IACD Institute meeting & Seminar. Dr Matthew Lancaster. 'Getting old at heart: How microstructural changes can lead to big problems.' Host: Anne McArdle
12:45pm - 1:45pm /
Wednesday 8th February 2017
/ Venue: G12 - G15 Ground floor, William Henry Duncan Building Apex Building
- 0151 794 9003
- Brenda Smith
- Suitable for: Staff and postgraduate students.
- Admission: Free to University staff and students.
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Institute meeting & Seminar.
Dr Matthew Lancaster, University of Leeds. 'Getting old at heart:How microstructural changes can lead to big problems.'
Host: Anne McArdle
Short(ish) biography:
Initially engineering was the big attraction to me, particularly electrical engineering and electronics but having had no previous background in biology I was persuaded by my grandparents next-door neighbour to sign up for A level biology (he was the teacher) and that was that – I was hooked on biology. After A levels I went to Leeds to study physiology and was lucky enough to encounter very enthusiastic physiologists who appeared to be electrical engineers in disguise, thanks to their wealth of electrophysiology and imaging equipment. Two summer placements and a dissertation in cardiac myocyte ion regulation later and I got a place on the new experiment – 4 year PhD schemes funded by the Wellcome Trust in Cellular and Molecular Physiology, as piloted at the University of Liverpool. One year was spent on rotation: learning histology in the veterinary department as well as many molecular biology techniques I’d otherwise avoided up to that point, as well as destroying some of the fastest calcium imaging equipment in the world at that time (it had 16mb of RAM!). It all settled down and cellular cardiology work became my mainstay again looking at disturbances in ionic regulation before moving back to Leeds for postdocs looking at the processes that regulate the pacemaker of the heart. This latter project I took on a bit further and started to look at what happened in old age when the pacemaker begins to fail promoting arrhythmias. I eventually gained a permanent post in Leeds pretending to be an exercise physiologist but still pursuing work investigating ageing of the heart - the reasons age is the single greatest risk factor for heart failure and arrhythmias and essentially what are the best routes to avoid cardiac age being the limit to (healthy) lifespan.
Dr Matthew Lancaster, University of Leeds. 'Getting old at heart:How microstructural changes can lead to big problems.'
Host: Anne McArdle
Short(ish) biography:
Initially engineering was the big attraction to me, particularly electrical engineering and electronics but having had no previous background in biology I was persuaded by my grandparents next-door neighbour to sign up for A level biology (he was the teacher) and that was that – I was hooked on biology. After A levels I went to Leeds to study physiology and was lucky enough to encounter very enthusiastic physiologists who appeared to be electrical engineers in disguise, thanks to their wealth of electrophysiology and imaging equipment. Two summer placements and a dissertation in cardiac myocyte ion regulation later and I got a place on the new experiment – 4 year PhD schemes funded by the Wellcome Trust in Cellular and Molecular Physiology, as piloted at the University of Liverpool. One year was spent on rotation: learning histology in the veterinary department as well as many molecular biology techniques I’d otherwise avoided up to that point, as well as destroying some of the fastest calcium imaging equipment in the world at that time (it had 16mb of RAM!). It all settled down and cellular cardiology work became my mainstay again looking at disturbances in ionic regulation before moving back to Leeds for postdocs looking at the processes that regulate the pacemaker of the heart. This latter project I took on a bit further and started to look at what happened in old age when the pacemaker begins to fail promoting arrhythmias. I eventually gained a permanent post in Leeds pretending to be an exercise physiologist but still pursuing work investigating ageing of the heart - the reasons age is the single greatest risk factor for heart failure and arrhythmias and essentially what are the best routes to avoid cardiac age being the limit to (healthy) lifespan.