2022
The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing? (Journal article)
Wilkinson, D. J. (2022). The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing?. OSTEOARTHRITIS AND CARTILAGE, 30(8), 1015-1018. doi:10.1016/j.joca.2022.03.010DOI: 10.1016/j.joca.2022.03.010
Wilkinson, D. J., Falconer, A. M. D., Wright, H. L., Lin, H., Yamamoto, K., Cheung, K., . . . Rowan, A. D. (2022). Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis. FEBS JOURNAL, 289(1), 121-139. doi:10.1111/febs.16127DOI: 10.1111/febs.16127
2021
Joint tissue destruction and proteolysis (Chapter)
Wilkinson, D. J., & Young, D. A. (n.d.). Joint tissue destruction and proteolysis. In Rheumatology 8th Edition. Elsevier.
Yamamoto, K., Wilkinson, D., & Bou-Gharios, G. (n.d.). Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. Calcified Tissue International. doi:10.1007/s00223-020-00739-7DOI: 10.1007/s00223-020-00739-7
Wilkinson, D. J. (2021). Serpins in cartilage and osteoarthritis: what do we know?. BIOCHEMICAL SOCIETY TRANSACTIONS, 49(2), 1013-1026. doi:10.1042/BST20201231DOI: 10.1042/BST20201231
2019
British Society for Matrix Biology Spring 2019 Meeting: "Stroma, Niche, Repair". (Conference Paper)
British Society for Matrix Biology Spring 2019 Meeting: "Stroma, Niche, Repair". (2019). In International journal of experimental pathology Vol. 100 (pp. A1-A45). doi:10.1111/iep.12332DOI: 10.1111/iep.12332
Falconer, A. M. D., Chan, C. M., Gray, J., Nagashima, I., Holland, R. A., Shimizu, H., . . . Wilkinson, D. J. (2019). Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover. JOURNAL OF BIOLOGICAL CHEMISTRY, 294(26), 10266-10277. doi:10.1074/jbc.RA119.006974DOI: 10.1074/jbc.RA119.006974
Young, D. A., Barter, M. J., & Wilkinson, D. J. (2019). Recent advances in understanding the regulation of metalloproteinases.. F1000Research, 8, F1000 Faculty Rev-195. doi:10.12688/f1000research.17471.1DOI: 10.12688/f1000research.17471.1
Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics (Journal article)
Wilkinson, D. J., Arques, M. D. C., Huesa, C., & Rowan, A. D. (2019). Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics. British journal of pharmacology, 176(1), 38-51. doi:10.1111/bph.14173DOI: 10.1111/bph.14173
2018
Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to <i>MMP1</i> expression in human chondrocytes (Journal article)
Macdonald, C. D., Falconer, A. M. D., Chan, C. M., Wilkinson, D. J., Skelton, A., Reynard, L., . . . Rowan, A. D. (2018). Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to <i>MMP1</i> expression in human chondrocytes. PLOS ONE, 13(11). doi:10.1371/journal.pone.0207240DOI: 10.1371/journal.pone.0207240
Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes (Journal article)
Baker, J., Falconer, A. M. D., Wilkinson, D. J., Europe-Finner, G. N., Litherland, G. J., & Rowan, A. D. (2018). Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes. PLOS ONE, 13(4). doi:10.1371/journal.pone.0195864DOI: 10.1371/journal.pone.0195864
Tissue Destruction and Repair (Chapter)
Rowan, A., Young, D., & Wilkinson, D. J. (2018). Tissue Destruction and Repair. In Rheumatology 7th Edition. Elsevier.
2017
Wilkinson, D. J., Desilets, A., Lin, H., Charlton, S., Arques, M. D. C., Falconer, A., . . . Rowan, A. D. (2017). The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-17028-3DOI: 10.1038/s41598-017-17028-3
Wilkinson, D. J., Habgood, A., Lamb, H. K., Thompson, P., Hawkins, A. R., Désilets, A., . . . Rowan, A. D. (2017). Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms. Arthritis & Rheumatology, 69(8), 1601-1611. doi:10.1002/art.40133DOI: 10.1002/art.40133
Cytokine-inducedMMP13Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation (Journal article)
Chan, C. M., Macdonald, C. D., Litherland, G. J., Wilkinson, D. J., Skelton, A., Europe-Finner, G. N., & Rowan, A. D. (2017). Cytokine-inducedMMP13Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation. Journal of Biological Chemistry, 292(5), 1625-1636. doi:10.1074/jbc.m116.756601DOI: 10.1074/jbc.m116.756601
2015
Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination (Journal article)
Radwan, M., Wilkinson, D. J., Hui, W., Destrument, A. P. M., Charlton, S. H., Barter, M. J., . . . Young, D. A. (2015). Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination. Annals of the Rheumatic Diseases, 74, 1580-1587. doi:10.1136/annrheumdis-2013-204962DOI: 10.1136/annrheumdis-2013-204962
2014
Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis (Journal article)
Litherland, G. J., Hui, W., Elias, M. S., Wilkinson, D. J., Watson, S., Huesa, C., . . . Rowan, A. D. (2014). Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis. Arthritis & Rheumatology, 66(8), 2175-2187. doi:10.1002/art.38681DOI: 10.1002/art.38681
2012
IDENTIFYING THE KEY ENZYMES INVOLVED IN MATRIPTASE-INDUCED CARTILAGE AGGRECAN AND COLLAGEN RESORPTION (Journal article)
Wilkinson, D. J., Rowan, D., & Milner, J. (2012). IDENTIFYING THE KEY ENZYMES INVOLVED IN MATRIPTASE-INDUCED CARTILAGE AGGRECAN AND COLLAGEN RESORPTION. OSTEOARTHRITIS AND CARTILAGE, 20, S119-S120. doi:10.1016/j.joca.2012.02.146DOI: 10.1016/j.joca.2012.02.146