Publications

The team are currently focusing on different research areas, including: 

• Zoonotic infection
• Pandemic infection
• Neurology
• Encephalitis
• Immune networks.

2023

• Michael BD, Dunai C, Needham EJ, Tharmaratnam K, Williams R, Huang Y, Boardman SA, Clark JJ, Sharma P, Subramaniam K, Wood GK, Collie C, Digby R, Ren A, Norton E, Leibowitz M, Ebrahimi S, Fower A, Fox H, Tato E, Ellul MA, Sunderland G, Held M, Hetherington C, Egbe FN, Palmos A, Stirrups K, Grundmann A, Chiollaz AC, Sanchez JC, Stewart JP, Griffiths M, Solomon T, Breen G, Coles AJ, Kingston N, Bradley JR, Chinnery PF, Cavanagh J, Irani SR, Vincent A, Baillie JK, Openshaw PJ, Semple MG, ISARIC4C Investigators, COVID-CNS Consortium, Taams LS and Menon DK. Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications. 2023 Dec 22: 14(1) 8487.
• Shil RSK, Hughes TW, Sargent B, Huang Y, Tamborska, AA, Frank B, Ellul MA, Michael BD. A clinical approach to the investigation and management of long COVID associated neuropathic pain. European Archives of Psychiatry and Clinical Neuroscience. 2023 Dec 8: 273(8).
• Frontera JA, Guekht A, Allegri RF, Ashraf M, Baykan B, Crivelli L, Easton A, Garcia-Azorin D, Helbok R, Joshi J, Koehn J, Koralnik I, Netravathi M, Michael B, Nilo A, Özge A, Padda K, Pellitteri G, Prasad K, Romozzi M, Saylor D, Seed A, Thakur K, Uluduz D, Vogrig A, Welte TM, Westenberg E, Zhuravlev D, Zinchuk M, Winkler AS. Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition. Journal of the Neurological Sciences. 2023 Oct 13: 454 120827
• Tamborska AA, Wood GK, Westenberg E, Garcia-Azorin D, Webb G, Schiess N, Netravathi M, Baykan B, Dervaj R, Helbok R, Lant S, Ozge A, Padovani A, Saylor D, Schmutzhard E, Easton A, Lileker JB, Jackson T, Beghi E, Ellul MA, Frontera JA, Pollak T, Nicholson TR, Wood N, Thakur KT, Solomon T, Stark RJ, Winkler AS, Michael BD and Global NeuroResearch Coalition. Global uncertainty in the diagnosis of neurological complications of SARS-CoV-2 infection by both neurologists and non-neurologists: An international inter-observer variability study. Journal of the Neurological Sciences. 2023 Jun 15: 449 120646
• Abdat Y, Butler M, Zandi M, Michael BD, Coutinho E, Nicholson TR, Easton A, Pollak TA. Mental health outcomes of encephalitis: an international web-based study.  (Pre-Print).
• Alam AM, Easton A, Bavikatte G, Mahendran S, Michael BD. Sequelae of neurological infection: management in primary care. Trends Urology and Men's Health. 2023 14(1):17-21.

