GSTT SEMINAR: Prof Roberto Mayor, University College London - Title: 'Neural crest migration as a model of cell invasion during development'
1:00pm - 2:00pm /
Monday 21st November 2016
/ Venue: Lecture Theatre 1 Life Sciences Building
- Violaine See
- Admission: Free
- Book now
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Collective cell migration has a key role during morphogenesis, during wound healing and tissue renewal in the adult, and it is involved in cancer spreading. In addition to displaying a coordinated migratory behaviour, collectively migrating cells move more efficiently than if they migrated separately, which indicates that cellular interplay occurs during collective cell migration. Here we will discuss the cellular and molecular basis of neural crest collective cell migration, an embryonic cell population whose invasive behaviour has been likened to cancer metastasis. We showed that each neural crest cell sense their neighbours by a combination of transient cell-cell adhesion and short range chemotaxis. The interaction with its neighbours leads to cell repolarization, which is at the basis of collective cell migration. We will discuss how leader cells at the front of cell groups drive migration by generating polarized forces and how the follower cells improve the efficiency of collective movement by producing contractile forces. Finally, we will present a mathematical model that integrates the behaviour of individual cells to generate an efficient directional collective cell migration of neural crest.