John D Scott

Exploring and Exploiting Local Cell Signalling

4:00pm - 5:00pm / Wednesday 23rd October 2019 / Venue: LT1 Life Sciences Building
Type: Seminar / Category: Research
  • Suitable for: Those interested in cell signaling
  • Admission: Free
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Speaker: John D Scott (HHMI, Department of Pharmacology, University of Washington, School of Medicine, Seattle)

Professor John Scott, FRS, is the Edwin G Krebs-Speights Professor of Cell Signalling and Cancer Biology and Chair of the Department of Pharmacology at the University of Washing Medical School, Seattle. A graduate of the University of Aberdeen, John is a biochemist who has made seminal contributions to our understanding of anchoring and scaffold proteins, which are key components in cellular signaling networks. John's research has enabled us to understand several fundamental mechanisms behind the events that control conserved signaling pathways, most notably those that decode the levels of cAMP in cells. In 1992, John discovered (and named) the 'A-kinase anchoring proteins' (AKAPs) and has since demonstrated that many signalling enzymes have a restricted range of motion within macromolecular assemblies. This 'signaling island' concept radically changes our view of how signaling complexes operate and indicates that protein phosphorylation is much more regionally confined than previously appreciated. An important concept emerging from these discoveries is that AKAP-enzyme interfaces are potential targets for disruption of pathological signaling. His lab focuses on modulating kinases and phosphatases within the confines of AKAP nano-compartments.