To Be or Not to Be: Central Role for Chromatin in RNA Quality Control and mRNA Fate in Cancer

1:00pm - 2:00pm / Monday 10th February 2020 / Venue: LT1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Those with an interest in Genomes, Systems and Therapeutic Targeting
  • Admission: Free
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Speaker: Manolis Papamichos-Chronakis (University of Newcastle)

Unproductive transcription by RNA Polymerase II is a frequent event in eukaryotic cells. To prevent abnormal gene expression, mRNAs are undergoing co-transcriptional RNA surveillance and aberrant, non-functional transcripts are prematurely terminated and subsequently eliminated. Eukaryotic DNA is packaged into nucleosomes in which the DNA is wrapped around a histone protein core. While nucleosomes compact the genome and limit access to the genetic material, they also serve as regulatory hubs for signal integration of different cellular processes. Histone post-translational covalent modifications, histone variants and ATP-dependent chromatin remodelling enzymes shape the chromatin landscape of the genome and act as critical regulators of every step of transcription, at initiation, elongation and termination level.

Manolis has been investigating how the structure and regulation of chromatin impacts on productive transcription. His talk will focus on his recent advances on the role of chromatin in orchestrating premature termination of mRNA synthesis, coupling RNA quality control to the transcriptional process. Manolis will further discuss how regulation of co-transcriptional RNA:DNA hybrids known as R-loops by chromatin can promote cancer cell proliferation and viability.