Orphan Enzymes as a Window into Untapped Bacterial Physiology

4:00pm - 5:00pm / Tuesday 3rd December 2019 / Venue: LT2 Life Sciences Building
Type: Seminar / Category: Research / Series: BEEM Seminar
  • Suitable for: Staff and students interested in Behaviour, Evolution, Ecology and Microbiology
  • Admission: Free
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Speaker: Luiz de Carvalho (The Crick Institute)

Despite advances in genomics and bioinformatics in the last two decades, approximately half of bacterial genomes remain unannotated. These proteins bear little to no similarity with proteins which have been characterised. This vast amount of unknown biological space is halting our understanding of fundamental aspects of microbiology and slowing down antibiotic drug discovery. In this seminar Luiz will demonstrate the power of multidisciplinary approaches centred on metabolomics, to identify de novo functions to annotated enzymes from the human pathogen Mycobacterium tuberculosis.