Publications

August 2017

Local protein kinase A action proceeds through intact holoenzymes
Smith, F.D., Esseltine, J.L., Nygren, P.J., Veesler, D., Byrne, D.P., Vonderach, M., Strashnov, I., Eyers, C.E., Eyers, P.A., Langeberg, L.K., Scott, J.D. (2017) Local protein kinase A action proceeds through intact holoenzymes. Science. doi: 10.1126/science.aaj1669

Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling
Ghadiali, R.S., Guimond, S.E., Turnbull, J.E., Pisconti, A. (2017). Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling. Matrix Biology. doi: 10.1016/j.matbio.2016.07.007

MRL proteins cooperate with activated Ras in glia to drive distinct oncogenic outcomes
Taylor, E., Alqadri, N., Dodgson, L., Mason, D., Lyulcheva, E., Messina, G., Bennett, D. (2017). MRL proteins cooperate with activated Ras in glia to drive distinct oncogenic outcomes. Oncogene. doi: 10.1038/onc.2017.68

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras
Lilja, J., Zacharchenko, T., Georgiadou, M., Jacquemet, G., Franceschi, N.D., Peuhu, E., Hamidi, H., Pouwels, J., Martens, V., Nia, F.H., Beifuss, M., Boeckers, T., Kreienkamp, H.-J., Barsukov, I.L., Ivaska, J. (2017). SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Nature Cell Biology. doi: 10.1038/ncb3487

 

September 2016

Specific Internalisation of Gold Nanoparticles into Engineered Porous Protein Cages via Affinity Binding
Paramelle D, Peng T, Free P, Fernig DG, Lim S, Tomczak N (2016). Specific Internalisation of Gold Nanoparticles into Engineered Porous Protein Cages via Affinity Binding. PLoS One. doi: 10.1371/journal.pone.0162848

Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold
Zacharchenko TBarsukov IRigden DJBennett D, Mayans O (2016). Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold. Protein J. 2016 Sep 3. doi: 10.1007/s10930-016-9677-7.

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex
Zhou T, Fleming JR, Franke B, Bogomolovas J, Barsukov IRigden DJ, Labeit S, Mayans O (2016). CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex. FEBS Lett. doi: 10.1002/1873-3468.12362

August 2016

19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy
Lima MA, Cavalheiro RP, M Viana G, Meneghetti MC, Rudd TR, Skidmore MA, Powell AK, Yates EA (2016). F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconj J. doi: 10.1007/s10719-016-9723-x

Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity
Ahmed YAYates EA, Moss DJ, Loeven MA, Hussain SA, Hohenester E, Turnbull JE, Powell AK (2016). Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity. Mol Biosyst. doi: 10.1039/c6mb00432f.

Targeting protein function: the expanding toolkit for conditional disruption
Campbell A and Bennett D (2016). Targeting protein function: the expanding toolkit for conditional disruption. Biochem J. doi: 10.1042/BCJ20160240

The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth
Bago R, Sinner E, Castel P, Baelga J, Bailey FP, Shpiro N, Cross DAE, Crafter C, Eyers PA, Alessi DR (2016). The hVPS34-SGK3 signalling module counteracts inhibition of the PI3K-Akt pathway to maintain mTORC1 and tumour growth. EMBO Journal. doi 10.15252/embj.20169392

Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling
Ghadiali RS, Guimond SE, Turnbull JEPisconti A (2016). Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling.  Matrix Biology. doi: 10.1016/j.matbio.2016.07.007.

Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast
Woods B, Lai H, Wu CF, Zyla TR, Savage NS, Lew DJ (2016). Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast. doi: 10.1016/j.cub.2016.06.047

July 2016

Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal
Horrell S, Antonyuk S.VEady R.RHasnain S, Hough MA, Strange RW (2016). Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal. IUCrJ. doi: 10.1107/S205225251600823X

Potential DNA binding and nuclease functions of ComEC domains characterized in silico
Baker JA, Simkovic F, Taylor HM, Rigden DJ (2016). Potential DNA binding and nuclease functions of ComEC domains characterized in silico. Proteins. doi: 10.1002/prot.25088

High colloidal stability of gold nanorods coated with a peptide-ethylene glycol: Analysis by cyanide-mediated etching and nanoparticle tracking analysis
Free P, Conger G, Siji W, Zhang JB, Fernig DG (2016). High colloidal stability of gold nanorods coated with apeptide-ethylene glycol: Analysis by cyanide-mediated etching andnanoparticle tracking analysis. Colloids Surf B Biointerfaces. doi: 10.1016/j.colsurfb.2016.07.006

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections
McPhillie M, Zhou Y, Bissati KE, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, Wang K, Kim TK, He Y, Santos T, Woods S, Lee P, Donkin D, Kim E, Fraczek L, Lykins J, Esaa F, Alibana-Clouser F, Dovgin S, Weiss L, Brasseur G, Wirth D, Kent M, Hood L, Meunieur B, Roberts CW, Hasnain SAntonyuk SV, Fishwick C, McLeod R (2016). New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Scientific Reports. doi: 10.1038/srep29179

June 2016

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo
Comenge J, Fraguiero O, Sharkey J, Taylor A, Held M, Burton NC, Park, BK, Wilm B, Murray P, Brust M, Levy R (2016). Preventing Plasmon Coupling between Gold Nanorods Improves the Sensistivity of Photoacoustic Detection of Labeled Stem Cells in Vivo.  ACS Nano 7106-7116. doi: 10.1021/acsnano.6b03246.

Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds
Simkovic F, Thomas JM, Keegan RM, Winn MD, Mayans O, Rigden DJ. Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds (2016). IUCrJ. doi: 10.1107/S2052252516008113.

Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils
Stewart KL, Hughes E, Yates EA, Akien GR, Huang TY, Lima MA, Rudd TR, Guerrini M, Hung SC, Radford SE, Middleton DA. Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils (2016). J Am Chem Soc. doi: 10.1021/jacs.6b02816.

A faulty interaction between SOD1 and hCCS in neurodegenerative disease
Wright GAntonyuk S.VHasnain SS (2016). A faulty interaction between SOD1 and hCCS in neurodegenerative disease. Scientific Reports. doi: 10.1038/srep27691.

Recent innovations in the structural analysis of heparin
Yates EA, Rudd TR (2016). Recent innovations in the structural analysis of heparin. Int J Cardiol. doi: 10.1016/S0167-5273(16)12002-9.

May 2016

Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation
Arecco N, Clarke CJ, Jones FK, Simpson DMMason DBeynon RJPisconti A (2016). Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation. Sci Rep. doi: 10.1038/srep24708

April 2016

A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells
Trevino V, Cassese A, Nagy Z, Zhuang X, Herbert JAntczak PClarke K, Davies N, Rahman A, Campbell MJ, Guindani M, Bicknell R, Vannucci M, Falciani F (2016).  A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells. PLOS Computational Biology, doi:10.1371/journal.pcbi.1004884

Fresh insight to functioning of selected enzymes of the nitrogen cycle
Eady RRAntonyuk SVHasnain SS(2016).  Fresh insight to functioning of selected enzymes of the nitrogen cycle.  Current Opinion in Chemical Biology 31: 103-112. doi:10.1016/j.cbpa.2016.02.009

Human neutrophils in auto-immunity
Thieblemont N, Wright HL, Edwards SW, Witko-Sarsat V (2016).  Human neutrophils in auto-immunity.  Seminars in Immunology doi: 10.1016/j.smim.2016.03.004

March 2016

Cell cycle progression in glioblastoma cells is unaffected by pathophysiological levels of hypoxia
Richards R, Jenkinson MD, Haylock BJ, See V. (2016Cell cycle progression in glioblastoma cells is unaffected by pathophysiological levels of hypoxiaPeerJ 4:e1755 https://doi.org/10.7717/peerj.1755

Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification
Li Y, Sun CYates EA, Jiang C, Wilkinson MCFernig DG (2016). Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification Open Biology 6: 150275.  DOI: 10.1098/rsob.150275

Selectivity in glycosaminoglycan binding dictates the distribution and diffusion of fibroblast growth factors in the pericellular matrix
Sun CMarcello M, Li Y, Mason DLevy RFernig DG (2016). Selectivity in glycosaminoglycan binding dictates the distribution and diffusion of fibroblast growth factors in the pericellular matrix.  Open Biology 6: 150277. http://dx.doi.org/10.1098/rsob.150277

February 2016

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization
Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EL, Eyers PA and Kannan N (2016) Hydrophobic core variations provide a structural framework for tyrosine kinase evolution and functional specialization. PLOS Genetics doi.org/10.1371/journal.pgen.1005885

January 2016

Fibroblast growth factors as tissue repair and regeneration therapeutics
Nunes QM, Li Y, Sun C, Kinnunen TK, Fernig DG (2015)  Fibroblast growth factors as tissue repair and regeneration therapeutics. PeerJ 4:e1535; doi:10.7717/peerj.1535.

December 2015

Differential Changes in Gene Expression in Human Neutrophils following TNF-α Stimulation: Up-Regulation of Anti-Apoptotic Proteins and Down-Regulation of Proteins involved in Death Receptor Signalling
Chiewchengchol D, Wright HL, Thomas HB, Lam C, Roberts K, Hirankarn N, Beresford M, Moots R, Edwards SW (2015)  Differential Changes in Gene Expression in Human Neutrophils following TNF-α Stimulation: Up-Regulation of Anti-Apoptotic Proteins and Down-Regulation of Proteins involved in Death Receptor Signalling. Immunity Inflammation & Diseasedoi: 10.1002/iid3.90.

Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid
Davies HAPhelan MMWilkinson MC, Migrino RQ, Truran S, Franco DA, Liu LN, Longmore CJ, Madine J. Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid. Biophysical journal. 2015 Dec 1;109(11):2363-70. doi: 10.1016/j.bpj.2015

November 2015

Multi-level functional genomics data integration as a tool for understanding physiology: A network perspective. 
Davidsen PK, Turan N, Egginton S, Falciani F (2015)  Multi-level functional genomics data integration as a tool for understanding physiology: A network perspective. Journal of Applied Physiology (1985) Nov 5:jap.01110.2014.  doi: 10.1152/japplphysiol.01110.2014. [Epub ahead of print]. doi: 10.1152/japplphysiol.01110.2014.

TRIBBLES: A twist in the pseudokinase tail
Eyers PA (2015) TRIBBLES: A twist in the pseudokinase tail. Structure 23:1974-1976. doi: 10.1016/j.str.2015.10.003.

Cutaneous immunopathology of long-standing complex regional pain syndrome
Osborne S, Farrell J, Dearman RJ, MacIver K, Naisbitt DJ, Moots RJ, Edwards SW, Goebel A. Cutaneous immunopathology of long‐standing complex regional pain syndrome. European Journal of Pain. 2015 Nov 1;19(10):1516-26. doi: 10.1002/ejp.685

Superresolution microscopy reveals a dynamic picture of cell polarity maintenance during directional growth Science Advances 
Ishitsuka Y, Savage N, Li Y, Bergs A, Grün N, Kohler D, Donnelly R, Ulrich Nienhaus G, Fischer R, Takeshita N (2015)  Superresolution microscopy reveals a dynamic picture of cell polarity maintenance during directional growth Science Advances  13 Nov 2015:Vol. 1, no. 10, e1500947. doi: 10.1126/sciadv.1500947.

