Developmental Regulation of Condensin Complex Expression, Composition and Function in Mice
1:00pm - 2:00pm /
Monday 18th November 2019
/ Venue: LT1, Life Sciences Building Life Sciences Building
- Urszula McClurg
- Suitable for: Staff and students with an interest in Genomes, Systems and Therapeutic Targeting
- Admission: Free
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Speaker: Andrew Wood (University of Edinburgh)
Mitotic chromosome condensation is driven by two condensin complexes, and has been studied extensively in cultured cells and in vitro. Whether the process by which mitotic chromosomes form changes during mammalian development is less well understood. Andrew previously showed that germline hypomorphic mutations in condensin subunits cause tissue-specific chromosome segregation failure in mice and humans, resulting in developmental diseases and cancer.
In this talk, Simon will describe his recent efforts to characterise the underlying mechanisms using new mouse models with fluorescent protein tags fused to NCAPH and NCAPH2: the rate limiting subunits of condensins I and II. These studies have uncovered previously unappreciated changes in the expression, composition and function of these essential architectural components of mitotic chromosomes during development. Simon proposes that the molecular requirements for efficient mitotic chromosome condensation and segregation can change over different mitotic cell cycles in multicellular organisms.
Mitotic chromosome condensation is driven by two condensin complexes, and has been studied extensively in cultured cells and in vitro. Whether the process by which mitotic chromosomes form changes during mammalian development is less well understood. Andrew previously showed that germline hypomorphic mutations in condensin subunits cause tissue-specific chromosome segregation failure in mice and humans, resulting in developmental diseases and cancer.
In this talk, Simon will describe his recent efforts to characterise the underlying mechanisms using new mouse models with fluorescent protein tags fused to NCAPH and NCAPH2: the rate limiting subunits of condensins I and II. These studies have uncovered previously unappreciated changes in the expression, composition and function of these essential architectural components of mitotic chromosomes during development. Simon proposes that the molecular requirements for efficient mitotic chromosome condensation and segregation can change over different mitotic cell cycles in multicellular organisms.