Actin Dynamics and Mechanosensing in Cancer Invasion and Metastasis

1:00pm - 2:00pm / Monday 7th October 2019 / Venue: LT1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Staff and students with an interest in Genomes, Systems and Therapeutic Targeting
  • Admission: Free
  • Add this event to my calendar
    (?)

    When you click on "Add this event to my calendar" your browser will download an ics file.

    Microsoft Outlook: Download the file, then you may be able to click on "Save & Close" to save it to your calendar. If that doesn't work go into Outlook, click on the File tab, then on Open, then Import. Select "Import an iCalendar (.ic or vCalendar file (.vcs)" then click on Next. Find the .ics file and click on OK.

    Google Calendar: download the file, then go into your calendar. On the right where it says "Other calendars" click on the arrow icon and then click on Import calendar. Click on Browse and select the .ics file, then click on Import.

    Apple Calendar: download the file, then you can either drag it to Calendar or import the file by going to File > Import > Import and choosing the .ics file.

Speaker: Laura Machesky (University of Glasgow)

Actin dynamics drives both cell migration and membrane trafficking and we study how these processes affect invasion and metastasis of cancers such as pancreatic ductal adenocarcinoma. Cancers also often produce dense stiff extracellular matrix that provokes mechanosensing. We find that matrix stiffness affects pancreatic cancer cell mechanoresponses and impacts on the ability of cells to generate and recycle ATP to power invasive migration. We propose that mechanosensing can drive tumour aggressiveness and impact on energy requirements as well as migration capacity.