Dr Georgina Ellison, Reader in Physiology, King's College London. 'Impact of ageing and senescence on endogenous cardiac stem/progenitor cells in the human heart.' Host: Tori Sprung
12:45pm - 1:45pm /
Friday 18th August 2017
/ Venue: G12 - G15, Ground floor, William Henry Duncan Apex Building
- 0151 794 9003
- Brenda Smith
- Suitable for: My talk will be suitable for biomedical scientists, stem cell scientists, regenerative medicine scientists, and clinicians with an interest in regenerative medicine, especially in the relation to the heart. Staff and students.
- Admission: Free to staff and students
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Short Bio: I am Reader of Physiology and Marie Curie Fellow at King’s College London. My research focuses on understanding the role of tissue-specific stem cells in the homeostasis and regeneration of striated (skeletal and cardiac) muscle, for repair and maintenance of muscle tissue, particularly preventing and treating a loss of muscle mass (i.e. with ageing and/or disease). My research has been at the forefront of pioneering research on adult-derived cardiac stem cells since its inception 15 years ago and has made a seminal contribution in the paradigm shifting work to establish the adult heart as a self-renewing organ with regenerative capacity.
My talk will focus on the impact of ageing and senescence on human eCSCs, and how this influences their myocardial regenerative potential. I will talk about the senescent associated secretory phenotype (SASP) of aged-senescent eCSCs. Finally, I will talk about whether it is possible to rejuvenate the aged-senescent eCSC population, overcome the cell cycle block and return them to the functional pool.
My talk will focus on the impact of ageing and senescence on human eCSCs, and how this influences their myocardial regenerative potential. I will talk about the senescent associated secretory phenotype (SASP) of aged-senescent eCSCs. Finally, I will talk about whether it is possible to rejuvenate the aged-senescent eCSC population, overcome the cell cycle block and return them to the functional pool.