Research Seminar - Dr Fabien Le Grand - Control of Muscle Stem Cell Fate by Wnt Signalling Pathway(s)
10:00am - 11:00am /
Thursday 30th November 2017
/ Venue: Lecture Theatre 2 Life Sciences Building
Type: Seminar /
Category: Research
- Kelly Welburn
- Suitable for: University Staff and Students
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Regeneration of the adult skeletal muscle tissue relies on a pool of quiescent muscle stem cells located in a niche around the myofibers: the satellite cells (MuSCs). We previously demonstrated that numerous Wnt molecules are secreted in the local milieu during muscle regeneration and showed that MuSC self-renewal is in part controlled by non-canonical Wnt7a/PCP. To elucidate the roles of the canonical Wnt/ß-catenin pathway in MuSCs, we generated mice with inducible MuSC-specific mutations. Mechanistically, we observed that Wnt/ß-catenin signaling orchestrate the cytoplasmic relocalisation of the H3K 9 methyltransferase Setdb1 during differentiation. Taken together, our results demonstrate that both canonical and non-canonical Wnt pathways are necessary for MuSC function.