Dr Sarah De Val, Ludwig Institute for Cancer Research, Oxford University. 'Understanding vessel growth in development and disease: an enhancer-centric approach to a complex problem.' Host: George Bou-Gharios
12:45pm - 1:45pm /
Friday 23rd June 2017
/ Venue: Rooms G12 - G15, Ground floor William Henry Duncan Apex Building
- 0151 794 9003
- Brenda Smith
- Suitable for: Staff and students
- Admission: Free to staff and students
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I currently lead a research group at the Ludwig Institute, part of the University of Oxford. My research aims to develop novel strategies to modulate vessel growth. Specifically, we investigate the many different transcriptional and cognate signalling pathways which regulate the growth of different types of endothelial cells, and then study the behaviour of these pathways in pathological situations. This work uses an enhancer-centric approach, in which we identify and analyse enhancers active in different types of endothelial cells. Analysing these enhancers, which act as the one-off switch for genes, allows us to determine the TFs and upstream signalling pathways that control gene expression in each endothelial type.
Once fully delineated, these enhancers and the transgenic models which express them can then be used to study these processes in the adult and in disease states.
Contact Host: George Bou-Gharios if you would like to meet the speaker.
Once fully delineated, these enhancers and the transgenic models which express them can then be used to study these processes in the adult and in disease states.
Contact Host: George Bou-Gharios if you would like to meet the speaker.