Mesenchymal Stem Cell-Derived Secretome and Extracellular Vesicles Attenuate Progression of Inflammation and Cartilage Destruction in Inflammatory Arthritis - Oksana Kehoe (Keele University)

12:00pm - 1:00pm / Monday 19th February 2018 / Venue: Lecture Theatre 1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Staff/students with an interest in Genomes, Systems and Therapeutic Targeting
  • Admission: Free
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Rheumatoid arthritis (RA) is a debilitating and painful disorder affecting more than 690,000 people in the UK, with 12,000 new cases diagnosed annually. Novel biological therapies have revolutionised the management of RA. However, up to 30% of RA patients fail to respond to currently available biological therapeutics and 50% of those prescribed the treatment discontinue use after 2 years. It is therefore vital to develop a new, effective therapy for RA. Mesenchymal stem cells (MSCs) possess anti-inflammatory and immunosuppressive properties that may be exploited therapeutically. We have previously demonstrated that intra-articular) injection of MSCs reduces inflammation and cartilage damage in antigen-induced arthritis (AIA). In my presentation, I will discuss data from our lab for the application of MSCs-derived secretome and extracellular vesicles in inflammatory arthritis.