luigi

CANCELLED It’s not all in the Head: Characterising the Mechanisms of Action of Antidepressants beyond the Alteration of Neurotransmitters Dynamics

1:00pm - 2:00pm / Monday 30th March 2020 / Venue: LT1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Those interested in Genomes, Systems and Therapeutic Targeting
  • Admission: Free
  • Add this event to my calendar
    (?)

    When you click on "Add this event to my calendar" your browser will download an ics file.

    Microsoft Outlook: Download the file, then you may be able to click on "Save & Close" to save it to your calendar. If that doesn't work go into Outlook, click on the File tab, then on Open, then Import. Select "Import an iCalendar (.ic or vCalendar file (.vcs)" then click on Next. Find the .ics file and click on OK.

    Google Calendar: download the file, then go into your calendar. On the right where it says "Other calendars" click on the arrow icon and then click on Import calendar. Click on Browse and select the .ics file, then click on Import.

    Apple Calendar: download the file, then you can either drag it to Calendar or import the file by going to File > Import > Import and choosing the .ics file.

Speaker: Luigi Margiotta-Casluci (Brunel University, London)

With more than 300 million people affected by major depressive disorder worldwide, the management of depression is rapidly becoming a global healthcare challenge. Up to 50% of patients do not respond to the first line of treatment and there is an urgent need to identify novel pharmacological and non-pharmacological strategies to tackle this condition. Recent research has demonstrated that patients resistant to antidepressants also display higher levels of pro-inflammatory markers and subtle alterations of the immune system. These findings suggest that advancing our understanding of the link between immunity, inflammation, and behaviour may lead to the identification of novel relevant drug targets and improve the efficacy of existing treatments. In this talk, Luigi will present his most recent research, which combines computational biology approaches and the zebrafish model to shed light on the inflammation-behaviour relationship and characterize the intrinsic anti-inflammatory and immunomodulatory properties of antidepressants.