Demystifying Cholera Global Epidemiology

1:00pm - 2:00pm / Monday 29th October 2018 / Venue: Lecture Theatre 2 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Staff and students with an interest in Genomes, Systems and Therapeutic Targeting
  • Admission: Free
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Cholera is thought by many to be a disease of the Victorian era. However, current reports from Yemen show that cholera continues to be a serious concern (one death per hour currently; >1 million cases annually; WHO statistics). Low-resolution tools and sparse sampling continue to confound our understanding of cholera transmission. We have applied high-resolution whole-genome approaches to study V. cholerae that represent every known significant cholera outbreak from across two continents, Latin America and Africa, over the last 50 years. In Africa we observe consistent and predictable patterns by which cholera spreads across the globe. In Latin America we provide phylogenetic clarity to what has been until now a confusing picture of pandemic disease. These studies explain how all significant reported cholera outbreaks within the seventh pandemic are related to one another. But more importantly that the current models of cholera do not accurately describe pandemic cholera or its transmission. We aim to change dogma and put global cholera transmission back on the map.