Mammary tissue morphogenesis by Integrins and Rac1
12:30pm - 2:00pm /
Tuesday 14th February 2017
/ Venue: Physiology Seminar Room Nuffield Wing
Type: Seminar /
Category: Department
/ Series: Department of Cellular and Molecular Physiology Seminar Series
- Michelle Nelson
- Admission: Free
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Dr Nasreen Akhtar, University of Sheffield will be presenting her seminar, titled Mammary tissue morphogenesis by Integrins and Rac1, on the 14th February 2017.
The Akhtar Lab focuses on how Rho family GTPases and cell-matrix adhesions regulate epithelial polarity and morphogenesis of normal breast tissue and how these signals are subverted in breast cancer. They are studying the mechanisms by which integrin signalling guides tissue morphogenesis at two levels: 1) how integrin adhesions influence epithelial cells to polarize and assemble correctly within tissues to form lumen spaces 2) how integrin mechanoforces engineer epithelial tissue shapes into tubes and alveoli which form the common units of internal organs. The mammary gland provides a useful model to uncover fundamental mechanisms of tissue morphogenesis. This tissue forms a network of branched ducts connected to alveoli with hollow lumens, similar to many other secretory organs. They use Cre-LoxP genetic deletion both in vivo and in primary 3D organoid cultures of mammary epithelia, to unravel the relative contribution of integrins and GTPases to mammary tissue organization and function.
This seminar will take place in the Physiology Seminar Room, Ground Floor, Nuffield Building and will be hosted by Dr Mark Morgan.
Coffee will be served from 12.30pm and the seminar will begin at 1.00pm.
The Akhtar Lab focuses on how Rho family GTPases and cell-matrix adhesions regulate epithelial polarity and morphogenesis of normal breast tissue and how these signals are subverted in breast cancer. They are studying the mechanisms by which integrin signalling guides tissue morphogenesis at two levels: 1) how integrin adhesions influence epithelial cells to polarize and assemble correctly within tissues to form lumen spaces 2) how integrin mechanoforces engineer epithelial tissue shapes into tubes and alveoli which form the common units of internal organs. The mammary gland provides a useful model to uncover fundamental mechanisms of tissue morphogenesis. This tissue forms a network of branched ducts connected to alveoli with hollow lumens, similar to many other secretory organs. They use Cre-LoxP genetic deletion both in vivo and in primary 3D organoid cultures of mammary epithelia, to unravel the relative contribution of integrins and GTPases to mammary tissue organization and function.
This seminar will take place in the Physiology Seminar Room, Ground Floor, Nuffield Building and will be hosted by Dr Mark Morgan.
Coffee will be served from 12.30pm and the seminar will begin at 1.00pm.