GSTT SEMINAR: Deciphering new secrets of the hypoxia inducible transcription factor
1:00pm - 2:00pm /
Monday 13th February 2017
/ Venue: Lecture Theatre 1 Life Sciences Building
- Dr Violaine See
- Admission: Free
- Book now
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GSTT SEMINAR: Edurne Berra, CICbioGUNe - Title: 'Deciphering new secrets of the hypoxia inducible transcription factor'
Abstract:
The Hypoxia-Inducible transcription Factor (HIF) is the central regulator of the adaptive cellular program in response to limited oxygen availability (hypoxia). In healthy cells, HIF signalling is tightly controlled via the availability of its α-subunit. HIF-α is degraded by the ubiquitin-proteasome system (UPS) in well-oxygenated cells but the protein is stable in hypoxia, dimerises with HIF-β, binds to RCGTG motives (Hypoxia Responsive Elements, HRE) within the regulatory domains of target genes, and transcriptionally drives their expression. HIF-targets involve among many others, genes that enhance glycolysis and metabolic rewiring, angiogenesis and resistance to apoptosis. HIF-α is also stabilised in a variety of cancer cells of different origin due to genetic alterations independently of the present oxygen level. Accordingly, sustained expression of HIF-α in tumours has been associated with higher aggressiveness, migratory and metastasis-initiating potential and therefore worse prognosis.
The research in our group is aimed at deciphering the molecular mechanisms underlying HIF regulation as a major step towards establishing its implications in health and disease, which could open future therapeutic applications. This lecture will cover the most promising data of the research lines we are carrying out in the lab.
Abstract:
The Hypoxia-Inducible transcription Factor (HIF) is the central regulator of the adaptive cellular program in response to limited oxygen availability (hypoxia). In healthy cells, HIF signalling is tightly controlled via the availability of its α-subunit. HIF-α is degraded by the ubiquitin-proteasome system (UPS) in well-oxygenated cells but the protein is stable in hypoxia, dimerises with HIF-β, binds to RCGTG motives (Hypoxia Responsive Elements, HRE) within the regulatory domains of target genes, and transcriptionally drives their expression. HIF-targets involve among many others, genes that enhance glycolysis and metabolic rewiring, angiogenesis and resistance to apoptosis. HIF-α is also stabilised in a variety of cancer cells of different origin due to genetic alterations independently of the present oxygen level. Accordingly, sustained expression of HIF-α in tumours has been associated with higher aggressiveness, migratory and metastasis-initiating potential and therefore worse prognosis.
The research in our group is aimed at deciphering the molecular mechanisms underlying HIF regulation as a major step towards establishing its implications in health and disease, which could open future therapeutic applications. This lecture will cover the most promising data of the research lines we are carrying out in the lab.