The Pharmacology of Mitochondria and their Social Habits in Health and Disease
1:00pm - 2:00pm /
Monday 29th April 2019
/ Venue: LT1 Life Sciences Building
- Pat Eyers
- Suitable for: Staff and students with an interest in Genomes, Systems and Therapeutic Targeting
- Admission: Free
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Michelangelo Campanella1,2
1Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, UK
2Consortium for Mitochondrial Research, University College London, London, UK
Mitochondria are central to the homeostasis of mammalian cells playing a role which goes beyond the production of energy as they are indeed key to the regulation of programmed cell death and intracellular signalling. Surprisingly though, their pharmacology remains under investigated limiting our capacity to devise innovative therapies to tackle conditions associated with their deregulation such as cancer, metabolic disorders and neurodegeneration. In my talk I shall overview the lines of research pursued to inform the pharmacology of mitochondria in health and disease highlighting our latest work on the interaction we have unveiled with the nucleus which drives the retrograde response.
The elements involved in this route of communication between mitochondria and nucleus will be illustrated together with the approaches we have devised to tackle and revert this mechanism of cellular maladaptation and therapy resistance.
Key words: Mitochondria, Pharmacology, Cholesterol and Therapy Resistance
References:
1. Gatliff J and Campanella M. Biochem J. 2016 Jan 15;473(2):107-2;
2. Strobbe D and Campanella M. Trends Pharmacol Sci. 2018 Mar 30. pii: S0165
6147(18)30046-4;
3. Gatliff, et al. Autophagy 2014 Dec 2;10(12):2279-96;
4. Gatliff J, East D, et al. Cell Death Dis. 2017 Jun 22;8(6):e2896;
5. Georgakopoulos ND et al. Nat Chem Biol. 2017 Jan 19;13(2):136-146.
1Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, UK
2Consortium for Mitochondrial Research, University College London, London, UK
Mitochondria are central to the homeostasis of mammalian cells playing a role which goes beyond the production of energy as they are indeed key to the regulation of programmed cell death and intracellular signalling. Surprisingly though, their pharmacology remains under investigated limiting our capacity to devise innovative therapies to tackle conditions associated with their deregulation such as cancer, metabolic disorders and neurodegeneration. In my talk I shall overview the lines of research pursued to inform the pharmacology of mitochondria in health and disease highlighting our latest work on the interaction we have unveiled with the nucleus which drives the retrograde response.
The elements involved in this route of communication between mitochondria and nucleus will be illustrated together with the approaches we have devised to tackle and revert this mechanism of cellular maladaptation and therapy resistance.
Key words: Mitochondria, Pharmacology, Cholesterol and Therapy Resistance
References:
1. Gatliff J and Campanella M. Biochem J. 2016 Jan 15;473(2):107-2;
2. Strobbe D and Campanella M. Trends Pharmacol Sci. 2018 Mar 30. pii: S0165
6147(18)30046-4;
3. Gatliff, et al. Autophagy 2014 Dec 2;10(12):2279-96;
4. Gatliff J, East D, et al. Cell Death Dis. 2017 Jun 22;8(6):e2896;
5. Georgakopoulos ND et al. Nat Chem Biol. 2017 Jan 19;13(2):136-146.