inhibitors in rheumatoid arthritis (Journal article)

Wright, H. L., Cox, T., Moots, R. J., & Edwards, S. W. (2016). Neutrophil biomarkers predict response to therapy with tumour necrosis factor inhibitors in rheumatoid arthritis. Journal of Leukocyte Biology. doi:10.1189/jlb.5A0616-258R

DOI: 10.1189/jlb.5A0616-258R

Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling (Journal article)

Wright, H. L., Makki, F. A., Moots, R. J., & Edwards, S. W. (2017). Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling. JOURNAL OF LEUKOCYTE BIOLOGY, 101(2), 599-611. doi:10.1189/jlb.5A0116-022R

DOI: 10.1189/jlb.5A0116-022R

Human neutrophils in auto-immunity (Journal article)

Thieblemont, N., Wright, H. L., Edwards, S. W., & Witko-Sarsat, V. (2016). Human neutrophils in auto-immunity. SEMINARS IN IMMUNOLOGY, 28(2), 159-173. doi:10.1016/j.smim.2016.03.004

DOI: 10.1016/j.smim.2016.03.004

The Cdk2 inhibitor, Purvalanol A, induces apoptosis is myeloid cells via p38-MAPK dependent turnover of Mcl-1 (Conference Paper)

Phoomvuthisarn, P., Wright, H. L., Clark, R. E., Mutirangura, A., & Edwards, S. W. (2016). The Cdk2 inhibitor, Purvalanol A, induces apoptosis is myeloid cells via p38-MAPK dependent turnover of Mcl-1. In EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Vol. 46 (pp. 81). Retrieved from http://gateway.webofknowledge.com/

2015

Whose Gene Is It Anyway? The Effect of Preparation Purity on Neutrophil Transcriptome Studies (Journal article)

Thomas, H. B., Moots, R. J., Edwards, S. W., & Wright, H. L. (2015). Whose Gene Is It Anyway? The Effect of Preparation Purity on Neutrophil Transcriptome Studies. PLOS ONE, 10(9). doi:10.1371/journal.pone.0138982

DOI: 10.1371/journal.pone.0138982

Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D (Journal article)

Flanagan, P. K., Chiewchengchol, D., Wright, H. L., Edwards, S. W., Alswied, A., Satsangi, J., . . . Campbell, B. J. (2015). Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D. INFLAMMATORY BOWEL DISEASES, 21(7), 1499-1510. doi:10.1097/MIB.0000000000000387

DOI: 10.1097/MIB.0000000000000387

Synovial fluid IL-6 concentrations associated with positive response to tocilizumab in an RA patient with failed response to anti-TNF and rituximab (Journal article)

Wright, H. L., Mewar, D., Bucknall, R. C., Edwards, S. W., & Moots, R. J. (2015). Synovial fluid IL-6 concentrations associated with positive response to tocilizumab in an RA patient with failed response to anti-TNF and rituximab. RHEUMATOLOGY, 54(4), 743-744. doi:10.1093/rheumatology/keu488

DOI: 10.1093/rheumatology/keu488

Differential changes in gene expression in human neutrophils following TNF-α stimulation: Up-regulation of anti-apoptotic proteins and down-regulation of proteins involved in death receptor signaling. (Journal article)

Chiewchengchol, D., Wright, H. L., Thomas, H. B., Lam, C. W., Roberts, K. J., Hirankarn, N., . . . Edwards, S. W. (2016). Differential changes in gene expression in human neutrophils following TNF-α stimulation: Up-regulation of anti-apoptotic proteins and down-regulation of proteins involved in death receptor signaling.. Immunity, inflammation and disease, 4(1), 35-44. doi:10.1002/iid3.90

DOI: 10.1002/iid3.90

Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy (Journal article)

Wright, H. L., Thomas, H. B., Moots, R. J., & Edwards, S. W. (2015). Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy. RHEUMATOLOGY, 54(1), 188-193. doi:10.1093/rheumatology/keu299

DOI: 10.1093/rheumatology/keu299

2014

A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry (Journal article)

Tamarozzi, F., Wright, H. L., Thomas, H. B., Edwards, S. W., & Taylor, M. J. (2014). A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry. IMMUNOLOGY LETTERS, 162(2), 194-198. doi:10.1016/j.imlet.2014.10.025

DOI: 10.1016/j.imlet.2014.10.025

Human filarial Wolbachia lipopeptide directly activates human neutrophils in vitro (Journal article)

