Immune Suppression by Salmonella

4:00pm - 5:00pm / Tuesday 18th February 2020 / Venue: Lecture Theatre 1 Life Sciences Building
Type: Seminar / Category: Research / Series: BEEM Seminar
  • Suitable for: Those with an interest in Behaviour, Evolution, Ecology and Microbiology
  • Admission: Free
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Speaker: David Holden

Strains of Salmonella enterica can cause gastroenteritis and systemic diseases such as typhoid fever. Following bacterial entry into host cells, the pathogen replicates in a membrane-bound compartment called the Salmonella-containing vacuole (SCV). Bacteria use the SPI-2 type III secretion system to translocate approximately 30 virulence proteins (effectors) from the SCV into the host cell.

I will discuss our recent progress on mechanisms used by effectors that suppress both innate and adaptive immune responses and which are likely to contribute to the ability of Salmonella to replicate and persist in host tissues.