Expanding the Catalytic Versatility of the Protein Kinase Superfamily

1:00pm - 2:00pm / Monday 24th June 2019 / Venue: Lecture Theatre 2 Life Sciences Building
Type: Seminar / Category: Research
  • Suitable for: Staff and students with an interest in Biochemistry.
  • Admission: Free
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Speaker: Vinnie Tagliabracci (University of Texas, Southwestern Medical Centre)

Dr Vinnie Tagliabracci is Assistant Professor in the Department of Molecular Biology at UT Southwestern Medical Center. He received his B.S. in Chemistry and Biology from the University of Indianapolis and his Ph.D. in Biochemistry and Molecular Biology from Indiana University. In 2010, he joined Jack Dixon's lab at the University of California, San Diego in La Jolla, CA. There, he discovered a novel family of “secreted” kinases that phosphorylate proteins destined for cellular secretion. As part of this work, he identified Fam20C as the bona fide "Golgi casein kinase", an enzyme that had escaped identification for many years. In 2015, he joined the faculty at UT Southwestern as an Assistant Professor in the Department of Molecular Biology. Vinnie is the recipient of a Pathway to Independence award from the National Institutes of Health, a Cancer Prevention Research Institute of Texas (CPRIT) recruitment of first-time, tenure-track faculty member award and is an Endowed Scholar in biomedical research. He recently reported the discovery and evaluation of the SelO and SidE pseudokinases, which perform previously unknown enzymology.

Key References:
1. Black MH et al., Bacterial pseudokinase catalyses protein polygluatamylation to inhibit the SidE-family ubiquitin ligases. Science (2019) 24th May
2. Sreeletha A et al., Protein AMPylation by an Evolutionary Conserved Pseudokinase. Cell (2018) 175:809
3.Tagliabqracci VS et al., A single kinase generates the majority of the secreted phosphoproteome. Cell (2015) 161:1619