Orphan enzymes and uncharted metabolic pathways in Mycobacterium tuberculosis
- Kelly Welburn
- Suitable for: Those with an interest in Evolution, Ecology and Behaviour
- Admission: Free
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Despite advances in genomics and bioinformatics in the last two decades, approximately half of bacterial genomes remain unannotated. These proteins bear little to no similarity with proteins which have been characterised. This vast amount of unknown biological space is halting our understanding of fundamental aspects of microbiology and slowing down antibiotic drug discovery. In this seminar Luiz will demonstrate the power of multidisciplinary approaches centred on metabolomics, to identify de novo functions to annotated enzymes from the human pathogen Mycobacterium tuberculosis.