Tamarozzi, F., Wright, H. L., Johnston, K. L., Edwards, S. W., Turner, J. D., & Taylor, M. J. (2014). Human filarial Wolbachia lipopeptide directly activates human neutrophils in vitro. PARASITE IMMUNOLOGY, 36(10), 494-502. doi:10.1111/pim.12122

DOI: 10.1111/pim.12122

Effect of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo (Journal article)

Wright, H. L., Cross, A. L., Edwards, S. W., & Moots, R. J. (2014). Effect of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo. Rheumatology. doi:10.1093/rheumatology/keu035

DOI: 10.1093/rheumatology/keu035

The multifactorial role of neutrophils in rheumatoid arthritis (Journal article)

Wright, H. L., Moots, R. J., & Edwards, S. W. (2014). The multifactorial role of neutrophils in rheumatoid arthritis. NATURE REVIEWS RHEUMATOLOGY, 10(10), 593-601. doi:10.1038/nrrheum.2014.80

DOI: 10.1038/nrrheum.2014.80

2013

DcR3 Mutations in Patients with Juvenile-onset Systemic Lupus Erythematosus Lead to Enhanced Lymphocyte Proliferation (Journal article)

Chokdeemeeboon, C., Ammarinthnukrowh, P., Tongkobpetch, S., Srichomtong, C., Deekajorndech, T., Rianthavorn, P., . . . Shotelersuk, V. (2013). DcR3 Mutations in Patients with Juvenile-onset Systemic Lupus Erythematosus Lead to Enhanced Lymphocyte Proliferation. The Journal of Rheumatology, 40(8), 1316-1326. doi:10.3899/jrheum.121285

DOI: 10.3899/jrheum.121285

Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo (Journal article)

Wright, H. L., Cross, A. L., Edwards, S. W., & Moots, R. J. (2014). Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo. RHEUMATOLOGY, 53(7), 1321-1331. doi:10.1093/rheumatology/keu035

DOI: 10.1093/rheumatology/keu035

Interferon gene expression signature in neutrophils from RA patients pre- and post- anti-TNF therapy. (Journal article)

Wright, H. L., Thomas, H. B., Moots, R. J., & Edwards, S. W. (2013). Interferon gene expression signature in neutrophils from RA patients pre- and post- anti-TNF therapy.. Rheumatology, 1(52), i46.

RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming. (Journal article)

Wright, H. L., Thomas, H. B., Moots, R. J., & Edwards, S. W. (2013). RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming.. PloS one, 8(3), e58598. doi:10.1371/journal.pone.0058598

DOI: 10.1371/journal.pone.0058598

2012

Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy. (Journal article)

Wright, H. L., Bucknall, R. C., Moots, R. J., & Edwards, S. W. (2012). Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy.. Rheumatology (Oxford, England), 51(3), 451-459. doi:10.1093/rheumatology/ker338

DOI: 10.1093/rheumatology/ker338

2011

Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy (Journal article)

Wright, H. L., Bucknall, R. C., Moots, R. J., & Edwards, S. W. (2012). Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy. Rheumatology, 51(3), 451-459. doi:10.1093/rheumatology/ker338

DOI: 10.1093/rheumatology/ker338

Neutrophil function in inflammation and inflammatory diseases. (Journal article)

Wright, H. L., Moots, R. J., Bucknall, R. C., & Edwards, S. W. (2010). Neutrophil function in inflammation and inflammatory diseases.. Rheumatology (Oxford, England), 49(9), 1618-1631. doi:10.1093/rheumatology/keq045

DOI: 10.1093/rheumatology/keq045

2010

Changes in expression of membrane TNF, NF-{kappa}B activation and neutrophil apoptosis during active and resolved inflammation. (Journal article)

Wright, H. L., Chikura, B., Bucknall, R. C., Moots, R. J., & Edwards, S. W. (2011). Changes in expression of membrane TNF, NF-{kappa}B activation and neutrophil apoptosis during active and resolved inflammation.. Annals of the rheumatic diseases, 70(3), 537-543. doi:10.1136/ard.2010.138065

DOI: 10.1136/ard.2010.138065

2009

Neutrophil function in rheumatoid arthritis (Thesis / Dissertation)

Wright, H. L. (2009). Neutrophil function in rheumatoid arthritis. (PhD Thesis, University of Liverpool).