'Dying or surviving the PERP way: Unexpected facets of apoptosis mechanisms.'

1:00pm - 2:00pm / Friday 19th July 2019 / Venue: William Henry Duncan Apex Building
Type: Seminar / Category: Research / Series: Institute of Ageing & Chronic Disease seminar series
  • 0151 794 9003
  • Suitable for: Staff and students
  • Admission: Free to staff and students
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Speaker: Professor Luminita Paraoan, Eye & Vision Science, University of Liverpool. Investigation of regulatory mechanisms of programmed cell death (apoptosis) is one of the main areas of interest for the Ocular Molecular Biology and Mechanisms of Disease led by Luminita. Following the initial discovery of the role of the p53 apoptosis effector PERP in the pathophysiology of uveal melanoma, the group has unveiled a novel positive feedback loop involving p53/p63 tumour suppressors, cross-talks between extrinsic and intrinsic apoptotic pathways and unexpected involvement of inter-organelles interactions modulating p53 signalling in ocular and non-ocular, normal and cancer cells.