Crossing Borders without a Visa: how Trypanosomes Infect and Migrate through the Tsetse

4:00pm - 5:00pm / Tuesday 19th February 2019 / Venue: Lecture Theatre 1 Life Sciences Building
Type: Seminar / Category: Research / Series: BEEM Seminar
  • Suitable for: Staff and students with an interest in Behaviour, Evolution, Ecology and Microbiology
  • Admission: Free
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Speaker: Alvaro Acosta-Serrano (LSTM)

My lab uses a combination of biochemistry, molecular genetics and cell biology to study the interactions between African trypanosomes and tsetse flies. These parasites undergo a complex life cycle in the tsetse that involves migration
through different fly tissues, including crossing of the peritrophic matrix, an acellular membrane that works as a barrier for oral pathogens and harmful molecules present in the blood meal. In the first part of this lecture, I will show microscopy evidence suggesting a novel route by which trypanosomes colonize the tsetse midgut. I will then show recent data on the characterization of a novel trypanosome protein that regulates parasite differentiation and transmissibility by the fly.

Recent submissions related to this talk:
• Rose C, Dyer N, Casas-Sanchez A. et al. bioRxiv, https://doi.org/10.1101/513689
• Casas-Sanchez A. et al. bioRxiv, https://doi.org/10.1101/47773
• Attardo G. et al. bioRxiv, https://doi.org/10.1101/531749