Deep Evolutionary Analyses of Bacterial Pathogens

1:00pm - 2:00pm / Monday 3rd December 2018 / Venue: Lecture Theatre 2 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Staff and students with an interest in Genomes, Systems and Therapeutic Targeting
  • Admission: Free Event
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Speaker: Mark Achtman (Warwick University)

Microevolution within bacterial pathogens is currently being addressed by two distinct areas of research. Comparative genomics of bacteria by epidemiologists and microbiologists has focused predominantly on bacteria from recent outbreaks and epidemics, and extend at most back to the beginnings of bacteriology at the end of the 19th century. Comparative genomics by anthropologists and population geneticists are providing exciting details on ancient DNA over the last few millennia but rarely on DNA from after the 1800s. Few analyses combine original investigations of bacteria across the entire span of their existence.

Recently, I have been developing a framework to support the combination of both areas and to provide a publicly accessible venue for their comparative genomics. EnteroBase [(http://enterobase.warwick.ac.uk/)] contains 100,000s of modern genomes of Salmonella, Escherichia, Yersinia, and Clostridiodes, and has recently been extended to allow the incorporation of reconstructed ancient genomes from metagenomic analyses (SPARSE). This approach has now been implemented for Yersinia pestis, the Para C Lineage of Salmonella enteritidis, and is being extended to the Red Complex from dental calculus.