Sonia Rocha - A Novel Role for the Oxygen Sensing Enzymes PHDs in the Control of the Cell Cycle

1:00pm - 2:00pm / Friday 6th October 2017 / Venue: Lecture Theatre 1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: Staff and students with an interest in Genomes, Systems and Therapeutic Targeting
  • Admission: Free
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Hypoxia Inducible Factor-1 (HIF-1) is essential for mammalian development and is the principal transcription factor activated by low oxygen tensions. HIF-α subunit quantities and their associated activity are regulated in a post-translational manner, through the concerted action of a class of enzymes called Prolyl Hydroxylases and Factor Inhibiting HIF respectively. These enzymes are the cell molecular oxygen sensors. We have been investigating other molecular processes altered by oxygen these include global chromatin structure and the cell cycle. We have found a novel and unexpected role for PHDs in the control of the cell cycle, independent of their role as HIF regulators. Using mass spectrometry we have developed a method for enriching for PHD targets, which will help define the hydroxylated-proteome. Given that this enzymes are targets in the clinic this work would help identify possible effects of long term usage of PHD inhibitors in the humans.