Dr Michele Madigan, University of New South Wales. 'Emerging from the Darkness: Spotlight on Human Choroidal Melanocytes and Naevi.'

1:00pm - 2:00pm / Wednesday 20th March 2019 / Venue: William Henry Duncan Apex Building
Type: Seminar / Category: Research
  • 0151 794 9003
  • Suitable for: Staff and students
  • Admission: Free to staff and students
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The choroid, ciliary body and iris (uvea) of the eye form a richly pigmented vascular tract between the neural retina and outer sclera, essential for outer retinal function and homeostasis. The pigmented, melanin-producing melanocytes are cranial neural-crest derived and populate a mesodermal microenvironment with distinct extracellular and cellular interactions, compared to the better-known skin melanocytes. The heterogeneously pigmented melanocytes (and melanins) are important fornormal eye physiology including photoprotection, and regulation of oxidative damage and immunological responses. They also display a unique cell biology and gene profile, as do primary uveal naevi (and melanomas). This seminar will highlight current research on human choroidal melanocytes, melanins and choroidal naevi.