CANCELLED It’s not all in the Head: Characterising the Mechanisms of Action of Antidepressants beyond the Alteration of Neurotransmitters Dynamics

1:00pm - 2:00pm / Monday 30th March 2020 / Venue: LT1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Those interested in Genomes, Systems and Therapeutic Targeting
  • Admission: Free
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Speaker: Luigi Margiotta-Casluci (Brunel University, London)

With more than 300 million people affected by major depressive disorder worldwide, the management of depression is rapidly becoming a global healthcare challenge. Up to 50% of patients do not respond to the first line of treatment and there is an urgent need to identify novel pharmacological and non-pharmacological strategies to tackle this condition. Recent research has demonstrated that patients resistant to antidepressants also display higher levels of pro-inflammatory markers and subtle alterations of the immune system. These findings suggest that advancing our understanding of the link between immunity, inflammation, and behaviour may lead to the identification of novel relevant drug targets and improve the efficacy of existing treatments. In this talk, Luigi will present his most recent research, which combines computational biology approaches and the zebrafish model to shed light on the inflammation-behaviour relationship and characterize the intrinsic anti-inflammatory and immunomodulatory properties of antidepressants.