Joseph Burgoyne

Seminar Dr Joseph Burgoyne, St Thomas' Hospital, London. 'A novel redox-dependent mechanism for regulating autophagy.' Host: Malcolm Jackson

12:45pm - 1:45pm / Friday 4th August 2017 / Venue: Ground floor, William Henry Duncan Apex Building
Type: Seminar / Category: Research / Series: Institute of Ageing & Chronic Disease seminar series
  • 0151 794 9003
  • Suitable for: Staff and students
  • Admission: Free to staff and students
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Profile: Joseph Burgoyne is a British Heart Foundation Intermediate Fellow and Associate Lecturer at King’s College London. His research interests include the identification and study of novel redox and autophagic processes within the cardiovascular system.

Abstract: Autophagy is a crucial process in maintaining cellular and tissue function through its ability to remove damaged and dysfunctional proteins and organelles, providing a source of fuel during energy deprivation and removing intracellular pathogens. During aging there is a decline in autophagy that predisposes individuals to increased risk of cardiovascular and neurological disease. Here we have identified a novel process that may explain in part how this catabolic process is lost during aging, due to elevated oxidant formation and oxidation of key autophagy enzymes.