2022

• Alam AM, Gillespie CS, Goodall J, Damodar T, Turtle L, Vasanthapuram R, Solomon T, Michael BD. Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality. PLoS Negl Trop Dis. 2022 Nov 28;16(11):e0010952.
• Grundmann, A, Wu, C-H, Hardwick, M, Baillie, J.K, Openshaw, P.J.M, Semple, M.G, Böhning, D, Pett, S, Michael, B.D, Rhys T.H, Galea, I and the ISARIC4C investigators. Fewer COVID-19 Neurological Complications with Dexamethasone and Remdesivir. Ann Neurol. 2022 Nov 9.
• Alam AM, Chen JPK, Wood GK, Facer B, Bhojak M, Das K, Defres S, Marson A, Granerod J, Brown D, Thomas RH, Keller SS. Solomon T, Michael BD. Increased volume of cerebral oedema is associated with risk of acute seizure activity and adverse neurological outcomes in encephalitis – regional and volumetric analysis in a multi-centre cohort. BMC Neurology 2022 Nov 7; 22, 412
• Wood GK, Thakur KT, Bharmabe V, Chomba M, García-Azorín D, Prasad K, Nattan Portes Souza M, Hsiang-Yi Chou S, Roa Giraldo JD, Fink E, Hoo FK, Siddiqi OK, Solomon T, Winkler AS, Michael BD. The global brain health clinical exchange platform: Translating concepts to collaborations. Journal of the Neurological Sciences. 2022 Oct 3; 442. 
• Duff E, Zelaya F, Almagro FA, Miller KL, Martin N, Nichols TE, Taschler B, Griffanti L, Arthofer C, Wang C, Bethlehem RAI, Eickel K, Günther M, Menon DK, Williams G, Facer B, Dell'Acqua F, Wood GK, Lythgoe DJ, Dell’Acqua F, Williams SCR, Houston G, Keller S, Holden C, Hartmann M, George L, Breen G, Michael BD, Jezzard P, Smith SM, Bullmore ET. COVID-CNS CONSORTIUM. Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads study PLOS ONE. 2022 Sep 29; 17 (9):e0273704.
• Needham, EJ, Ren, AL, Digby, RJ, Outtrim, JG, Chatfield, DA, Manktelow, AE, Newcombe, VFJ, Doffinger, R, Barcenas-Morales, G, Fonseca, C, Taussig,MJ, Burnstein, RM, Dunai, C, Sithole, N, Ashton, NJ, Zetterberg, H, Gisslen, M, Edén, A, Marklund, E, Griffiths, MJ, Cavanagh,J, Breen,G, Irani, SR, Elmer, A, Kingston, N, Bradley, JR, Taams, LS, Michael, BD, Bullmore, ET, Smith, KGC, Lyons, PA, Coles, AJC, Menon, DK, the Cambridge NeuroCOVID Group, the NIHR COVID-19 BioResource, Cambridge NIHR Clinical Research Facility. Brain Injury in COVID-19 is associated with dysregulated innate and adaptive immune responses  Brain. 2022, September 6.
• Wood GK, Babar R, Ellul MA, et al. Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts. BMJ Neurology Open 2022, Sept 5, 4(2) :e000323.
• Alam AM, Easton A, Nicholson TR, Irani SR, Davies NW, Solomon T, Michael BD. Encephalitis: diagnosis, management and recent advances in the field of encephalitides. Postgrad Med J. Pre-Print 2022, June 23.
• Dunai, C, Collie, C. Michael, B.D. Immune-Mediated Mechanisms of COVID-19 Neuropathology. Front. Neurol. 2022 May 19.
• Seehauen F, Clark JJ, Sharma P, Subramainiam K, Wunderlin Giuliani S, Hughes GL, Patterson EI, Michael BD, Owen A, Hiscox JA, Stewart JP, Kipar A. Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse. Viruses. 2022, May 11; 14,1020.
• Ariño H, Heartshorne R, Michael BD, Nicholson TR, Vincent A, Pollak TA, Vogrig A. Neuroimmune disorders in COVID-19. J Neurol. 2022 Mar 30. 
• Grundmann, A, Wu, C-H, Hardwick, M, Baillie, J.K, Openshaw, P, Semple, M.G, Böhning, D, Pett, S, Michael, B.D, Rhys T.H, Galea, I. Impact of Dexamethasone and Remdesivir on Neurological Complications during COVID-19. (2022, Mar 24). Pre-Print.
• Tooren HVD, Easton A, Hooper C, Mullin J, Fish J, Carson A, Nicholson T, Solomon T, Michael BD. How should we define a 'good' outcome from encephalitis? A systematic review of the range of outcome measures used in the long-term follow-up of patients with encephalitis. Clin Med (Lond). 2022 Mar;22(2):145-148.
• Palmos, AP, Millischer, V, Menon, DK, Nicholson, TR, Taams, L, Michael, BD, COVID Clinical Neuroscience Study Consortium, Hübel, C, Breen, GD. Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19. PLOS Genetics 18(3);2022 Mar 3. 
• Michael, B.D, Walton, D, Westenberg, E, García-Azorín, D, Singh, B, Tamborska, A.A, Netravathi, M, Chomba, M, Wood, G.K, Easton, A, Siddiqi, O.K, Jackson, T.A, Pollak, T.A, Nicholson, T.R, Nair, S, Breen, G, Prasad, K, Thakur, K.T, Chou, S H-Y, Schmutzhard, E, Frontera, J.A, Helbok, R, Padovani, A, Menon, D.K, Solomon, T, Winkler, A.S. On behalf of the Global COVID-19 Neuro-Research Coalition. Consensus clinical guidance for diagnosis and management of adult COVID-19 encephalopathy patients. The Journal of Neuropsychiatry and Clinical Neurosciences. Feb 2022. Peer Reviewed.
• Badenoch,J.B, Rengasamy, E.R, Watson, C, Jansen, K, Chakraborty, S, Sundaram, R.D, Hafeez, D, Burchill, E, Saini, A, Thomas, L, Cross, B, Hunt, C.K, Conti, I, Ralovska, S, Hussain, Z, Butler, M, Pollak, T.A, Koychev, I, Michael, B.D, Holling, H, Nicholson, T.R, Rogers, J.P, Rooney, A.G. Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis. Brain Communications, 4 (1). 2022, Jan.

