LHNC Research Education Development Lecture Series

Professor Mererid Evans and Terry Jones - 'Integration of transoral surgery plus radiotherapy: PATHOS and beyond'

7:00pm - 8:00pm / Tuesday 10th February 2026 / Online event
Type: Lecture / Category: Research
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LIVERPOOL HEAD AND NECK CENTRE SEMINAR SERIES: RESEARCH EDUCATION DEVELOPMENT LECTURES 2026

'Integration of Transoral Surgery plus Radiotherapy: PATHOS and beyond'

Speakers:Professor Mererid Evans, Professor of Clinical Oncology and Director of Wales Cancer Research Centre, Cardiff Professor Terry Jones, Professor of Head and Neck Surgery and Director of Liverpool Head and Neck CentrePATHOS is a landmark international randomised trial designed to assess the oncological safety and functional outcomes of de-intensified adjuvant treatment in patients with HPV-associated oropharyngeal cancer treated with transoral surgery.

The trial completed recruitment of 1,349 patients in October 2024. Following a planned three-year follow-up period, final results are anticipated in early 2028. PATHOS has been instrumental in facilitating the development and adoption of transoral surgery—particularly transoral robotic surgery—across many UK centres, establishing a new paradigm in the management of this patient group.

With recruitment now complete but final outcome data still pending, there is ambiguity regarding optimal treatment strategies for patients presenting during this interim period. This talk will outline the early data emerging from PATHOS and provide practical guidance on the management of patients with HPV-associated oropharyngeal cancer while awaiting the final trial results.