Photo of Professor Simon Harding

Professor Simon Harding MB ChB, FRCS, FRCOphth, MD

Chair Professor of Clinical Ophthalmology, Head of Department Eye & Vision Sciences

    Research

    Detection, prevention and treatment of retinal diseases

    My research interests are focussed on the early detection and medical management of retinal diseases particularly in relation to diabetic retinopathy and age-related macular degeneration. I lead research programmes in screening and grading, treatment development, imaging, clinical trials and techniques for the assessment of retinal structure and function. I have applied my research experience to the study of the eye in cerebral malaria.
    With colleagues in the Department of Eye and Vision Science I am developing internal and external collaborations in laboratory studies including segmentation and analysis algortims for image analysis of retinal images and the biology of retinal vascular cells.

    Research Grants

    Introducing personalised risk based intervals in screening for diabetic retinopathy: development, implementation and assessment of safety, cost-effectiveness and patient experience.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    April 2016 - March 2017

    Individualised screening for diabetic retinopathy (ISDR) cohort study

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    December 2016 - April 2020

    Malarial retinopathy screening system for improved diagnosis of cerebral malaria

    NATIONAL INSTITUTES OF HEALTH (NIH) (USA)

    June 2014 - May 2016

    OCT in Africa Phase 1

    UNIVERSITY OF LEICESTER (UK)

    January 2016 - June 2017

    Clinical Development of an Ultrasensitive OCT Device to Improve the Management of Eye Disease

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    November 2017 - June 2022

    Clinical Efficacy and Mechanistic Evaluation of Aflibercept for Proliferative Diabetic Retinopathy Clinical Efficacy and Mechanistic Evaluation of Aflibercept for Proliferative Diabetic Retinopathy A Multicentre Phase llb Randomised Active-Controlled Clinical Trial (CLARITY Reading Centre)

    QUEEN'S UNIVERSITY BELFAST (UK)

    August 2014 - June 2018

    Defining Post Ebola Virus Disease Ophthalmic Sequelae and Opportunities for Intervention

    BAYER CORPORATION (USA)

    August 2016 - December 2018

    A virtual trial of follow up in the community setting versus hospital eye clinics in patients with neovascular age-related macular degeneration (nAMD) treated with drugs targeting vascular endothelial growth factor (anti-VEGF drugs) (ECHoES)

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    January 2013 - June 2014

    IVAN:Five year observational follow-up of the IVAN trial cohort: a study of function and morphology

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    October 2015 - February 2018

    Establishing a real time data platform for whole population health research in diabetes and diabetic retinopathy

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    January 2018 - March 2018

    Introducing personalised risk based intervals in screening for diabetic retinopathy: development, implementation and assessment of safety, cost-effectiveness and patient experience (ISDR study)

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    February 2013 - April 2021

    EUROCONDOR

    EUROPEAN COMMISSION

    March 2012 - June 2016

    Transplantation of IPE beneath the neuroretina in ARMD.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    September 2003 - August 2006

    Regulation of proteolysis in the retinal pigment epithelium of the eye and its significance for age-related macular degeneration

    FOUNDATION FOR THE PREVENTION OF BLINDNESS (UK), ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    December 2009 - November 2014

    The Retinal Microvasculature in Cerebral Malaria in African Children

    WELLCOME TRUST (UK)

    January 2011 - May 2015

    Discriminant Function Analysis for Longitudinal Data: Applications in Medical Research (DiALog)

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2014 - September 2017

    A Multicentre Prospective Phase III double-masked Randomised Controlled Non-Inferiority Trial comparing the relative clinical efficacy and cost-effectiveness of intravitreal therapy with bevacizumab (Avastin) vs ranibizumab (Lucentis) vs aflibercept (Eylea) for Central Retinal Vein Occlusion (CRVO). [LEAVO]

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    October 2014 - September 2019

    Early Detection in Macular Disease (EDiMaD)

    DUNHILL MEDICAL TRUST (UK)

    October 2013 - March 2017

    Ultrasensitive OCT Imaging for Eye Disease

    DEPARTMENT OF HEALTH & SOCIAL CARE (UK) (DOH/DHSC/NIHR)

    February 2015 - January 2019

    Development of effective algorithms of deblurring fundus images for improving diagnosis and management of retinal disease

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    February 2010 - January 2013

    Living with age-related macular degeneration treatment

    MACULAR DISEASE SOCIETY (UK)

    October 2010 - May 2012

    Sleep Mask pilot production capability development, and safety trials of a home based treatment and monitoring model as a primary care intervention for Diabetic Retinopathy and Wet Age-Related Macular Degeneration.

    INNOVATE UK (UK)

    July 2012 - July 2015

    Research Collaborations

    Prof Robert Heyderman

    Internal

    collaboration in retinal microvasculature in cerebral malaria in african children with Malawi-Liverpool-Wellcome Clinical Research Programme

    Prof Juan Grunwald

    External: University of Pennsylvania

    collaboration on blood flow in retinal disease

    Prof Marilyn James

    External: University of Nottingham

    health economics in screening for diabetic retinopathy

    Prof Mark Gabbay

    Internal

    Development of programme grant in screening for diabetic retinopathy

    Dr Frans Coenen

    Internal

    trend mining in large datasets in diabetic retinopathy

    Prof Alister Craig

    Internal

    Host parasite interactions in cerebral malaria

    Prof Charles Riva

    External: Universita di Bologna

    Studies of ocular blood flow in neurovascular and retinal disease

    Prof David Wong

    External: Hong Kong University

    Development of joint projects in diabetic retinopathy, age-related macular degeneration, animal research, cell biology, clinical research, epidemiology

    Prof Benedetto Falsini

    External: Università Cattolica del Sacro Cuore

    electrophysiology of the eye in cerebral malaria

    Dr Richard White

    External: Walton Centre for Neurology and Neurosurgery NHS Trust

    optic nerve head blood flow in intracranial hypertension and neurovascular diseases

    Dr Benno Petrig

    External: University of Indiana, Bloomington, Indiana, US

    Ocular blood flow in neurovascular and retinal disease

    Prof Asoke Nandi

    Internal

    image analysis in diabetic retinopathy

    Dr Marta Garcia-Finana

    Internal

    statistical analysis of large datasets in age-related macular degeneration

    Prof Malcolm Molyneux

    Internal

    the eye in cerebral malaria

    Prof Barnaby Reeves

    External: University of Bristol

    Verteporfin Cohort Study and IVAN study - two large multicentre HTA funded clinical trials

    Prof Usha Chakravarthy

    External: University of Belfast

    verteporfin cohort study, IVAN study, two large HTA funded clinical trials

    Prof TerrieTaylor

    External: Michigan State University

    eye in cerebral malaria