Metaviromics for the Detection of Pathogenic Viruses in the Conwy River Catchment, Wales - Evelien Adriaenssens

12:00pm - 1:00pm / Monday 5th February 2018 / Venue: Lecture Theatre 1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Suitable for staff and students with an interest in Genomes, Systems and Therapeutic Targeting
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Enteric viruses, causing gastro-intestinal illness, are commonly transmitted through the fecal-oral route and enter river catchment areas through contamination with sewage. As a case study, the presence of these types of viruses in the Conwy river catchment (Wales, UK) was investigated using whole-genome-shotgun RNASeq metagenomics. Extensive bioinformatics analyses showed diverse RNA virus communities in wastewater and mussels but fewer RNA viruses in river water, while the methods developed here seem to be ideal for the recovery of full length RNA genomes, including those of noroviruses, sapoviruses and rotaviruses.