Dr Simone Dario Scilabra.‘Use of shotgun proteomics to identify sheddase substrates.’ Host: George Bou-Gharios
- 0151 794 9003
- Brenda Smith
- Suitable for: Staff and students
- Admission: Free to staff and students
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Membrane-tethered proteases that are able to release extracellularly the ectodomain of specific transmembrane proteins are known as "sheddases". The function of a sheddase strictly depends on the plethora of its substrates. The major focus of my study is using shotgun proteomics to identify substrates of specific sheddases in a systematic manner, thus understanding their physiological functions and potential links with pathological conditions.