Epi-Evo: Insight into Epigenetic Mechanisms through Evolutionary Analyses
1:00pm - 2:00pm /
Thursday 7th November 2019
/ Venue: SR12, 3rd Floor Life Sciences Building
Type: Seminar /
Category: Research
- Mark Viney
- Suitable for: Those interested in Evolution.
- Admission: Free
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Speaker: Dr Peter Sarkies (MRC London Institute of Medical Sciences)
Epigenetic gene regulation is fundamental for development of multicellular organisms, hence the deep conservation of many of the molecular pathways involved. However, despite their ancient origin, many epigenetic pathways evolve surprisingly rapidly, including repeated losses in many independent metazoan lineages. Interestingly, similar diversification of epigenetic mechanisms occurs in cancer. We are interested in understanding how epigenetic mechanisms evolve across species and identifying the factors that drive repeated loss of epigenetic gene regulatory pathways. I will demonstrate how this approach allows us to obtain new insights into why epigenetic mechanisms are perturbed in cancer cell evolution.
Epigenetic gene regulation is fundamental for development of multicellular organisms, hence the deep conservation of many of the molecular pathways involved. However, despite their ancient origin, many epigenetic pathways evolve surprisingly rapidly, including repeated losses in many independent metazoan lineages. Interestingly, similar diversification of epigenetic mechanisms occurs in cancer. We are interested in understanding how epigenetic mechanisms evolve across species and identifying the factors that drive repeated loss of epigenetic gene regulatory pathways. I will demonstrate how this approach allows us to obtain new insights into why epigenetic mechanisms are perturbed in cancer cell evolution.