Cilia in Development and Disease: Dynamics, Diversity and Dogma
1:00pm - 2:00pm /
Monday 20th January 2020
/ Venue: Physiology Seminar Room, Ground Floor Nuffield Wing
- Urszula McClurg
- Suitable for: Those interested in Genomes, Systems and Therapeutic Targeting
- Admission: Free
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Speaker: Pleasantine Mill (MRC, Edinburgh)
The Mill lab aims to understand genetic disease and disease mechanisms arising from dysfunction of mammalian cilia, termed the ciliopathies. While mammalian cilia are ubiquitous and highly conserved structures, the clinical features associated with cilia dysfunction are highly pleiotropic with varying degrees of severity and penetrance among tissues. The cellular and developmental basis to this phenotypic complexity is poorly understood and remains controversial. However, it is quite clear that not all cilia are created equal. In order to better understand the functional and structural diversity of the mammalian cilia repertoire, our strategy has been to engineer genetic tools to allow us to deeply molecularly phenotype cilia with organelle-resolution in vivo, using cutting-edge proteomics and imaging.
The Mill lab aims to understand genetic disease and disease mechanisms arising from dysfunction of mammalian cilia, termed the ciliopathies. While mammalian cilia are ubiquitous and highly conserved structures, the clinical features associated with cilia dysfunction are highly pleiotropic with varying degrees of severity and penetrance among tissues. The cellular and developmental basis to this phenotypic complexity is poorly understood and remains controversial. However, it is quite clear that not all cilia are created equal. In order to better understand the functional and structural diversity of the mammalian cilia repertoire, our strategy has been to engineer genetic tools to allow us to deeply molecularly phenotype cilia with organelle-resolution in vivo, using cutting-edge proteomics and imaging.