The spherical nucleic acids mRNA detection paradox
Mason D, Carolan G, Held M, Comenge J, Levy R (2015) The spherical nucleic acids mRNA detection paradox.  Science Open Research DOI: 10.14293/S2199-1006.1.SOR-CHEM.AZ1MJU.v1.

October 2015

2-O Heparan Sulfate Sulfation by Hs2st is required for Erk/Mapk Signalling Activation at the Mid-gestational Mouse Telencephalic Midline
Chan WK, Howe K, Clegg J, Guimond S, Price D, Turnbull J, Pratt T (2015). 2-O Heparan Sulfate Sulfation by Hs2st is required for Erk/Mapk Signalling Activation at the Mid-gestational Mouse Telencephalic Midline. PLoSOne 10(6):e0130147. doi: 10.1371/journal.pone.0130147

Stromal transcriptional profiles reveal hierarchies of anatomical site, serum response and disease and identify disease specific pathways.
Filer A, Antczak P, Parsonage GN, Legault HM, O'Toole M, Pearson MJ, Thomas AM, Scheel-Toellner D, Raza K, Buckley CD, Falciani F (2015). Stromal transcriptional profiles reveal hierarchies of anatomical site, serum response and disease and identify disease specific pathways. PLoS One. Mar 25;10(3):e0120917. doi: 10.1371/journal.pone.0120917.

Sulf1 and Sulf2 differentially modulate heparan sulfate proteoglycan sulfation during postnatal cerebellum development thereby acting as neuroprotective and neurite outgrowth promoting enzymes
Kalus I, Rohn S, Puvirajesinghe T, Guimond SE, Eyckerman-Kölln PJ, van Kuppevelt T, ten Dam G, Turnbull JE, and Dierks T (2015). Sulf1 and Sulf2 differentially modulate heparan sulfate proteoglycan sulfation during postnatal cerebellum development thereby acting as neuroprotective and neurite outgrowth promoting enzymes. PLoSOne. 10(10):e0139853. doi : 10.1371/journal.pone.0139853

Tribbles pseudokinases: novel targets for chemical biology and drug discovery?
Foulkes DM, Byrne DP, Bailey, FP and Eyers PA (2015) Tribbles pseudokinases: novel targets for chemical biology and drug discovery? Biochemical Society Transactions 43:1095-1103. doi: 10.1042/BST20150109.

Sequencing and ion mobility separation of heparan sulfate-like octasaccharide isomers differing in glucuronic and iduronic acid.
Miller RL, Wei W, Schwörer R, Zubkova OV, Tyler PC, Turnbull JE, Leary JA (2015). Sequencing and ion mobility separation of heparan sulfate-like octasaccharide isomers differing in glucuronic and iduronic acid. European Journal of Mass Spectrometry 21, 245-54. 

Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding
Solari V, Rudd T, Guimond S, Turnbull JEYates E (2015). Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. Organic and Biomolecular Chemistry 13, 6066-72. doi: 10.1039/c5ob00564g.

Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding.
Zacharchenko T, von Castelmur E, Rigden DJ, Mayans O (2015).  Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding.  Biochemical Society Transactions Oct 09, 2015, 43 (5) 850-855. doi: 10.1042/BST20150084

The metastasis-inducing protein AGR2 is O-glycosylated upon secretion from mammary epithelial cells
Osborne S, Farrell J, Dearman RJ, MacIver K, Naisbitt DJ, Moots RJ, Edwards SW, Goebel A. Cutaneous immunopathology of long‐standing complex regional pain syndrome. European Journal of Pain. 2015 Nov 1;19(10):1516-26. doi: 10.1007/s11010-015-2502-3

September 2015

Cytokines and growth factors cross-link heparin sulfate.
Migliorini E, Thakar D, Kuhnle J, Sadir R, Dyer DP, Li Y, Sun C, Volkman BF, Handel TM, Coche-Guerente L, Fernig DG, Lortat-Jacob H, Richter RP (2015)  Cytokines and growth factors cross-link heparin sulfate.  Open Biology 5: 150056. doi/10.1098/rsob.15.0046

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription 
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhäuser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F and Biffo S (2015). eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription. Nature Communications Sep 18;6:8261. doi: 10.1038/ncomms9261.

Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes Centrin 2 function
Sawant DB, Majumder S, Perkins JL, Yang CH, Eyers PA and Fisk HA (2015) Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes Centrin 2 function. Molecular Biology of the Cell. Sep 0 E14-07-1248. doi: 10.1091/mbc.E14-07-1248

Diadenosine 5 ', 5 '''-P-1,P-4-tetraphosphate (Ap(4)A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication
Marriott AS, Copeland NA, Cunningham R, Wilkinson MC, McLennan AG, Jones NJ (2015) Diadenosine 5 ', 5 '''-P-1,P-4-tetraphosphate (Ap(4)A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication.  DNA Repair.  Sep; 33: 90-100. doi: 10.1016/j.dnarep.2015.06.008.

Whose Gene Is It Anyway? The Effect of Preparation Purity on Neutrophil Transcriptome Studies
Thomas HB, Moots RJ, Edwards SW, Wright HL. Whose Gene Is It Anyway? The Effect of Preparation Purity on Neutrophil Transcriptome Studies. PloS one. 2015 Sep 24;10(9):e0138982. doi: 10.1371/journal.pone.0138982

August 2015

Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signalling
Lee J, Wee S, Gunaratne J, Chua RJE, Smith RAA, Ling L, Fernig DG, Swaminathan K, Nurcombe V, Cool SM (2015).  Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signalling. Glycobiology 1-14. doi: 10.1093/glycob/cwv064.

July 2015

Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer
Clarke K, Daubon T, Turan N, Soulet F, Mohd Zahari M, Ryan KR, Durant S, He S, Herbert JAnkers J, Heath JK, Bjerkvig R, Bicknell R, Hotchin NA, Bikfalvi A, Falciani F (2015).  Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer. PLoS Genetics  Jul 1;11(7):e1005325.  doi: 10.1371/journal.pgen.1005325

The metastasis-inducing protein AGR2 is O-glycosylated upon secretion from mammary epithelial cells
Clarke C, Rudland P, Barraclough R (2015).  The metastasis-inducing protein AGR2 is O-glycosylated upon secretion from mammary epithelial cells. Molecular and Cellular Biochemistry doi: 10.1007/s11010-015-2502-3

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
Duckworth CA, Guimond SE, Sindrewicz P, Hughes AJ, French NS, Lian L-YYates EA, Pritchard DM, Rhodes JM, Turnbull JE, Yu L-G (2015).  Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis.  Oncotarget doi: 10.18632/oncotarget.4409

Diadenosine 5’, 5’’’-P1,P4-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication
Marriott AS, Copeland NA, Cunningham R, Wilkinson MC, McLennan AG, Jones NJ (2015).  Diadenosine 5’, 5’’’-P1,P4-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication.  DNA Repair 33: 90-100. doi:10.1016/j.dnarep.2015.06.008.

Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation.
Theodoraki A, Hu Y, Poopalasundaram S, Oosterhof A, Guimond SE, Disterer P, Khoo B, Hauge-Evans AC, Jones PM, Turnbull JE, van Kuppevelt TH, Bouloux PM (2015).  Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation. Molecular Cellular Endocrinology 399: 296-310. doi:10.1016/j.mce.2014.09.011.

Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions
Pandalaneni S, Karuppiah V, Saleem M, Haynes LP, Burgoyne RD, Mayans O, Derrick JP, Lian LY. Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions. Journal of Biological Chemistry. 2015 Jul 24;290(30):18744-56. doi: 10.1074/jbc.M114.627059

Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D
Flanagan PK, Chiewchengchol D, Wright HL, Edwards SW, Alswied A, Satsangi J, Subramanian S, Rhodes JM, Campbell BJ. Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D. Inflammatory bowel diseases. 2015 Jul 1;21(7):1499-510. doi: 10.1097/MIB.0000000000000387.

Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding
Solari V, Rudd TR, Guimond SE, Powell AK, Turnbull JE, Yates EA. Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. Organic & biomolecular chemistry. 2015;13(21):6066-72. doi: 10.1039/c5ob00564g.

TD-60 links RalA GTPase function to the CPC in mitosis. Nature Communications
Papini D, Langemeyer L, Abad MA, Kerr A, Samejima I, Eyers PA, Jeyaprakash A, Higgins JM, Barr FA and Earshaw WC (2015).  TD-60 links RalA GTPase function to the CPC in mitosis. Nature Communications doi: 10.1038/ncomms8678.

June 2015

Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue.
Armstrong JPK, Shakur R, Horne JP, Dickinson SC, Armstrong CT, Lau K, Kadiwala J, Lowe R, Seddon A, Mann S, Anderson JLR, Perriman AW, Hollander AP (2015).  Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue.  Nature Communications 6, Article number 7405. doi: 10.1038/ncomms8405

HaloTag is an effective expression and solubilisation fusion partner for a range of fibroblast growth factors
Sun C, Li Y, Taylor SE, Mao X, Wilkinson MCFernig DG. HaloTag is an effective expression and solubilisation fusion partner for a range of fibroblast growth factors. PeerJ. 2015 Jun 25;3:e1060. doi: 10.7717/peerj.1060

April 2015

TAT and HA2 Facilitate Cellular Uptake of Gold Nanoparticles but Do Not Lead to Cytosolic Localisation
Cesbron Y, Shaheen U, Free P, Lévy R (2015) TAT and HA2 Facilitate Cellular Uptake of Gold Nanoparticles but Do Not Lead to Cytosolic Localisation. PLoS ONE 10(4): e0121683. doi:10.1371/journal.pone.0121683.

Contemporary evolution of resistance at the major insecticide target site gene Ace-1 by mutation and copy number variation in the malaria mosquito Anopheles gambiae.
Weetman D, Mitchell SN, Wilding CS, Birks DP, Yawson AE, Essandoh J, Mawejje HD, Djogbenou LS, Steen K, Rippon EJ, Clarkson CS, Field SG, Rigden DJ, Donnelly MJ (2015) Contemporary evolution of resistance at the major insecticide target site gene Ace-1 by mutation and copy number variation in the malaria mosquito Anopheles gambiae. Molecular Ecology doi: 10.1111/mec.13197.

Synovial fluid IL-6 concentrations associated with positive response to tocilizumab in an RA patient with failed response to anti-TNF and rituximab
Wright HL, Mewar D, Bucknall RC, Edwards SW, Moots RJ. Synovial fluid IL-6 concentrations associated with positive response to tocilizumab in an RA patient with failed response to anti-TNF and rituximab. Rheumatology. 2015 Feb 8:keu488. doi: 10.1093/rheumatology/keu488

The tribbles 2 (TRB2) pseuodkinase binds to ATP and autophosphorylates in a metal-independent manner
Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat KM, Kannan N and Eyers PA (2015) The tribbles 2 (TRB2) pseuodkinase binds to ATP and autophosphorylates in a metal-independent manner. Biochem J doi: 10.1042/BJ20141441

March 2015

Comparisons with Amyloid-beta Reveal an Aspartate Residue That Stabilizes Fibrils of the Aortic Amyloid Peptide Medin
Davies HAMadine J, Middleton DA. Comparisons with amyloid-β reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medin. Journal of Biological Chemistry. 2015 Mar 20;290(12):7791-803. doi: 10.1074/jbc.M114.602177

Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22
Sohn Y-S, Shin H-C, Park WS, Ge J, Kim CH, Lee BL, Heo WD, Jung JU, Rigden DJ, Oh B-H (2015)  Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22. PLOS ONE doi: 10.1371/journal.pone.0118683. eCollection 2015.