2021

• Misra, S, Kolappa,K, Prasad,M, Radhakrishnan,D, Thakur,K.T, Solomon,T, Michael,B.D, Winkler,A.S, Beghi,E, Guekht,A, Pardo,C.A, Wood,GK. Chou,S.HY, Fink,E.L, Schmutzhard,E, Kheradmand,A, Hoo,F.K, Kumar,A, Das,A, Srivastava,A.K, Agarwal,A, Dua,T, Prasad, K. Frequency of neurological manifestations in COVID-19: a systematic review and meta-analysis of 350 studies. Neurology 2021 Oct 11. 
• Rogers JP, Watson CJ, Badenoch J, Cross B, Butler M, Song J, Hafeez D, Morrin H, Rengasamy ER, Thomas L, Ralovska S, Smakowski A, Sundaram RD, Hunt CK, Lim MF, Aniwattanapong D, Singh V, Hussain Z, Chakraborty S, Burchill E, Jansen K, Holling H, Walton D, Pollak TA, Ellul M, Koychev I, Solomon T, Michael BD, Nicholson TR, Rooney AG. Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives. J Neurol Neurosurg Psychiatry. 2021 Sep;92(9):932-941.
• Benjamin LA, Paterson RW, Moll R, Pericleous C, Brown R, Mehta PR, Athauda D, Ziff OJ, Heaney J, Checkley AM, Houlihan CF, Chou M, Heslegrave AJ, Chandratheva A, Michael BD, Blennow K, Vivekanandam V, Foulkes A, Mummery CJ, Lunn MP, Keddie S, Spyer MJ, Mckinnon T, Hart M, Carletti F, Jäger HR, Manji H, Zandi MS, Werring DJ, Nastouli E, Simister R, Solomon T, Zetterberg H, Schott JM, Cohen H, Efthymiou M; UCLH Queen Square COVID-19 Biomarker Study group. Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study. EClinicalMedicine. 2021 Aug 12
• Hosoya T, Cordelia D, Michael BD, Miyabe C, Nagai J, Murooka TT and Miyabe Y (2021) Editorial: Targeting the Chemoattractant System in Inflammation. Front. Pharmacol. 12:2122
• Butler M, Tamborska A, Wood GK, Ellul M, Thomas RH, Galea I, Pett S, Singh B, Solomon T, Pollak TA, Michael BD, Nicholson TR. Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder. J Neurol Neurosurg Psychiatry 2021 Aug 6, 0:1–8. 
• Ross Russell AL, Hardwick M, Jeyanantham A, White LM, Deb S, Burnside G, Joy HM, Smith CJ, Pollak TA, Nicholson TR, Davies NWS, Manji H, Easton A, Ray S, Zandi MS, Coles JP, Menon DK, Varatharaj A, McCausland B, Ellul MA, Thomas N, Breen G, Keddie S, Lunn MP, Burn JPS, Quattrocchi G, Dixon L, Rice CM, Pengas G, Salman RAS, Carson A, Joyce EM, Turner MR, Benjamin LA, Solomon T, Kneen R, Pett S, Thomas RH, Michael BD, Galea I, on behalf of the CoroNerve Studies Group. Spectrum, risk factors and outcomes of neurological and psychiatric complications of COVID-19: a UK-wide cross-sectional surveillance study. Brain Communications. 2021 July 22. 3(3)
• Ray, S.T., Abdel-Mannan, O, Sa, M, Fuller, C, Wood, G.K, Psyden, K,Yoong, M, Ramas, S, McCullagh, H, Scott, D, McMahon, M, Thomas, N,Taylor, M,Vollmer, B,Illingworth, M, McCrea, N, Davies, V, Whitehouse, W, Zuberi, S, Guthrie, K, Wassmer, E, Shah, N, Baker, M.R, Tiwary, S, Petropoulos, C, Vlachou, V, Kinali, M, Tan, H.J, Varma, U, Ram, D, Avula, S, Breen, G, Enright, N, Hassell, J, Ross Russell, A.L, Kumar, R, Mulholland, R.E, Pett, S, Galea, I, Thomas, R.H, Lim, M, Hacohen, Y, Solomon, T, Griffiths, M.J, Michael, B.D, Kneen, R and Group, CoroNerve Studies. Neurological manifestations of Covid-19 infection in UK hospitalised children and adolescents: a prospective national cohort study. Lancet Child & Adol Health. 2021 July 14: 5 (9) 631-641.
