Actin Dynamics and Mechanosensing in Cancer Invasion and Metastasis
1:00pm - 2:00pm /
Monday 7th October 2019
/ Venue: LT1 Life Sciences Building
- Raphael Levy
- Suitable for: Staff and students with an interest in Genomes, Systems and Therapeutic Targeting
- Admission: Free
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Speaker: Laura Machesky (University of Glasgow)
Actin dynamics drives both cell migration and membrane trafficking and we study how these processes affect invasion and metastasis of cancers such as pancreatic ductal adenocarcinoma. Cancers also often produce dense stiff extracellular matrix that provokes mechanosensing. We find that matrix stiffness affects pancreatic cancer cell mechanoresponses and impacts on the ability of cells to generate and recycle ATP to power invasive migration. We propose that mechanosensing can drive tumour aggressiveness and impact on energy requirements as well as migration capacity.
Actin dynamics drives both cell migration and membrane trafficking and we study how these processes affect invasion and metastasis of cancers such as pancreatic ductal adenocarcinoma. Cancers also often produce dense stiff extracellular matrix that provokes mechanosensing. We find that matrix stiffness affects pancreatic cancer cell mechanoresponses and impacts on the ability of cells to generate and recycle ATP to power invasive migration. We propose that mechanosensing can drive tumour aggressiveness and impact on energy requirements as well as migration capacity.