February 2015

Routine phasing of coiled-coil protein crystal structures with AMPLE
Thomas JM, Keegan RM, Bibby J, Winn MD, Mayans ORigden DJ. Routine phasing of coiled-coil protein crystal structures with AMPLE. IUCrJ. 2015 Mar 1;2(2):198-206. doi: 10.1107/S2052252515002080.

Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells
Herrmann A, Rice M, Lévy R, Pizer BL, Losty PD, Moss D, Sée V (2015)  Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells.  Oncogenesis 3, e138. doi: 10.1038/oncsis.2014.52.

Detection of interaction between protein Trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism
Hughes AJ, Rudd TR, Wright GSAFernig DG, Siligardi G, Yates EA (2014).  Detection of interaction between protein Trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism. Analytical Methods.  doi: 10.1039/C4AY02618G

Targeting cell membrane lipid rafts by stoichiometric functionalization of gold nanoparticles with a spingolipid-binding domain pepetide. 
Paramelle D, Nieves D, Brun B, Kraut RS, Fernig DG (2015)  Targeting cell membrane lipid rafts by stoichiometric functionalization of gold nanoparticles with a spingolipid-binding domain pepetide. Advanced Healthcare Materials 2015 Feb 3. doi: 10.1002/adhm.201400730.

Routine phasing of coiled-coil protein crystal structures with AMPLE. International Union of Crystallography Journal 
Thomas J, Keegan R, Bibby J, Winn M, Mayans ORigden D (2015).  Routine phasing of coiled-coil protein crystal structures with AMPLE. International Union of Crystallography Journal doi: 10.1107/S2052252515002080.

Synovial fluid IL-6 concentrations associated with positive response to tocilizumab in an RA patient with failed response to anti-TNF and rituximab.
Wright HL, Mewar D, Bucknall RC, Edwards SW, Moots RJ (2015). Synovial fluid IL-6 concentrations associated with positive response to tocilizumab in an RA patient with failed response to anti-TNF and rituximab. Rheumatology. doi: 10.1093/rheumatology/keu488

Exploring speed and performance of Molecular Replacement with AMPLE using QUARK ab initio protein models.
Keegan R, Bibby J, Thomas J, Xu D, Zhang Y, Mayans O, Winn M, Rigden D (2015) Exploring speed and performance of Molecular Replacement with AMPLE using QUARK ab initio protein models. Acta Cryst. D doi: 10.1107/S1399004714025784

Single Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications. Angewandte Chemie.
Tyler PC, Guimond SE, Turnbull JE, Zubkova OV (2015) Single Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications. Angewandte Chemie. doi: 10.1002/anie.201410251 

January 2015

Going for broke: targeting the human cancer pseudokinome
Bailey FP, Byrne DP, McSkimming D, Kannan N, Eyers PA (2015) Going for broke: targeting the human cancer pseudokinome. Biochem J 465:195-211. doi: 10.1042/BJ20141060.

Antimalarial 4(1H)-pyridones bind to the Qi site of Cytochrome bc1
Capper MJ, O’Neil PM, Fisher N, Strange RW, Moss D, Ward SA, Berry NG, Lawrenson AS, Hasnain S, Biagini GA, Antonyuk SV (2015) Antimalarial 4(1H)-pyridones bind to the Qi site of Cytochrome bc1.  PNAS. doi: 10.1073/pnas.1416611112. 

The 2015 Nucleic Acids Research Database Issue and Molecular Biology Database Collection.
Galperin MY, Rigden D, Fernandez-Suarez XM (2015) The 2015 Nucleic Acids Research Database Issue and Molecular Biology Database Collection. Nucleic Acids Research, 2015, Vol. 43, Database issue D1–D5. doi: 10.1093/nar/gku1241.