Subversion of NF-kB signalling pathway by oncogenic Kapsoi's sarcoma herpes virus

1:00pm - 2:00pm / Monday 10th December 2018 / Venue: Lecture Theatre 2 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Admission: Free
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Speaker: Tracey Barrett, Birkbeck University of London

It is estimated that between 20-40% of all cancers may be caused by viruses. As obligate intercellular pathogens, viruses directly interfere with key cellular signalling pathways a consequence of which is cancer. Kaposi's sarcoma is the most common form of AIDs-related cancer whose main causative agent is the Kaposi's Sarcoma-Associated Herpes Virus (KSHV). KSHV infection is also responsible for multicentric Castleman's disease and primary effusion lymphoma, an aggressive cancer for which there are currently no effective treatments. Our research seeks to understand how KSHV subverts cellular signalling mechanisms which may lead to uncontrolled cellular proliferation.

Mechanisms 'hijacked' by KSHV include the canonical and alternative NF-kB pathways that have been directly linked to malignancy. These pathways are aberrantly activated by virally encoded, host mimetic proteins. Our approach is to dissect key protein-protein, protein-nucleic acid complexes, as key underlying mechanisms involved in virus-initiated malignancies.