Bacteriophage Genomics: from Seawater to Slurry - Andrew Millard (University of Leicester)

12:00pm - 1:00pm / Monday 5th March 2018 / Venue: Lecture Theatre 1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Staff and students with an interest in Genomes, Systems and Therapeutic Targeting
  • Admission: Free event
  • Add this event to my calendar

    When you click on "Add this event to my calendar" your browser will download an ics file.

    Microsoft Outlook: Download the file, then you may be able to click on "Save & Close" to save it to your calendar. If that doesn't work go into Outlook, click on the File tab, then on Open, then Import. Select "Import an iCalendar (.ic or vCalendar file (.vcs)" then click on Next. Find the .ics file and click on OK.

    Google Calendar: download the file, then go into your calendar. On the right where it says "Other calendars" click on the arrow icon and then click on Import calendar. Click on Browse and select the .ics file, then click on Import.

    Apple Calendar: download the file, then you can either drag it to Calendar or import the file by going to File > Import > Import and choosing the .ics file.

Viruses that infect bacteria (bacteriophages) are the most abundant biological entity on the planet; they can influence global biogeochemical cycles, pathogenicity and bacterial evolution. Despite their importance and small genome size, relatively few bacteriophage genomes have been sequenced, compared to their bacterial hosts.

The vast diversity of bacteriophages results in most genomes containing a high proportion of genes f unknown function. From studying phages present in seawater and cattle slurry, we have begun to uncover the vast diversity of phages and to determine a function for some of the genes they carry. Our work on cyanophages that infect the globally important primary producers Synechococcus and Prochlorococcus have shown they can alter their host's photosynthetic capability and ability to fix CO2. By decoupling C02 fixation from photosynthesis, cyanophage can change their host`s metabolism to provide more energy for phage replication.