Amino Acid-Dependent mTORC1 Signalling; Controlling Stress Responses Both Inside and Outside Cells - Deborah Goberdhan

12:00pm - 1:00pm / Monday 29th January 2018 / Venue: Lecture Theatre 1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Suitable for staff and students with an interest in Genomes, Systems and Therapeutic Targeting
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Cellular growth and metabolism are modulated by amino acids and other microenvironmental factors via the mTORC1 (mechanistic Target of Rapamycin) signalling hub. Proton-assisted amino acid transporters have emerged as key amino acid sensors for mTORC1 control through analysis in fruit flies and human cancer cell lines. I will present data highlighting a role for these sensors in modulating different pools of mTORC1 with specific activities, such as the regulation of small extracellular vesicles, called exosomes, by glutamine sensing. I discuss evidence that modulating these different mTORC1 pools can produce distinct biological outcomes supporting cellular stress responses and driving tumour adaptation.