Dr Simone Dario Scilabra.‘Use of shotgun proteomics to identify sheddase substrates.’ Host: George Bou-Gharios

1:00pm - 2:00pm / Wednesday 4th September 2019 / Venue: William Henry Duncan Apex Building
Type: Seminar / Category: Research
  • 0151 794 9003
  • Suitable for: Staff and students
  • Admission: Free to staff and students
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I am Principal Investigator in proteomics at the newly funded Ri.MED Institute in Palermo, Italy. Since my PhD in Medical Sciences at the Imperial College London, I have been interested in metalloproteinases, a class of enzymes with major roles in extracellular matrix turnover and processing of transmembrane proteins.

Membrane-tethered proteases that are able to release extracellularly the ectodomain of specific transmembrane proteins are known as "sheddases". The function of a sheddase strictly depends on the plethora of its substrates. The major focus of my study is using shotgun proteomics to identify substrates of specific sheddases in a systematic manner, thus understanding their physiological functions and potential links with pathological conditions.