CANCELLED Disruptions to Stem Cell Signalling Networks in Human Developmental Disorders

1:00pm - 2:00pm / Monday 16th March 2020 / Venue: LT1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Those with an interest in Genomes, Systems and Therapeutic Targeting
  • Admission: Free
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Speaker: Greg Findlay (University of Dundee)

Greg’s lab applies cutting-edge chemical, genetic, proteomic and transcriptomic technologies to investigate signalling mechanisms that regulate Embryonic Stem (ES) cell biology. Using these approaches, they have uncovered a series of exciting new ES cell signalling pathways, providing key insights into regulation of stem cell maintenance and differentiation. Recently, they have begun exploring how disruptions to stem cell signalling networks lead to human developmental disorders, particularly intellectual disability. Greg will describe his approaches to pinpoint novel signalling components that are mutated in intellectual disability syndromes, and elucidate the molecular mechanisms underpinning the development of these disorders in patients.

Greg Findlay obtained his PhD at the Institute of Cancer Research, London, working with Richard Lamb to investigate novel components of the mTOR pathway. He then moved to the lab of Tony Pawson FRS at the Lunenfeld-Tanenbaum Research Institute, Toronto, where he used synthetic approaches to understand how modular protein complexes regulate ES cell biology. Greg established his research group in the MRC Protein Phosphorylation & Ubiquitylation Unit at the University of Dundee in 2014. In 2018, he was awarded a Sir Henry Dale Fellowship from the Wellcome Trust/Royal Society and promoted to Senior Lecturer.