• Butler, M, Coebergh, J, Safavi, F, Carson, A, Hallett, M, Michael, B.D, Pollak, T.A, Solomon, T, Stone,J, Nicholson,T.R,; on behalf of the Coronerve Studies Group. Functional Neurological Disorder After SARS-CoV-2 Vaccines: Two Case Reports and Discussion of Potential Public Health Implications. Journal Neuropsychiatry & Clin Neurosciences. 2021 July 15.
• Thakur, KT, Tamborska, A , Wood, G.K, McNeil, E, Roh, D, Akpan, I.J, Miller, E.C, Bautista, A, Claassen, J, Kim, C.Y, Guekht, A, Pardo, C.A, Williams, O, Garcia-Azorin, D, Prasad, K, Schmutzhard, E, Michael, B.D, Chou, S.H.Y, Winkler, A.S, Solomon, T, Elkind, M.S. Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions. J Neurological Sciences. 2021 June 4;427:117532.
• Wood GK, Glavin D, Kelly D, McCausland BMS, Ellul MA, Varatharaj A, Galea I, Thomas RH, Gallen B, Michael BD. COVID-19 encephalitis with SARS-CoV-2 detected in cerebrospinal fluid presenting as a stroke mimic. J Stroke Cerebrovasc Dis. 2021 May 30; 30(9):105915.
• Walton D, Spencer DC, Nevitt SJ, Michael BD. Transcranial magnetic stimulation for the treatment of epilepsy. Cochrane Database Syst Rev. 2021 Apr 15;4:CD011025
• Butler, M, Tamborska, A, Wood, G.K, Ellul, M, Thomas, R.H, Galea, I, Pett, S, Solomon, T, Pollak, T, Michael, B.D, Nicholson, T. Defining Causality in Neurological & Neuropsychiatric COVID-19 Vaccine Complications: What Have We Learnt from Current and Previous Vaccination Campaigns? (April 9, 2021) pre-print.
• Beghi E, Michael BD, Solomon T, Westenberg E, Winkler AS; COVID-19 Neuro Research Coalition. Approaches to understanding COVID-19 and its neurological associations. Ann Neurol. 2021 Apr 9
• Winkler AS, Leonardi M, Michael BD, Abd-Allah F, Carroll W, Guekht A; Global COVID-19 Neuro Research Coalition. A WHO resolution on epilepsy and other neurological disorders. Lancet Neurol. 2021 Mar;20(3):171-172.
• Easton A, Michael BD. An extraordinary World Encephalitis Day. Lancet Neurol. 2021 Mar;20(3):172. 
• Hafeez D, Song J, Watson C, Rooney A, Nicholson TR; SARS-COV-neuro collaboration. Increased ethnicity and socioeconomic data collection required in stroke associated with COVID-19. J Neurol Neurosurg Psychiatry. 2021 Mar;92(3):336-337.
• Walton DWA, Thakur KT, Venkatesan A, Breen G, Solomon T, Michael BD. Encephalitis in a Pandemic. Front Neurol. 2021 Feb 10;12:637586.
• Watson CJ, Thomas RH, Solomon T, Michael BD, Nicholson TR, Pollak TA. COVID-19 and psychosis risk: Real or delusional concern? Neurosci Lett. 2021 Jan 10;741:135491.

