A Platform for Generating and Screening Cyclic Peptide Libraries of Over a Hundred Million Members for Protein-Protein Interaction Inhibitors - Ali Tavassoli (University of Southampton)

1:00pm - 2:00pm / Monday 30th October 2017 / Venue: Lecture Theatre 1 Life Sciences Building
Type: Seminar / Category: Research / Series: GSTT Seminar Series
  • Suitable for: University of Liverpool Staff and Students
  • Admission: No cost
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Ali Tavassoli (University of Southampton).
The main focus of the Tavassoli lab is the identification of cyclic peptide inhibitors of protein-protein interaction using a genetically encoded high-throughput screening platform. The goal is the development of compounds capable of disrupting the association and assembly of protein complexes. The compounds uncovered serve as valuable tools that allow better understanding of the role of individual protein-protein interactions in cells. These compounds also form the starting point for the development of therapeutic compounds that target key protein-protein interactions in disease. Research is focused on training scientists at the chemistry-biology interface, and using these interdisciplinary skills to help understand the fundamentals of cell biology and to develop new therapeutic agents.