Valitor Presents Preclinical Data on its Long-acting Anti-VEGF Biologic in Development for Durable Treatment of Wet AMD at the Association for Research in Visio

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Valitor, a biotechnology company engineering better medicines to conquer drug limitations, today announced new data from VLTR-557, its long-acting anti-VEGF biologic in development for durable wet age-related macular degeneration (AMD) treatment. These data are being presented at the 2023 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting taking place April 23-27, 2023 in New Orleans, LA.

The preclinical results demonstrated highly-localized and sustained drug exposure to ocular tissues and also confirmed the anti-VEGF bioactivity of VLTR-557. In addition, VLTR-557 exhibited high binding affinity to VEGF-A and remained stable under physiologic conditions for six months.   Importantly, the initial formulations were well-tolerated. These data suggest that a single intravitreal (ITV) injection of VLTR-557 has potential to maintain clinical efficacy for more than six months.

“These are exciting data, which demonstrate a highly differentiated profile compared to available AMD treatments. Specifically, results show that a single administration of VLTR-557, our long-acting anti-VEGF biologic for AMD, has the potential to maintain clinical efficacy with a standardized administration protocol of once every six months, which is longer than the current anti-VEGF biologics that require patient-specific dosing intervals,” said Wesley Jackson, Ph.D., chief scientific officer of Valitor. “Current available AMD treatments are limited by the need for more frequent injections and inconsistent patient-to-patient dosing protocols, which often leads to poor compliance and lower long-term efficacy. Our multivalent polymer technology, as demonstrated with VLTR-557, is designed to overcome these challenges by enabling long-acting results with reliable intravitreal durability and providing better treatment options for patients with AMD.”

This article was originally posted by Globe Newswire. Read the original article here.

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