2020

• Van Den Tooren H, Ellul MA, Davies NW, Easton A, Vincent A, Solomon T, Michael BD; CoroNerve Studies Group. Standing on the shoulders of giants: 100 years of neurology and epidemic infections. J Neurol Neurosurg Psychiatry. 2020 Nov;91(11):1129-1131.
• Varatharaj A, Pollak TA, Nicholson TR, Coles JP, Benjamin LA, Carson A, Thomas RH, Michael BD; study authors. Characterising neuropsychiatric disorders in patients with COVID-19 - Authors' reply. Lancet Psychiatry. 2020 Nov;7(11):934-935.
• Butler M, Pollak TA, Rooney AG, Michael BD, Nicholson TR. Neuropsychiatric complications of covid-19. BMJ. 2020 Oct 13;371
• Varatharaj A, Thomas N, Ellul MA, Davies NWS, Pollak TA, Tenorio EL, Sultan M, Easton A, Breen G, Zandi M, Coles JP, Manji H, Al-Shahi Salman R, Menon DK, Nicholson TR, Benjamin LA, Carson A, Smith C, Turner MR, Solomon T, Kneen R, Pett SL, Galea I, Thomas RH, Michael BD; CoroNerve Study Group. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. Lancet Psychiatry. 2020 Oct;7(10):875-882
• Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, Kneen R, Defres S, Sejvar J, Solomon T. Neurological associations of COVID-19. Lancet Neurol. 2020 Sep;19(9):767-783.
• Michael BD, Bricio-Moreno L, Sorensen EW, Miyabe Y, Lian J, Solomon T, Kurt-Jones EA, Luster AD. Astrocyte- and Neuron-Derived CXCL1 Drives Neutrophil Transmigration and Blood-Brain Barrier Permeability in Viral Encephalitis. Cell Rep. 2020 Sep 15;32(11):108150.
• Mitchell JW, Valdoleiros SR, Jefferson S, Hywel B, Solomon T, Marson AG, Michael BD. Autoimmune encephalitis as an increasingly recognised cause of non-convulsive status epilepticus: A retrospective, multicentre evaluation of patient characteristics and electroencephalography (EEG) results. Seizure. 2020 Aug;80:153-156.
• Ellul M, Varatharaj A, Nicholson TR, Pollak TA, Thomas N, Easton A, Zandi MS, Manji H, Solomon T, Carson A, Turner MR, Kneen R, Galea I, Pett S, Thomas RH, Michael BD; CoroNerve Steering Committee. Defining causality in COVID-19 and neurological disorders. J Neurol Neurosurg Psychiatry. 2020 Aug;91(8):811-812.
• Ellul MA, Wood G, Tooren HVD, Easton A, Babu A, Michael BD. Update on the diagnosis and management of autoimmune encephalitis. Clin Med (Lond). 2020 Jul;20(4):389-392.
• Winkler AS, Knauss S, Schmutzhard E, Leonardi M, Padovani A, Abd-Allah F, Charway-Felli A, Emmrich JV, Umapathi T, Satishchandra P, Hoo FK, Dalmau J, Oreja-Guevara C, Ferreira MLB, Pfausler B, Michael BD, Tagliavini F, Höglinger G, Endres M, Klein C, Hemmer B, Carroll W, Sejvar J, Solomon T. A call for a global COVID-19 Neuro Research Coalition. Lancet Neurol. 2020 Jun;19(6):482-484.

Back to: Neurosciences Research Unit